Dr. Hannes Mutschler
Dr. Hannes Mutschler
Group Leader
Phone:+49 89 8578-3420

MPI of Biochemistry, Am Klopferspitz 18, 82152 Martinsried

Biomimetic Systems



Journal Publications

Mutschler H#*, Taylor AI*, Porebski BT, Lightowlers A, Houlihan G, Abramov M, Herdewijn P, Holliger P#. Random-sequence genetic oligomer pools display an innate potential for ligation and recombination (2018) eLife, 7:e43022 
#corresponding authors, *joint first-authors

Drobot B, Iglesias-Artola JM*, Le Vay K#, Mayr V, Kar M, Kreysing M#, Mutschler H#, Tang TYD#. Compartmentalized RNA catalysis in membrane - free coacervate protocells (2018) Nature Communications, 9, 3643 
#corresponding authors, *contributed equally

Weise LI, Libicher K, Mutschler H. Copy, paste, repeat – über die Synthese von Minimalzellen (2018) BIOspektrum, 4, 365-367.

Schwille P, Spatz J, Landfester K, Bodenschatz E, Herminghaus S, Sourjik V, Erb T, Bastiaens P, Lipowsky R, Hyman A, Dabrock P, Baret JC, Vidakovic-Koch T, Bieling P, Dimova R, Mutschler H, Robinson T, Tang D, Wegner S, Sundmacher K. MaxSynBio ‐ Avenues towards creating cells from the bottom up (2018) Angewandte Chemie International Edition, 130, 13566-13577

Litschel T, Ganzinger KA, Movinkel T, Heymann M, Robinson T, Mutschler H*, Schwille P*. Freeze-thaw cycles induce content exchange between cell-sized lipid vesicles (2018) New Journal of Physics, 20, 055008
*corresponding authors

Cozens C*, Mutschler H*, Nelson GM, Houlihan G, Taylor AI, Holliger P. Enzymatic Synthesis of Nucleic Acids with Defined Regioisomeric 2′-5′ Linkages (2015) Angewandte Chemie International Edition, 54, 15570–15573
*joint first-author

Mutschler H, Wochner A, Holliger P. Freeze-thaw cycles as drivers of complex ribozyme assembly. (2015) Nature Chemistry, 7, 502–508

Mutschler H, Holliger P. Non-canonical 3'-5' extension of RNA with prebiotically plausible ribonucleoside 2', 3'-cyclic phosphates. (2014) Journal of the American Chemical Society, 136, 5193–5196.

Mutschler H, Meinhart A. ε/ζ systems: their role in resistance, virulence, and their potential for antibiotic development. (2011) Journal of Molecular Medicine, 89, 1183-1194.

Mutschler H, Gebhardt M, Shoeman RL, Meinhart A. A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis. (2011) PLoS Biology, 9, e1001033.

Lunde BM, Reichow SL, Kim M, Suh H, Leeper TC, Yang F, Mutschler H, Buratowski S, Meinhart A, Varani G. Cooperative interaction of transcription termination factors with the RNA polymerase II C-terminal domain. (2010) Nature Structural & Molecular Biology, 17, 1195-1201.

Mutschler H, Reinstein J, Meinhart A. Assembly dynamics and stability of the pneumococcal epsilon zeta antitoxin toxin (PezAT) system from Streptococcus pneumoniae. (2010) Journal of Biological Chemistry, 285, 21797-806.

Kress W, Mutschler H, Weber-Ban E. Both ATPase domains of ClpA are critical for processing of stable protein structures. (2009) Journal of Biological Chemistry, 284, 31441-52.

Vasiljeva L, Kim M*, Mutschler H*, Buratowski S, Meinhart A. The Nrd1-Nab3-Sen1 termination complex interacts with the Ser5-phosphorylated RNA polymerase II C-terminal domain. (2008) Nature Structural & Molecular Biology, 15, 795-804.
*contributed equally

Kress W, Mutschler H, Weber-Ban E. Assembly pathway of an AAA+ protein: tracking ClpA and ClpAP complex formation in real time. (2007) Biochemistry, 46, 6183-93.


Use of a new class of nucleotide sugar as antibiotic or cytostatic agent, Mutschler H, Meinhart A. WO Patent 2,012,038,097 (2012)

Book Chapters

Mutschler H, Meinhart A. Type II Toxin-Antitoxin Loci: The Epsilon/Zeta Family in: Prokaryotic Toxin-Antitoxins, 205-223. Springer Berlin Heidelberg (2013)

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