Prof. Dr. Stefan Jentsch


Phone:+49 89 8578-3010

MPI of Biochemistry, Am Klopferspitz 18, 82152 Martinsried

Molecular Cell Biology

Klara Schwander


Phone:+49 89 8578-3000Fax:+49 89 8578-3011

Department of Molecular Cell Biology

Ubiquitin Family Proteins,
DNA Transactions, Chromatin Biology

Our laboratory has a long-standing interest in protein modification by the ubiquitin system. Covalent modification of proteins by attachment of the small protein ubiquitin ("ubiquitylation") mediates a variety of different cellular functions. The best-known function of ubiquitylation is to label proteins for degradation by the 26S proteasome. Other, non-proteolytic functions of ubiquitylation are regulatory roles in e.g. protein sorting, gene expression and DNA repair. In addition to ubiquitin, eukaryotes also express ubiquitin-like proteins and some of these can form conjugates with cellular proteins similar to ubiquitin.

Our research focuses primarily on functional aspects of the ubiquitin pathway. We identify from yeast and mammalian cells the enzymatic components of this system, clone the corresponding genes, and study their functions in vitro and in vivo. We are increasingly interested in the non-proteolytic functions of ubiquitylation (in particular in DNA transactions), the role of the ubiquitin-selective Cdc48 chaperone-like enzyme, and the function of the ubiquitin-like proteins SUMO and Hub1.



STEFAN JENTSCH - Director and Group Leader

PhD 1983 Free University Berlin and the Max Planck Institute of Molecular Genetics, Berlin, Germany
Postdoctoral work at Massachusetts Institute of Technology (MIT), Cambridge, USA
Group Leader at Friedrich Miescher Laboratory of the Max Planck Society, Tuebingen, Germany
Professor at Center for Molecular Biology (ZMBH), Ruprecht-Karls University, Heidelberg, Germany
Director at MPI of Biochemistry and Member of the Max Planck Society  since 1998
At the Max Planck Institute of Biochemistry since 1998

ERC Advanced Grant (2013)
Louis-Jeantet Prize for Medicine (2011)
Honorary Professorship of Fudan University, Shanghai (2006)
Max-Planck Research Award (2003)
Otto Bayer Award (1996)
Gottfried Wilhelm Leibniz Prize (1993)
Otto Klung Prize for Chemistry (1992)
Elected member of EMBO, German Academy of Sciences Leopoldina, Academia Europaea, AAAS Fellow



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