Two postdoc positions (m/f/d)

Max Planck Institute of Biochemistry, Martinsried

Type of Job

Scientist

Developmental and Evolutionary Biology & Genetics Immunobiology and Infection Biology & Medicine Structural and Cell Biology

Job Code: 336

Job offer from July 09, 2020

The Max Planck Institute of Biochemistry is one of the leading research institutes within the fields of biochemistry, cell- and structural biology and biomedicine. With its eight scientific departments, about 25 research groups, and a staff of around 850 people, the institute is one of the largest institutes within the Max Planck Society.

The Department of Molecular Medicine is seeking two Post-doctoral applicants (m/f/d) to support projects aimed at studying

  1. the endosomal transport and stability of integrins,
  2. the role of integrins in healthy and malignant hematopoietic stem cells (HSCs).

Position 1: Integrins are the main family of adhesion molecules mediating cell interactions with the extracellular matrix. We have shown that integrin trafficking through the endosomal pathway affects their function and cell surface distribution. To further investigate the underlying mechanisms, we are seeking a highly motivated candidate with a strong background in cell biology and biochemistry, with in depth experience

  • in analyzing protein interactions
  • microscope techniques
  • and excellent skills in spoken as well as written English.

Position 2: Integrins are essential for the regulation of the normal hematopoietic system. In an ongoing project, we have identified the protein Kindlin-3 as an essential regulator of integrin-mediated adhesion required for both healthy and malignant stem cell retention within the supportive bone marrow microenvironment.

Using different knock-out mouse strains combined with a mouse model of chronic myeloid leukemia (CML) and HSC-derived cell lines the aim of the project is to dissect the changes occurring within healthy and malignant HSCs in the presence or absence of fully functional integrins. In order to understand the alterations not only on a bulk cell level, in vitro/ex vivo/in vivo derived single cells will be analyzed by proteomic and RNA sequencing approaches.

We are seeking a highly motivated candidate with a strong background in hematology, oncology or immunology, with in depth experience

  • in isolation/culture/analysis of HSCs
  • in flow cytometry and cell sorting
  • with animal models, mouse handling, and mouse genetics
  • in single cell RNA sequencing
  • and excellent skills in spoken as well as written English.

The initial contract will be for two years, with the possibility for extension.

The salary level will be according to TVöD (Bund) (public salary scale).

The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.

Furthermore, the Max Planck Society seeks to increase the number of women in those areas where they are underrepresented and therefore explicitly encourages women to apply.

Informal enquiries can be directed to Dr. Peter Krenn () / Dr. Ralph Böttcher ().

If you are interested, please submit your appropriate documents (including motivation letter, CV, names of two referees and transcripts) via our online application portal as pdf files until 16 August 2020.

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