Rubén Fernández-Busnadiego CV

Academic Education

2010 Doctor. Rer. Nat., Technical University of Munich, Germany

M. Sc. (Licenciado) in Physics, Universidad Complutense de Madrid, Spain


Professional Experience

2013-Present Project Group Leader, Max Planck Institute of Biochemistry, Martinsried, Germany
2011-2013 Postdoctoral Fellow, Yale University School of Medicine, New Haven, CT, USA
2010-2011 Postdoctoral Fellow, Max Planck Institute of Biochemistry, Martinsried, Germany
2005-2010 Graduate Student, Max Planck Institute of Biochemistry, Martinsried, Germany
2005 Trainee, University of Leiden, The Netherlands
2003-2004 Master Student, Universidad Complutense de Madrid / Universidad Politécnica de Madrid, Spain


Awards and Fellowships


FEBS Anniversary Prize 2017

2011-2013 Feodor Lynen Postdoctoral Fellowship, Alexander von Humboldt Foundation
2010 Junior Investigator Award, Max Planck Institute of Biochemistry
2003 Research Fellowship, Spanish Ministry of Education



A. Gruber, D. Hornburg, M. Antonin, N. Krahmer, J. Collado, M. Schaffer, G. Zubaite, C. Lüchtenborg, T. Sachsenheimer, B. Brügger, M. Mann, W. Baumeister, F.U. Hartl, M.S. Hipp and R. Fernández-Busnadiego. Molecular and structural architecture of polyQ aggregates in yeast. PNAS (2018), 115(15): E3446-E3453. PubMed

Q. Guo, B. Huang, J. Cheng, M. Seefelder, T. Engler, G. Pfeifer, P. Oeckl, M. Otto, F. Moser, M. Maurer, A. Pautsch, W. Baumeister, R. Fernández-Busnadiego* and S. Kochanek. The cryo-EM structure of huntingtin. Nature (2018), 555(7694): 117-120. *Co-corresponding author. PubMed

Q. Guo, C. Lehmer, A. Martínez-Sánchez, T. Rudack, F. Beck, H. Hartmann, M.S. Hipp, F.U. Hartl, D. Edbauer and W. Baumeister and R. Fernández-Busnadiego. In situ structure of neuronal C9orf72 poly-GA aggregates reveals proteasome recruitment. Cell (2018), 172(4): 696-705. PubMed

F.J. Bäuerlein, I. Saha, A. Mishra, M. Kalemanov, A. Martinez-Sanchez, R. Klein, I. Dudanova, M.S. Hipp, F.U. Hartl, W. Baumeister and R. Fernández-Busnadiego. In situ architecture and cellular interactions of polyQ inclusions. Cell (2017), 171(1): 179-187. PubMed

J. Wagner, M. Schaffer and R. Fernández-Busnadiego. Cryo-electron tomography: the cell biology that came in from the cold. FEBS Letters (2017), 591(17): 2520-2533. PubMed

J. Collado and R. Fernández-Busnadiego. Deciphering the molecular architecture of membrane contact sites by cryo-electron tomography. Biochim Biophys Acta (2017), 1864(9): 1507-1512. PubMed

K.J. Vargas, N. Schrod, T. Davis, R. Fernandez-Busnadiego, Y.V. Taguchi, U. Laugks, V. Lučić and S.S. Chandra. Synucleins have multiple effects on presynaptic architecture. Cell Rep (2017) 18(1):161-173. PubMed

V. Lučić, R. Fernández-Busnadiego, U. Laugks and W. Baumeister. Hierarchical detection and analysis of macromolecular complexes in cryo-electron tomograms using Pytom software. J Struct Biol (2016) 196(3):503-514. PubMed

I. Nagy, R.W. Knispel, C. Kofler, M. Orsini, M. Boicu, S. Varga, E. Weyher-Stingl, N. Sun, R. Fernandez-Busnadiego, J. Kukolya, S. Nickell and W. Baumeister. Lipoprotein-like particles in a prokaryote: quinone droplets of Thermoplasma acidophilum. FEMS Microbiol Lett (2016) 363(18). PubMed

R. Fernández-Busnadiego. Supramolecular architecture of endoplasmic reticulum - plasma membrane contact sites. Biochem Soc Trans (2016) 44 (2) 534-540. PubMed

R. Fernández-Busnadiego*, Y. Saheki* and P. De Camilli. Three dimensional architecture of E-Syt-mediated endoplasmic reticulum-plasma membrane contact sites, PNAS (2015) 112 (16) E2004-13. *Equal Contribution. PubMed.

M. Messa, R. Fernández-Busnadiego, E.W. Sun, H. Chen, H. Czapla, K. Wrasman, Y. Wu, G. Ko, T. Ross, B. Wendland and P. De Camilli. Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin coated pits, eLife (2014), 10.7554/eLife.03311. PubMed.

E.C. Goodwin, N. Motamedi, A. Lipovsky, R. Fernández-Busnadiego and D. DiMaio. Expression of DNAJB12 or DNAJB14 causes coordinate invasion of the nucleus by membranes associated with a novel nuclear pore structure, PLoS One (2014), 9(4):e94322. PubMed.

R. Fernández-Busnadiego*, S. Asano*, A.M. Oprisoreanu, E. Sakata, M. Doengi, Z. Kochovski, M. Zürner, V. Stein, S. Schoch, W. Baumeister and V. Lučić. Cryo-electron tomography reveals a critical role of RIM1α in synaptic vesicle tethering, J. Cell Biol. (2013) 201 725-740. *Equal Contribution. PubMed.

R. Fernández-Busnadiego and V. Lučić. The cell at molecular resolution: principles and applications of cryo-electron tomography, in Cellular imaging techniques for neuroscience and beyond, Academic Press, London (2012).

R. Fernández-Busnadiego, N. Schrod, D. Vanhecke, S. Asano, Z. Kochovski, W. Baumeister, V. Lučić. Insights into the molecular organization of the neuron by cryo-electron tomography, J. Elec. Microsc. (2011) 60 (Suppl 1), S137-S148. PubMed.

D. Vanhecke, S. Asano, Z. Kochovski, R. Fernández-Busnadiego, N. Schrod, W. Baumeister, V. Lučić. Cryo-electron tomography: methodology, developments and biological applications, J. Microsc. (2011) 242 (3), 221-227. PubMed.

R. Fernández-Busnadiego, B. Zuber, U.E. Maurer, M. Cyrklaff, W. Baumeister and V. Lučić. Quantitative analysis of the native presynaptic cytomatrix by cryo-electron tomography, J. Cell Biol. (2010) 188, 145-156 (cover illustration, recommended by Faculty of 1000). PubMed.

M. D. Vlasie, R. Fernández-Busnadiego, M. Prudêncio and M. Ubbink. Conformation of pseudoazurin in the 152 kDa electron transfer complex with nitrite reductase determined by paramagnetic NMR, J. Mol. Biol.  (2008) 375, 1405-1415 (cover illustration). PubMed.

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