Publications

2018

Haas DA, Meiler A, Geiger K, Vogt C, Preuss E, Kochs G and Pichlmair A.;Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity. Plos Pathogens, accepted

Holze C, Michaudel C, Mackowiak C, Haas DA, Benda C, Hubel P, Pennemann FL, Schnepf D, Wettmarshausen J, Braun M, Leung DW, Amarasinghe GK, Perocchi F, Staeheli P, Ryffel B, Pichlmair A.Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway.Nat Immunol. 2018 Feb;19(2):130-140. doi: 10.1038/s41590-017-0013-y.

2017

Vonderstein K, Nilsson E, Hubel P, Nygård Skalman L, Upadhyay A, Pasto J, Pichlmair A, Lundmark R, Överby AK.; Viperin targets flavivirus virulence by inducing assembly of non-infectious capsid particles. J Virol. 2017 Oct 18. pii: JVI.01751-17

Goonawardane N, Gebhardt A, Bartlett C, Pichlmair A, Harris M. Phosphorylation of Serine 225 in Hepatitis C Virus NS5A Regulates Protein-Protein Interactions.J Virol.2017 Aug 10;91(17).

Brady G, Haas DA, Farrell PJ, Pichlmair A, Bowie AG.Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase Activation. J Virol. 2017 Jul 12;91(15). pii: e00545-17.

Gebhardt A., Laudenbarch B., Pichlmair A.; Discrimination of self and non-self ribonucleic acids.: J Interferon Cytokine Res. 2017 May;37(5):184-197.

Abbas YM, Laudenbach BT, Martínez-Montero S, Cencic R, Habjan M, Pichlmair A, Damha MJ, Pelletier J, Nagar B.; Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations. Proc Natl Acad Sci. 2017 Mar 14;114(11):E2106-E2115.

Willemsen J, Wicht O, Wolanski JC, Baur N, Bastian S, Haas DA, Matula P, Knapp B, Meyniel-Schicklin L, Wang C, Bartenschlager R, Lohmann V, Rohr K, Erfle H, Kaderali L, Marcotrigiano J, Pichlmair A, Binder M.; Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening. Mol Cell.2017 Feb 2;65(3):403-415.e8. doi: 10.1016/j.molcel.2016.12.021. 


2016

Mazouzi A, Stukalov A, Müller AC, Chen D, Wiedner M, Prochazkova J, Chiang SC, Schuster M, Breitwieser FP, Pichlmair A, El-Khamisy SF, Bock C, Kralovics R, Colinge J, Bennett KL, Loizou JI.; A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN. Cell Reports, 2016 Apr 14. doi: 10.1016/j.celrep.2016.03.077. 

2015

Stukalov A, Pichlmair A.Gambling with Flu: "All in" to Maximize Reward. Cell Host Microbe, 2015 Dec 9;18(6):643-5. 

Gebhardt A., Habjan M., Benda C., Meiler A., Haas D.A., Hein M.Y., Mann A., Mann M., Habermann B. and Pichlmair A.mRNA export through an additional cap-binding complex consisting of NCBP1 and -3. Nature Communications, 2015, Sep 18;6:8192. doi: 10.1038/ncomms9192.

Heinz L.X., Baumann C.L., Köberlin M.S., Snijder B., Gawish R., Shui G., Sharif O., Aspalter I.M., Müller A.C., Kandasamy R.K., Breitwieser F.P., Pichlmair A., Bruckner M., Rebsamen M., Blüml S., Karonitsch T., Fauster A., Colinge J., Bennett K.L., Knapp S., Wenk M.R., Superti-Furga G.; The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity. Cell Reports, 2015, Jun 30;11(12):1919-28.

Brady G., Haas D.A., Farrell P.J., Pichlmair A., Bowie A.G.; Poxvirus protein MC132 from Molluscum Contagiosum Virus inhibits NFκB activation by targeting p65 for degradation. J Virol, 2015, Aug;89(16):8406-15.

Habjan M., Pichlmair A.Cytoplasmic sensing of viral RNA; Curr op. Virology, 2015, Apr;11:31-37.

2014

The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production.Virology. 2014 Aug;462-463:34-41. Eberle C.A., Zayas M., Stukalov A., Pichlmair A., Alvisi G., Müller A.C., Bennett K.L., Bartenschlager R. and Superti-Furga G.

Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH.J Virol. 2014 Mar;88(6):3464-73. Kainulainen M., Habjan M., Hubel P., Busch L., Lau S., Colinge J., Superti-Furga G., Pichlmair A. and Weber F.

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.Nat Med. 2014 Jan;20(1):47-53. Liehl P., Zuzarte-Luís V., Chan J., Zillinger T., Baptista F., Carapau D., Konert M., Hanson K.K., Carret C., Lassnig C., Müller M., Kalinke U., Saeed M., Chora A.F., Golenbock D.T., Strobl B., Prudêncio M., Coelho L.P., Kappe S.H., Superti-Furga G., Pichlmair A., Vigário A.M., Rice C.M., Fitzgerald K.A., Barchet W. and Mota M.M.

Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity. Cell Microbiol. 2013 Nov 19. doi: 10.1111. Upadhyay A.S., Vonderstein K., Pichlmair A., Stehling O., Bennett K.L., Dobler G., Guo J.T., Superti-Furga G., Lill R., Overby A.K., Weber F.

2013

Sequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA. PLoS Pathog. 2013 Oct;9(10):e1003663. Habjan M., Hubel P., Lacerda L., Benda C., Holze C., Eberl C.H., Mann A., Kindler E., Gil-Cruz C., Ziebuhr J., Thiel V., Pichlmair A

Structural basis for viral 5′-PPP-RNA recognition by human IFIT proteins. Nature. 2013 Feb 7;494(7435).60-4. Abbas, YM., Pichlmair, A., Górna, MW., Superti-Furga, G., Nagar, B

2012

Viral immune modulators perturb the human molecular network by common and unique strategies. Nature. 2012 Jul 26;487(7408):486-90. Pichlmair, A., Kandasamy, K., Alvisi, G., Mulhern, O., Sacco, R., Habjan, M., Binder, M., Stefanovic, A., Eberle, C.A., Goncalves, A., Bürckstümmer, T., Müller, A., Fauster, A., Holze, C., Lindsten, K., Goodbourn, S., Kochs, G., Weber, F., Bartenschlager, R., Bowie, A.G., Bennett, K.L., Colinge, J. and Superti-Furga. G

2011

IFIT1 is an antiviral protein that recognizes 5’-triphosphate RNA. Nat Immunol 2011 Jun 5;12(7):624-30. Pichlmair, A., Lassnig. C., Eberle C.A., Górna M.W., Baumann C.L., Burkard T.R., Bürckstümmer T., Stefanovic A., Krieger S., Bennett K.L., Rülicke T., Weber F., Colinge J., Müller M., Superti-Furga G

2010

CD14 is a coreceptor of Toll-like receptors 7 and 9.; J Exp Med. 2010 Nov 22;207(12):2689-701. Baumann, C.L., Aspalter, I.M., Sharif, O., Pichlmair. A., Blüml, S., Grebien, F., Bruckner, M., Pasierbek, P., Aumayr, K., Planyavsky, M., Bennett, K.L., Colinge, J., Knapp, S., Superti-Furga, G

Virus-Like Particles Expressing the Nucleocapsid Gene as an Efficient Vaccine Against Rift Valley Fever Virus. Vector-Borne and Zoonotic Diseases, 2010 Oct;10(7):701-3. Pichlmair, A., Habjan, M., Unger, H., Weber, F

Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity.; Cell Host Microbe. 2010 May 20;7(5):354-61. Schulz, O., Pichlmair, A., Rehwinkel, J., Rogers, NC., Scheuner, D., Kato, H., Takeuchi, O., Akira, S., Kaufman, RJ., Reis e Sousa, C

RIG-I detects viral genomic RNA during negative-strand RNA virus infection. Cell. 2010 Feb 5;140(3):397-408. Rehwinkel, J., Tan, CP., Goubau, D., Schulz, O., Pichlmair, A., Bier, K., Robb, N., Vreede, F., Barclay, W., Fodor, E., Reis e Sousa, C

2009

Activation of MDA5 requires higher-order RNA structures generated during virus infection.; J Virol. 2009 Oct;83(20):10761-9. Pichlmair, A., Schulz, O., Tan, CP., Rehwinkel, J., Kato, H., Takeuchi, O., Akira, S., Way, M., Schiavo, G., Reis e Sousa, C

NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase; J Virol. 2009 May; 83(9):4365-75. Habjan, M.*, Pichlmair, A.*, Elliott, RM., Overby, AK., Glatter, T., Gstaiger, M., Superti-Furga, G., Unger, H., Weber, F

*contributed equally

2008

Processing of genome 5' termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction; PLoS One. 2008 Apr 30; 3(4):e2032. Habjan, M., Andersson, I., Klingström, J., Schümann, M., Martin, A., Zimmermann, P., Wagner, V., Pichlmair, A., Schneider, U., Mühlberger, E., Mirazimi, A., Weber, F

2007

Innate recognition of viruses; Immunity, 2007, Sep 21;27(3): 370-383. Pichlmair, A. and Reis e Sousa, C

Tubulovesicular Structures within Vesicular Stomatitis Virus G Protein-Pseudotyped Lentiviral Vector Preparations Carry DNA and Stimulate Antiviral Responses via Toll-Like Receptor 9; J Virol., 2007, Jan; 81(2): 539-47. Pichlmair, A., Diebold, S.S., Gschmeissner, S., Takeuchi, Y., Ikeda, Y., Collins, M.K. and Reis e Sousa, C

2006

RIG-I-mediated antiviral responses to single stranded RNA bearing 5’ phosphates; Science, 2006, Nov; 314: 997-1001. Pichlmair, A., Schulz, O., Tan, C.P., Näslund, T.I., Liljeström, P., Weber, F. and Reis e Sousa, C

2005

Inhibition of interferon-beta induction by SARS coronavirus suggests a two-step model for activation of interferon regulatory factor 3; J Virol., 2005, Feb; 79(4): 2079-86. Spiegel, M., Pichlmair, A., Martínez-Sobrido, L., Cros, J., García-Sastre, A., Haller, O. and Weber, F

2004

Thogoto Virus lacking interferon – antagonistic factor ML is strongly attenuated in Mx1-positive but not Mx1-negative mice; J Virol., 2004, Oct; 78(20): 11422-4. Pichlmair, A., Buse, J., Jennings, S., Haller, O., Kochs, G. and Staeheli, P

The first answer to viral infections: Type I Interferons [german]; BMTW, 2004, Jul-Aug; 117: 252-265. Pichlmair, A., Pollak, M., Bergthaler, A

The antiviral effect of interferon-beta against SARS-Coronavirus is not mediated by MxA protein; J Clin Virol., 2004, Jul; 30(3): 211-3. Spiegel, M., Pichlmair, A., Muehlberger, E., Haller, O. and Weber, F

2003

Retrospective and prospective screening for West Nile virus infections in susceptible species in Austria; Epidemiol Infect. 2003 Oct; 131(2): 1023-7. Weissenbock, H., Hubálek, Z., Halouzka, J., Pichlmair, A., Maderner, A., Fragner, K., Kolodziejek, J., Loupal, G., Kölbl, S. and Nowotny, N

 
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