Research Group "Molecular Mechanisms of DNA Repair"
Structural Biology, DNA Repair, DNA Replication, DNA Recombination, Protein-DNA-Interactions
DNA lives under fire: the genetic material is constantly exposed to dangerous influences such as radioactive radiation, UV light or toxic chemicals. Because DNA damage can cause serious diseases such as cancer or birth defects, it is removed from the cell as quickly as possible. Christian Biertümpfel and his research group "Molecular Mechanisms of DNA Repair" aim to identify the factors involved and study how they interact and are regulated. DNA damage bears several risks: If the damage cannot be repaired, a cell is forced to destroy itself by "programmed suicide". If the damage is repaired incorrectly, however, massive changes in the genetic material can remain - a characteristic of cancer and other diseases.