Molecular Imaging and Bionanotechnology

We are a group of interdisciplinary researchers interested in the development of novel imaging tools for biological and biomedical applications.

We combine tools from structural and dynamic DNA nanotechnology with single-molecule fluorescence methods, especially targeted towards the development and application of super-resolution microscopy techniques.

Using the unique programmability of DNA molecules, we are working on extending DNA-PAINT to eventually being able to perform highly multiplexed (hundreds of targets), ultra-resolution (<5 nm), and quantitative (integer counting of molecules) imaging of biomolecules (i.e. proteins and nucleic acids) and their interactions.

Our vision is to unravel the location and interplay of a multitude of genes, RNAs, and proteins in a truly quantitative fashion with highest spatial resolution in single cells.

Got Interested? Learn more about what we do and how we do it in the Research Section.