Former publications 1990-2001

Publications 2009

Czabanka, M., Vinci, M., Heppner, F., Vajkoczy, P., and Ullrich, A. (2009), Effects of sunitinib on tumor hemodynamics and delivery of chemotherapy, Int Journal of Cancer 124 (6), 1293-300

Ho, HK., Pok, S., Streit, S., Ruhe JE., Hart, S., Lim, KS., Loo, HL., Aung, MO., Lim, SG., and Ullrich, A. (2009), Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic intervention, Journal Hepatology 50 (1), 118-27

Roidl, A., Berger, HJ., Kumar, S., Bange, J., Knyazev, P. and Ullrich, A. (2009), Resistance to chemotherapy is associated with fibroblast growth factor receptor 4 up-regulation, Clinical Cancer Research 15, 2058-66

Feng, X., Lu, X., Zhou, W., Jiang, LG., Knyazev, P., Lei, L., Huang, Q., Ullrich, A., Zhang, Z. and Chen, Z. (2009), Overexpression of Csk-binding protein contributes to renal cell carcinogenesis, Oncogene 28, 3320-32

Reinhard, J., Horvat-Bröcker, A., Illes, S., Zaremba, A., Knyazev, P., Ullrich, A. and Faissner, A. (2009), Protein tyrosine phosphatases expression during development of mouse superior colliculus, Exp Brain Res 199, 279-97

Descot, A., Hoffmann, R., Shaposhnikov, D., Reschke, M., Ullrich, A. and Posern, G. (2009), Negative regulation of the EGFR-MAPK cascade by actin-MAL-mediated Mig6/Errfi-1 induction, Mol Cell. 35, 291-304

Roidl, A., Foo, P., Wong, W., Mann, C., Bechtold, S., Berger, HJ., Streit, S., Ruhe, JE., Hart, S., Ullrich A. and Ho, HK. (2009), The FGFR4 Y367C mutant is a dominant oncogene in MDA-MB453 breast cancer cells, Oncogene 29:1543-52

Chua, BT., Gallego-Ortega, D., Ramirez de Molina, A., Ullrich, A., Lacal, JC. and Downward, J. (2009), Regulation of Akt(ser473) phosphorylation by Choline kinase in breast carcinoma cells, Mol. Cancer 8:131

Publications 2008

Hutterer, M., Knyazev, P., Abate, A., Reschke, M., Maier, H., Stefanova, N., Stockhammer, G., and Ullrich, A. (2008), AxlandGrowthArrest-Specific Gene 6 Are Frequently Overexpressed in Human Gliomas and Predict Poor Prognosis in Patients with GlioblastomaMultiforme, Clin. Cancer Research 14 (1), 130-138

Zhang, Y.-X., Knyazev, P. G., Cheburkin, Y. V., Knyazev, Y. P., Kéri, G., and Ullrich, A. (2008), AXL is a Potential Target for Therapeutic Intervention in Breast Cancer Progression, Cancer Research 68 (6), 1905-1915

Sobota, R. M., Müller, P. J., Khouri, C., Ullrich, A., Poli, V., Noguchi, T., Heinrich, P. C., and Schaper, F. (2008), SHPS-1/SIRP1α contributes to interleukin-6 signalling, Cellular Signalling 20 (7), 1385-1391

Horvat-Bröcker, A., Reinhard, J., Illes, S., Paech, T., Zoidl, G., Harroch, S., Distler, C., Knyazev, P., Ullrich, A., and Faissner, A. (2008), Receptor protein tyrosine phosphatases are expressed by cycling retinal progenitor cells and involved in neuronal development of mouse retina, Neuroscience 152 (3), 618-645

Stoecklein, N. H., Hosch, S. B., Bezler, M., Stern, F., Hartmann, C. H., Vay, C., Siegmund, A., Scheunemann, P., Schurr, P., Knoefel, W. T., Verde, P. E., Reichelt, U., Erbersdobler, A., Grau, R., Ullrich, A., Izbicki, J. R., and Klein, C.A. (2008), Direct Genetic Analysis of Single Disseminated Cancer Cells for Prediction of Outcome and Therapy Selection in Esophageal Cancer., Cancer Cell 13 (5), 441-453

Strebhardt, K., and Ullrich, A. (2008), Paul Ehrlich's magic bullet concept: 100 years of Progress, Nature Reviews Cancer 8 (6), 473-480

Mertins, P., Eberl, H.C., Renkawitz, J., Olsen, J.V., Tremblay, M.L., Mann, M., and Ullrich, A., Daub, H. (2008), Investigation of protein tyrosine phosphatase 1B function by quantitative proteomics, Mol Cell Proteomics 7 (9), 1763-1777

Reschke, M., Mihic-Probst, D., Buschbeck, M., Knyazev, P., Wild, P. J., Hutterer, M., Meyer, S., Di Croce, L., Dummer, R., Moch, H., and Ullrich, A. (2008), HER3 is a Determinant for Poor Prognosis in Melanoma, Clinical Cancer Research 14 (16), 5188-5197

Singh, B., Schneider, M., Knyazev, P., and Ullrich, A. (2008), UV-Induced EGFR Signal Transactivation is Dependent on Proligand Shedding by Activated Metalloproteases in Skin Cancer Cell Lines, Int Journal of Cancer 124 (3), 531-9

Publications 2007

Stetak, A., Veress, R., Ovadi, J., Csermely, P., Keri, G. and Ullrich, A. (2007), Nuclear Translocation of the Tumor Marker Pyruvate Kinase M2 Induces Programmed Cell Death, Cancer Research 67 (4), 1602-1608

Ruhe, J. E., Streit, S., Hart, S., Wong, C.-H., Specht, K., Knyazev, P., Knyazeva, T., Tay, L. S., Loo, H. L., Foo, P., Wong, W., Pok, S., Lim, S. J., Ong, H., Luo, M., Ho, H. K., Peng, K., Lee, T. C., Bezler, M., Mann, C., Gaertner, S., Hoefler, H., Iacobelli, S., Peter, S., Tay, A., Brenner, S., Venkatesh, B., and Ullrich, A. (2007), Genetic Alterations in the Tyrosine Kinase Transcriptome of Human Cancer Cell Lines, Cancer Research 67 (23), 11368-11376

Publications 2006

Sasaki, T., Knyazev, P.G., Clout, N.J., Cheburkin, Y., Göhring, W., Ullrich, A., Timpl, R., and Hohenester, E. (2006) Structural Basis for Gas6-Axl Signalling. EMBO J.  25 (1), 80-87.

Stadler, C., Knyazev, P., Bange, J. and Ullrich, A. (2006) FGFR4 GLY388 Isotype Suppresses Motility of MDA-MB-231 Breast Cancer Cells by EDG-2 Gene Repression. Cell Signal.  18, 783-794.3

Szantai-Kis, C., Kövesdi, I., Erös, D., Banhegyi, P., Ullrich, A., Keri, G., and Örfi, L. (2006) 
Prediction Oriented QSAR Modelling of EGFR Inhibition. Curr. Med. Chem. 13 (3), 277-287.

Erber, R., Eichelsbacher, U., Powajbo, V., Korn, T., Djonov, V., Lin, J., Hammes, H.-P., Grobholz, R., Ullrich, A. and Vajkoczy, P. (2006) EphB4 Controls Blood Vascular Morphogenesis During Postnatal Angiogenesis. 
EMBO J.  25 (3), 628-641.

Strebhardt, K., and Ullrich, A. (2006) Targeting Polo-Like Kinase 1 for Cancer Therapy. Nat. Rev. Cancer 6 (4), 321-330.

Vajkoczy, P., Knyazev, P., Kunkel, A., Capelle, H.-H., Behrndt, S., von Tengg-Kobligk, H., Kiessling, F., Eichelsbacher, U., Essig, M., Read, T.-A., Erber, R., and Ullrich, A. (2006) Dominant-negative Inhibition of the Axl Receptor Tyrosine Kinase Suppresses Brain Tumor Cell Growth and Invasion, and Prolongs Survival. Proc. Natl. Acad. Sc. USA 103 (15), 5799-5804

Sukocheva, O., Wadham, C., Albanese, N., Holmes, A., Verrier, E., Feng, F., Bernal, A., Derian, C.K., Ullrich, A., Vadas, M.A., and Xia, P. (2006) Estrogen Transactivates EGFR via the Sphingosine 1-Phosphate Receptor Edg-3: The Role of Sphingosine Kinase-1. J.  Cell.  Biol. 173 (2), 301-310.

Anders, L., Mertins, P., Lammich, S., Murgia, M., Saftig, P., Haass, C. and Ullrich, A. (2006) Furin-, ADAM10- and g-Secretase-Mediated Cleavage of a Receptor Tyrosine Phosphatase and Regulation of b-Catenin’s Transcriptional Activity. Mol. Cell. Biol. 26 (10), 3917-3934.

Ferby, I., Reschke, M., Kudlacek, O., Knyazev, P., Pante, G., Amman, K., Sommergruber, W., Kraut, N., Ullrich, A., Fässler, R., and Klein, R. (2006): Mig6 is a Negative Regulator of EGF Receptor-Mediated Skin Morphogenesis and Tumor Formation. Nat. Med. 12 (5), 568-573.

Streit, S., Mestel, D.S., Schmidt, M., Ullrich, A., and Berking, C. (2006) FGFR4 Arg388 Allele Correlates with Tumour Thickness and FGFR4 Protein Expression with Survival of Melanoma Patients. Br. J.  Cancer 94 (12), 1979-1886.

Sánchez-Ramírez, S., Suárez Pestana, E., Garrido Hidalgo, G., Hernández García, T., Pérez Rodríguez, R., Ullrich, A., Enrique Férnandez, L. (2006), Active antimetastatic immunotherapy in Lewis lung carcinoma with self EGFR extracellular domain protein in VSSP adjuvant, Int. J. Cancer 119, 2190-99

Ruhe, J., Streit, S., Hart, S., and Ullrich, A. (2006) EGFR Signaling Leads to Downregulation of PTP-LAR via TACE-Mediated Proteolytic Processing. Cell Signal. 18 (9), 1515-1527.

Fischer, O.M., Hart, S., and Ullrich, A. (2006) Dissecting the Epidermal Growth Factor Receptor Signal Transactivation Pathway. Methods Mol. Biol. 327, 85-97.

Thussbas, C., Nährig, J., Streit, S., Bange, J., Seebauer, M., Kates, R., Ulm, K., Kiechle, M., Höfler, H., Ullrich, A., and Harbeck, N. (2006) FGFR4 Arg388 Allele is Associated with Resistance to Adjuvant Therapy in Primary Breast Cancer. J.  Clin. Oncol. 24 (23), 3747-3755.

Ramirez, B.S., Pestana, E.S., Hidalgo, G.G., Rodriguez, R.P., Ullrich, A., and Fernandez, L.E. (2006) Active Anti- Metastatic Immunotherapy in Lewis Lung Carcinoma with Self EGFR Extra Cellular Domain Protein in VSSP Adjuvant. Int. J. Cancer 119 (9), 2190-2199.

Jiang, L.Q., Feng, X., Zhou, W., Knyazev, P.G., Ullrich, A., and Chen, Z. (2006) Csk-Binding Protein (Cbp) Negatively Regulates Epidermal Growth Factor-Induced Cell Transformation by Controlling Src Activation. Oncogene 25 (40), 5495-5506.

Tanner, B., Hasenclever, D., Stern, K., Schormann, W., Bezler, M., Hermes, M., Brulport, M., Bauer, A., Schiffer, I.B., Gebhard, S., Schmidt, M., Steiner, E., Sehouli, J., Edelmann, J., Lauter, J., Lessig, R., Krishnamurthi, K., Ullrich, A., and Hengstler, J.G. (2006) ErbB-3 Predicts Survival in Ovarian Cancer. J. Clin. Oncol. 24 (26), 4317-4323.

Streit S., Ruhe, J.E., Knyazev, P., Knyazeva, T., Iacobelli, S., Peter, S., Hoefler, H., and Ullrich, A. (2006) PTP-PEST Phosphatase Variations in Human Cancer. Cancer. Genet. Cytogenet. 170 (1), 48-53.

Bhattacharya, I., and Ullrich, A. (2006) Endothelin-1 Inhibits Adipogenesis: Role of Phosphorylation of Akt and ERK 1/2, FEBS Letters 580 (24), 5765-5771.

Strebhardt, K. and Ullrich, A. (2006) Another Look at Imatinib Mesylate. N Engl J Med 355 (23), 2481-2482.

Wang, Y., Du, D., Fang, L.H., Yang, G., Zhang, C., Zeng, R., Ullrich, A., Lottspeich, F., and Chen, Z. (2006) Tyrosine Phosphorylated Par3 Regulates Epithelial Tight Junction Assembly promoted by EGFR Signaling. EMBO J. 25 (21), 5058-5070.

Publications 2005

Htun-van der Horst, E., Weber, I., and Ullrich, A. (2005), Tyrosine Phosphorylation of PYK2 Mediates Heregulin-induced Glioma Invasion: Novel Heregulin/HER3-stimulated Signaling Pathway in Glioma, Int. J. Cancer, 113 (5), 689-698

Fuchs, M., Hermannstädter, C., Specht, K., Knyazev, P., Ullrich, A., Rosivatz, E., Hutzler, P., Busch, R., Höfler, H., and Luber, B. (2005), Effect of Tumor-associated Mutant E-Cadherin Variants with Defects in Exons 8 or 9 on Matrix Metalloproteinase 3, Cell. Physiol 202 (3), 805-813

Buschbeck, M., Hofbauer, S., DiGroce, L., Keri, G., and Ullrich, A. (2005), Abl Kinase-sensitive Levels of ERK5 and its Intrinsic Basal Activity Contribute to Leukaemia Cell Survival, EMBO Reports 6 (1), 63-69

Farhadi, M., Capelle, H.H., Erber, R., Ullrich, A., and Vajkoczy P. (2005), Combined Inhibition of Vascular Endothelial Growth Factor and Platelet-derived Growth Factor Signaling: Effects on the Angiogenesis, Microcirculation, and Growth of Orthotopic Malignant Gliomas, J. Neurosurg. 102 (2), 363-370

Buschbeck, M., and Ullrich, A. (2005), The Unique C-Terminal Tail of the Mitogen-activated Protein Kinase ERK5 Regulates its Activation and Nuclear Shuttling, J. Biol. Chem. 280 (4), 2659-2667

Htun van der Horst, E., Murgia, M., Treder, M., and Ullrich, A. (2005), Anti-HER-3 MAbs Inhibit HER-3-Mediated Signaling in Breast Cancer Cell Lines Resistant to Anti-HER-2 Antibodies, Int. J. Cancer 115 (4), 519-527

Berger, I.R., Buschbeck, M., Bange, J., and Ullrich, A. (2005), Identification of a Transcriptionally Active hVH-5 Pseudogene on 10q22.2, Cancer  Genet. Cytogenet. 159 (2), 155-159

Godl, K., Gruss, O.J., Eickhoff, J., Wissing, J., Blencke, S., Weber, M., Degen, H., Brehmer, D, Orfi, L., Horvath, Z., Keri, G., Müller, S., Cotton, M., Ullrich, A., and Daub, H. (2005), Proteomic Characterization of the Angiogenesis Inhibitor SU6668 Reveals Multiple Impacts on Cellular Kinase Signalling, Cancer Res. 65 (15), 6919-1926

Hart, S., Fischer, O.M., Prenzel, N., Zwick-Wallasch, E., Schneider, M., Hennighausen, L., and Ullrich, A. (2005), GPCR-Induced Migration of Breast Carcinoma Cells Depends on Both EGFR Signal Transduction and EGFR-Independent Pathways, Biol.  Chem.  386 (9), 845-855

Abraham, R., Schäfer, J., Rothe, M., Bange, J., Knyazev, P. and Ullrich, A. (2005), Identification of MMP-15 as an Anti-Apoptotic Factor in Cancer Cells, J. Biol.  Chem 280 (40), 34123-34132

Kéri, G., Székelyhidi, Z., Bánhegyi, Z., Varga, Z., Hegymegi-Barakonyi, B., Szántai-Kis, C., Hafenbradl, D., Klebl, B., Müller, G., Ullrich, A., Erös, D., Horváth, Z., Greff, Z., Marosfalvi, J., Pató, J., Szabadkai, I., Szilágyi, I., Szegedi, Z., Varga, I., Wáczek, F., and Örfi, L.  (2005), Drug Discovery in the Kinase Inhibitory Field Using the Nested Chemical LibraryTM Technology, Assay Drug Dev. Technol. 3 (5), 543-551

Publications 2004

Htun van der Horst, E., Leupold, J.H., Schubbert, R., Ullrich, A., and Allgayer, H. (2004), TaqMan-based quantification of Invasive Cells in the Chick Embryo Metastasis Assay, Biotechniques 37 (6), 940-942, 944, 946

Daub, H., Specht, K., and Ullrich, A. (2004), Strategies to Overcome Resistance to Targeted Protein Kinase Inhibitors, Nat. Rev. Drug Discov. 3 (12), 1001-1010 

Farhadi, M., Capelle, H.H., Erber, R., Ullrich, A., and Vajkoczy P. (2004), Combined Inhibition of VEGF and PDGF Signalling: Effects on Orthotopic Glioma Angiogenesis, Microcirculation, and Growth, Vascular Res. 41 (1), 96-96  

Schäfer, B., Gschwind, A., and Ullrich, A. (2004), Distinct ADAM Metalloproteinases Regulate G Protein Coupled Receptor-Induced Cell Proliferation and Survival, Biol. Chem. 279 (46), 47929-47938 

Zhao, L., Hart, S., Chen, J., Melenhorst, J.J., Ernst, M., Stewart, C., Schaper,F., Heinrich, P.C., Ullrich,A., Robinson, G.W., and Hennighausen, L. (2004), Mammary Gland Remodeling Depends on gp130 Signaling Through Stat3 and MAPK, Biol.Chem. 279 (42), 44093-44100  

Fischer, O.M., Giordano, S., Comoglio, P.M., and Ullrich, A. (2004), Reactive Oxigen Species Mediate Met Receptor Transactivation by GPCRs and the EGFR in Human Carcinoma Cells, In Press J. Biol. Chem

Ruschel, A. and Ullrich, A. (2004), Protein Tyrosine Kinase Syk Modulates EGFR Signalling in Human Mammary Epithelial Cells, In Press CLS 

Blencke, S., Zech, B., Engkvist, O., Greff, Z., Örfi, L., Horváth, Z., Kéri, G., Ulrich, A., and Daub, F. (2004), Characterization of a Structural Determinant Controlling Protein Kinase Sinsitivity to Selective Inhibitors, Chem. Biol. 11 (5), 691-701 

Streit, S., Bange, J., Fichtner, A., Ihrler, S., Issing, W., and Ullrich, A. (2004), Involvement of the FGFR4 Arg 388 Allele in Head and Neck Squamous Cell Carcinoma, Int. J. Cancer 111 (2), 213-217. 

Cardone, L., Carlucci, A., Afaitati, A., Livigni, A., DeCristofaro, T., Garbi,C., Varrone, S., Ullrich, A., Gottesmann , M.E. , Avvedimento, E.V., and Feliciello,A. (2004), Mitochondrial AKAP121 Binds and Targets Protein Tyrosine Phosphatase D1, a Novel Positive Regulator of src Signaling, Mol. Cell. Biol. 24 (11), 4613-4626.  

Fischer, O.M., Hart, S., Gschwind, A., Prenzel, N., and Ullrich, A. (2004), Oxidative and Osmotic Stress Signaling in Tumor Cells is Mediated by ADAM Proteases and HB-EGF, Mol. Cell Biol. 24 (12), 5172-5183  

Koul, A., Herget, T., Klebl, B., and Ullrich, A. (2004), Interplay between Mycobacteria Host Signalling Pathways, Nat Rev Microbiol. 2, 189-202  

Gschwind, A., Fischer, O.M. and Ullrich, A. (2004), The Discovery of Receptor Tyrosine Kinases: Targets for Cancer Therapy, Nat. Rev. Cancer 4 (5), 361-170  

Neznanov, N., Neznanova, L, Kondratov.R.V., O'Rourke, D.M., Ullrich, A., and Gudkov, A.V. (2004), The Ability of Proteintyrosine Phosphatase SHP-1 to Suppress NF k B Can Be Inhibited by Dominant Negative Mutant of SIRP a , DNA Cell Biol 23(3), 175-182  

Gensler, M., Buschbeck, M. and Ullrich, A. (2004), Negative Regulation of HER2 Signaling by the PEST-Type Protein Tyrosine Phospahatase BDP1, J. Biol. Chem. 279 (13), 12110-6  

Hart, S., Fischer, O.M., and Ullrich, A. (2004), Cannabiniods Induce Cancer Cell Proliferation via TACE/ADAM17-Mediated Transactivation of the EGFR, Cancer Res. 64(6), 1943-50  

Pulido, R., Zuniga, A., and Ullrich, A. (2004), Detection of ERK1/2 Kinase Activities Using Affinity Reagents, Methods Mol. Biol. 250, 49-60  

Liu, Y., O'Connor, M.B., Mandell, K.J., Zen, K., Ullrich, A., Bühring, H.-J., and Parkos, C.A. (2004), Peptide-Mediated Inhibition of Neutrophil Transmigration by Blocking CD47 Interactions with Signal Regulatory Protein Alpha, J. Immunol. 172 (4), 2578-2585  

Schäfer, B., Gschwind, A., and Ullrich, A. (2004), Multiple G-Protein-Coupled Receptor Signals Converge on the Epidermal Growth Factor Receptor to Promote Migration and Invasion, Oncogene  23, 991-999  

Erber, R., Thurnher, A., Katsen, A.D., Groth, G., Kerger, H., Hammes, H.P., Menger, M.D., Ullrich, A., and Vajkoczy, P. (2004), Combined Inhibition of VEGF and PDGF Signaling Enforces Tumor Vessel Regression by Interfering with Pericyte-Mediated Endothelial Cell Survival Mechanisms, FASEB J. (2), 338-340  

Publications 2003

Aoki, N., Ueno, S., Mano, H., Yamasaki, S., Shiota, M., Miyazaki , H., Yamaguchi-Aoki, Y., Matsuda, T., and Ullrich, A. (2003), Mutual Regulation of PTP20 and PTK Tec Activities by Tyrosine Phosphorylation and Dephosphorylation, J. Biol. Chem. 279 (11), 10765-75

Büchler, P., Reber, H.A., Ullrich, A., Shiroiki, M., Roth, M., Büchler M.W., Lavey, R.S., Friess, H., and Hines, O.J. (2003), Pancreatic Cancer Growth Is Inhibited by Blockade of VEGF-RII, Surgery 134 (5), 772-782

Hart, S., Gschwind, A., Roidl, A., and Ullrich, A. (2003), Epidermal Growth Factor Receptor Signal Transactivation, Chem. Probes in Biology , 93-103

Fischer, O.M., Hart, S., Gschwind, A., and Ullrich, A (2003), EGFR Signal Transactivation in Cancer Cells, Biochem Soc Trans 31 (6), 1203-1208  

Fischer, O.M., Streit, S., Hart, S., and Ullrich, A. (2003), Beyond Herceptin and Gleevec, Curr. Opin. Chem. Biol. 7 (4), 490-495  

Knyazev I., Cheburkin, I., Spiekermann, K., Peter S., Jenster, G., Bangma KH., Karelin, MI., Shkolnik, MI., Urbanskii, AI., Evtushenko, VI., Ullrich, A., and Knyazev, PG. (2003), Gene Expression Profiles of Protein Kinases and Phosphatases Obtained by Hybridization With cDNA Arrays: Molecular Portrait of Human Prostate Carcinoma, Mol Biol (Mosk.) 37 (1), 97-111 

Tejeda, M., Gaal, D., Csuka, O., Ullrich, A., Schwab, R., Pap, A., Horvath, A., and Keri, G. (2003), The Antitumour Effect of the Somatostatin Analogue TT-232 Depends on the Treatment Regimen, Cancer Detect Prev. 27 (2), 155-62  

Wu, Y., Chen, Z., and Ullrich, A. (2003), EGFR and FGFR Signaling Through FRS2 Is Subject to Negative Feedback Control by ERK1/2, Biol. Chem. 384, 1215-1226

Gschwind , A., Hart, S., Fischer, O.M., and Ullrich, A. (2003), TACE Cleavage of Proamphiregulin Regulates GPCR-Induced Proliferation and Motility of Cancer Cells, EMBO J . 22 (10), 2411-2421  

Minoo, P., Chughtai, N., Campiglio, M., Stein-Gerlach, M., Lebrun, J.J., Ullrich, A., and Ali, S. (2003), The Adapter Function of SHP-2 Downstream of the Prolactin Receptor Is Required for the Recruitment of p29, a Substrate of SHP-2, Cell Signal. 15 (3), 319-326  

Neznanov, N., Neznanova, L., Kondratov, R.V., Burdelya, L., Kandel, E.S., O'Rourke, D.M., Ullrich, A., and Gudkov, A.V. (2003), Dominant Negative Form of Signal-Regulatory Protein- a (SIRP a /SHPS-1) Inhibits Tumor Necrosis Factor-Mediated Apoptosis by Activation of NF- k B, J. Biol. Chem. 278 (6), 3809-15  

Su, I.H., Basavaraj, A., Krutchinsky, A.N., Hobert, O., Ullrich, A., Chait, B.T., and Tarakhovsky, A. (2003), Ezh2 Controls B Cell Development Through Histone H3 Methylation and Igh Rearrangement, Nature Immunol. 4 (2), 124-131  

Blencke, S., Ullrich, A., and Daub, H. (2003), Mutation of Threonine 766 in the Epidermal Growth Factor Receptor Reveals a Hotspot for Resistance Formation against Selective Tyrosine Kinase Inhibitors, J. Biol. Chem. 278 (17), 15435-40  

Shiota, M., Tanihiro, T., Nakagawa, Y., Aoki, N., Ishida, N., Miyazaki , K., Ulrich, A., and Miyazaki , H. (2003), Protein Tyrosine Phosphatase PTP20 Induces Actin Cytoskeleton Reorganization by Dephosphorylating p190Rho GAP in Rat Ovarian Granulosa Cells Stimulated with follicle-stimulating hormone, Mol. Endocrinol. 17 (4), 534-549  

Publications 2002

Zwick, E., Bange, J., and Ullrich, A. (2002), Receptor Tyrosine Kinases as Targets for Anticancer Drugs, Trends Mol. Med.  8 (1), 17-23

Strack, V., Krützfeldt, J., Kellerer, M., Lammers, R., Ullrich, A., and Häring, H.U. (2002), The Protein-Tyrosine Phosphase SHP2 is Phosphorylated on Serine Residues 576 and 591 by Protein Kinase C Isoforms Alpha, Beta1, Beta2 and Eta. Biochemistry-US 41 (2), 603-608

Neznanov, N., Chumakov, K.P., Ullrich, A., Agol V.I., and Gudkov, A.V. (2002), Unstable Receptors Disappear from Cell Surface during Poliovirus Infection, Med. Sci. Monit. 8 (10), 391-396.

Bange, J., Prechtel, D., Cheburkin, Y., Specht, K., Harbeck, N., Schmitt, M., Knyazeva, T., Müller, S., Gärtner, S., Sures, I., Wang, H., Imyanitov, E., Häring, H.U., Knyazev, P., Iacobelli, S., Höfler, H., and Ullrich, A. (2002), Cancer Progression and Tumor Cell Motility are Associated with the FGFR4 Arg388 Allele, Cancer Res.  62 (3), 840-847

Shawver, L.K., Slamon, D., and Ullrich, A. (2002), Smart Drugs: Tyrosine Kinase Inhibitors in Cancer Therapy, Cancer Cell 1, 117-123

Casanova, M.L., Larcher, F., Casanova, B., Murillas, R., Fernandez-Acenero, M.J., Villanueva, C., Martinez-Palacio, J., Ullrich, A., Conti, C.J., and Jorcano, J.L. (2002), A critical Role for ras-Mediated, Epidermal Growth Factor Receptor-Dependent Angiogenesis in Mouse Skin Carcinogenesis, Cancer Res. 62, 3402-3407

Wallasch, C., Crabtree, J.E., Bevec, D., Robinson, P.A., Wagner, H., and Ullrich, A. (2002), Heliobacter Pylori-Stimulated EGF Receptor Transativation Requires Metalloprotease Cleavage of HB-EGF. Biochem, Biophys, Res. Commun. 295, 695-701

Daub, H., Blencke, S., Habenberger, P., Kurtenbach, A., Dennenmoser, J., Wissing, J., Ullrich, A., and Cotton, M. (2002), Identification of SRPK1 and SRPK2 as the major Cellular Protein Kinases Phosphorylating Hepatitis B Virus Core Protein, J. Virol.  76, 8124-8137

Marchetti, A., Tinari, N., Buttitta, F., Chella, A., Angeletti, C.A., Sacco, R., Mucilli, F., Ullrich, A., and Iacobelli, S. (2002), Expression of 90K (Mac-2 BP) Correlates with distant Metastasis and Predicts Survival in Stage I non-small Cell Lung Cancer Patients, Cancer Res. 622535-2539

Buschbeck, M., Eickhoff, J., Sommer, M.N., and Ullrich, A. (2002), Phosphotyrosine-Specific PTP-SL Regulates the ERK5 Signalling Pathway, J. Biol. Chem. 277, 29503-29509

Zeng, J.-Z., Wang, H.-Y., Chen, Z.-J., Ullrich, A., and Wu, M.-C. (2002), Molecular Cloning and Characterization of a Novel Gene which is highly Expressed in Hepatocellular Carcinoma, Oncogene 21, 4932-4943

Ullrich, A. (2002), Molecular Targets in Cancer Therapy and their Impact on Cancer Management, Oncology 63 (suppl 1), 1-5

Sasaki, T., Knyazev P.G., Cheburkin, Y., Göhring, W., Tisi, D., Ullrich, A., Timpl, R., and Hohenester, E. (2002), Crystal Structure of a C-Terminal Fragment of Growth Arrest-Specific Protein Gas6, J. Biol. Chem. 277 (46), 44164-44170

Gschwind, A., Prenzel, N., and Ullrich, A. (2002), Lysophosphatidic Acid-Induced Squamous Cell Carcinoma Cell Proliferation and Motility Involves Epidermal Growth Factor Receptor Signal Transactivation, Cancer Res. 62 (21), 6329-6336

Cheburkin, I., Knyazeva, T., Peter S., Karelin, MI., Shkolnik, MI., Evtushenko, VI., Hanson, KP., Ullrich, A., and Kniazev PG. (2002), Molecular Portrait of Human Kidney Carcinomas: The Gene Expression Profiling of Protein-Tyrosine Kinases and Tyrosine Phosphatases which Controlled Regulatory Signals in the Cells, Mol. Bio.l (Mosk.) 36 (3), 480-90

Publications 2001

Steták, A., Csermely, P., Ullrich, A., and Kéri, G. (2001) Physical and Functional Interactions between Protein Tyrosine Phosphatase a , PI 3-Kinase and PKC d . BBCR 288, 564-572

Steták A., Lankenau, A., Vántus, T., Csrmely, R., Ullrich, A., and Kéri, G. (2001) The Antitumor Somatostatin Analogue TT-232 Induces Cell Cycle Arrest through PKC d and c-Src. BBCR 285, 483-488

Kellerer M., Mushack, J., Seffer, E., Mischak, H., Ullrich, A., and Häring, H.U. (2001) Protein Kinase C Isoforms Alpha, Delta and Theta Require Insulin Receptor Substrate-1 to Inhibit the Tyrosine Kinase Activity of the Insulin Receptor in human Kidney embryonic Cells (HEK 293 cells). Diabetologia 41 (7), 833-838

Hackel, P.O., Gishitzky, M., and Ullrich, A. (2001) Mig-6 is a negative Regulator of the Epidermal Growth Factor Receptor Signal. Biol. Chem. 832 (12), 1649-1662

Koul, A., Choidas, A., Tyagi, A.K., Drlica, K., Singh, Y., and Ullrich, A. (2001) Serine/Threonine Protein Kinases PknF and PknG of Mycobacterium Tuberculosis : Characterization and Localization. Microbiology 147, 2307-2314

Zwick, E., Bange, J., and Ullrich, A. (2001) Receptor Tyrosine Kinase Signalling as Target for Cancer Intervention Strategies. Endocrine-Related Cancer 8, 161-173

Latour, S., Tanaka, H., Demeure, C., Mateo, V., Rubio, M., Brown, E.J., Maliszewski, C., Lindberg, F., Oldenborg, A., Ullrich, A., Delespesse, G., and Sarfati, M. (2001) Bi-directional Negative Regulation of Human T and Dendritic Cells by CD47 and its Cognate Receptor Signal-Regulator Protein- a : Downregulation of IL-12 Responsiveness and Inhibition of dendritic Cell Activation. J. of Immunology, 2547-2554

Hennige, A.M., Lammers, R., Höppner, W., Arlt, D., Strack, V., Teichmann, R., Machicao, F., Ullrich, A., Häring, H.U., and Kellerer, M. (2001) Inhibition of Ret Oncogene Activity by the Protein Tyrosine Phosphatase SHP1. Endocrinology 142 (10), 4441-4447

Kellerer, M., Lammers, R., Fritsche, A., Strack, V., Machicao, F., Borboni, P., Ullrich, A., and Häring, H.U. (2001) Insulin Inhibits Receptor Signalling in HEK293 Cells at the Level of Janus Kinase-2; a Potential Mechanism for Hyperinsulinaemia-Associated Leptin Resistance. Diabetologia 44 (9), 1125-1132

Bange, J., Zwick, E., and Ullrich, A. (2001) Molecular Targets for Breast Cancer Therapy and Prevention. Nature Medicine 7, 548-552

Schultz, J., Jones, T., Bork, P., Sheer, D., Blencke, S., Steyerer, S., Wellbrock, U., Bevec, D., Ullrich, A., and Wallasch, C. (2001) Molecular Characterization of a cDNA Encoding functional Human CLK4 Kinase and Localization to Chromosome 4q35. Genomics 71, 368-70

Prenzel, N., Fischer, O.M., Streit, S., Hart, S., and Ullrich, A. (2001) The Epidermal Growth Factor Receptor Family as a Central Element for Cellular Signal Transduction and Diversification . Endocrine-Related Cancer 8 (1), 11-31

Gschwind, A., Zwick, E., Prenzel, N., Leserer, M., and Ullrich, A. (2001) Cell Communication Networks: Epidermal Growth Factor Receptor Transactivation as the Paradigm for Interreceptor Signal Transmission. Oncogene 20, 1594-1600

Seiffert, M., Brossart, P., Cant, C., Cella, M., Colonna, M., Brugger, W., Kranz, L., Ullrich, A., and Bühring, H.-J. (2001) Signal-regulatory Protein (SIRP) a but not SIRP b Interacts with CD47, is Expressed on Hematopoietic Stem Cells and Involved in T Cell Activation. Blood 97, 2741-9

Cant, C. and Ullrich, A. (2001) Signal Regulation by Family Conspiracy. Cell. Mol. Life Sci. 58, 117-124

Horvath, A., Schwaiger, F.-W., Hager, G., Bröcker, F., Streif, R., Ullrich, A., and Kreutzberg, W. (2001). A Novel Role for Protein Tyrosine Phosphatase SHP1 in Controlling Glial Activation in the normal and Injured Nervous System . J. of Neuroscience, 21 (3) 865-874

Publications 2000

Koul, A., Choidas, A., Treder, M., Tyagi, A.K., Drlica, K., Singh, Y., and Ullrich, A. (2000) Cloning and Characterization of Secretory Tyrosine Phosphatases of Mycobacterium tuberculosis, J. of Bacteriology , 182 (19), 5425-5432

Stofega, M.R., Argetsinger, L.S., Wang, H., Ullrich, A. and Carter-Su, C. (2000) Negative Regulation of Growth Hormone Receptor/JAK2 Signaling by Signal Regulatorey Protein a. J. Biol. Chem. 275, 28222-28229

Tomasello, E., Cant, C., Bühring, H.-J., Vély, F., André , P., Seiffert, M., Ullrich, A., and Vivier, E. (2000) Association of Signal-Regulatory Proteins b with KARAP/DAP-12. Eur. J. Immunol. 30, 2147-2156

Bossenmaier, B., Strack, V., Stoyanov, B., Krützfeldt, J., Beck, A., Lehmann, R., Kellerer, M., Klein, H., Ullrich, A., Lammers, R., and Häring, H.-U. (2000) Serine Residues 1177/78/82 of the Insulin Receptor are Required for Substrate Phosphorylation but not Autophosphorylation. Diabetes 49, 889-895

Leserer, M., Gschwind, A., and Ullrich, A. (2000) Epidermal Growth Factor Receptor Signal Transactivation. IUBMB Life 49, 405-409

Arcaro, A., Zvelebil, M.J., Wallasch, C., Ullrich, A., Waterfield, M.W., and Domin, J (2000) Class II Phosphoinositide 3-Kinases are downstream Targets of Activated Polypeptide Growth Factor Receptors. MCB 20, 3817-3830

Laird, A.D., Vajkoczy, P., Shawver, L.K., Thurnher, A., Liang, C., Mohammadi, M., Schlessinger, J., Ullrich, A., Hubbard, S.R., Blake, R.A., Fong, A.T., Strawn, L.M., Sun, L., Tang, C., Hawtin, R., Tang, F., Hirth, K.P., McMahon, G., and Cherrington, J. (2000) SU6668 is a potent Anti-Angiogenic and Anti-Tumor Agent which Induces Regression of Established Tumors. Cancer Res. 60 (15), 4152-4160

Zwick, E., Wallasch, C,. and Ullrich, A. (2000) HER2/neu: A Target for Breast Cancer Therapy. Breast Disease 11, 7-18

Lammers, R., Lerch, M., and Ullrich, A. (2000) The Carboxyterminal Tyrosine Residue of PTP a Mediates Association with Focal Adhesion Plaques. J. Biol. Chem. 275 (5), 3391-3396

Vajkoczy, P., Menger, M.D. Goldbrunner, R., Ge, S., Fong, T.A.T., Vollmar, B., Schilling, L., Ullrich, A., Hirth, K.P., Tonn, J.C., Schmiedek, P., and Rempel, S.A. (2000) Targeting Angiogenesis Inhibits Tumor Infiltration and Expression of the Pro-Invasive Protein SPARC. Int. J. Cancer 87, 261-268

Vajkoczy, P., Thurner, A., Hirth, P., Schilling, L., Schmiedek, P., Ullrich, A., and Menger, M.D. (2000) Measuring VEGF-Flk-1 Activity and Consequences of VEGF-Flk-1 Targeting in vivo using Intravital Microscopy: Clinical Applications. Oncologist 5 (Suppl 1), 16-19

Prenzel, N., Zwick, E., Leserer, M., and Ullrich, A. (2000) Tyrosine Kinase Signalling in Breast Cancer. Epidermal Growth Factor Receptor: Convergence Point for Signal Integration and Diversification. Breast Cancer Res . 2, 184-190

Vajkoczy, P., Ullrich, A., and Menger, D. (2000) Intravital Fluorescence Videomicroscopy to Study Tumor Angiogenesis and Microcirculation. Neoplasia 2, 53-61

Publications 1999

Rogers , J.H., Ciossek, T., Ullrich, A., West, E., Hoare M., and Muir E.M. (1999) Distribution of the Receptor EphA7 and its Ligands in Development of the Mouse Nervous System. Mol. Brain Res. 74 (1-2), 225-230

Ciossek, T., Ullrich, A., West, E., and Rogers , J.H. (1999) Segregation of the Receptor EphA7 from its Tyrosine Kinase-negative Isoform on Neurons in adult Mouse Brain. Mol. Brain Res . 74 (1-2), 231-236

Häcker, H., Mischak, H., Häcker, G., Eser, S., Prenzel, N., Ullrich, A., and Wagner, H. (1999) Cell Type-Dependent Activation of Mitogen Activated Protein Kinases by CpG-DNA Control Interleukin-12 release from Antigen Presenting Cells. EMBO J. 18 (24), 6973-6982

Dorner, C., Ullrich, A., Häring, H.-U., and Lammers, R. (1999) The Kinesin like Motor Protein KIF1C Occurs in intact Cells as a Dimer and Associates with Proteins of the 14-3-3 Family. J. Biol. Chem. 274, 33654-33660

Prenzel, N., Zwick, E., Daub, H., Leserer, M., Abraham, R. Wallasch, C., and Ullrich, A. (1999) EGF Receptor Transactivation by G-Protein-Coupled Receptors Requires Metalloproteinase Cleavage of proHB-EGF. Nature, 402, 884-888

Seiffert, M., Cant, C., Chen, Z., Rappold, I., Bautz, F., Brugger, W., Kanz, L., Brown, E.J., Ullrich, A., and Bühring, H.J. (1999) Human Signal-Regulatory Protein is Expressed on Normal, but not on Subsets of Leukemic Myeloid Cells and Mediates Cellular Adhesion Involving its Counterreceptor CD47. Blood 94 (11), 3633-3643

Bagowski, C., Stein-Gerlach, M., Choidas, A., and Ullrich, A. (1999) Cell-Type specific Phosphorylation of Threonines T654 and T669 by PKD Defines the Signal Capacity of the EGF-Receptor. EMBO J. 18 (20), 5567-5576

Zwick, E., Hackel, P.O., Prenzel, N., and Ullrich, A. (1999) EGF Receptor as central Transducer of heterologous Signaling Systems. TIPS 20 (10), 391-429

Zwick, E., Wallasch, C., Daub, H., and Ullrich, A. (1999) Distinct Calcium-dependent Pathways of Epidermal Growth Factor Receptor Transactivation and PYK2 Tyrosine Phosphorylation in PC12 Cells. J. Biol. Chem. 274, 20989-20996

Vajkoczy, P., Menger, M.D., Vollmar, B., Schilling, L., Schmiedek, P., Hirth, P., Ullrich, A., and Fong, A. (1999) Inhibition of Tumor Growth, Angiogenesis, and Microcirculation by the novel Flk-1 Inhibitor SU5416 as Assessed by intravital Multi-Fluorescence Videomicroscopy. Neoplasia 1 (1) 31-41

Hackel, P.O., Zwick, E., Prenzel, N., and Ullrich, A. (1999) Epidermal Growth Factor Receptors: Critical Mediators of multiple Receptor Pathways. Current Op. in Cell Biol. (11) 2, 184-189

Campiglio, M., Ali, S., Knyazev, P.G., and Ullrich, A. (1999) Characteristics of EGFR Family-Mediated HRG Signals in Human Ovarian Cancer. J. of Cellular Biochemistry 73, 522-532

Müller, T., Choidas, A., and Ullrich, A. (1999) Phosphorylation and Free Pool of b -Catenin are Regulated by Tyrosine Kinases and Tyrosine Phosphatases during Epithelial Cell Migration. J. Biol. Chem. 274, 1073-10183

Brakebusch, C., Sures, I. , Jallal, B., Mossie, K., Fusco, O., Iacobelli , S., and Ullrich, A. (1999) Isolation and functional Characterization of the Human 90K Promoter. Genomics 57, 268-278

Fong, T.A.T., Shawver, L.K., Sun, L., Tang, C., App, H., Powell, T.J., Kim, Y.H., Schreck, R., Wang, X.Y., Risau, W., Ullrich, A., Hirth, K.P., and McMahon, G. (1999) SU5416 is a potent and selective Inhibitor of the Vascular Endothelial Growth Factor Receptor (Flk-1/KDR) that Inhibits Tyrosine Kinase Catalysis, Tumor Vascularization, and Growth of Multiple Tumor Types. Cancer Res 59 (1), 99-106

Publications 1998

Pulido, R. Zúniga, Á., and Ullrich, A. (1998) PTP-SL and STEP Protein Tyrosine Phosphatases Regulate the Activation of the extracellular signal-regulated Kinases, ERK1 and ERK2, by Association through a Kinase Interaction Motif. Embo J. (17) 24, 7337-7350

Silvestri, B., Calderazzo, F., Coppola, V., Rosato, A., Iacobelli , S., Natoli, C., Ullrich, A., Sures, I. , Azam, M., Brakebusch, C., Chiecho-Bianchi, L., and Amadori, A. (1998) Differential Effect on TCR:CD3 Stimulation of a 90 kD Glycoprotein (90K/Mac-2BP), a Member of the Scavenger Receptor Cysteine-Rich Domain Protein Family. Clin. & Exp. Immunol. 113, 394-400

Herrlich, A., Daub, H., Knebel, A., Herrlich, P., Ullrich, A., Schultz, G., and Gudermann, T. (1998) Ligand-independent Activation of platelet-derived Growth Factor Receptor Is a necessary Intermediate in lysophosphatidic, acid-stimulated mitogenic Activity in L Cells. Proc. Natl. Acad. Sci. 95, 8985-8990

Nayler, O., Schnorrer, F., Stamm, S., and Ullrich, A. (1998) The cellular Localization of the Murine Serine/Arginine-rich Protein kinase CLK2 Is Regulated by Serine 141 Autophosphorylation. J .Biol. Chem. 273, 34341-34348

Choidas, A., Jungbluth, A., Sechi, A., Murphy, J., Ullrich, A., and Marriott, G. (1998) The Suitability and Application of a GFP-Actin Fusion Protein for long-term Imaging of the Organization and Dynamics of the Cytoskeleton in Mammalian Cells. Eur. J. Cell Biol. 77, 81-90

Nayler, O., Strätling, W., Fackelmayer, F., Bourquin, J.-P., Stagljar, I. , Lindemann, L., Jasper, H., Hartmann, A,., Ullrich, A., and Stamm, S. (1998) SAF-B Protein Couples Transcription and pre-mRNA Splicing to SAR/MAR Elements. Nucleid Acid Resh 26, 3542-3549

Dorner, C., Ciossek, T., Müller, S., Møller, N.P.H., Ullrich, A., and Lammers, R. (1998) Characterization of KIF1C, a new Kinesin-like Protein Involved in Vesicle Transport from the Golgi Apparatus to the Endoplasmic Reticulum. J. Biol. Chem. 273, 20267-20275

Vajkoczy, P., Schilling, L., Ullrich, A., Schmiedek, P. and Menger, M.D. (1998) Characterization of Angiogenesis and Micorcirculation of high grade glioma: An intravital multi-fluorescence microscopic approach in the athymic nude mouse. J. Cerebral Blood Flow and Metabolism 18, 510-520

Fusco, O., Querzoli, P., Nenci, I. , Natoli,C., Brakebusch, C, Ullrich, A. and Iacobelli , S. (1998) 90 K (MAC-2 BP) Gene Expression in Breast Cancer And Evidence for the Production of 90K by Peripheral Blood Mononuclear Cells. Int .J. Cancer 79, 23-26

Fuchs, M., Wang, H., Ciossek, T., Chen, Z. and Ullrich, A. (1998) Differential Expression of MAM-Subfamily Protein Tyrosine Phosphatases During Mouse Development. MoD 70, 91-109

Stofega, M., Wang, H., Ullrich, A. and Carter-Su, C. (1998) Growth Hormone Regulation of SIRP and SHP-2 Tyrosol Phosphorylation and Association. J. Biol. Chem. 273, 7112-7117

Kubota, Y., Angelotti, T., Niederfellner, G., Herbst, R. and Ullrich, A. (1998) Activation of Phosphatidylinositol 3-Kinase Is Necessary for Differentiation of FDC-P1 Cells following Stimulation of Type III Receptor Tyrosine Kinases. Cell Growth & Diff. 9, 247-256

Martell, K.J., Angelotti, T. and Ullrich, A. (1998) The "VH1-like" Dual Specificity Protein Tyrosine Phosphatases. Mol. Cells 8, 2-11

Stein-Gerlach, M., Wallasch, C. and Ullrich, A. (1998) SHP-2, SH2-containing protein tyrosine phosphatase-2 . Int. .J of Biochemistry & Cell Biol. 30, 559-566

Lammers, R., Møller, N.P.H. and Ullrich, A. (1998) Mutant forms of the protein tyrosine phosphatase alpha show differential activities towards intracellular substrates. Biochem & Biophys .Res. Comm. 242, 32-38

Publications 1997

Daub, H., Wallasch, C., Lankenau, A., Herrlich, A. and Ullrich, A. (1997) Signal characteristics of G protein-transactivated EGF receptor. EMBO J. 16, 7032-7044

Bossenmaier, B., Mosthaf, L., Mischak, H., Ullrich, A., and Haring, H.U. (1997) Protein kinase C isoforms beta 1 and beta 2 inhibit the tyrosine kinase activity of the insulin receptor. Diabetologia 40, 863-866

Nayler, O., Stamm, S. and Ullrich, A. (1997) Characterization and comparison of four serine- and arginine-rich (SR) protein kinases. Biochem J. 326, 693-700

Kabrun, N., Bühring, H.-J., Choi, K., Ullrich, A., Risau, W. and Keller, G. (1997) FLK-1 Expression defines a unique population of embryonic hematopoietic precursors. Development 124, 2039-2048

Zwick, E., Daub, H., Aoki, N., Yamaguchi-Aoki, Y., Tinhofer, I., Maly, K. and Ullrich, A. (1997) Critical Role of Calcium-dependent Epidermal Growth Factor Receptor Transactivation in PC12 Cell Membrane Depolarization and Bradykinin Signaling. J.Biol.Chem. 272, 24767-24770

Aicher, B., Lerch, M., Schilling, J. and Ullrich, A. (1997) Cellular redistribution of protein tyrosine phosphatases LAR and SIGMA by inducible proteolytic processing. J.Cell Biol. 138, 681-696

Weiß, F.U., Wallasch, C., Campiglio, M., Issing W. and Ullrich, A. (1997) Distinct characteristics of Heregulin signals mediated by HER3 or HER4. J.Cell.Physiol. 173, 187-195

Braunger, J., Schleithoff, L., Schulz, A.S., Kessler, H., Lammers, R., Ullrich, A., Bartram, C.R. and Janssen, W.G. (1997) Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking site. Oncogene 14, 2619-2631

Jallal, B., Mossie, K., Vasiloudis, G., Knyazev, P., Zachwieja, J., Clairvoyant, F., Schilling, J. and Ullrich, A. (1997) The Receptor-like Protein-tyrosine Phosphatase DEP-1 Is Constitutively Associated with a 64-kDa Protein Serine/Threonine Kinase. J.Biol.Chem. 272, 12158-12163

Lammers, R., Møller, N.P.H. and Ullrich, A. (1997) The transmembrane protein tyrosine phosphatase a dephosphorylates the insulin receptor in intact cells. FEBS Letters 404, 37-40

Kharitonenkov, A., Chen, Z., Sures, I. , Wang, H., Schilling, J. and Ullrich, A. (1997) A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 386, 181-186

Tenev, T., Keilhack, H., Tomic, S., Stoyanov, B., Stein-Gerlach, M., Krivtsov, A., Ullrich, A. and Böhmer, F.-D. (1997) Both SH2-domains are involved in interaction of SHP-1 with the epidermal growth factor receptor but cannot confer receptor-directed activity to SHP-1/SHP-2 chimera. J.Biol.Chem. 272, 5966-5973

Ciossek, T. and Ullrich, A. (1997) Identification of Elf-1 and B61 as high affinity ligands for the receptor tyrosine kinase MDK1. Oncogene 14, 35-43

Shawver, L.K., Schwartz, D.P., Mann, E., Chen, H., Tsai, J., Chu, L., Taylorson, L., Longhi, M., Jacobs, J.S., Tang, C., Ullrich, A., Berens, M.E., Hersh, E., McMahon, G., Hirth, K.P. and Powell, T.J., (1997) Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(Trifluoromethyl)-phenyl]5-methylisoxazole-4-carboxamide. Clin.Cancer Res. 3 (7), 1167-1177

Weiss, F.U., Daub, H. and Ullrich, A. (1997) Novel mechanisms of RTK signal generation. Current Opinion in Genetics & Development 7, 80-86

Brakebusch, C., Jallal, B., Fusco, O., Iacobelli , S. and Ullrich, A (1997) Expression of the 90K immunostimmulator gene is controlled by a promoter with unique features. J.Biol.Chem. 272, 3674-3682

Rappold, I., Ziegler L.B., Köhler, I. , Marchetto, S., Rosnet, O., Birnbaum, D., Simmons P.J., Zannettino, A.C.W., Hill, B., Neu, S., Knapp, W., Alitalo, R., Alitalo, K., Ullrich, A., Kranz, L. and Bühring, H.-J. (1997) Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 receptor tyrosine kinase. Blood 90, 111-125

Publications 1996

Vogel, W. and Ullrich, A. (1996) Multiple in Vivo Phosphorylated Tyrosine Phosphatase SHP-2 Engages Binding to Grb2 via Tyrosine 584 1 . Cell Growth & Differentiation 7, 1589-1597

Kim, Y.W., Wang, H., Sures, I., Lammers, R., Martell, K. and Ullrich, A. (1996) Characterization of the PEST family protein tyrosine phosphatase BDP1. Oncogene 13, 2275-2279

Aoki, N., Yamaguchi-Aoki, Y. and Ullrich, A. (1996) The novel protein-tyrosine phosphatase PTP20 is a positive regulator of PC12 cell neuronal differentiation. J.Biol.Chem. 271, 29422-29426

Wang, H., Lian, Z., Lerch, M., Chen, Z., Xie, W. and Ullrich, A. (1996) Characterization of PCP-2, a novel receptor protein tyrosine phosphatase of the MAM domain family. Oncogene 12, 2555-2562

Knebel, A., Rahmsdorf, H.J., Ullrich, A. and Herlich, P. (1996) Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents. EMBO J. 15, 5314-5325

Ali, S., Chen, Z., Lebrun, J.-J., Vogel, W., Kharitonenkov, A., Kelly, P.A. and Ullrich, A. (1996) PTP1D is a positive regulator of the prolactin signal to b -casein promoter activation. EMBO J. 15, 135-142

Koman, A., Cabauzon, S., Courod, P.O., Ullrich, A. and Strosberg, A.D. (1996) Molecular characterization and in vitro biological activity of placentin, a new member of the insulin gene family. J.Bio.Chem . 271, 20238-20241

Adachi, M., Fischer, E.H., Ihle, J., Imai, K., Jirik, F., Neel, B., Pawson, T., Shen, S.H., Thomas, M., Ullrich, A.and Zhao, Z.Z.(1996) Mammalian SH2-Containing Protein Tyrosine Phosphatases. Cell 85, 15

Kroder, G., Bossenmaier, B., Kellerer, M., Capp, E., Berti, L., Horikoshi, H., Ullrich, A., and Häring, H. (1996) TNF a - and hyperglycemia-induced insulin resistance: Evidence for different mechanisms and different effects on insulin signalling. J.of Clinical Investigation , 97, 1471-1477

Besser, J., Zahalka, M. and Ullrich, A. (1996) Exclusive expression of the receptor tyrosine kinase MDK4 in skeletal muscle and the decidua. MoD , 59, 41-52

D'Ostilio, N., Sabatino, G., Natoli, C., Ullrich, A., and Iacobelli , S. (1996) 90K (Mac-2 BP) in human milk. Clinical & Experimental Immunology, 104, 543-546

Ouwens, D.M., Mikkers, H.M.M., van der Zon, G.C.M., Stein-Gerlach, M., Ullrich, A., and Maassen, J.A. (1996) Insulin-induced tyrosine dephosphorylation of paxillin and focal adhesion kinase requires active PTP 1D. Biochemical J. 318, 609-614

Kéri, G., Érchegyi, J., Vántus, T., Horváth, A., Mezô, I., Balogh, A., Idei, M., Vadász, Z., Bökönyi, G., Teplán, I., Csuka, O., Tajeda, M., Gál, D., Szende, B., Roze, C., Kalthoff, H., Hofland, J., Lamberts, S.W.J., and Ullrich, A. (1996) A tumor-selective somatostatin analog (TT-232) with strong in vitro and in vivo antitumor activity. Proc.Natl.Acad.Sci.. 93, 12513-12518

Strawn, L.M., McMahon, G., App, H., Schreck, R., Kuchler, W.R., Longhi, M.P., Hui, T.H., Tang, C., Levitzki, A., Gazit, A., Chen, I., Kéri, G., Orfi,, L., Risau, W., Flamme, I., Ullrich, A., Hirth, K.P. and Shawver, L.K. (1996) Flk-1 as a Target for Tumor Growth Inhibition. Cancer Research 56, 3540-3545

Fuchs, M., Müller, T., Lerch, M.M. and Ullrich, A. (1996) Association of Human PTP k with Members of the Armadillo Family. J.Biol.Chem . 271, 16712-16719

Hobert, O., Jallal, B., and Ullrich, A. (1996) Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression. Molecular and Cellular Biology 16, 3066-3073

Daub, H., Weiss, F.U., Wallasch, C. and Ullrich, A. (1996) Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 379, 557-560

Sachs, M., Weidner, K.M., Brinkmann, V., Walther, I. , Obermeier, A., Ullrich, A., and Birchmeier, W. (1996) Motogenic and morphogenic activity of epithelial receptor tyrosine kinases. The Journal of Cell Biology 133, 1-13

Hallek, M., Herbst, R., Danhauser-Riedl, S., Warmuth, M., Winkler, A., Kolb, H-J., Druker, B., Emmerich, B., Griffin , J.D., and Ullrich, A. (1996) Interaction of the receptor tyrosine kinase p145 c-kit with the p210 bcr/abl -kinase in myeloid cells. British Journal of Haematology 94, 5-16

Lechner, C., Giot, J-F., Zahalka, M.A., Møller, N.P.H., and Ullrich, A. (1996) ERK6, a novel MAP kinase involved in C2C12 myoblast differentiation. Proc.Natl.Acad.Sci. 93, 4355-4359

Hobert, O., Sures, I. , Ciossek, T., Fuchs, M., and Ullrich, A. (1996) Isolation and developmental expression analysis of Enx-1, anovel mouse Polycomb group gene. MoD 55, 171-184

Hobert, O., Schilling, J.W., Beckerle, M.C., Ullrich, A., and Jallal, B. (1996) SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin. Oncogene 12, 1577-1581

Issing, W.J., Liebich, C., Wustrow, T.P. and Ullrich, A. (1996) Coexpression of epidermal growth factor receptor and TGF-alpha and survival in upper aerodigestive tract cancer. Anticancer Research 16, 283-288

Millauer, B., Longhi, M.P., Plate, K.H., Shawver, L.K., Risau, W., Ullrich, A., and Strawn, L.M. (1996) Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo. Cancer Res. 56, 1615-1620

Bühring, H-J., Müller, T., Herbst, R., Cole, S., Rappold, I., Schuller, W., Zhu, X., Fritzsche, U., Ullrich, A., Klein, G., and Schmidt, H. (1996) The adhesion molecule E-cadherin and a surface antigen recognized by the antibody 9C4 are selectively expressed on erythroid cells of defined maturational stages. Leukemia 10, 106-116

Obermeier, A., Tinhofer, I. , Grunicke, H.H., and Ullrich, A. (1996) Transforming potentials of EGF and NGF receptors inversely correlate with their PLC g affinity and signal activation . EMBO J. 15, 73-82

Publications 1995

Obermeier, A., Bradshaw, R., Seedorf, K., Choidas, A., Schlessinger, J. and Ullrich, A. (1995) Definition of Signals for Neuronal Differentiation. Annals of NY Acad.of Sci. 766, 1-17

Nucifora, F.C. jr., Li, S.H., Danoff, S., Ullrich, A. and Ross, C.A. (1995) Molecular cloning of a cDNA for the human inosistol 1,4,5-triphosphate receptor type 1, and the identification of a third alternatively spliced variant. Molecular Brain Research 32, 291-296

Shawver, L.K., Strawn, L.M. and Ullrich, A. (1995) Membrane bound receptor tyrosine kinases and chemical carcigonesis. Mutation Resarch 333, 23-2

Böhmer, F-D., Böhmer, A., Obermeier, A., and Ullrich, A. (1995) Use of selective tyrosine kinase blockers to monitor growth factor receptor dephosphorylation in intact cells. Analytic Biochemistry 228, 267-2773

Thümmler, F., Herbst, R., and Ullrich, A. (1995) Anlysis of the protein kinase activity of moss phytochrome expressed in fibroblast cell culture. Planta 197, 592-596

Kharitonenkov, A., Schnekenburger, J., Chen, Z., Knyazev, P., Ali, S., Zwick, E., White, M., and Ullrich, A. (1995) Adapter function of PTP1D in insulin receptor/IRS-1 interaction. J. Biol. Chem. 270, 29189-29193

Tomic, S., Greiser, U., Lammers, R., Kharitonenkov, A., Imyanitov, E., Ullrich, A., and Böhmer, F.-D. (1995) Association of SH2 domain protein tyrosine phosphatases with the epidermal growth factor receptor in human tumour cells: Phosphatidic acid activates receptor dephosphorylation by PTP1C. J. Biol. Chem. 270, 21277-21284

Stein-Gerlach, M., Kharitonenkov, A., Vogel, W., Ali, S., and Ullrich, A. (1995) Protein-tyrosine phosphatase 1D modulates its own state of tyrosine phosphorylation. J. Biol. Chem. 270, 24635-24637

Ciossek, T., Lerch, M.M., and Ullrich, A. (1995) Cloning, characterization, and differential expression of MDK2 and MDK5, two novel receptor tyrosine kinases of the eck/eph family. Oncogene 11, 2085-2095

Mossie, K., Jallal, B., Alves, F., Sures, I., Plowman, G., and Ullrich, A. (1995) Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family. Oncogene 11, 2179-2184

Wallasch, C., Weiß, F.U., Niederfellner, G., Jallal, B., Issing, W., and Ullrich, A. (1995) Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3. EMBO J. 14, 4267-4275

Møller, N.P.H., Møller, K., Lammers, R., Kharitonenkov, A., Hoppe, E., Wiberg, F.C., Sures, I. , and Ullrich, A. (1995) Selective down regulation of the insulin signal by protein-tyrosine phosphatases a and e . J. Biol. Chem. 270, 23126-23131

Baxter, R.M., Cohen, P., Ullrich, A., Downes, C.P., and Doza, Y.N. (1995) Phosphotyrosine residues in the NGF receptor (Trk-A): their role in the activation of phosphoinositide metabolism and protein kinase cascades in phaeochromocytoma (PC12) cells. Eur. J. Biochem. 234, 84-91

Mosthaf, L., Berti, L., Kellerer, M., Mushack, J., Seffer, E., Bossenmaier, B., Coghlan, M., Siddle, K., Ullrich, A., and Häring, H.U. (1995) C-terminus or juxtamembrane deletions in the insulin receptor do not affect the glucose-dependent inhibition of the tyrosine kinase activity. Eur. J. Biochem. 227, 787-791

Seedorf, K., Shearman, M., and Ullrich, A. (1995) Rapid and long-term effects of protein kinase C on receptor tyrosine kinase phosphorylation and degradation. J. Biol. Chem. 270, 18953-18960

Iacobelli , S., Ullrich, A., Tinari, N., Ortona, L., Tamburrini, E., D'Egidio, M., Ghinelli, F., Sighinolfi, L., Piazza, M., Chirianni, A., Guerra, L., and Natoli, C. (1995) The 90K tumor-associated antigen and clinical progression in human immunodeficiency virus infection. J. Acquired Immune Deficiency Syndrome and Human Retrovirology 10, 450-456

Dikic, I. , Batzer, A.G., Blaikie, P., Obermeier, A., Ullrich, A., Schlessinger, J., and Margolis, B. (1995) Shc binding to nerve growth factor rreceptor is mediated by the phosphotyrosine interaction domain. J. Biol. Chem. 270, 15125-15129

Murillas, R., Larcher, F., Conti, C.J., Santos, M., Ullrich, A., and Jorcano, J.L. (1995) Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure. EMBO J. 14, 5216-5223

Bühring, H-J., Sures, I., Jallal, B., Weiß, F.U., Busch, F.W., Ludwig, W-D., Handgretinger, R., Waller, H-D., and Ullrich, A. (1995) The receptor tyrosine kinase p185 HER2 is expressed on a subset of B-lymphoid blasts from patients with acute lymphoblastic leukemia and chronic myelogenous leukemia. Blood 86, 1916-1923

Powell, T.J., Schreck, R., McCall, M., Hui, T., Rice, A., App, H., Azam, M., Ullrich, A., and Shawver, L.K. (1995) A tumor-derived protein which provides T-cell costimulation through accessory cell activation. J. Immunotherapy 17, 209-221

Lebrun, J-J., Ali, S., Goffin, V., Ullrich, A., and Kelly, P.A. (1995) A single phosphotyrosine residue of the prolactin receptor is responsible for activation of gene transcription. Proc. Natl. Acad. Sci. USA 92, 4031-4035

Lebrun, J-J., Ali, S., Ullrich, A., and Kelly, P.A. (1995) Proline-rich sequence-mediated Jak2 association to the prolactin receptor is required but not sufficient for signal transduction. J. Biol. Chem. 270, 10664-10670

Ullrich, A. (1995) Inhibition of tumor growth by dominant negative inhibition of growth factor receptor signals. Restorative Neurology and Neuroscience 8, 75-76

Wellbrock, C., Lammers, R., Ullrich, A., and Schartl, M. (1995) Association between the melanoma-inducing receptor tyrosine kinase Xmrk and src family tyrosine kinases in Xiphophorus. Oncogene 10, 2135-2143

Jallal, B., Powell, J., Zachwieja, J., Brakebusch, C., Germain, L., Jacobs, J., Iacobelli , S., and Ullrich, A. (1995) Suppression of tumour growth in vivo by local and systemic 90K level increase. Cancer Research 55, 3223-3227

Herbst, R., Shearman, M.S., Jallal, B., Schlessinger, J., and Ullrich, A. (1995) Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro . Biochemistry 34, 5971-5979

Lichtner, R.B., Kaufmann, A.M., Kittmann, A., Rohde-Schulz, B., Walter, J., Williams, L., Ullrich, A., Schirrmacher, V., and Khazaie, K. (1995) Ligand mediated activation of ectopic EGF receptor promotes matrix protein adhesion and lung colonization of rat mammary adenocarcinoma cells. Oncogene 10, 1823-1832

Alves, F., Vogel, W., Mossie, K., Millauer, B., Höfler, H., and Ullrich, A. (1995) Distinct structural characteristics of discoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer. Oncogene 10, 609-618

Herbst, R., Munemitsu, S., and Ullrich, A. (1995) Oncogenic activation of v- kit involves deletion of a putative tyrosine-substrate interaction site. Oncogene 10, 369-379

Ciossek, T., Millauer, B., and Ullrich, A. (1995) Identification of alternatively spliced mRNAs encoding variants of MDK1, a novel receptor tyrosine kinase expressed in the murine nervous system. Oncogene 9, 97-108

Publications 1994

Kohda, D., Terasawa, H., Ichikawa , S., Ogura, K., Hatanaka, H., Mandiyan, V., Ullrich, A., Schlessinger, J., and Inagaki, F. (1994) Solution structure and ligand-binding site of the C-terminal SH3 domain of GRB2. Structure 2, 1029-1040

Terasawa, H., Kohda, D., Hatanaka, H., Tsuchiya, S., Ogura, K., Nagata, K., Ishii, S., Mandiyan, V., Ullrich, A., Schlessinger, J., and Inagaki, F. (1994) Structure of N-terminal SH3 domain of GRB2 complexed with a peptide from the guanine nucleotide releasing factor Sos. Nature Structural Biology 1, 891-897

Kaufmann, A.M., Khazaie, K., Wiedemuth, M., Rohde-Schulz, B., Ullrich, A., Schirrmacher, V., and Lichtner, R.B. (1994) Expression of epidermal growth factor receptor correlates with metastatic potential of 13762NF rat mammary adenocarcinoma cells. Int. J. Oncology 4, 1149-1155

Marth, C., Dreps, A., Natoli, C., Zeimet, A.G., Lang, T., Widschwendter, M., Daxenbichler, G., Ullrich, A., and Iacobelli , S. (1994) Effects of type-I and -II interferons on 90K antigen expression in ovarian carcinoma cells. Int. J. Cancer 59, 808-813

Hobert, O., Jallal, B., Schlessinger, J., and Ullrich, A. (1994) Novel signaling pathway suggested by SH3 domain-mediated p95 vav heterogeneous ribonucleoprotein K interaction. J. Biol. Chem. 269, 20225-20228

Sorokin, A., Lemmon, M.A., Ullrich, A., and Schlessinger, J. (1994) Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond. J. Biol. Chem. 269, 9752-9759

Salmon, S.E., Lam, K.S., Felder, S., Yeoman, H., Schlessinger, J., Ullrich, A., Krchnak, V., Lebl, M. (1994) One bead, one chemical compound: use of the selectide process for anticancer drug discovery. Acta Oncol. 33, 127-131

Hoppe, E., Berne, P-F., Stock, D., Rasmussen, J.S., Møller, N.P.H., Ullrich, A., and Huber, R. (1994) Expression, purification, and crystallization of human phosphotyrosine phosphatase 1B. Eur. J. Biochem . 223, 1069-1077

Plowman, G.D., Ullrich, A., and Shawver, L.K. (1994) Receptor tyrosine kinases as targets for drug intervention. Drug News and Perspectives 7, 334-339

Strawn, L.M., Mann, E., Elliger, S.S., Chu , L.M., Germain, L.L., Niederfellner, G., Ullrich, A., and Shawver, L.K. (1994) Inhibition of glioma cell growth by a truncated platelet-derived growth factor- b receptor. J. Biol. Chem. 269, 21215-21222

Lebrun, J-J., Ali, S., Sofer, L., Ullrich, A., and Kelly, P.A. (1994) Prolactin-induced proliferation of Nb2 cells involves tyrosine phosphorylation of the prolactin receptor and its associated tyrosine kinase JAK2. J. Biol. Chem. 269, 14021-14026

Fischer, G.A., Clementi, E., Raichman, M., Südhof, T., Ullrich, A., and Meldolesi, J. (1994) Stable expression of truncated inositol 1,4,5-trisphosphate receptor subunits in 3T3 fibroblasts: coordinate signaling changes and differential suppression of cell growth and transformation. J. Biol. Chem. 269, 19216-19224

Traverse, S., Seedorf, K., Paterson, H., Marshall, C.J., Cohen, P., and Ullrich, A. (1994) EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Current Biology 4, 694-701

Ullrich, A., Sures, I. , D'Egidio, M., Jallal, B., Powell, T.J., Herbst, R., Dreps, A., Azam, M., Rubinstein, M., Natoli, C., Shawver, L., Schlessinger, J., and Iacobelli , S. (1994) The secreted tumor-associated antigen 90K is a potent immune stimulator. J. Biol. Chem. 269, 18401-18407

Seedorf, K., Kostka, G., Lammers, R., Bashkin, P., Daly, R., Burgess, W.H., van der Bliek, A.M., Schlessinger, J., and Ullrich, A. (1994) Dynamin binds to SH3 domains of phospholipase C g and GRB-2. J. Biol. Chem. 269, 16009-16014

Møller, N.P.H., Møller, K.B., Lammers, R., Kharitonenkov, A., Sures, I. , and Ullrich, A. (1994) Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain. Proc. Natl. Acad. Sci. USA 91, 7477-7481

Malitschek, B., Wittbrodt, J., Lammers, R., Ullrich, A., and Schartl, M. (1994) Autocrine stimulation of the Xmrk receptor tyrosine kinase in Xiphophorus melanoma cells and identification of a source for the physiological ligand. J. Biol. Chem. 269, 10423-10430

Winkler, C., Wittbrodt, J., Lammers, R., Ullrich, A., and Schartl, M. (1994) Ligand-dependent tumor induction in medakafish embryos by a X mrk receptor tyrosine kinase transgene. Oncogene 9, 1517-1525

Accili, D., Mosthaf, L., Levy-Toledano, R., Ullrich, A., and Taylor , S.I. (1994) Mutagenesis of Phe 381 and Phe 382 in the extracellular domain of the insulin receptor: effects on receptor biosynthesis, processing, and ligand-dependent internalization. FEBS Letters 341, 104-108

Obermeier, A., Bradshaw, R.A., Seedorf, K., Choidas, A., Schlessinger, J., and Ullrich, A. (1994) Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC g . EMBO J. 13, 1585-1590

Millauer, B., Shawver, L.K., Plate, K.H., Risau, W., and Ullrich, A. (1994) Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature 367, 576-579

Publications 1993

Plate, K.H., Breier, G., Millauer, B., Ullrich, A., and Risau, W. (1993) Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis. Cancer Research 53, 5822-5827

Kellerer, M., Machicao, F., Berti, L., Sixt, B., Muschack, J., Seffer, E., Mosthaf, L., Ullrich, A., and Häring, H.U. (1993) Inositol phospho-oligosaccharides from rat fibroblasts and adipocytes stimulate 3-O-methylglucose transport. Biochem. J. 295, 699-704

Obermeier, A., Lammers, R., Wiesmüller, K-H., Jung, G., Schlessinger, J., and Ullrich, A. (1993) Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signalling complex. J. Biol. Chem. 268, 22963-22966

Lammers, R., Bossenmaier, B., Cool, D.E., Tonks, N.K., Schlessinger, J., Fischer, E.H., and Ullrich, A. (1993) Differential activities of protein tyrosine phosphatases in intact cells. J. Biol. Chem. 268, 22456-22462

von Rüden, T., Stingl, L., Ullrich, A., and Wagner, E.F. (1993) Rescue of W associated mast cell defects in W / W v bone marrow cells by ectopic expression of normal and mutant epidermal growth factor receptors. Blood 82, 1463-1470

Bühring, H.-J., Herbst, R., Kostka, G., Bossenmaier, B., Bartke, I., Kropshofer, H., Kalbacher, H., Busch, F.W., Müller, C.A., Schlessinger, J., and Ullrich, A. (1993) Modulation of p145 c-kit function in cells of patients with acute myeloblastic leukemia. Cancer Research 53, 4424-4431

Shearman, M.S., Herbst, R., Schlessinger, J., and Ullrich, A. (1993) Phosphatidylinositol 3'-kinase associates with p145 c-kit as part of a cell type-characteristic multimeric signalling complex. EMBO J. 12, 3817-3826

Mohammadi, M., Honegger, A., Sorokin, A., Ullrich, A., Schlessinger, J., and Hurwitz, D.R. (1993) Aggregation induced activation of the epidermal growth factor receptor protein tyrosine kinase. Biochemistry 32, 8742-8748

Zhou, M., Felder, S., Rubinstein, M., Hurwitz, D.R., Ullrich, A., Lax, I., and Schlessinger, J. (1993) Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation. Biochemistry 32, 8193-8198

Skolnik, E.Y., Lee, C.-H., Batzer, A., Vicentini, L.M., Zhou, M., Daly, R., Myers Jr., M.J., Backer, J.M., Ullrich, A., White, M.F., and Schlessinger, J. (1993) The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signaling. EMBO J. 12, 1929-1936

Kohda, D., Hatanaka, H., Odaka, M., Mandiyan, V., Ullrich, A., Schlessinger, J., and Inagaki, F. (1993) Solution structure of the SH3 domain of phospholipase C g . Cell 72, 953-960

Millauer, B., Wizigmann-Voos, S., Schnürch, H., Martinez , R., Møller, N.P.H., Risau, W., and Ullrich, A. (1993) High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72, 835-846

Mosthaf, L., Eriksson, J., Häring, H-U., Groop, L., Widen, E., and Ullrich, A. (1993) Insulin receptor isotype expression correlates with risk of non-insulin-dependent diabetes. Proc. Natl. Acad. Sci. USA 90, 2633-2635

Vogel, W., Lammers, R., Huang, J., and Ullrich, A. (1993) Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. Science 259, 1611-1614

Obermeier, A., Halfter, H., Weismüller, K.-H., Jung, G., Schlessinger, J., and Ullrich, A. (1993) Tyrosine 785 is a major determinant of Trk substrate interaction. EMBO J. 12, 933-941

Felder, S., Zhou, M., Hu, P., Urena, J., Ullrich, A., Chaudhuri, M., White, M., Shoelson, S.E., and Schlessinger, J. (1993) SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange. Mol. Cell. Biol. 13, 1449-1455

Schumacher, R., Soos, M.A., Schlessinger, J., Brandenburg , D., Siddle, K., and Ullrich, A. (1993) Signalling-competent receptor chimeras allow mapping of major insulin receptor binding domain determinants. J. Biol. Chem . 268, 1087-1094

Natali, P.G., Nicotra, M.R., Sures, I., Santoro, E., Bigotti, A., and Ullrich, A. (1993) Expression of c-kit receptor in normal and transformed human nonlymphoid tissues. Cancer Research 52, 6139-6143

Futter, C.E., Felder, S., Schlessinger, J., Ullrich, A., and Hopkins, C.R. (1993) Annexin-I is phosphorylated in the multivesicular body during the processing of the epidermal growth factor receptor. J. Cell Biol. 120, 77-83

Kohda, D., Odaka, M., Lax, I., Kawasaki, H., Suzuki, K., Ullrich, A., Schlessinger, J., and Inagaki, F. (1993) A 40-kDa epidermal growth factor/transforming growth factor-alpha binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor. J. Biol. Chem. 268, 1976-1981

Reisbach, G., Bartke, I., Kempkes, B., Kostka, G., Ellwart, J., Birner, A., Thalmeier, K., Mailhammer, R., Bornkamm, G.W., Ullrich, A., and Dörmer, P. (1993) Characterization of hemopoietic cell populations from human cord blood expressing c-kit . Exp. Hematol. 21, 74-79

Gottschalk, W.K., Lammers, R., and Ullrich, A. (1993) The carboxy-terminal 110 amino acid portion of the insulin receptor is important for insulin signalling to pyruvate dehydrogenase. Biochem. Biophys. Res. Comm. 189, 906-911

Seedorf, K., Millauer, B., Schlessinger, J., and Ullrich, A. (1992) Differential effects of carboxy-terminal sequence deletions on platelet-derived growth factor receptor signalling activities and interaction with cellular substrates. Mol. Cell. Biol. 12, 4347-4356

Margolis, B., Silvennoinen, O., Comoglio, P., Roonprapunt, C., Skolnik, E., Ullrich, A., and Schlessinger, J. (1993) High efficiency expression/cloning of epidermal growth factor receptor binding proteins with src homology 2 domains. Proc. Natl. Acad. Sci. USA 89, 8894-8898

Publications 1992

Li, W., Hu, P., Skolnik, E.Y., Ullrich, A., and Schlessinger, J. (1992) The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors. Mol. Cell. Biol. 12, 5824-5833

Wittbrodt, J., Lammers, R., Malitschek, B., Ullrich, A., and Schartl, M. (1992) The Xmrk receptor tyrosine kinase is activated in Xiphophorus malignant melanoma. EMBO J. 11, 4239-4246

Schlessinger, J. and Ullrich, A. (1992) Growth factor signaling by receptor tyrosine kinases. Neuron 9, 383-391

Natali, P.G., Nicotra, M.R., Sures, I. , Mottolese, M., Botti, C., and Ullrich, A. (1992) Breast cancer is associated with loss of the c- kit oncogene product. Int. J. Cancer 52, 713-717

Marth, C., Lang, T., Cronauer, M.V., Doppler, W., Zeimet, A.G., Bachmair, F., Ullrich, A., and Daxenbichler, G. (1992) Epidermal growth factor reduces HER-2 protein level in human ovarian carcinoma cells. Int. J. Cancer 52, 311-316

Natali, P.G., Nicotra, M.R., Winkler, A.B., Cavaliere, R., Bigotti, A., and Ullrich, A. (1992) Progression of human cutaneous melanoma is associated with loss of expression of c-kit proto-oncogene receptor. Int. J. Cancer 52, 197-201

Herbst, R., Shearman, M.S., Obermeier, A., Schlessinger, J., and Ullrich, A. (1992) Differential effects of W mutations on p145 c- kit tyrosine kinase activity and substrate interaction. J. Biol. Chem . 267, 13210-13216

Lowenstein, E.J., Daly, R.J., Batzer, A.G., Li, W., Margolis, B., Lammers, R., Ullrich, A., Skolnik, E.Y., Bar-Sagi, D., and Schlessinger, J. (1992) The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell 70, 431-442

Pietrzkowski, Z., Sell, C., Lammers, R., Ullrich, A., and Baserga, R. (1992) The role of insulinlike growth factor 1 (IGF-1) and the IGF-1 receptor in epidermal growth factor-stimulated growth of 3T3 cells. Mol. Cell. Biol. 12, 3883-3889

Schlessinger, J., Mohammadi, M., Margolis, B., and Ullrich, A. (1992) Role of SH2-containing proteins in cellular signaling by receptor tyrosine kinases. Cold Spring Harbor Symp. Quant. Biol. 57, 67-74

Pietrzkowski, Z., Lammers, R., Carpenter, G., Soderquist, A.M., Limardo, M., Phillips, P.D., Ullrich, A., and Baserga, R. (1992) Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors. Cell Growth and Differentiation 3, 199-205

Soos, M.A., Field, C.E., Lammers, R., Ullrich, A., Zhang, B., Roth, R.A., Andersen, A.S., Kjeldsen, T., and Siddle, K. (1992) A panel of monoclonal antibodies for the type I insulin-like growth factor receptor: epitope mapping, effects on ligand binding, and biological activity. J. Biol. Chem . 267, 12955-12963

von Rüden, T., Kandels, S., Radaszkiewicz, T., Ullrich, A., and Wagner, E.F. (1992) Development of a lethal mast cell disease in mice reconstituted with bone marrow cells expressing the v-erbB oncogene. Blood 79, 3145-3158

Lichtner, R.B., Wiedemuth, M., Kittmann, A., Ullrich, A., Schirrmacher, V., and Khazaie, K. (1992) Ligand-induced activation of epidermal growth factor receptor in intact rat mammary adenocarcinoma cells without detectable receptor phosphorylation. J. Biol. Chem. 267, 11872-11880

Ross, C.A., Danoff, S.K., Schell, M.J., Snyder, S.H., and Ullrich, A. (1992) Three additional inositol 1,4,5-trisphosphate receptors: Molecular cloning and differential localization in brain and peripheral tissues. Proc. Natl. Acad. Sci. USA 89, 4265-4269

Kellerer, M., Lammers, R., Ermel, B., Tippmer, S., Vogt, B., Obermaier-Kusser, B., Ullrich, A., and Häring, H.U. (1992) Distinct a -subunit structures of human insulin receptor-A and receptor-B variants determine differences in tyrosine kinase activities. Biochemistry 31, 4588-4596

Rotin, D., Honegger, A.M., Margolis, B.L., Ullrich, A., and Schlessinger, J. (1992) Presence of SH2 domains of phospholipase C g 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor. J. Biol. Chem. 267, 9678-9683

Bacus, S.S., Stancovski, I. , Huberman, E., Chin, D., Hurwitz, E., Mills, G.B., Ullrich, A., Sela, M., and Yarden, Y. (1992) Tumor-inhibitory monoclonal antibodies to the HER2/neu receptor induce differentiation of human breast cancer cells. Cancer Research 52, 2580-2589

Spivak-Kroizman, T., Rotin, D., Pinchasi, D., Ullrich, A., Schlessinger, J., and Lax, I. (1992) Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses. J. Biol. Chem. 267, 8056-8063

Felder, S., LaVin, J., Ullrich, A., and Schlessinger, J. (1992) Kinetics of binding, endocytosis and recycling of EGF receptor mutants. J. Cell Biol. 117, 203-212

Hu, P., Margolis, B., Skolnik, E.Y., Lammers, R., Ullrich, A., and Schlessinger, J. (1992) Interaction of phosphatidyl 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors. Mol. Cell. Biol. 12, 981-990

Jallal, B., Schlessinger, J., and Ullrich, A. (1992) Tyrosine phosphatase inhibition permits analysis of signal transduction complexes in p185 HER2/ neu -overexpressing human tumor cells. J. Biol. Chem. 267, 4357-4363

Margolis, B., Hu, P., Katzav, S., Li, W., Oliver, J.M., Ullrich, A., Weiss, A., and Schlessinger, J. (1992) Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Nature 356, 71-74

Redemann, N., Holzmann, B., von Rüden, T., Wagner, E.F., Schlessinger, J., and Ullrich, A. (1992) Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants. Mol. Cell. Biol. 12, 491-498

Germain-Lee, E.L., Janicot, M., Lammers, R., Ullrich, A., and Casella, S.J. (1992) Expression of a type I insulin-like growth factor receptor with low affinity for insulin-like growth factor II. Biochem. J. 281, 413-417

Tartare, S., Ballotti, R., Lammers, R., Filloux, C., Chauvel, A., Schlessinger, J., Ullrich, A., and Van Obberghen, E. (1992) Activation of insulin-epidermal growth factor (EGF) receptor chimerae regulates EGF receptor binding affinity. J. Cell Biol. 116, 627-633

Rotin, D., Margolis, B., Mohammadi, M., Daly, R., Daum, G., Li, N., Fischer, E.H., Burgess, W.H., Ullrich, A., and Schlessinger, J. (1992) SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C g . EMBO J. 11, 559-567

Marth, C., Cronauer, M.V., Doppler, W., Ofner, D., Ullrich, A., and Daxenbichler, G. (1992) Effects of interferons on the expression of the proto-oncogene HER2 in human ovarian carcinoma cells. Int. J. Cancer 50, 64-68

Sesti, G., Marini, M.A., Montemurro, A., Condorelli, L., Borboni, P., Häring, H-U., Ullrich, A., Goldfine, I.D., De Pirro, R., and Lauro, R. (1992) Evidence that two naturally occurring human insulin receptor a -subunit variants are immunologically distinct. Diabetes 41, 6-11

Ballotti, R., Baron, V., Gautier, N., Hainaut, P., Scimeca, J.C., Dolais-Kitabgi, J., Lammers, R., Schlessinger, J., Ullrich, A., and Van Obberghen, E. (1992) Activation and regulation of the insulin receptor kinase. Diabete Metab. 18, 98-103

Accili, D., Kadowaki, T., Kadowaki, H., Mosthaf, L., Ullrich, A., and Taylor, S.I. (1992) Immunoglobulin heavy chain-binding protein binds to misfolded mutant insulin receptors with mutations in the extracellular domain. J. Biol. Chem. 267, 586-590

Publications 1991

Kellerer, M., Machicao, F., Seffer, E., Mushack, J., Ullrich, A., and Häring, H.U. (1991) Stimulation of phospholipase-C activity by insulin is mediated by both isotypes of the human insulin receptor. Biochem. Biophys. Res. Comm . 181, 566-572

Hudziak, R.M. and Ullrich, A. (1991) Cell transformation potential of a HER2 transmembrane domain deletion mutant retained in the endoplasmic reticulum. J. Biol. Chem. 266, 24109-24115 Soos, M.A., Taylor, C.E., Lammers, R., Ullrich, A., and Siddle, K. (1991) Monoclonal antibodies for studying the structure and function of type I IGF receptors and IGF receptor/insulin receptor hybrids. Proceedings of the 2nd International Symposium on IGFs (San Francisco, January 1991)

Hurwitz, D.R., Emanuel, S.L., Nathan, M.H., Sarver, N., Ullrich, A., Felder, S., Lax, I., and Schlessinger, J. (1991) EGF induces increased ligand binding affinity and dimerization of soluble epidermal growth factor (EGF) receptor extracellular domain. J. Biol. Chem. 266, 22035-22043

Herbst, R., Lammers, R., Schlessinger, J., and Ullrich, A. (1991) Substrate phosphorylation specificity of the human c- kit receptor tyrosine kinase. J. Biol. Chem. 266, 19908-19916

Pillay, T.S., Whittaker, J., Lammers, R., Ullrich, A., and Siddle, K. (1991) Multisite serine phosphorylation of the insulin and IGF-1 receptors in transfected cells. FEBS Letters 288, 206-211

Bühring, H-J., Ullrich, A., Schaudt, K., Müller, C., and Busch, F.W. (1991) Proto-oncogene c-kit (p145c-kit) is a human bone marrow surface antigen of hemopoietic precursor cells which is expressed on a subset of acute non-lymphoblastic leukemic cells. Leukemia 5, 854-860

Schumacher, R., Mosthaf, L., Schlessinger, J., Brandenburg, D., and Ullrich, A. (1991) Insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors. J. Biol. Chem. 266, 19288-19295

Stancovski, I. , Hurwitz, E., Leitner, O., Ullrich, A., Yarden, Y., and Sela, M. (1991) Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth. Proc. Natl. Acad. Sci. USA 88, 8691-8695

Avivi, A., Lax, I. , Ullrich, A., Schlessinger, J., Givol, D., and Morse, B. (1991) Comparison of EGF receptor sequences as a guide to study the ligand binding site. Oncogene 6, 673-676

Skolnik, E.Y., Margolis, B., Mohammadi, M., Lowenstein, E., Fischer, R., Dreps, A., Ullrich, A., and Schlessinger, J. (1991) Cloning of PI3 kinase associated P85 utilizing a novel method for expression cloning of target proteins for receptor tyrosine kinases. Cell 65, 83-90

Vogt, B., Carrascosa, J.M., Ermel, B., Ullrich, A., and Häring, H.U. (1991) The two isotypes of the human insulin receptor (HIR-A and HIR-B) follow different internalization kinetics. Biochem. Biophys. Res. Comm. 177, 1013-1018

Mosthaf, L., Vogt, B., Häring, H.U., and Ullrich, A. (1991) Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients. Proc. Natl. Acad. Sci. USA 88, 4728-4730

Shepard, H.M., Lewis, G.D., Sarup, J.S., Fendly, B.M., Maneval, D., Mordenti, J., Figari, I., Kotts, C.E., Palladino, Jr., M.A., Ullrich, A., and Slamon, D. (1991) Monoclonal antibody therapy of human cancer: Taking the HER2 protooncogene to the clinic. J. Clinical Immunology 11, 117-127

Giovanella, B., Vardeman, D.M., Williams, L.J., Taylor, D.J., de Iplyi, P.D., Greeff, P.J., Stehlin, J.S., Ullrich, A., Cailleau, R., Slamon, D.J., and Gary, Jr., H.E. (1991) Heterotransplantation of human breast carcinomas in nude mice: Correlation between successful heterotransplants, poor prognosis and amplification of the HER-2/ neu oncogene. Int. J. Cancer 47, 66-71

Scott, G.K., Dodson, J.M., Montgomery , P.A., Johnson, R.M., Sarup, J.C., Wong, W.L., Ullrich, A., Shepard, H.M., and Benz, C.C. (1991) p185-HER2 signal transduction in breast cancer cells. J. Biol. Chem. 266, 14300-14305

Sarup, J.C., Johnson, R.M., King, K.L., Fendly, B.M., Lipari, M.T., Napier, M.A., Ullrich, A., and Shepard, H.M. (1991) Characterization of an anti-p185 HER2 monoclonal antibody that stimulates receptor function and inhibits tumor cell growth. Growth Regulation 1, 72-82

Carrascosa, J.M., Vogt, B., Ullrich, A., and Häring, H.U. (1991) Activation of phosphatidylinositol-3-kinase by insulin is mediated by both A and B human insulin receptor types. Biochem. Biophys. Res. Comm. 174, 123-127

Seedorf, K., Felder, S., Millauer, B., Schlessinger, J., and Ullrich, A. (1991) Analysis of platelet-derived growth factor receptor domain function using a novel chimeric receptor approach. J. Biol. Chem. 266, 12424-12431

Danoff, S.K., Ferris, C.D., Donath, C., Fischer, G., Munemitsu, S., Ullrich, A., Snyder, S.H., and Ross , C.A. (1991) Inositol 1,4,5-trisphosphate receptors: distinct neuronal and non-neuronal forms derived by alternative splicing differ in phosphorylation. Proc. Natl. Acad. Sci. USA 88, 2951-2955

Hack, N., Margolis, B.L., Ullrich, A., Schlessinger, J., and Skorecki, K.L. (1991) Distinct structural specificities for functional coupling of the epidermal growth factor receptor to calcium-signalling versus phospholipase-A2 responses. Biochem. J. 275, 563-567

Tartare, S., Ballotti, R., Lammers, R., Alengrin, F., Dull, T., Schlessinger, J., Ullrich, A., and Van Obberghen, E. (1991) Insulin-EGF receptor chimerae mediate tyrosine transphosphorylation and serine/threonine phosphorylation of kinase-deficient EGF receptors. J. Biol. Chem. 266, 9900-9906

Strohmeyer, T., Peter, S., Hartmann, M., Munemitsu, S., Ackermann, R., Ullrich, A., and Slamon, D.J. (1991) Expression of the hst1 and c-kit proto-oncogenes in human testicular germ cell tumors. Cancer Research 51, 1811-1816

Li, W., Hack, N., Margolis, B., Ullrich, A., Skorecki, K., and Schlessinger, J. (1991) Carboxy-terminal truncations of EGF-receptor affect diverse EGF-induced cellular responses. Mol. Biol. Cell. 2, 641-649

App, H., Hazan, R., Zilberstein, A., Ullrich, A., Schlessinger, J., and Rapp, U. (1991) EGF stimulates association with c- raf and its kinase activity in living cells. Mol. Cell Biol. 11, 913-919

Lax, I., Mitra, A.K., Ravera, C., Hurwitz, D.R., Rubinstein, M., Ullrich, A., Stroud, R.M., and Schlessinger, J. (1991) EGF induces oligomerization of soluble, extracellular, ligand binding domain of EGF-receptor -- a low resolution projection structure of the ligand binding domain. J. Biol. Chem. 266, 13828-13833

Ullrich, A., Gray, A., Munemitsu, S., Schlessinger, J., and Massoglia, S. (1991) Epidermal growth factor receptor autophosphorylation is not required for normal mitogenic or transforming signal generation. In: Biological Signal Transduction , NATO ASI Series, Vol. H52, pp. 17-29

Accili, D., Mosthaf, L., Ullrich, A., and Taylor, S.I. (1991) A mutation in the extracellular domain of the insulin receptor impairs the ability of insulin to stimulate receptor autophosphorylation. J. Biol. Chem. 266, 434-439

Treadway, J.L., Morrison, B.D., Soos, M.A., Siddle, K., Olefsky, J., Ullrich, A., McClain, D.A., and Pessin, J.E. (1991) Transdominant inhibition of tyrosine kinase activity in mutant insulin/insulin-like growth factor-1 hybrid receptors. Proc. Natl. Acad. Sci. USA 88, 214-218

Ullrich, A. (1991) IGF-I receptor cDNA cloning. Meth. Enzymol. 198, 17-26

Lammers, R. and Ullrich, A. (1991) Construction and expression of chimeric cell surface receptors. Meth. Enzymol. 198, 225-232

Backer, J.M., Schroeder, G.G., Cahill, D.A., Ullrich, A., Siddle, K., and White, M.F. (1991) Cytoplasmic juxtamembrane region of the insulin receptor: A critical role in ATP binding, endogenous substrate phosphorylation, and insulin-stimulated bioeffects in CHO cells. Biochemistry 30, 6366-6372

Peles, E., Levy, R.B., Or, E., Ullrich, A., and Yarden, Y. (1991) Oncogenic forms of the neu /HER2 tyrosine kinase are permanently coupled to phospholipase C g . EMBO J. 10, 2077-2086

Kashles, O., Yarden, Y., Fischer, R., Ullrich, A., and Schlessinger, J. (1991) A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization. Mol. Cell. Biol. 11, 1454-1463

Publications 1990

Eldar, H., Zisman, Y., Ullrich, A., and Livneh, E. (1990) Overexpression of protein kinase C a -subtype in Swiss/3T3 fibroblasts causes loss of both high and low affinity receptor numbers for epidermal growth factor. J. Biol. Chem. 265, 13290-13296

Margolis, B., Li, N., Koch, A., Mohamaddi, M., Hurwitz, D., Zilberstein, A., Ullrich, A., Pawson, T., and Schlessinger, J. (1990) The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC- g . EMBO J. 9, 4375-4380

Ballotti, R., Baron, V., Gautier, N., Hainaut, P., Scimeca, J.C., Dolaiskitabgi, J., Lammers, R., Schlessinger, J., Ullrich, A., and Van Obberghen, E. (1990) Activation and regulation of the insulin receptor kinase. Hormones and Cell Regulation 210, 29-36

Backer, J.M., Kahn, C.R., Cahill, D.A., Ullrich, A., and White, M.F. (1990) Receptor-mediated internalization of insulin requires a 12 amino acid sequence in the juxtamembrane region of the insulin receptor b -subunit. J. Biol. Chem. 265, 16450-16454

Munemitsu, S., Innis, M.A., Clark, R., McCormick, F., Ullrich, A., and Polakis, P. (1990) Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC 42. Mol. Cell. Biol. 10, 5977-5982

Williams, J.F., McClain, D.A., Dull, T.J., Ullrich, A., and Olefsky, J.M. (1990) Characterization of an insulin receptor mutant lacking the subunit processing site. J. Biol. Chem. 265, 8463-8469

Hudziak, R.M., Lewis, G.D., Holmes, W.E., Ullrich, A., and Shepard, H.M. (1990) Selection for transformation and met protooncogene amplification in NIH 3T3 fibroblasts using tumor necrosis factor a. Cell Growth and Differentiation 1, 129-134

Ullrich, A. and Schlessinger, J. (1990) Signal transduction by receptors with tyrosine kinase activity. Cell 61, 203-212

Fendly, B.M., Kotts, C., Vetterlein, D., Lewis, G.D., Winget, M., Carver, M.E., Watson, S.R., Sarup, J., Saks, S., Ullrich, A., and Shepard, H.M. (1990) The extracellular domain of HER2/neu is a potential immunogen for active specific immunotherapy of breast cancer. J. Biol. Response Modifiers 9, 449-455

Hoffman, B.L., Ullrich, A., Wold, W.S.M., and Carlin, C.R. (1990) Retrovirus-mediated transfer of an adenovirus gene encoding an integral membrane protein is sufficient to down regulate the receptor for epidermal growth factor. Mol. Cell. Biol. 10, 5521-5524

Barbry, P., Champe, M., Chassande, O., Munemitsu, S., Champigny, G., Lingueglia, E., Maes, P., Frelin, C., Tartar, A., Ullrich, A., and Lazdunski, M. (1990) Human kidney amiloride binding protein: cDNA structure and functional expression. Proc. Natl. Acad. Sci . 87, 7347-7351

Barbry, P., Simon-Bouy, B., Mattei, M.-G., Le Guern, E., Jaume-Roig, B., Chassande, O., Ullrich, A., and Lazdunski, M. (1990) Localization of the gene for amiloride binding protein on chromosome 7 and RFLP analysis in cystic fibrosis families. Human Genetics 85, 587-589

Soos, M.A., Whittaker, J., Lammers, R., Ullrich, A., and Siddle, K. (1990) Receptors for insulin and insulin-like growth factor-I can form hybrid dimers: characterization of hybrid receptors in transfected cells. Biochemical Journal 270, 383-390

Felder, S., Miller, K., Moehren, G., Ullrich, A., Schlessinger, J., and Hopkins, C.R. (1990) Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body. Cell 61, 623-634

Lammers, R., Van Obberghen, E., Ballotti, R., Schlessinger, J., and Ullrich, A. (1990) Transphosphorylation as a possible mechanism for insulin and EGF receptor activation. J. Biol. Chem. 265, 16886-16890

Hsu, C-Y.J., Mohammadi, M., Nathan, M., Honegger, A.M., Ullrich, A., Schlessinger, J., and Hurwitz, D.R. (1990) Generation of cytoplasmic domain of EGF-receptor with intrinsic protein tyrosine kinase activity. Cell Growth and Differentiation 1, 191-200

Honegger, A.M., Schmidt, A., Ullrich, A., and Schlessinger, J. (1990) Separate endocytic pathways of kinase defective and active EGF-receptor mutants expressed in same cells. J. Cell. Biol 10, 1541-1548

Hazan, R., Margolis, B., Dombalagian, M., Ullrich, A., Zilberstein, A., and Schlessinger, J. (1990) Identification of autophosphorylation sites of HER2/ neu . Cell Growth and Differentiation 1, 3-7

Honegger, A.M., Schmidt, A., Ullrich, A., and Schlessinger, J. (1990) Evidence for epidermal growth factor-induced intermolecular autophosphorylation of the EGF receptors in living cells. Mol. Cell. Biol. 10, 4035-4044

Bellot, F., Moolenaar, W., Kris, R., Mirakhur, B., Ullrich, A., Schlessinger, J., and Felder, S. (1990) A monoclonal anti-EGF-receptor antibody reduces high affinity binding and early responses of cells to low doses of EGF. J. Cell Biol. 110,491-502

Massoglia, S., Gray, A., Dull, T.J., Munemitsu, S., Kung, H-J., Schlessinger, J., and Ullrich, A. (1990) Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformation. Mol. Cell. Biol. 10, 3048-3055

Margolis, B., Zilberstein, A., Franks, C., Felder, S., Kremer, S., Ullrich, A., Rhee, S.G., Skorecki, K., and Schlessinger, J. (1990) Effect of phospholipase-C- g overexpression on PDGF-induced second messengers and mitogenesis. Science 248, 607-610

Margolis, B.L., Bellot, F., Honegger, A.M., Ullrich, A., Schlessinger, J., and Zilberstein, A. (1990) Tyrosine kinase activity is essential for the association of phospholipase C- g with the epidermal growth factor receptor. Mol. Cell. Biol. 10, 435-441

Mosthaf, L., Grako, K., Dull, T.J., Coussens, L., Ullrich, A., and McClain, D.A. (1990) Functionally distinct insulin receptors generated by tissue-specific alternate splicing. EMBO J. 9, 2409-2413

Natali, P.G., Nicotra, M.R., Bigotti, A., Venturo, I. , Slamon, D.J., Fendly, B.M., and Ullrich, A. (1990) Expression of the p185 encoded by HER2 oncogene in normal and transformed human tissues. Int. J. Cancer 45, 457-461

Lax, I. , Bellot, F., Honegger, A.M., Schmidt, A., Ullrich, A., Givol, D., and Schlessinger, J. (1990) Domain deletion in the extracellular portion of the EGF-receptor reduces ligand binding and impairs cell surface expression. Cell Regulation 1, 173-188

Lammers, R., Riedel, H., and Ullrich, A. (1990) Chimeric receptors reveal distinct signalling characteristics of receptor tyrosine kinase cytoplasmic domains. In: Growth Factors : From Genes to Clinical Application . Eds: Sara, V.R., Hall, K., and Löw, H., Karolinska Institute Nobel Conference Series, pp. 51-63, Raven Press, New York

Fendly, B.M., Winget, M., Hudziak, R., Lipari, M.T., Napier, M.A., and Ullrich, A. (1990) Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/ neu gene product. Cancer Research 50, 1550-1558

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