Phosphorylations in tumor tissue
One of the major interests of my research is to apply MS-based phosphoproteomics to tumor tissue studies and evaluate if phosphorylations could be useful to classify and diagnose tumors at different stages. Up to now I investigated the identification of phosphorylation sites in fresh and frozen (stored at -80 C) mouse tumor tissues (melanomas) by applying different phospho-enrichment protocols followed by MS analysis and map an in depth proteome and phosphoproteome of melanoma (JPR 2008 Oct 31. [Epub ahead of print]).
Current studies are devoted at quantifying phosphorylation sites in mouse tumors at different stages by using SILAC tissue as internal standard for the different stages. These projects are in collaboration with the Department of Molecular Medicine (Head: Prof. Reinhard Faessler)
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