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Prof. Dr. Matthias Mann
Prof. Dr. Matthias Mann
Director
Phone:+49 89 8578-2557Fax:+49 89 8578-2412
Email:mmann@...

MPI of Biochemistry

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Department of Proteomics and Signal Transduction

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Matthias Mann Lab

 

ABOUT US

The department of Proteomics and Signal Transduction is headed by Prof. Matthias Mann and was established in 2005. Matthias Mann is the highest cited German researcher with an h-index of more than 200 and more than 200,000 citations (google scholar). The Mann lab is a leader in the technology and application of mass spectrometry-based proteomics and has been at the forefront of the field  for over two decades. In addition to his group at the Max Planck Institute of Biochemistry, Matthias Mann is the director of the proteomics program at the Novo Nordisk Foundation Center for Protein Research (NNF-CPR) in Copenhagen where he also leads the (clinical proteomics group). We are a highly collaborative team and involved in a large number of international projects including the MSmed EU project, the ERC Synergy Grant ToPAG, Michael J. Fox Foundation for Parkinson’s Research projects, and Digimed Bayern.

NEWS

Systematic proteomic analysis

Eavesdropping on Immune Cells

BoxCar acquisition

A protein atlas of the brain

Multi-level Proteomics

Social network architecture 



Molecular & Cellular Proteomics February 12, 2019, mcp.TIR118.001131; https://doi.org/10.1074/mcp.TIR118.001131Christoph Wichmann, Florian Meier, Sebastian Virreira Winter, Andreas-David Brunner, Jürgen Cox and Matthias Mann

MaxQuant.Live enables global targeting of more than 25,000 peptides

Molecular & Cellular Proteomics February 12, 2019, mcp.TIR118.001131; https://doi.org/10.1074/mcp.TIR118.001131

Christoph Wichmann, Florian Meier, Sebastian Virreira Winter, Andreas-David Brunner, Jürgen Cox and Matthias Mann
Cell Systems 7, Open Access - Published: December 5, 2018 - DOI:https://doi.org/10.1016/j.cels.2018.10.012  Nicolai J. Wewer Albrechtsen, Philipp E. Geyer, Sophia Doll, Peter V. Treit, Kirstine N. Bojsen-Møller, Christoffer Martinussen, Nils B. Jørgensen, Signe S. Torekov, Florian Meier, Lili Niu, Alberto Santos, Eva C. Keilhauer, Jens J. Holst, Sten Madsbad, Matthias Mann

Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery

Cell Systems 7, Open Access - Published: December 5, 2018 - DOI:https://doi.org/10.1016/j.cels.2018.10.012 

Nicolai J. Wewer Albrechtsen, Philipp E. Geyer, Sophia Doll, Peter V. Treit, Kirstine N. Bojsen-Møller, Christoffer Martinussen, Nils B. Jørgensen, Signe S. Torekov, Florian Meier, Lili Niu, Alberto Santos, Eva C. Keilhauer, Jens J. Holst, Sten Madsbad, Matthias Mann [more]
bioRxiv preprint first posted online Nov. 30, 2018; doi: http://dx.doi.org/10.1101/478305. Philipp Emanuel Geyer, Eugenia Voytik, Peter V. Treit, Sophia Doll, Alisa Kleinhempel, Lili Niu, Johannes Bruno Mueller, Jakob Bader, Daniel Teupser, Lesca Miriam Holdt, Matthias Mann

Plasma proteome profiling to detect and avoid sample-related biases in biomarker studies

bioRxiv preprint first posted online Nov. 30, 2018; doi: http://dx.doi.org/10.1101/478305.

Philipp Emanuel Geyer, Eugenia Voytik, Peter V. Treit, Sophia Doll, Alisa Kleinhempel, Lili Niu, Johannes Bruno Mueller, Jakob Bader, Daniel Teupser, Lesca Miriam Holdt, Matthias Mann [more]
The Human Gut-Liver-Axis in Health and Disease pp 165-193 Niu L, Geyer P, Mann M

Proteomics in the Study of Liver Diseases

The Human Gut-Liver-Axis in Health and Disease pp 165-193
Niu L, Geyer P, Mann M [more]
PNAS October 23, 2018 115 (43) 10820-10823; https://doi.org/10.1073/pnas.1816320115S. Porsdam Mann, Y. Donders, C. Mitchell, V. J. Bradley, M. F. Chou, M. Mann, G. Church, and H. Porsdam

Opinion: Advocating for science progress as a human right

PNAS October 23, 2018 115 (43) 10820-10823; https://doi.org/10.1073/pnas.1816320115

S. Porsdam Mann, Y. Donders, C. Mitchell, V. J. Bradley, M. F. Chou, M. Mann, G. Church, and H. Porsdam [more]
Dev Cell. 2018 Oct 22;47(2):205-221.e7. doi: 10.1016/j.devcel.2018.09.017. Krahmer N, Najafi B, Schueder F, Quagliarini F, Steger M, Seitz S, Kasper R, Salinas F, Cox J, Uhlenhaut NH, Walther TC, Jungmann R, Zeigerer A, Borner GHH, Mann M. [Preview]

Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis

Dev Cell. 2018 Oct 22;47(2):205-221.e7. doi: 10.1016/j.devcel.2018.09.017.

Krahmer N, Najafi B, Schueder F, Quagliarini F, Steger M, Seitz S, Kasper R, Salinas F, Cox J, Uhlenhaut NH, Walther TC, Jungmann R, Zeigerer A, Borner GHH, Mann M.

[Preview] [more]
Cell. 2018 Sep 20;175(1):159-170.e16. doi: 10.1016/j.cell.2018.08.065. Coscia F, Lengyel E, Duraiswamy J, Ashcroft B, Bassani-Sternberg M, Wierer M, Johnson A, Wroblewski K, Montag A, Yamada SD, López-Méndez B, Nilsson J, Mund A, Mann M, Curtis M.

Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer.

Cell. 2018 Sep 20;175(1):159-170.e16. doi: 10.1016/j.cell.2018.08.065.

Coscia F, Lengyel E, Duraiswamy J, Ashcroft B, Bassani-Sternberg M, Wierer M, Johnson A, Wroblewski K, Montag A, Yamada SD, López-Méndez B, Nilsson J, Mund A, Mann M, Curtis M. [more]
Nature Protocols | Published: 06 September 2018http://dx.doi.org/10.1038/s41596-018-0014-9Sean J. Humphrey, Ozge Karayel, David E. James and Matthias Mann

High-throughput and high-sensitivity phosphoproteomics with the EasyPhos platform

Nature Protocols | Published: 06 September 2018
http://dx.doi.org/10.1038/s41596-018-0014-9

Sean J. Humphrey, Ozge Karayel, David E. James and Matthias Mann [more]
Science 22 Jun 2018: Vol. 360, Issue 6395, eaao4927,DOI: 10.1126/science.aao4927[Full text]Jeffrey J. Liu, Kirti Sharma, Luca Zangrandi, Chongguang Chen, Sean J. Humphrey, Yi-Ting Chiu, Mariana Spetea, Lee-Yuan Liu-Chen, Christoph Schwarzer, Matthias Mann 

In vivo brain GPCR signaling elucidated by phosphoproteomics


Science 22 Jun 2018: Vol. 360, Issue 6395, eaao4927,DOI: 10.1126/science.aao4927
[Full text]

Jeffrey J. Liu, Kirti Sharma, Luca Zangrandi, Chongguang Chen, Sean J. Humphrey, Yi-Ting Chiu, Mariana Spetea, Lee-Yuan Liu-Chen, Christoph Schwarzer, Matthias Mann 
Sophia Doll, Maximilian C. Kriegmair, Alberto Santos, Michael Wierer, Fabian Coscia, Helen Michele Neil, Stefan Porubsky, Philipp E. Geyer, Andreas Mund, Philipp Nuhn, Matthias Mann

Rapid proteomic analysis for solid tumors reveals LSD1 as a drug target in an end‐stage cancer patient

Sophia Doll, Maximilian C. Kriegmair, Alberto Santos, Michael Wierer, Fabian Coscia, Helen Michele Neil, Stefan Porubsky, Philipp E. Geyer, Andreas Mund, Philipp Nuhn, Matthias Mann [more]
Molecular & Cellular Proteomics November 1, 2018, mcp.TIR118.000900; https://doi.org/10.1074/mcp.TIR118.000900 Florian Meier, Andreas-David Brunner, Scarlet Koch, Heiner Koch, Markus Lubeck, Michael Krause, Niels Goedecke, Jens Decker, Thomas Kosinski, Melvin A Park, Nicolai Bache, Ole Hoerning, Juergen Cox, Oliver Raether, Matthias Mann

Online parallel accumulation − serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer

Molecular & Cellular Proteomics November 1, 2018, mcp.TIR118.000900; https://doi.org/10.1074/mcp.TIR118.000900

Florian Meier, Andreas-David Brunner, Scarlet Koch, Heiner Koch, Markus Lubeck, Michael Krause, Niels Goedecke, Jens Decker, Thomas Kosinski, Melvin A Park, Nicolai Bache, Ole Hoerning, Juergen Cox, Oliver Raether, Matthias Mann

A novel LC system embeds analytes in pre-formed gradients for rapid, ultra-robust proteomics

Nicolai Bache, Philipp E. Geyer, Dorte B. Bekker-Jensen, Ole Hoerning, Lasse Falkenby, Peter V. Treit, Sophia Doll, Igor Paron, Florian Meier, Jesper V. Olsen, Ole Vorm, Matthias Mann [more]
Nature Methods (2018) doi:10.1038/s41592-018-0003-5 Meier F, Geyer PE, Winter SV, Cox J & Mann M

BoxCar acquisition method enables single-shot proteomics at a depth of 10,000 proteins in 100 minutes

Nature Methods (2018) doi:10.1038/s41592-018-0003-5

Meier F, Geyer PE, Winter SV, Cox J & Mann M [more]
Elife. 2017 Nov 10;6. pii: e31012. doi: 10.7554/eLife.31012. Steger M, Diez F, Dhekne HS, Lis P, Nirujogi RS, Karayel O, Tonelli F, Martinez TN, Lorentzen E, Pfeffer SR, Alessi DR, Mann M.

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

Elife. 2017 Nov 10;6. pii: e31012. doi: 10.7554/eLife.31012.

Steger M, Diez F, Dhekne HS, Lis P, Nirujogi RS, Karayel O, Tonelli F, Martinez TN, Lorentzen E, Pfeffer SR, Alessi DR, Mann M.

A Primer on Concepts and Applications of Proteomics in Neuroscience

Neuron Volume 96, Issue 3, 1 November 2017, Pages 558–571;
https://doi.org/10.1016/j.neuron.2017.09.025

Fabian Hosp and Matthias Mann [more]
schoolar.google.com pnas.org

First German researcher, Matthias Mann, has reached an h-index higher than 200 - Congrats!

schoolar.google.com
pnas.org

Matthias Mann talks about clinical proteomics in interview with Evosep Biosystems

Cell Rep. 2017 Jun 13;19(11):2396-2409. doi: 10.1016/j.celrep.2017.05.054. Murgia M, Toniolo L, Nagaraj N, Ciciliot S, Vindigni V, Schiaffino S, Reggiani C, Mann M. Highlights •Single-fiber proteomic analysis of human muscle aging •Oxidative phosphorylation decreases similarly in slow and fast fibers •Enzymes of carbohydrate metabolism increase in slow and decrease in fast aging fibers •Proteomics elucidates why fast fibers age more rapidly than slow ones

Single Muscle Fiber Proteomics Reveals Fiber-Type-Specific Features of Human Muscle Aging

Cell Rep. 2017 Jun 13;19(11):2396-2409. doi: 10.1016/j.celrep.2017.05.054.

Murgia M, Toniolo L, Nagaraj N, Ciciliot S, Vindigni V, Schiaffino S, Reggiani C, Mann M.

Highlights
•Single-fiber proteomic analysis of human muscle aging
•Oxidative phosphorylation decreases similarly in slow and fast fibers
•Enzymes of carbohydrate metabolism increase in slow and decrease in fast aging fibers
•Proteomics elucidates why fast fibers age more rapidly than slow ones
Bekker-Jensen et al. show that proteomics can now provide an essentially complete HeLa proteome. They provide measurements acquired simultaneously for more than 12,200 protein-coding genes, 10,000 phosphorylation sites, and 7,000 N-acetylation sites. Their approach is fast, accessible, and requires modest amounts of starting material, making it easily extendable to other human cell lines and patient samples. - Bekker-Jensen et al., 2017, Cell Systems 4, 1–13 June 28, 2017

Novo Nordisk Foundation Center for Protein Research

Olsen Group defines the HeLa cell proteome

Bekker-Jensen et al. show that proteomics can now provide an essentially complete HeLa proteome. They provide measurements acquired simultaneously for more than 12,200 protein-coding genes, 10,000 phosphorylation sites, and 7,000 N-acetylation sites. Their approach is fast, accessible, and requires modest amounts of starting material, making it easily extendable to other human cell lines and patient samples. - Bekker-Jensen et al., 2017, Cell Systems 4, 1–13 June 28, 2017
“Matthias Mann, former Group Leader in EMBL’s Instrumentation Programme (1992-1998), has been selected as the 2017 Lennart Philipson Award winner for his pioneering work in the field of mass spectrometry-based proteomics. Matthias has contributed breakthroughs that have revolutionised proteomics techniques in biomedical laboratories around the world. His contributions include the “peptide sequence tag” approach which allows proteins to be computationally identified by the fragment spectra; nanoelectrospray which allows minute quantities of protein to be tested; and methods for analysing proteins after extracting them from gels."

EMBL Alumni Award 2017
Matthias Mann winner of Lennart Philipson Award

“Matthias Mann, former Group Leader in EMBL’s Instrumentation Programme (1992-1998), has been selected as the 2017 Lennart Philipson Award winner for his pioneering work in the field of mass spectrometry-based proteomics.

Matthias has contributed breakthroughs that have revolutionised proteomics techniques in biomedical laboratories around the world. His contributions include the “peptide sequence tag” approach which allows proteins to be computationally identified by the fragment spectra; nanoelectrospray which allows minute quantities of protein to be tested; and methods for analysing proteins after extracting them from gels."
Jan C Rieckmann, Roger Geiger, Daniel Hornburg, Tobias Wolf, Ksenya Kveler, David Jarrossay, Federica Sallusto, Shai S Shen-Orr, Antonio Lanzavecchia, Matthias Mann & Felix Meissner Immune cells give rise to the most interconnected system in the body. Here, we perform comprehensive proteomics and secretomics (http://immprot.org/) to describe in detail the 'social network' of human immune cells and throw light on novel cell connectivities

Social network architecture of human immune cells unveiled by quantitative proteomics

Jan C Rieckmann, Roger Geiger, Daniel Hornburg, Tobias Wolf, Ksenya Kveler, David Jarrossay, Federica Sallusto, Shai S Shen-Orr, Antonio Lanzavecchia, Matthias Mann & Felix Meissner

Immune cells give rise to the most interconnected system in the body. Here, we perform comprehensive proteomics and secretomics (http://immprot.org/) to describe in detail the 'social network' of human immune cells and throw light on novel cell connectivities
Cell Metabolism 25, 1–10January 10, 2017 ª 2016 Elsevier Inc. Robles MS, Humphrey SJ, Mann M.

Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology

Cell Metabolism 25, 1–10January 10, 2017 ª 2016 Elsevier Inc.

Robles MS, Humphrey SJ, Mann M.

NATURE | INSIGHT | REVIEW

Mass-spectrometric exploration of proteome structure and function

Ruedi Aebersold & Matthias Mann

Nature 537, 347–355 (15 September 2016) doi:10.1038/nature19949
Received 11 January 2016 Accepted 15 July 2016 Published online 14 September 2016
Nat Commun. 2016 Aug 26;7:12645. doi: 10.1038/ncomms12645. Coscia F, Watters KM, Curtis M, Eckert MA, Chiang CY, Tyanova S, Montag A, Lastra RR, Lengyel E, Mann M.

Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status

Nat Commun. 2016 Aug 26;7:12645. doi: 10.1038/ncomms12645.

Coscia F, Watters KM, Curtis M, Eckert MA, Chiang CY, Tyanova S, Montag A, Lastra RR, Lengyel E, Mann M.
Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):E1673-82. doi: 10.1073/pnas.1519650113. Epub 2016 Feb 9. Neufeld-Cohen A, Robles MS, Aviram R, Manella G, Adamovich Y, Ladeuix B, Nir D, Rousso-Noori L, Kuperman Y, Golik M, Mann M, Asher G Highlighted at www.pnas.org

Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):E1673-82. doi: 10.1073/pnas.1519650113. Epub 2016 Feb 9.

Neufeld-Cohen A, Robles MS, Aviram R, Manella G, Adamovich Y, Ladeuix B, Nir D, Rousso-Noori L, Kuperman Y, Golik M, Mann M, Asher G

Highlighted at www.pnas.org

cell systems, Volume 2, Issue 3, p185–195, 23 March 2016 Geyer et al. Preview

Cell Systems: featured article

Plasma Proteome Profiling to Assess Human Health and Disease

cell systems, Volume 2, Issue 3, p185–195, 23 March 2016
Geyer et al.

Preview

Cell Systems, Volume 2, Issue 3, p142-143, 23 March 2016Sacco et al.

Deep Proteomics of Breast Cancer Cells Reveals that Metformin Rewires Signaling Networks Away from a Pro-growth State

Cell Systems, Volume 2, Issue 3, p142-143, 23 March 2016

Sacco et al.
Identification of bona fide and verifiable substrates of the Parkinson’s disease kinase LRRK2 has eluded researchers for over ten years and was considered as one of the greatest challenges in the field. Using phosphoproteomics, we identified and validated Rab GTPases as key physiological LRRK2 substrates. Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases eLife, January 28, 2016 http://dx.doi.org/10.7554/eLife.12813 Steger, M et al. Press Release Dispatch in Current Biology Comment in Movement Disorders

Breakthrough in Parkinson’s Research

Identification of bona fide and verifiable substrates of the Parkinson’s disease kinase LRRK2 has eluded researchers for over ten years and was considered as one of the greatest challenges in the field. Using phosphoproteomics, we identified and validated Rab GTPases as key physiological LRRK2 substrates.




Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases

eLife, January 28, 2016
http://dx.doi.org/10.7554/eLife.12813

Steger, M et al.

Press Release
Dispatch in Current Biology
Comment in Movement Disorders

Her Majesty the Queen of Denmark recognizes Matthias for his outstanding contribution to mankind in general, and science in particular.

Matthias Mann receives The Order of Dannebrog Knights Cross

Her Majesty the Queen of Denmark recognizes Matthias for his outstanding contribution to mankind in general, and science in particular. [more]

Matthias Mann awarded Inaugural Barry L. Karger Medal on October 16, 2015 at Northeastern University, Boston , US.

the Medal is a biennial award recognizing an individual who has significantly contributed to the development of new bioanalytical methods. [more]
J. Proteome Res., November 5, 2015 Meier F, Beck S, Grassl N, Lubeck M, Park MA, Raether O, Mann M.

Parallel accumulation – serial fragmentation (PASEF): Multiplying sequencing speed and sensitivity by synchronized scans in a trapped ion mobility device

J. Proteome Res., November 5, 2015

Meier F, Beck S, Grassl N, Lubeck M, Park MA, Raether O, Mann M.
Nat Neurosci. 2015 Nov 2. doi: 10.1038/nn.4160 Sharma K, Schmitt S, Bergner CG, Tyanova S, Kannaiyan N, Manrique-Hoyos N, Kongi K, Cantuti L, Hanisch UK, Philips MA, Rossner MJ, Mann M, Simons M   Press Release

Cell type– and brain region–resolved mouse brain proteome

Nat Neurosci. 2015 Nov 2. doi: 10.1038/nn.4160

Sharma K, Schmitt S, Bergner CG, Tyanova S, Kannaiyan N, Manrique-Hoyos N, Kongi K, Cantuti L, Hanisch UK, Philips MA, Rossner MJ, Mann M, Simons M

 

Press Release

Cell 163(3):712-23 (2015). doi: 10.1016/j.cell.2015.09.053 Marco Y. Hein, Nina C. Hubner, Ina Poser, Jürgen Cox, Nagarjuna Nagaraj, Yusuke Toyoda, Igor A. Gak, Ina Weisswange, Jörg Mansfeld, Frank Buchholz, Anthony A. Hyman & Matthias Mann   Press Release Research Highlight in Nature Reviews Molecular Cell Biology

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

Cell 163(3):712-23 (2015). doi: 10.1016/j.cell.2015.09.053

Marco Y. Hein, Nina C. Hubner, Ina Poser, Jürgen Cox, Nagarjuna Nagaraj, Yusuke Toyoda, Igor A. Gak, Ina Weisswange, Jörg Mansfeld, Frank Buchholz, Anthony A. Hyman & Matthias Mann

 

Press Release

Research Highlight in Nature Reviews Molecular Cell Biology

Nat Biotechnol. 2015 Aug 17. doi: 10.1038/nbt.3327.Humphrey SJ, Azimifar SB, Mann M.   Press Release Nature Biotechnology | NEWS AND VIEWS

High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics

Nat Biotechnol. 2015 Aug 17. doi: 10.1038/nbt.3327.

Humphrey SJ, Azimifar SB, Mann M.

 

Press Release

Nature Biotechnology | NEWS AND VIEWS

Mol Cell Proteomics. 2015 Jul;14(7):2014-29. doi: 10.1074/mcp.M114.047407.Beck S, Michalski A, Raether O, Lubeck M, Kaspar S, Goedecke N, Baessmann C, Hornburg D, Meier F, Paron I, Kulak NA, Cox J, Mann M

The Impact II, a Very High-Resolution Quadrupole Time-of-Flight Instrument (QTOF) for Deep Shotgun Proteomics

Mol Cell Proteomics. 2015 Jul;14(7):2014-29. doi: 10.1074/mcp.M114.047407.

Beck S, Michalski A, Raether O, Lubeck M, Kaspar S, Goedecke N, Baessmann C, Hornburg D, Meier F, Paron I, Kulak NA, Cox J, Mann M
Molecular Systems Biology, July 6, 2015H.B. Schiller, I.E. Fernandez, G. Burgstaller, C. Schaab, R.A. Scheltema, T. Schwarzmayr, T.M. Strom, O. Eickelberg and M. Mann

Time- and compartment-resolved proteome profiling of the extracellular niche in lung injury and repair

Molecular Systems Biology, July 6, 2015

H.B. Schiller, I.E. Fernandez, G. Burgstaller, C. Schaab, R.A. Scheltema, T. Schwarzmayr, T.M. Strom, O. Eickelberg and M. Mann [more]
Mol Cell Proteomics. 2015 Apr 17. Hosp F, Scheltema RA, Eberl C, Kulak NA, Keilhauer EC, Mayr K, Mann M.

A double-barrel LC-MS/MS system to quantify 96 interactomes per day

Mol Cell Proteomics. 2015 Apr 17.

Hosp F, Scheltema RA, Eberl C, Kulak NA, Keilhauer EC, Mayr K, Mann M. [more]
Cell, May 7, 2015 DOI: 10.1016/j.cell.2015.03.032 Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU.

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

Cell, May 7, 2015 DOI: 10.1016/j.cell.2015.03.032

Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU.
Science 1 May 2015Räschle M, Smeenk G, Hansen RK, Temu T, Oka Y, Hein MY, Nagaraj N, Long DT, Walter JC, Hofmann K, Storchova Z, Cox J, Bekker-Jensen S, Mailand N, Mann M

Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

Science 1 May 2015

Räschle M, Smeenk G, Hansen RK, Temu T, Oka Y, Hein MY, Nagaraj N, Long DT, Walter JC, Hofmann K, Storchova Z, Cox J, Bekker-Jensen S, Mailand N, Mann M
EMBO Rep. 2015 Feb 2Murgia M, Nagaraj N, Deshmukh AS, Zeiler M, Cancellara P, Moretti I, Reggiani C, Schiaffino S, Mann M

Single muscle fiber proteomics reveals unexpected mitochondrial specialization

EMBO Rep. 2015 Feb 2

Murgia M, Nagaraj N, Deshmukh AS, Zeiler M, Cancellara P, Moretti I, Reggiani C, Schiaffino S, Mann M
Mol Cell Proteomics (2015)Bassani-Sternberg M, Pletscher-Frankild S, Jensen LJ, Mann M

Mass spectrometry of HLA-I peptidomes reveals strong effects of protein abundance and turnover on antigen presentation

Mol Cell Proteomics (2015)

Bassani-Sternberg M, Pletscher-Frankild S, Jensen LJ, Mann M

[more]

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Cell-Type-Resolved Quantitative Proteomics of Murine Liver

Cell Metabolism

S. Babak Azimifar, Nagarjuna Nagaraj, Juergen Cox, Matthias Mann

Image: Max Iglesias

Molecular Cell (2014)Christian Benda, Judith Ebert, Richard A. Scheltema, Herbert B. Schiller, Marc Baumgärtner, Fabien Bonneau, Matthias Mann, Elena Conti

Structural Model of a CRISPR RNA-Silencing Complex Reveals the RNA-Target Cleavage Activity in Cmr4

Molecular Cell (2014)

Christian Benda, Judith Ebert, Richard A. Scheltema, Herbert B. Schiller, Marc Baumgärtner, Fabien Bonneau, Matthias Mann, Elena Conti

[more]
MCP (2014) Richard Alexander Scheltema,  Jan-Peter Hauschild, Oliver Lange, Daniel Hornburg, Eduard Denisov, Eugen Damoc, Andreas Kuehn, Alexander Makarov and Matthias Mann  

The Q Exactive HF, a Benchtop Mass Spectrometer with a Pre-filter, High Performance Quadrupole and an Ultra-High Field Orbitrap Analyzer

MCP (2014)


Richard Alexander Scheltema,  Jan-Peter Hauschild, Oliver Lange, Daniel Hornburg, Eduard Denisov, Eugen Damoc, Andreas Kuehn, Alexander Makarov and Matthias Mann

 

[more]
Cell Reports (2014)Kirti Sharma, Rochelle C.J. D’Souza, Stefka Tyanova, Christoph Schaab, Jacek R. Wisniewski, Juergen Cox and Matthias Mann

Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling

Cell Reports (2014)

Kirti Sharma, Rochelle C.J. D’Souza, Stefka Tyanova, Christoph Schaab, Jacek R. Wisniewski, Juergen Cox and Matthias Mann

[more]
 
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