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Quantitative proteomic analysis of single pancreatic islets.Waanders LF, Chwalek K, Monetti M, Kumar C, Lammert E, Mann M., Lysine acetylation targets protein complexes and co-regulates major cellular functions.Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.,Science 14 August 2009: 834-840. - www.sciencemag.org BREAKTHROUGH OF THE YEAR:The Runners-UpScience news stories - www.sciencemag.orgSequencing and quantitation of the first entire yeast proteome was selected by Science as one of the 10 Breakthroughs of the year. (See the paper here and see item 5 in "Watching proteins at work"). more... Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeastL. M. F. de Godoy et al., Nature 455, 1251-1254 (2008)Mass spectrometry is a powerful technology for the analysis of large numbers of endogenous proteins. However, the analytical challenges associated with comprehensive identification and relative quantification of cellular proteomes have so far appeared to be insurmountable. Here, using advances in computational proteomics, instrument performance and sample preparation strategies, we compare protein levels of essentially all endogenous proteins in haploid yeast cells to their diploid counterparts. more... Proteomics Ponders Prime Timenewsfocus in ScienceImproved technologies for tracking thousands of proteins at once have spawned talk of a full-scale project to reveal all the proteins in each tissue—but the price tag would be daunting. more... Bioinformatics analysis of mass spectrometry-based proteomics data setsKumar C, Mann M., FEBS Letters, Volume 583, Issue 11
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Open Symposium“20 Years of Electrospray Mass Spectrometry for Large Molecules”
MaxQuant Summerschool 2009
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