Group

About us
-Overview for non-scientists-

Über uns
-Einführung für Interessierte-

Director

Prof. Dr. Matthias Mann

MaxQuant

Cox J, Mann M., Nat. Biotech. 26, 1367 - 1372.
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. more...

Cox J et al., Nat Protoc. 2009;4(5):698-705.
A practical guide to the MaxQuant computational platform for SILAC-based
quantitative proteomics. more...

News & Selected Publications

The Coming Age of Complete, Accurate, and Ubiquitous Proteomes

Molecular Cell, Volume 49, Issue 4, 583-590, 21 February 2013
Mann M, Kulak N, Nagaraj N, Cox J

High-resolution mass spectrometry (MS)-based proteomics has progressed tremendously over the years. For model organisms like yeast, we can now quantify complete proteomes in just a few hours. Developments discussed in this Perspective will soon enable complete proteome analysis of mammalian cells, as well, with profound impact on biology and biomedicine.
 

http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00093-2

EU Grant Awarded for Dementia Research Max Planck Researchers receive 13.9 Million Euros in EU funding [more]   Press Release (PDF)

	We have contributed a chapter to the Handbook of Systems Biology, edited by Marian Walhout, Job Dekker and Marc Vidal:     Marco Hein, Kirti Sharma, Jürgen Cox and Matthias Mann, Proteomic Analysis of Cellular Systems, in Handbook of Systems Biology, 2013

New Insights into a Virus Proteom Max Planck Scientists Identify Unknown Proteins of the Herpesvirus  [more]   Press Release (PDF)

Matthias Mann awarded 2012 Körber European Science Prize

Physicist Matthias Mann to receive the Körber European Science Prize 2012 for his ground-breaking work on the proteome, the entirety of all the proteins of a living organism.

Körber Foundation

Press Release Körber-Foundation (PDF)

Matthias Mann awarded 2012 Jeantet Prize for Medicine

Matthias Mann has been awarded the 2012 Louis-Jeantet Prize for medicine for his work on developments in mass spectrometry that have revolutionised the analysis of proteins and of their functions.

Press Release Louis-Jeantet Foundation (PDF)

Laureats 2012

Video on Matthias Mann

Louis-Jeantet Prize Winner 2012: Perspective Proteomics for biomedicine: a half-completed journey 25 Jan 2012 EMBO Molecular Medicine. Matthias Mann [article]

Mol Cell Proteomics
Special Issue: Prospects in Space and Time

The EU-funded PROSPECTS project (PROteomics SPECification in Time and Space) brings together leading European research groups spanning from instrumentation to biomedicine in an initiative to develop novel technology and applications for the functional analysis of proteins. The wide range of approaches taken in this collaboration is illustrated in this composition of experimental results. more...

Matthias Mann awarded 2012 Ernst Schering Prize

The Schering Foundation, Berlin, honors the biochemist for the development of novel methods for the analysis of proteins.
[Press Release Schering Foundation (PDF)]

Matthias Mann awarded 2012 Leibniz Prize

In recognition of new methods of protein analysis
[Press Release German Research Foundation]

Mann group most highly cited in protein research.

According to an ISI analysis performed by LabTimes, the Mann group has the most citations of researchers working in protein science related areas. For the years of 1998-2009. Mann’s group topped the list at 37,178 citations for 287 papers. See pdf here.

Science Webinar Series

The Proteomics of Posttranslational Modifications: Unraveling Cellular Signaling Through Mass Spectrometry.

[View Webinar]

Quantitative, High-Resolution Proteomics for Data-Driven Systems Biology.
	Annu Rev Biochem. May 2011.  Cox J, Mann M.  - www.annualreviews.org     [abstract] [pubmed]

Matthias Mann on the First Quantitative & Proteome-Wide Study of Lysine Acetylation

Article Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.

Precision Mapping of an In Vivo N-Glycoproteome Reveals Rigid Topological and Sequence Constraints.

Cell, Volume 141, Issue 5, 897-907, 28 May 2010
D. Zielinska, F. Gnad, J. Wisniewski, M. Mann - www.cell.com -

[abstract] [phosida]

Decoding signalling networks by mass spectrometry-based proteomics.

Nature Reviews Molecular Cell Biology 11, 427-439 (June 2010)
Chunaram Choudhary and Matthias Mann - www.nature.com -

[abstract]

Super-SILAC mix for quantitative proteomics of human tumor tissue.

Nat Methods. 2010 Apr 4. Geiger T, Cox J, Ostasiewicz P, Wisniewski JR, Mann M. - www.nature.com -

[abstract] [Recommended by Faculty of 1000 Biology]

Quantitative Proteomics Reveals Subset-Specific Viral Recognition in Dendritic Cells.

Immunity, Volume 32, Issue 2, 279-289, 18 February 2010

Luber CA, Cox J, Lauterbach H, Fancke B, Selbach M, Tschopp J, Akira S, Wiegand M, Hochrein H, O'Keeffe M, Mann M. - www.cell.com -

[abstract]

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

Sci. Signal., 12 January 2010 Vol. 3, Issue 104, p. ra3 Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M. - www.sciencemag.org - [abstract]

MaxQuant Summerschool 2013

the FASP procedure

Wisniewski J.R. et al.
Nat. Methods 6:359-362.

Filter Aided Sample Preparation (FASP) method allows proteomic analysis of SDS-lysates with essentially any class of proteins and origin of biological material. In particular, FASP enables digestion of membrane proteins under conditions previously applied only to soluble proteins.
more...