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Proteomics and Signal Transduction
Matthias Mann
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Mass spectrometry
SILAC
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Mass spectrometry
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Phosphorylation
Glycosylation
Acetylation
Phosida
Interaction proteomics
Publications
Phosphoproteins of the chicken eggshell calcified layer
Quantitative proteomic profiling of membrane proteins
SILAC
Time-Lapse Proteomics
SILAC
Molecular approaches for the identification of novel egg components
SILAC
The low molecular weight proteome of Halobacterium salinarum.
In-gel digestion
In-depth analysis of the adipocyte proteome
Analysis of Nucleolar Protein Dynamics
Quantitative proteomic assessment of very early cellular signaling events.
Urine release of systemically administered bone morphogenetic protein hybrid molecule
A mass spectrometry-friendly database for cSNP identification
Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation.
Stable isotope labeling by amino acids in cell culture for quantitative proteomics.
Analysis of the Mouse Liver Proteome Using Advanced Mass Spectrometry
Stable isotope labeling by amino acids in cell culture for quantitative proteomics.
The chicken egg white proteome
Perlinhibin, a cysteine-, histidine-, and arginine-rich miniprotein from abalone
Stable isotope labeling by amino acids in cell culture for quantitative proteomics.
Selective Anchoring of TFIID to Nucleosomes
Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation
Top-down quantitation and characterization of SILAC- labeled proteins
Nanoelectrospray peptide mapping revisited: Composite survey spectra allow high dynamic range protein characterization without LCMS
Motif decomposition of the phosphotyrosine proteome reveals a new N-terminal binding motif for SHIP2
Phosida
N-Formylation of lysine
Integrated Analysis of the Cerebrospinal Fluid Peptidome and Proteome
The chicken egg yolk plasma and granule proteomes
In vivo identification of human SUMO polymerization sites
Absolute SILAC for Accurate Quantitation of Proteins in Complex Mixtures Down to the Attomole Level
Dissection of the insulin signaling pathway via quantitative phosphoproteomics.
Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation
The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2
The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2
Stable isotope labeling by amino acids in cell culture (SILAC) and proteome quantitation of mouse embryonic stem cells to a depth of 5,111 proteins
Global and Site-Specific Quantitative Phosphoproteomics: Principles and Applications.
Constitutive and dynamic phosphorylation and acetylation sites on NUCKS, a hypermodified nuclear protein, studied by quantitative proteomics
Protocol to enrich and analyze plasma membrane proteins from frozen tissues
Proteomic analysis of the chicken egg vitelline membrane
Iodoacetamide-induced artifact mimics ubiquitination in mass spectrometry
The ubiquitin-proteasome system is a key component of the SUMO-2/3 cycle.
Identification of new chicken egg proteins by mass spectrometry-based proteomic analysis
Phosphorylation of the human full-length protein kinase Ciota
SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function
Multi-spectra peptide sequencing and its applications to multistage mass spectrometry.
Can Proteomics Retire the Western Blot?
High confidence determination of specific protein-protein interactions using quantitative mass spectrometry
How Much Peptide Sequence Information Is Contained in Ion Trap Tandem Mass Spectra?
The sea urchin (Strongylocentrotus purpuratus) test and spine proteomes.
Combined use of RNAi and quantitative proteomics to study gene function in Drosophila.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Ubc9 sumoylation regulates SUMO target discrimination.
Phosphorylation of SUMO-1 Occurs in Vivo and Is Conserved through Evolution.
Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast
Special Feature: Precision proteomics: The case for high resolution and high mass accuracy.
A high confidence, manually validated human blood plasma protein reference set.
Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics.
The Ser/Thr/Tyr phosphoproteome of Lactococcus lactis IL1403 reveals multiply phosphorylated proteins.
Detergent-Based but Gel-Free Method Allows Identification of Several Hundred Membrane
Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors
Solid Tumor Proteome and Phosphoproteome Analysis by High Resolution Mass Spectrometry
Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential
Peptide separation with immobilized pI strips is an attractive alternative to in-gel protein digestion for proteome analysis
Evidence for insertional RNA editing in humans
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
In-depth, high-accuracy proteomics of sea urchin tooth organic matrix
MAPU 2.0: high-accuracy proteomes mapped to genomes
A SILAC-based DNA protein interaction screen that identifies candidate binding proteins to functional DNA elements
Comparative proteomic phenotyping of cell lines and primary cells to assess preservation of cell type specific functions
The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2
Bioinformatics analysis of mass spectrometry-based proteomics data sets.
Comparative Proteomic Profiling of Membrane Proteins in Rat Cerebellum, Spinal Cord, and Sciatic Nerve.
Ser/Thr/Tyr protein phosphorylation in the archaeon Halobacterium salinarum--a representative of the third domain of life.
Universal sample preparation method for proteome analysis
Large-scale proteomics analysis of the human kinome
A practical guide to the MaxQuant computational platform for SILAC-based quantitative proteomics
Host cell interactome of tyrosine-phosphorylated bacterial proteins
Isolation, Characterisation and Molecular Imaging of a High-Molecular-Weight Insect Biliprotein, a Member of the Hexameric Arylphorin Protein Family
Systems-wide analysis of a phosphatase knock down by quantitative proteomics and phosphoproteomics
System-wide changes to SUMO modifications in response to heat shock
Computational Principles of Determining and Improving Mass Precision and Accuracy for Proteome Measurements in an Orbitrap
Phosphorylation of histone h3 thr-45 is linked to apoptosis
Unbiased RNA-protein interaction screen by quantitative proteomics
C. elegans has a phosphoproteome atypical for metazoans that is enriched in developmental and sex determination proteins
Red Blood Cell (RBC) membrane proteomics- Part I: Proteomics and RBC physiology
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics
Mapping of lysine monomethylation of linker histones in human breast and its cancer.
High-accuracy identification and bioinformatic analysis of in vivo protein phosphorylation sites in yeast.
Proteome differences between brown and white fat mitochondria reveal specialized metabolic functions.
A dual pressure linear ion trap - Orbitrap instrument with very high sequencing speed.
Quantitative proteomic analysis of single pancreatic islets
Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics
Combination of FASP and StageTip-based fractionation allows in-depth analysis of the hippocampal membrane proteome
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis
MSQuant, an open source platform for mass spectrometry-based quantitative proteomics
A domesticated transposon mediates the effects of a single-nucleotide polymorphism responsible for enhanced muscle growth
Red blood cell (RBC) membrane proteomics--Part I: Proteomics and RBC physiology.
Red blood cell (RBC) membrane proteomics--Part II: Comparative proteomics and RBC patho-physiology.
A domesticated transposon mediates the effects of a single-nucleotide polymorphism responsible for enhanced muscle growth
Quantitative Proteomics Reveals Subset-Specific Viral Recognition in Dendritic Cells
Phosphoproteomes of Strongylocentrotus purpuratus shell and tooth matrix
Regulation of translesion synthesis DNA polymerase eta by monoubiquitination
The HLA-B 2705 peptidome.
Super-SILAC mix for quantitative proteomics of human tumor tissue.
Predicting Posttranslational Lysine Acetylation Using Support Vector Machines
Precision Mapping of an In Vivo N-Glycoproteome Reveals Rigid Topological and Sequence Constraints
Decoding signalling networks by mass spectrometry-based proteomics
The phosphoproteome of toll-like receptor-activated macrophages
Perseoartcheomic analysis of sea urchin (Strongylocentrotus purpuratus) spicule matrix
Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology
Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) Applied to Quantitative Proteomics of Bacillus subtilis
Proteome, Phosphoproteome, and N-Glycoproteome Are Quantitatively Preserved in Formalin-Fixed Paraffin-Embedded Tissue and Analyzable by High-Resolution Mass Spectrometry
Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming.
Evolutionary constraints of phosphorylation in eukaryotes, prokaryotes and mitochondria
Mass spectrometry-based proteomics in cell biology
Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif
Red blood cell proteomics
Proteomic changes resulting from gene copy number variations in cancer cells
Quantitative proteome and transcriptome analysis of the archaeon Thermoplasma acidophilum cultured under aerobic and anaerobic conditions
Proteomics on an Orbitrap benchtop mass spectrometer using all ion fragmentation
Quantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers
Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae
Accurate quantification of more than 4,000 mouse tissue proteins reveals minimal proteome changes during aging
Comparison of ultrafiltration units for proteomic and N-glycoproteomic analysis by the filter-aided sample preparation method
Feasibility of large-scale phosphoproteomics with higher energy collisional dissociation fragmentation
PHOSIDA 2011: the posttranslational modification database
Quantitative Analysis of the Intra- and Inter-Individual Variability of the Normal Urinary Proteome
Resources for proteomics in mouse embryonic stem cells
Andromeda - a peptide search engine integrated into the MaxQuant environment
Proteomic snapshot of the EGF-induced ubiquitin network
Quantitative proteomics for epigenetics
In-depth analysis of the chicken egg white proteome using an LTQ Orbitrap Velos
Effective representation and storage of mass spectrometry-based proteomic data sets for the scientific community
More than 100,000 Detectable Peptide Species Elute in Single Shotgun Proteomics Runs but the Majority is Inaccessible to Data-Dependent LC-MS/MS
Use of stable isotope labeling by amino acids in cell culture as a spike-in standard in quantitative proteomics.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation
Quantitative, High-Resolution Proteomics for Data-Driven Systems Biology
Identification and characterization of a novel ubiquitous nucleolar protein 'NARR' encoded by a gene overlapping the rab34 oncogene
Deep and highly sensitive proteome coverage by LC-MS/MS without pre-fractionation
Mass spectrometry-based proteomics using Q Exactive, a high-performance benchtop quadrupole Orbitrap mass spectrometer
Comparative proteomic analysis identifies a role for SUMO in protein quality control
High Recovery FASP Applied to the Proteomic Analysis of Microdissected Formalin Fixed Paraffin Embedded Cancer Tissues Retrieves Known Colon Cancer Markers
High Recovery FASP Applied to the Proteomic Analysis of Microdissected Formalin Fixed Paraffin Embedded Cancer Tissues Retrieves Known Colon Cancer Markers
A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles
In Vivo Quantitative Proteomics: The SILAC Mouse
A protein epitope signature Tag (PrEST) library allows SILAC-based absolute quantification and multiplexed determination of protein copy numbers in cell lines
Systems-wide perturbation analysis with near complete coverage of the yeast proteome by single-shot UHPLC runs on a bench-top Orbitrap
Deep proteome and transcriptome mapping of a human cancer cell line
Systems-wide Proteomic Analysis in Mammalian Cells Reveals Conserved, Functional Protein Turnover
Triple SILAC to Determine Stimulus Specific Interactions in the Wnt Pathway
Ultra high resolution linear ion trap Orbitrap mass spectrometer (Orbitrap Elite) facilitates top down LC MS/MS and versatile peptide fragmentation modes
Quantitative proteomics reveals that Hsp90 inhibition preferentially targets kinases and the DNA damage response
A framework for intelligent data acquisition and real-time database searching for shotgun proteomics
The eggshell: structure, composition and mineralization
Reduced CD36-dependent tissue sequestration of Plasmodium-infected erythrocytes is detrimental to malaria parasite growth in vivo
2006
Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap
Nucleolar Proteome Database
Actin homolog MreB and RNA polymerase interact and are both required for chromosome segregation in Escherichia coli.
Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC).
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6.
Amino acid sequences and phosphorylation sites of emu and rhea eggshell C-type lectin-like proteins
Regulation of ubiquitin-binding proteins by monoubiquitination
Top-down protein sequencing
Repo-Man recruits PP1
Robust Salmonella metabolism
In-depth analysis of the membrane
Quantitative proteomic comparison of rat mitochondria from muscle, heart and liver.
Modular Stop and Go Extraction
A Mammalian Organelle Map
A Wiring of the Human Nucleolus
Large-scale and high-confidence proteomic analysis
Status of complete proteome analysis
Identification of 491 proteins
The human urinary proteome
Proteomic analysis of the acid-soluble organic matrix of the chicken calcified eggshell layer
Organellar proteomics
Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics
Protein interaction screening by quantitative immunoprecipitation combined with knockdown (QUICK)
Mass spectrometric mapping of linker histone H1 variants reveals multiple acetylations, methylations and phosphorylation as well as differences between cell culture and tissue
Perlwapin, an abalone nacre protein with three four-disulfide core (whey acidic protein) domains, inhibits the growth of calcium carbonate crystals
Site-Specific Phosphorylation
Quantitative proteomics to study mitogen-activated protein kinases.
Functional and quantitative proteomics using SILAC
On the proper use of mass accuracy in proteomics
Profile
Proteomic Forum 2007
Jobs
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