Publications

2011

Krahmer, N., Guo, Y., Wilfling, F., Hilger, M., Lingrell, S., Heger, K., Newman, H. W., Schmidt-Supprian, M., Vance, D. E., Mann, M., Farese, R. V., Jr. and Walther, T. C. Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase. (2011) Cell Metab. 14(4): 504-15

Bertossi A, Aichinger M, Sansonetti P, Lech M, Neff F, Pal M, Wunderlich FT, Anders HJ, Klein L, Schmidt-Supprian M. Loss of Roquin induces early death and immune deregulation but not autoimmunity. (2011) J Exp Med. 208(9):1749-56

Birbach, A., Eisenbarth, D., Kozakowski, N., Ladenhauf, E., Schmidt-Supprian, M. and Schmid, J. A. Persistent inflammation leads to proliferative neoplasia and loss of smooth muscle cells in a prostate tumor model. (2011) Neoplasia. 13(8): 692-703

Matmati M, Jacques P, Maelfait J, Verheugen E, Kool M, Sze M, Geboes L, Louagie E, Guire CM, Vereecke L, Chu Y, Boon L, Staelens S, Matthys P, Lambrecht BN, Schmidt-Supprian M, Pasparakis M, Elewaut D, Beyaert R, van Loo G. A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis. (2011) Nat Genet. 43(9):908-12

Hofmann J, Mair F, Greter M, Schmidt-Supprian M, Becher B. NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses. (2011) J Exp Med. 208(9):1917-29

Hampel F, Ehrenberg S, Hojer C, Draeseke A, Marschall-Schröter G, Kühn R, Mack B, Gires O, Vahl CJ, Schmidt-Supprian M, Strobl LJ, Zimber-Strobl U. CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling. (2011) Blood. 2011 Jul 27.

Vlantis K, Wullaert A, Sasaki Y, Schmidt-Supprian M, Rajewsky K, Roskams T, Pasparakis M. Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice. (2011) J Clin Invest.121(7):2781-93.

Hadian K, Griesbach RA, Dornauer S, Wanger TM, Nagel D, Metlitzky M, Beisker W, Schmidt-Supprian M, Krappmann D. NF-{kappa}B Essential Modulator (NEMO) Interaction with Linear and Lys-63 Ubiquitin Chains Contributes to NF-{kappa}B Activation. (2011) J Biol Chem. 286(29):26107-17.

Green MR, Monti S, Dalla-Favera R, Pasqualucci L, Walsh NC, Schmidt-Supprian M, Kutok JL, Rodig SJ, Neuberg DS, Rajewsky K, Golub TR, Alt FW, Shipp MA, Manis JP. Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program. (2010) Proc Natl Acad Sci Feb 15;108(7):2873-8.

Keren Z, Naor S, Nussbaum S, Golan K, Itkin T, Sasaki Y, Schmidt-Supprian M, Lapidot T, Melamed D. B cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging. (2011) Blood. 2011 Jan 12. [Epub ahead of print]

2010

Calado DP, Zhang B, Srinivasan L, Sasaki Y, Seagal J, Unitt C, Rodig S, Kutok J, Tarakhovsky A, Schmidt-Supprian M, Rajewsky K. Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma. (2010) Cancer Cell. 18(6):580-9.

Chu Y, Vahl JC, Kumar D, Heger K, Bertossi A, Wójtowicz E, Soberon V, Schenten D, Mack B, Reutelshöfer M, Beyaert R, Amann K, van Loo G, Schmidt-Supprian M. B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation, hyperactivation, cause inflammation and autoimmunity in aged mice. (2010) Blood. 2010 Nov 18. [Epub ahead of print]

Vereecke L, Sze M, Mc Guire C, Rogiers B, Chu Y, Schmidt-Supprian M, Pasparakis M, Beyaert R, van Loo G. Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis. (2010) J Exp Med. 207: 1513-23.

Ashida H, Kim M, Schmidt-Supprian M, Ma A, Ogawa M, Sakawa C. A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response. (2010) Nat Cell Biol. 12, 66-73.

2009

Derudder E, Cadera EJ, Vahl JC, Wang J, Fox CJ, Zha S, van Loo G, Pasparakis M, Schlissel MS, Schmidt-Supprian M*, Rajewsky K*. Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals (2009). Nat Immunol 10, 647-654.

*Equal contribution.

2008

Wunderlich, F.T., Luedde, T., Singer, S., Schmidt-Supprian, M., Baumgartl, J., Schirmacher, P., Pasparakis, M., and Bruning, J.C., Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis (2008). Proc Natl Acad Sci U S A, 105, 1297-302.

Sasaki, Y., Calado, D.P., Derudder, E., Zhang, B., Shimizu, Y., Mackay, F., Nishikawa, S., Rajewsky, K.*, and Schmidt-Supprian, M.*, NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells (2008). Proc Natl Acad Sci U S A, 105, 10883-8.

*Equal contribution.

Otipoby, K.L., Sasaki, Y., Schmidt-Supprian, M., Patke, A., Gareus, R., Pasparakis, M., Tarakhovsky, A., and Rajewsky, K., BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells (2008). Proc Natl Acad Sci U S A, 105, 12435-8.

2007

Schmidt-Supprian, M., Wunderlich, F.T., and Rajewsky, K., Excision of the Frt-flanked neo (R) cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination (2007). Transgenic Res, 16, 657-60.

Liu, H., Schmidt-Supprian, M., Shi, Y., Hobeika, E., Barteneva, N., Jumaa, H., Pelanda, R., Reth, M., Skok, J., Rajewsky, K., and Shi, Y., Yin Yang 1 is a critical regulator of B-cell development (2007). Genes Dev, 21, 1179-89.

Greve, B., Weissert, R., Hamdi, N., Bettelli, E., Sobel, R. A., Coyle, A. J., Kuchroo, V. K., Rajewsky, K., and Schmidt-Supprian, M. (2007). IKK2 Deficiency Controls Expansion of Autoreactive T Cells and Suppresses Experimental Autoimmune Encephalomyelitis. J Immunol, 179, 179-85.

Schmidt-Supprian, M., and Rajewsky, K. (2007). Vagaries of Conditional Gene Targeting. Nat Immunol, 8, 665-8.

Thai, T. H., Calado, D. P., Casola, S., Ansel, K. M., Xiao, C., Xue, Y., Murphy, A., Frendewey, D., Valenzuela, D., Kutok, J. L., Schmidt-Supprian, M., Rajewsky, N., Yancopoulos, G., Rao, A., and Rajewsky, K. (2007). Regulation of the germinal center response by microRNA-155. Science 316, 604-608.

Ben-Neriah, Y., and Schmidt-Supprian, M. (2007). Epithelial NF-kappaB maintains host gut microflora homeostasis. Nat Immunol 8, 479-481.

Tsytsykova, A. V., Falvo, J. V., Schmidt-Supprian, M., Courtois, G., Thanos, D., and Goldfeld, A. E. (2007). Post-induction, stimulus-specific regulation of tumor necrosis factor mRNA expression. J Biol Chem 282, 11629-11638.

Sasaki, Y., Schmidt-Supprian, M., Derudder, E., and Rajewsky, K. (2007). Role of NFkappaB signaling in normal and malignant B cell development. Adv Exp Med Biol 596, 149-154

2006

Pasparakis, M., Luedde, T., and Schmidt-Supprian, M. (2006). Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice. Cell Death Differ 13, 861-872.

Wegener, E., Oeckinghaus, A., Papadopoulou, N., Lavitas, L., Schmidt-Supprian, M., Ferch, U., Mak, T. W., Ruland, J., Heissmeyer, V., and Krappmann, D. (2006). Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation. Mol Cell 23, 13-23.

Sasaki, Y., Derudder, E., Hobeika, E., Pelanda, R., Reth, M., Rajewsky, K., and Schmidt-Supprian, M. (2006). Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. Immunity 24, 729-739.

Nenci, A., Huth, M., Funteh, A., Schmidt-Supprian, M., Bloch, W., Metzger, D., Chambon, P., Rajewsky, K., Krieg, T., Haase, I., and Pasparakis, M. (2006). Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling. Hum Mol Genet 15, 531-542.

van Loo, G., De Lorenzi, R., Schmidt, H., Huth, M., Mildner, A., Schmidt-Supprian, M., Lassmann, H., Prinz, M. R., and Pasparakis, M. (2006). Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice. Nat Immunol 7, 954-961.

2005

Luedde, T., Assmus, U., Wustefeld, T., Meyer zu Vilsendorf, A., Roskams, T., Schmidt-Supprian, M., Rajewsky, K., Brenner, D. A., Manns, M. P., Pasparakis, M., and Trautwein, C. (2005). Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest 115, 849-859

2004

Sasaki, Y., Casola, S., Kutok, J. L., Rajewsky, K., and Schmidt-Supprian, M. (2004). TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology. J Immunol 173, 2245-2252.

Schmidt-Supprian, M., Tian, J., Grant, E. P., Pasparakis, M., Maehr, R., Ovaa, H., Ploegh, H. L., Coyle, A. J., and Rajewsky, K. (2004a). Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. Proc Natl Acad Sci USA 101, 4566-4571.

Schmidt-Supprian, M., Tian, J., Ji, H., Terhorst, C., Bhan, A. K., Grant, E. P., Pasparakis, M., Casola, S., Coyle, A. J., and Rajewsky, K. (2004b). I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion. J Immunol 173, 1612-1619.

2003

Schmidt, C., Peng, B., Li, Z., Sclabas, G. M., Fujioka, S., Niu, J., Schmidt-Supprian, M., Evans, D. B., Abbruzzese, J. L., and Chiao, P. J. (2003). Mechanisms of proinflammatory cytokine-induced biphasic NF-kappaB activation. Mol Cell 12, 1287-1300.

Schmidt-Supprian, M., Courtois, G., Tian, J., Coyle, A. J., Israel, A., Rajewsky, K., and Pasparakis, M. (2003). Mature T cells depend on signaling through the IKK complex. Immunity 19, 377-389.

2002

Pasparakis, M.*, Schmidt-Supprian, M.*, and Rajewsky, K. (2002b). IkappaB kinase signaling is essential for maintenance of mature B cells. J Exp Med 196, 743-752.
*Equal Contribution

Pasparakis, M., Courtois, G., Hafner, M., Schmidt-Supprian, M., Nenci, A., Toksoy, A., Krampert, M., Goebeler, M., Gillitzer, R., Israel, A., Krieg, T., Rajewsky, K., and Haase, I. (2002a). TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature 417, 861-866.

2000

Schmidt-Supprian, M., Bloch, W., Courtois, G., Addicks, K., Israel, A., Rajewsky, K., and Pasparakis, M. (2000a). NEMO/IKK gamma-deficient mice model incontinentia pigmenti. Mol Cell 5, 981-992.

Schmidt-Supprian, M., Murphy, C., While, B., Lawler, M., Kapurniotu, A., Voelter, W., Smith, O., and Bernhagen, J. (2000b). Activated protein C inhibits tumor necrosis factor and macrophage migration inhibitory factor production in monocytes. Eur Cytokine Netw 11, 407-413.

White, B., Schmidt, M., Murphy, C., Livingstone, W., O'Toole, D., Lawler, M., O'Neill, L., Kelleher, D., Schwarz, H. P., and Smith, O. P. (2000). Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line. Br J Haematol 110, 130-134.

1999

Duggan, C., Schmidt, M., Lawler, M., White, B., Cusack, S., McCann, S., and Smith, O. (1999). The prothrombin gene variant G20210A but not factor V leiden may be associated with veno-occlusive disease (VOD) following bone marrow transplantation, Bone Marrow Transplant. 6, 693-694.