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MPI für Biochemie  

Chromosome Biology
Wolfgang Zachariae

 

Welcome to the laboratory of Chromosome Biology

The laboratory of Chromosome Biology studies how chromosome segregation is controlled in meiosis, the type of cell division that gives rise to haploid gametes. We use classical and molecular genetics, biochemistry, cytology, and live-cell imaging in budding yeast to investigate how the key events of meiosis are ordered into the correct sequence.

 

 

Surface-spread chromatin from a wild-type (right) and a mnd2 mutant cell (left). Blue, DNA; red, cohesin; geen, one of the two chromosome V homologs marked with green flourescent protein.
Surface-spread chromatin from a wild-type (left) and a mnd2 mutant cell (right). Blue, DNA; red, cohesin; geen, one of the two chromosome V homologs marked with green flourescent protein.

Live-cell imaging of meiosis in a wild-type (top) and a ddk mutant (bottom) cell. Green, tubulin; red, histone. Time between selected frames: 15 min.
Live-cell imaging of meiosis in a wild-type (top) and a ddk mutant (bottom) cell. Green, tubulin; red, histone. Time between selected frames: 15 min.