Proteomics

By definition, proteomics describes the technology that is able to identify proteins expressed from a genome at a certain time point under strictly defined conditions, the proteome.
Differential quantitative analysis of protein expression patterns of tissues or body fluids of diseased/non-diseased species or cellular systems, treated under different conditions, allows to identify sets of proteins that are specifically related to those states.

Since different technologies produce in many cases different but often complementary data, no single approach provides a comprehensive view of a biological system.

The main focus of our department is to develop and establish methods and techniques to improve the relative quantification of protein expression pattern.

The ICPL-technology (Isotope coded protein label) has been developed as a powerful tool to identify and relatively quantify thousands of proteins within complex protein mixtures. In it´s quadruplex version four proteomic states can be analyzed and relatively quantified within one experiment. The ICPLQuant software supports a exact and reproducible quantification on the MS-level without furher fragmentation.