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A PhD position is available at the Max Planck Institute of Biochemistry in Martinsried, Germany

Project Title: Identification of genes that facilitate or inhibit the growth of aneuploidy cells.

Description: Aneuploidy arises from missegregation of chromosomes during mitosis; however, most of the human cells die after chromosome missegregation. In order to understand the mechanisms which determine  survival of aneuploid cells, we will identify the triggers of the p53 dependent cell cycle arrest that follows after chromosome missegregation in most human cells and the mechanisms that enable to escape this fate. We have recently finished high-throughput screen to determine genes that affect proliferation of cells after abnormal mitosis. To verify the results and to uncover the involved mechanisms, we will knock down promising candidates either in chromosomally unstable cancer cell lines or in our recently established model of human aneuploid cells with defined karyotype changes. Using live cell imaging, we will then analyze the fate of these cells. After identifications of pathways required for survival of aneuploid and chromosomally unstable cells, we will test known inhibitors of these pathways for selective killing of chromosomally unstable cancer cell lines. These experiments will directly address the mechanisms by which aneuploidy triggers the cell cycle delay or cell cycle arrest and may open a novel window of opportunities for cancer treatment.

Objectives:

  • Identify genes that are required for survival or arrest of cells after chromosome missegregation.
  • Test selected candidates in cancer cells lines and in model human aneuploids.
  • Identify inhibitors of confirmed candidate pathways and assess their feasibility for cancer therapy.           

Eligibility (who can apply): Early Stage Researchers (ESR).

Eligibility will be checked based on the following cumulative criteria:

a) Applicants Career Stage: Only Early Stage Researchers (ESR) should apply, that is, researchers who, at the time of recruitment by the partner of PloidyNet [1] have not yet been awarded a PhD degree and [2] are in the first 4 years of his/her research career, counted from the date he/she obtained the degree that allows him/her to embark in a PhD degree. 

b) Mobility: At the time of recruitment, the researcher must not have resided or carried out his/her main activity (work, studies, etc.) in the country of the partner of Ploidynet he/she is applying for, for more than 12 months in the 3 years immediately prior to the his/her recruitment under the project. Compulsory national service and/or short stays such as holidays are not taken into account.

IMPORTANTE NOTE: the career stage of eligible applicants and the mobility rule is determined in terms of full-time research equivalent years. This means that research experience is measured from the date when a researcher obtained the degree which would formally entitle him/her to embark in a PhD degree, either in the country in which the degree was obtained or in the country in which the researcher is recruited, irrespective of whether or not a PhD degree is or was ever envisaged.

Location: Max Planck Institute of Biochemistry in Martinsried, Germany; enrolled at the Ludwig-Maximilians University Munich

Supervisor: Zuzana Storchova (storchov@biochem.mpg.de)

Length of appointment: 36 months (3 years)

Indicative Starting date: January 2014

Application:  eligible candidates should contact Zuzana Storchova (storchov@biochem.mpg.de).  

Type of Contract: temporary.

This position is funded by the EU Seventh Framework Programme, Marie Curie Actions, Initial Training Networks. More information can be found at   www.aneuploidy.nl.

 

 

 

 

 

Applications of talented and motivated people are welcome. We are looking for candidates interested in maintenance of genome stability and its role in cancer development and evolution. Previous experience with molecular genetics and cell biology of budding yeast Saccharomyces cerevisiae or with tissue cell cultures and cell biology of mammalian cells are welcome, but not required.

Please, send your application to:
storchov[a]biochem.mpg.de.

 
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