Publications in Journals

Publications in Journals 2012-2103

Musiol, H.-J.; Moroder, L. (2012) Diselenides as proxies of disulfides in cystine-rich peptides. Chemistry Today, 30, 14-19.

Deeg, A. A.; Schrader, T. E.; Strzalka, H.; Pfizer, J.; Moroder, L.; Zinth, W. (2012) Amyloid-like structures formed by azobenezene-peptides: Light-triggered disassembly. Spectroscopy – An International Journal 27, 387-391; DOI 10.3233/SPE-2012-0585.

Schreier, W. J.; Aumueller, T.; Haiser, K.; Koller, F. O.; Löweneck, M.; Musiol, H.-J.; Schrader, T.; Kiefhaber, T.; Moroder, L.; Zinth, W. (2013) Following the energy transfer in and out of a polyproline peptide. Biopolymers (Peptide Science) 100, 38-50; DOI 10.1002/bip.2271.

Publications in Journals 2011

Schrader, T. E.; Cordes, T.; Schreier, W. J.; Koller, Florian. O.; Dong, S.-L.; Moroder, L.; Zinth, W. (2011) Folding and unfolding of light-triggered β-hairpin model peptides. J. Phys. Chem B, 115, 5219-5226; DOI: dx.doi.org/10.1021/jp107683d.


Deeg, A. A.; Schrader, T, E.; Kempter, S.; Pfizer, J.; Moroder, L.; Zinth, W. (2011) Light-triggered aggregation and disassembly of amyloid-like structures. ChemPhysChem, 12, 559-562; DOI: 10.1002/cphc.201001012.

Publications in Journals 2010

Moroder, L.; Budisa, N. (2010) Synthetic Biology of Protein Folding. ChemPhysChem 11, 1181-1187; DOI: 10.1002/cphc.201000035.

Denschlag, R.; Schreier, W. J.; Rieff, B.; Schrader, T. E.; Koller, F. O.; Moroder, L.; Zinth, W.; Tavan, P. (2010) Relaxation time prediction for a light switchable peptide by molecular dynamics. Phys. Chem. Chem.Phys. 12, 6204-6218; DOI: 10.1039/b921803c.

Groll, M.; Gallastegui, N.; Maréchal, X.; Le Ravalec, V.; Basse, N.; Richy, N.; Genin, E.; Huber, R.; Moroder, L.; Vidal, J.; Reboud-Ravaux, M. (2010) 20S Proteasome inhibition: Designing new non-covalent linear peptide mimics of the natural product TMC-95A. ChemMedChem 5, 1701-1705; DOI: 10.1002/cmdc.201000293.

Musiol, H.-J.; Moroder, L. (2010) Two-chain insulin by a single-chain branched depsipeptide precursor - The end of a long journey. Angew. Chem. Int. Ed., 49, 7624-7626; DOI: 10.1002/anie.201003018; Angew. Chem. 122, 7788-7790; DOI: 10.1002/anie.201003018.

Publications in Journals 2009

Langer, I.; Tikhonova, I. G.; Boulégue, C.; Estéve J.-P.; Vatinel, S.; Ferrand, A.; Moroder, L.; Robberecht, P.; Fourmy, D. (2009) Evidence for a direct and functional interaction between the regulators of G protein signaling-2 and phosphorylated C-terminus of cholecystokinin-2 receptor. Mol. Pharmacol. 75, 502-513, doi:10.1124/mol.108.051607.


Groll, M.; Huber, R.; Moroder, L. (2009) The persisting challenge of selective and specific proteasome inhibition. J. Peptide Sci. 15, 58-66. DOI: 10.1002/psc.1107.


Dong, S.; Moroder, L.; Budisa, N. (2009) Protein iodination by click chemistry. ChemBioChem, 10, 1149-1151; DOI: 10.1002/cbic.2008008.


Wolschner, C.; Giese, G.; Kretzschmar, H.; Huber, R.; Moroder, L.; Budisa, N. (2009) Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in prion protein. Proc. Natl. Acad. Sci. USA, 106, 7756-7761; DOI: 10.1073/pnas.0902688106.

Publications in Journals 2008

Boulègue, C.; Musiol, H.-J.; Renner, C.; Moroder, L. (2008) Natural and artificial cystine knots for assembly of homo- and heterotrimeric collagen models. Antioxidants & Redox Signaling, 10(1), 113-126; DOI: 10.1089/ars.2007.1868.


Cadamuro, S. A.; Reichold, R.; Kusebauch, U.; Musiol, H.-J.; Renner, C.; Tavan, P.; Moroder, L. (2008) Conformational properties of 4-mercaptoproline and related derivatives. Angew. Chem. Int. Ed., 47, 2143-2146 (DOI: 10.1002/anie.200704310); Angew. Chem. 120, 2174-2177 (DOI: 10.1002/ange.200704310).


Steiner, T.; Hess, P.; Bae, J. H.; Wiltschi, B.; Moroder, L.; Budisa, N. (2008) Synthetic biology of proteins: Tuning GFPs folding and stability with fluoroproline. Plos One, 3, e1680.


Nielsen, M. L.; Vermeulen, M.; Bonaldi, T.; Cox, J.; Moroder, L.; Mann, M. (2008) Iodoacetamide-induced artifact mimics ubiquitination in mass spectrometry. Nature Methods, 5, 459-460 (DOI:10.1038/nmeth0608-457).


Dong, S.; Merkel, L.; Moroder, L.; Budisa, N. (2008) Convenient Syntheses of homoprogargylglycine. J. Peptide Sci. 14, 1148-1150; DOI: 10.1002/psc.1065.

Publications in Journals 2007

Fiorino, F.; Gil-Parrado, S.; Assfalg-Machleidt, I.; Machleidt, W.; Moroder, L. (2007) A new cell-permeable calpain inhibitor. J. Peptide Sci. 13, 70-73.


Kusebauch, U.; Cadamuro, S. A.; Musiol, H.-J.; Moroder, L.; Renner, R. (2007) Photocontrol of the collagen triple helix. Synthesis and conformational characterization of bis-cysteinyl collagenous peptides with an azobenzene clamp. Chem. Eur. J. 13, 2966-2973.


Purrucker, O.; Gönnewein, S.; Förtig, A.; Jordan, R.; Rusp, M.; Bärmann, M.; Moroder, L.; Sackmann, E.; Tanaka, M. (2007) Polymer-tethered membranes as quantitative models for the study of integrin-mediated cell adhesion. Soft Matter 3, 333-336.


Boulègue, C.; Löweneck, M.; Renner, C.; Moroder, L. (2007) Redox potential of azobenzene as amino acid residue in peptides. ChemBioChem 8, 591-594.


Koller, F. O.; Reho, R.; Schrader, T. E.; Renner, C.: Moroder, L.; Wachtveitl, J.; Zinth, W. (2007) Infrared studies of small azobenzene peptides - unexpectedly slow reactions on the time range of minutes. J. Phys. Chem. B 111, 10481-10486.


del Pino, P.; Weiss, A.; Bertsch, U.; Renner, C.; Mentler, M.; Grantner, K.; Fiorino, F.; Meyer-Klaucke, W.; Moroder, L.; Kretzschmar, H. A.; Parak, F. G. (2007) Spectroscopic investigation on the Cu2+ binding of full-length human prion protein. Eur. Biophys. J. 36, 239-252.


Weiss, A.; del Pino, P.; Bertsch, U.; Renner, C.; Mentler, M.; Grantner, K.; Moroder, L.; Kretzschmar, H. A.; Parak, F. G. (2007) The configuration of the Cu2+ binding region on full-length human prion protein compared with the isolated octapeptide. Vet. Microbiol. 123, 358-366.


Schrader, T. E.; Schreier, W. J.; Cordes, T.; Koller, F. O.; Babitzki, G. B.; Denschlag, R.; Renner, C.; Löweneck, M.; Dong, S.-L.; Moroder, L.; Tavan, P.; Zinth, W. (2007) Light triggered b-hairpin folding and unfolding. Proc. Natl. Acad. Sci. USA 104, 15729-15734.


Barazza, A.; Götz, M.; Cadamuro, S. A.; Goettig, P.; Willem, M.; Steuber, H.; Mosbacher, T.; Jestel, A.; Reinemer, P.; Renner, C.; Bode, W.; Moroder, L. (2007) Macrocyclic statine-based inhibitors of BACE-1. ChemBioChem, 8, 2078 – 2091; DOI: 10.1002/cbic.200700383.


Dong, S.-L.; Cadamuro, S. A.; Fiorino, F.; Bertsch, U.; Moroder, L.; Renner, C. (2007) Copper binding and conformation of the N-terminal octarepeats of the prion protein in the presence of DPC micelles as membrane mimetic. Biopolymers (Pept. Sci.), 88, 840–847; 2007; DOI 10.002/bip 20860.


Publications in Journals 2006


Dong, S.-L.; Löweneck, M.; Schrader, T. E.; Schreier, W.; Zinth, W.; Moroder, L.; Renner, C. (2006) A photo-controlled b-hairpin peptide. Chem. Eur. J. 12, 1114-1120

Löweneck, M.; Milbradt, A.G.; Root, C.; Satzger, H.; Zinth, W.; Moroder, L.; Renner, C. (2006) A conformational two-state peptide model system containing an ultrafast, but soft light switch. Biophys. J. 90, 2099-2108.

Renner, C; Moroder, L. (2006) Azobenzene as conformational switch in model peptides. ChemBioChem, 7, 868-878.

Boulègue, C.; Milbradt, A. G.; Renner, C.; Moroder, L. (2006) Single proline residues can dictate folding pathways of cysteine-rich peptides. J. Mol. Biol. 358, 846-856.

Gonscherowski, V.; Becker, B. F.; Moroder, L.; Motrescu, E.; Gil- Parrado, S.; Gloe, T.; Keller, M.; Zahler, S. (2006) Calpains: a physiological regulator of the endothelial barrier? Amer. J. Physiology - Heart and Circulatory Physiology, 290, H2035-H2042.

Moroder; L. (2006) From basic synthesis to automated technology. ChemBioChem. 7, 551.

Groll, M.; Götz, M.; Kaiser, M.; Weyher, E.; Moroder, L. (2006) TMC-95 based inhibitor design provides evidence for the catalytic versatility of the proteasome. Chem. Biol., 13, 807-614.

Kusebauch, U.; Cadamuro, S. A.; Musiol, H.-J.; Lenz, M. O.; Wachtveitl, J.; Moroder, L.; Renner, C. (2006) Photo-Controlled Folding and Unfolding of a Collagen Triple Helix. Angew. Chem. Int. Ed., submitted.

Boulègue, C.; Musiol, H.-J.; Prasad, V.; Moroder, L. (2006) Synthesis of cystine-rich peptides. Chemistry Today, in press.

Fiorino, F.; Gil-Parrado, S.; Assfalg-Machleidt, I.; Machleidt, W.; Moroder, L. (2006) A new cell-permeable calpain inhibitor. J. Peptide Sci., in press.

Publications in Journals 2005

Renner, C.; Kusebauch, U.; Löweneck, M.; Milbradt, A. G.; Moroder, L. (2005): Azobenzene as photoresponsive conformational switch in cyclic peptides. J. Pept. Res. 65,4-14.

Musiol, H.-J.; Dong, S.; Kaiser, M.; Bausinger, R.; Zumbusch, A.; Moroder, L. (2005) Toward semisynthetic lipoproteins by convergent strategies based on click and ligation chemistry. ChemBioChem 6, 625-628.

Archer-Lahlou, E.; Tikhonova, I.; Escrieut, C.; Dufresne, M.; Seva, C.; Pradayrol, L.; Moroder, L.; Maigret, B.; Fourmy, D. (2005) Modeled structure of a G-protein-coupled receptor: the cholecystokinin-1 receptor. J. Med. Chem. 48, 180-191.

Mentler, M.; Weiss, A.; Grantner, K.; del Pino, P.; Deluca, D.; Fiori, S.; Renner, C.; Meyer Klaucke, W.; Moroder, L.; Bertsch, U.; Kretzschmar, H. A.; Tavan, P.; Parak, F. G. (2005) A new method to determine the structure of the metal environment in metalloproteins: investigation of the prion protein octapeptide repeat Cu2+ -complex. Eur. J. Biophys. 34, 97-112.

Moroder, L. (2005) Isosteric replacement of sulfur by other chalcogens in peptides and proteins. J. Pept. Sci. 11, 187-214.

Milbradt, A. G.; Löweneck, M.; Krupka, S. S.; Reif, M.; Sinner, E.-K.; Moroder, L.; Renner, C. (2005) Photomodulation of conformational states. IV. Integrin-binding RGD-Peptides with (4-aminomethyl)phenylazobenzoic acid as backbone constituent. Biopolymers 77, 304-313.

Carstens, H.; Renner, C.; Milbradt, A. G.; Moroder, L.; Tavan, P. (2005) Molecular dynamics simulations can predict multiple loop conformations of peptides as validated by NMR. Biochemistry 44, 4829-4840.

Archer-Lahlou, E.; Escrieut, C.; Clerc, P.; Martinez, J.; Moroder, L.; Logsdon, C.; Kopin, A.; Seva, C.; Dufresne, M.; Pradayrol, L.; Maigret, B.; Fourmy, D. (2005) Molecular mechanism underlying partial and full agonism mediated by the human cholecystokinin-1 receptor. J. Biol. Chem. 280, 10664-10774.

Pal, P. P.; Bae, J. H.; Azim, M. K.; Hess, P.; Friedrich, R.; Huber, R.; Moroder, L.; Budisa, N. (2005) Structural and spectral response of Aequorea victoria green fluorescent proteins to chromophore fluorination. Biochemistry 44, 3663-3672.

Moroder, L. (2005) Model peptides for protein folding and structure. J. Pept. Sci. 11, 258-261.

Moroder, L.; Musiol, H.-J.; Götz, M.; Renner, C. (2005) Synthesis of single- and multiple-stranded cystine-rich peptides. Biopolymers (Peptide Science) 80, 85-97.

Banke, I. L.; Arlt, M. J. E.; Mueller, M. M.; Sperl, S.; Stemberger, A.; Stürzebecher, J.; Amirkhosravi, A.; Moroder, L.; Krüger, A. (2005) Efficient inhibition of experimental metastasis and prolongation of survival by a factor Xa-specific synthetic serine protease inhibitor with weak anti-coagulant activity. Thromb. Haemost. 94, 1084-1093.

Dong, S.-L.; Löweneck, M.; Schrader, T. E.; Schreier, W.; Zinth, W.; Moroder, L.; Renner, C. (2006) A photo-controlled b-hairpin peptide. Chem. Eur. J. 12, 1114-1120.

Milbradt, A. G.; Boulègue, C.; Moroder, L.; Renner, C. (2005) The two cysteine-rich head domains of minicollagen from Hydra nematocysts differ in their cystine framework and overall fold despite an identical cysteine sequence pattern. J. Mol. Biol. 354, 591-600.

Mulinacci, B.; Breithaupt, C.; Pal, P. P.; Budisa, N.; Pazzagli, M.; Mazzari, B.; Rovero, P.; Moroder, L.; Papini, A. M. (2005) Cross-reactivity studies of rMOGED with synthetic putative autoantigens CSF114(Glc) and (N31(Glc)hMog(30-50) in multiple sclerosis patients´ sera. Biopolymers (Peptide Science) 80, 484.

Moroder, L. (2005) Peptides in the days of photonics. Biopolymers (Peptide Science) 80, 491.

Löweneck, M.; Dong, S.-L.; Schrader, T. E.; Schreier W. J.; Zinth, W.; Moroder, L.; Renner, C. (2005) A photocontrolled b-hairpin. Biopolymers (Peptide Science) 80, 547.

Barazza, A.; Renner, C.; Willem, M.; Moroder, L. (2005) Cyclic phenylstatine-based tetrapeptides as inhibitors of b-secretase. Biopolymers (Peptide Science) 80, 554.

Kusebauch, U.; Moroder, L.; Renner, C. (2005) Towards photo-controlled collagens. Biopolymers (Peptide Science) 80, 575.

Milbradt, A. G.; Boulegue, C.; Moroder, L.; Renner, C. (2005) The two cysteine rich head domains from Hydra minicollagen show different disulfide bridges and different novel folds despite identical cysteine sequence pattern. Biopolymers (Peptide Science) 80, 590.

Golbik, R.; Yu, C.; Weyher-Stingl, E.; Huber, R.; Moroder, L,; Budisa, N.; Schiene-Fischer, C. (2005) Peptidyl prolyl cis/trans isomerases: Comparative reactivities of cyclophilins, FK506-binding proteins and parvulins with fluorinated oligopeptide and protein substrates. Biochemistry 44, 16026-16034.

Publications in Journals 2004

Barth, D.; Milbradt, A. G.; Renner, C.; Moroder, L. (2004) (4R)- and (4S)-fluoroproline in position Xaa of the (Xaa-Yaa-Gly) collagen repeat affects severely triple-helix formation. ChemBioChem 5, 79-86.

Kaiser, M.; Milbradt, A. G.; Siciliano, C.; Assfalg-Machleidt, I.; Machleidt, W.; Groll, M.; Renner, C.; Moroder L. (2004) TMC-95A analogues with endocyclic biphenyl ether group as proteasome inhibitors. ChemBioDiv 1, 161-173.

Sartori, E.; Toffoletti, A.; Corvaja, C.; Moroder, L.; Formaggio, F.; Toniolo, C. (2004) An oligopeptide doubly labelled with an azulene chromophore and a TEMPO radical. New insights into azulene excited state properties. Chem. Phys. Lett. 385, 362-367.

Renner, C.; Fiori, S.; Fiorino, F.; Landgraf, D.; Deluca, D.; Mentler, M.; Grantner, K.; Parak, F. G.; Kretzschmar, H.; Moroder, L. (2004) Micellar environments induce structuring of the N-terminal tail of the prion protein. Biopolymers 73, 421-433.

Bae, J. H.; Pal, P. P.; Moroder, L.; Huber, R.; Budisa, N. (2004) Crystallographic evidence for isomeric chromophores in 3-fluorotyrosyl-green fluorescent protein. ChemBioChem 5, 720-722.

Renner, C.; Saccà, B.; Moroder, L. (2004) Synthetic heterotrimeric collagen peptides as mimics of cell adhesion sites of the basement membrane. Biopolymers (Peptide Science) 76, 34-47.

Wachtveitl, J.; Spörlein, S.; Satzger, H.; Fonrobert, B.; Renner, C.; Behrendt, R.; Oesterhelt, D.; Moroder, L.; Zinth, W. (2004) Ultrafast conformational dynamics in cyclic azobenzene peptides of increased flexibility. Biophys. J. 86, 2350-2362.

Štern, I.; Schaschke, N.; Moroder, L.; Turk, D. (2004) Crystal structure of NS-134 in complex with bovine cathepsin B: a two headed epoxysuccinyl inhibitor extends along the entire active site cleft. Biochem. J. 381, 511-517.

Kaiser, M.; Groll, M.; Siciliano, C.; Assfalg-Machleidt, I.; Weyher, E.; Kohno, J.; Milbradt, A. G.; Renner, C.; Huber, R.; Moroder, L. (2004) Binding mode of TMC-95A analogues to eukaryotic 20S proteasome. ChemBioChem 5, 1256-1266.

Venanzi, M.; Valeri, A.; Palleschi, A.; Stella, L.; Moroder, L.; Formaggio, F.; Toniolo, C.; Pispisa, B. (2004) Structural properties and photophysical behavior of conformationally constrained hexapeptides functionalized with a new fluorescent analog of tryptophan and a nitroxide radical quencher. Biopolymers 75, 128-139.

Pokidysheva, E.; Milbradt, A. G.; Meier, S.; Renner, C.; Häussinger, D.; Bächinger, H. P.; Moroder, L.; Grzesiek, S.; Holstein, T. W.; Özbek, S.;Engel, J. (2004):The structure of the Cys-rich terminal domains of Hydra minicollagen, which are involved in disulfide networks of the nematocyst wall. J. Biol. Chem. 279, 30395-30401.

Arnould, M.; Tassa, A.; Ferrand, A.; Archer, E.; Estève, J.-P.; Pénalba, V.; Portolan, G.; Escherich, A.; Moroder, L.; Fourmy, D.; Seva, C.; Dufresne, M. (2004): The G-protein coupled CCK2 receptor associates with phospholipase Cg1. FEBS Lett. 568/1-3, 89-93.

Sinner, E.-K.; Reuning, U.; Kök, F.N.; Saccá, B.; Moroder, L.; Knoll, W.; Oesterhelt, D. (2004) Incorporation of integrins into artificial planar lipid membranes: characterization by plasmon enhanced fluorescence spectroscopy. Anal. Biochem. 333, 216-224.

Özbek, S.; Pokidysheva, E.; Schwager, M.; Schulthess, T.; Tariq, N.; Barth, D.; Milbradt, A. G.; Moroder, M.; Engel, J.; Holstein, T. W. (2004) The glycoprotein NOWA and minicollagens are part of a disulfide-linked polymer that forms the cnidarian nematocyst wall. J. Biol. Chem. 279, 52016-52023.

Satzger, H.; Root, C.; Renner, C.; Behrendt, R.; Moroder, L.; Wachtveitl, J.; Zinth, W. (2004) Picosecond dynamics in water soluble azobenzene-peptides. Chem. Phys. Lett. 396, 191-197.

Giragossian, C.; Schaschke, N.; Moroder, L.; Mierke, D. F. (2004) Conformational and molecular modeling studies of beta-cyclodextrin-heptagastrin and the third extracellular loop of the cholecystokinin 2 receptor. Biochemistry 43, 2724-2731.

Archer, E.; Escrieut, C.; Martinez, L.; Maigret, B.; Logsdon, C.; Kopin, A.; Seva, C.; Dufresne, M.; Pradayrol, L.; Fourmy, D. (2004) Molecular mechanism underlying partial agonism mediated by G-protein-coupled receptor, human cholecystokinin-1 receptor. Regul. Pept. 122 (1), 5-5A2.

Escrieut, C.; Dufresne, M.; Seva, C.; Pradayrol, L.; Moroder, L.; Maigret, B.; Fourmy, D. (2004) Modeled stucture of a G-protein-coupled receptor, the human cholecystokinin-1 receptor. Regul. Pept. 122 (1), 5-5A3.

Vatinel, S.; Lopez, F.; Esteve, J.-P.; Monsarrat, B.; Moroder, L.; Pradayrol, L.; Dufresne, M.; Fourmy, D.; Seva, C. (2004) Proteomics approaches to identify signalling complexes interacting with the CCK2 receptor C-terminus. Regul. Pept. 122 (1), 46-46A.

Moroder, L. (2004) Murray Goodman (1928-2004): Peptide chemistry. Angew. Chem. Int. Ed. 43, 3628-3628.

Kaiser, M.; Groll, M.; Siciliano, C.; Assfalg-Machleidt, I.; Weyher, E.; Kohno, J.; Milbradt, A. G.; Renner, C.; Huber, R.; Moroder, L. (2004) Structural determination for 20S proteasome inhibition by TMC-95A. J. Pept. Sci. 10 (Suppl.), 211.

Milbradt, A. G.; Moroder, L.; Renner, C. (2004) The multiple cysteine-containing head domain of minicollagen from hydra nematocysts folds oxidatively into a compact globular structure. J. Pept. Sci. 10 (Suppl.), 229.

Moroder, L. (2004) Disulfides in peptides and proteins: a personal challenge from past to present. J. Pept. Sci. 10 (Suppl.), 89.

Musiol, H.-J.; Kaiser, M.; Dong, S.; Moroder, L. (2004) Click and ligation chemistry for the synthesis of GPI-anchored membrane proteins. J. Pept. Sci. 10 (Suppl.), 200.

Pfizer, J.; Assfalg-Machleidt, I.; Machleidt, W.; Moroder, L.; Schaschke, N. (2004) Primed site probing of papain-like cysteine proteases. J. Pept. Sci. 10 (Suppl.), 214.

Publications in Journals 2003

Schäfer, F.; Deluca, D.; Majdic, U.; Kirchner, J.; Schliwa, M.; Moroder, L.; Woehlke, G. (2003): A conserved tyrosine in the neck of a fungal kinesin regulates the catalytic motor core. EMBO J. 22, 450-458.

Gil-Parrado, S.; Assfalg-Machleidt, I.; F. Fiorino; Deluca, D.; Pfeiler, D.; Schaschke, N.; Moroder, L.; Machleidt, W. (2003) Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: enhancing cell permeability by conjugation with penetratin. Biol. Chem. 384,395-402.

Holland, N. B.; Hugel, T.; Neuert, G.; Cattani-Scholz, A.; Renner, C.; Oesterhelt, D.; Moroder, L.; Seitz, M.; Gaub, H. E. (2003) Single molecule force spectroscopy of azobenzene polymers: switching elasticity of single photochromic macromolecules. Macromolecules 36, 2015-2023.

Milbradt, A. G.; Kerek, F.; Moroder, L.; Renner, C. (2003) Structural characterization of hellethionins from Helleborus purpurescens. Biochemistry 42, 2404-2411.

Goennenwein, S.; Tanaka, M.; Hu, B.; Moroder, L.; Sackmann, E. (2003) Functional incorporation of integrins into solid supported membranes on ultrathin films of cellulose: impact on adhesion. Biophys. J. 85, 646-655.

Saccà, B.; Fiori, S.; Moroder, L. (2003) Studies of the local conformational properties of the cell-adhesion domain of collagen type IV in synthetic heterotrimeric peptides. Biochemistry 42, 3429-3436.

Galés, C.; Poirot, M.; Taillefer, J.; Bernard, M.; Martinez, J.; Moroder, L.; Chantal, E.; Pradayrol, L.; Fourmy, D.; Silvente-Poirot, S. (2003) Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis and structure/affinity studies. Mol. Pharmacol. 63, 973-982.

Barth, D.; Musiol, H.-J.; Schütt, M.; Fiori, S.; Milbradt, A. G.; Renner, C.; Moroder, L. (2003) The role of cystine knots in collagen folding and stability. I. Conformational properties of (Pro-Hyp-Gly)5 and (Pro-(4S)-FPro-Gly)5 model trimers with an artificial cystine knot. Chem. Eur. J. 9, 3692-3702.

Barth, D.; Kyrieleis, O.; Frank, S.; Renner, C.; Moroder, L. (2003) The role of cystine knots in collagen folding and stability. II. Conformational properties of (Pro-Hyp-Gly)n model trimers with N- and C-terminal collagen type III cystine knots. Chem. Eur. J. 9, 3703-3714.

Bredenbeck, J.; Helbing, J.; Behrendt, R.; Renner, C.; Moroder, L.; Wachtveitl J.; Hamm, P. (2003) Transient 2D-IR spectroscopy: snapshots of the non-equilibrium ensemble during the picosecond conformational transition of a small peptide. J. Phys. Chem. B 107, 8654-8660.

Bae, J. H.; Rubini, M.; Jung, G.; Wiegand, G.; Seifert, M. H.; Azim, M. K.; Kim, J.-S.; Zumbusch, A.; Holak, T. A.; Moroder, L.; Huber, R.; Budisa, N. (2003) Expansion of the genetic code enables design of a novel „gold“ class of green fluorescent proteins. J. Mol. Biol. 328, 1071-1081.

Deluca, D.; Woehlke, G.; Moroder, L. (2003) Synthesis and conformational characterization of peptides related to the neck domain of a fungal kinesin. J. Pept. Sci. 9, 203-211.

Bredenbeck, J.; Helbing, J.; Sieg, A.; Schrader, T.; Zinth, W.; Wachtveitl, J.; Renner, C.; Behrendt, R.; Moroder, L.; Hamm, P. (2003) Picosecond conformational transition and equilibration of a cyclic peptide. Proc. Natl. Acad. Sci. USA 100, 6452-6457.

Schütt, M.; Krupka, S.; Milbradt, A. G.; Deindl, S.; Sinner, E.-K.; Renner, C.; Oesterhelt D.; Moroder L. (2003) Photocontrol of cell adhesion processes. Model studies with cyclic azobenzene-RGD peptides. Chem. Biol. 10, 487-490.

Kaiser, M.; Siciliano, C.; Machleidt-Assfalg, I.; Groll, M.; Milbradt A. G.; Moroder L. (2003) Synthesis of a TMC-95A ketomethylene analog by cyclization via intramolecular Suzuki coupling. Org. Lett. 5, 3435-3437.

Kaiser, M.; Milbradt, A.G.; Renner, C.; Assfalg-Machleidt, I.; Groll, M.; Huber, R.; Moroder, L. (2003) Cyclic biphenyl ether tripeptides as proteasom inhibitors. Biopolymers 71, P432.

Müller, M. M.; Musiol, H.-J.; Moroder, L. (2003) Synthesis of guanidine compounds using resin-bound guanidinylating reagents. Biopolymers 71, 269.

Schütt, M.; Milbradt, A. G.; Moroder, L.; Renner, C. (2003) Light-induced two-state structural transition of a cyclic PDI-related azobenzene-peptide. Biopolymers 71, 131.

Publications in Journals 2002

Cattani-Scholz, A.; Renner, C.; Cabrele, C.; Behrendt, R.; Oesterhelt, D.; Moroder, L. (2002) Photoresponsive cyclic bis-cysteinyl-peptides as catalysts of oxidative protein folding. Angew. Chem. Int. Ed. 41, 289-292.

Escrieut, C.; Gigoux, V.; Archer, E.; Verrier, S.; Maigret, B.; Behrendt, R.; Moroder, L.; Bignon, E.; Silvente-Poirot, S.; Pradayrol, L.; Fourmy, D. (2002) The biologically crucial C-terminus of cholecystokinin and the non-peptide agonist SR-146,131 share a common binding site in the human CCK1 receptor. Evidence for a crucial role of Met-121 in the activation process. J. Biol. Chem. 277, 7546-7555.

Renner, C.; Behrendt, R.; Heim, N.; Moroder, L. (2002) Photomodulation of conformational states. III. Water-soluble bis-cysteinyl-peptides with (4-aminomethyl)phenylazobenzoic acid as backbone constituent. Biopolymers 63, 382-393.

Cabrele, C.; Cattani-Scholz, A.; Renner, C.; Behrendt, R.; Oesterhelt, D.; Moroder, L. (2002) Photomodulation of the redox and folding adjuvant properties of bis(cysteinyl)peptides. Eur. J. Org. Chem. 2144-2150.

Renner, C.; Schleicher, M.; Moroder, L.: Holak, T. A. (2002) Practical aspects of the 2D 15N-{1H}-NOE experiment. J. Biomol. NMR 23, 23-33.

Kaiser, M.; Groll, M.; Renner, C.; Huber, R.; Moroder, L. (2002) The core structure of TMC-95A is a promising lead for reversible proteasome inhibition. Angew. Chem. Int. Ed. 41, 780-783.

Saccà, B.; Moroder, L. (2002) Synthesis of heterotrimeric collagen peptides containing the α1β1 integrin recognition site of collagen type IV. J. Pept. Sci. 8, 192-204.

Saccà, B.; Barth, D.; Musiol, H.-J.; Moroder, L. (2002) Conformation-dependent side reactions in interstrand-disulfide bridging of trimeric collagenous peptides by regioselective cysteine chemistry. J. Pept. Sci. 8, 205-210.

Müller, M. M.; Sperl, S.; Stürzebecher, J.; Bode, W.; Moroder, L. (2002) (R)-3-Amidinophenylalanine-derived inhibitors of factor Xa with a novel active-site binding mode. Biol. Chem. 383, 1185-1191.

Fiori, S.; Saccá, B.; Moroder, L. (2002) Structural properties of a collagenous heterotrimer that mimics the collagenase cleavage site of collagen type I. J. Mol. Biol. 319, 1235-1242.

Spörlein, S.; Carstens, H.; Satzger, H.; Renner, C.; Behrendt, R.; Moroder, L.; Tavan, P.; Zinth, W.; Wachtveitl, J. (2002) Ultrafast spectroscopy reveals subnanosecond peptide conformational dynamics and validates molecular dynamics simulation. Proc. Natl. Acad. Sci. USA 99, 7998-8002.

Kerek, F.; Stimac, R.; Apell, H.-J.; Freudemann, F.; Moroder, L. (2002) Characterization of the macrocyclic carbon suboxide factors as potent Na,K-ATPase and SR Ca-ATPase inhibitors. Biochim. Biophys. Acta 1567, 213-220.

Hugel, T.; Holland, N. B.; Cattani, A.; Moroder, L.; Seitz, M.; Gaub, H. E. (2002) Single-molecule optomechanical cycle. Science 296, 1103-1106.

Cabrele, C.; Fiori, S.; Pegoraro, S.; Moroder, L. (2002) Redox-active bis(cysteinyl)peptides as catalysts for in vitro oxidative protein folding. Chem. Biol. 9, 731-740.

Albrizio, S.; Carotenuto, A.; Fattorusso, C.; Moroder, L.; Picone, D.; Temussi, P. A.; D´Ursi A. (2002) Environmental mimic of receptor interaction: conformational analysis of CCK-15 in solution. J. Med. Chem. 45, 762-769.

Saccà, B.; Sinner, E.-K.; Fiori, S.; Kaiser, J.; Lübken, Ch.; Eble, J. A.; Moroder, L. (2002) Structural characterization of the cell adhesion epitope of collagen type IV. ChemBioChem 9, 904-907.

Kim, J.-S.; Groll, M.; Musiol, H.-J.; Behrendt, R.; Kaiser, M.; Moroder, L.; Huber, R.; Brandstetter, H. (2002) Navigation inside a protease: substrate selection and product exit in the tricorn protease from Thermoplasma acidophilum. J. Mol. Biol. 324, 1041-1050.

Budisa, N.; Rubini, M.; Bae, J. H.; Weyher, E.; Wenger, W.; Golbick, R.; Huber, R.; Moroder, L. (2002) Global replacement of tryptophan with aminotryptophans generates non-invasive protein-based optical pH sensors. Angew. Chem. Int. Ed. 41, 4066-4069.

Saccà, B.; Renner, C.; Moroder, L. (2002) The chain register in heterotrimeric collagen peptides affects triple helix stability and folding kinetics. J. Mol. Biol. 324, 309-318.

Ashcroft, A. E.; Brinker, A.; Coyle, J. E.; Weber, F.; Kaiser, M.; Moroder, L.; Parsons, M. R.; Jager, J.; Hartl, U. F.; Hayer-Hartl, M.; Radford, S. E. (2002): Structural plasticity and non-covalent substrate binding in the GroEL apical domain: a study using electrospray ionisation mass spectrometry and fluorescence binding studies. J. Biol. Chem. 277, 33115-33126.

Giragossian, C.; Stone, S.; Papini, A. M.; Moroder, L.; Mierke, D. F. (2002) Conformational and molecular modeling studies of sulfated cholecystokinin-15. Biochem. Biophys. Res. Commun. 293, 1053-1059.

Fourmy, D.; Escrieut, C.; Archer, E.; Gales, C.; Gigoux, V.; Maigret, B.; Moroder, L.; Silvente-Poirot, S.; Martinez, J.; Fehrentz, J. A.; Pradayrol, L. (2002) Structure of cholecystokinin receptor binding sites and mechanisms of activation/inactivation by agonists/antagonists. Pharmacol. Toxicol. 91, 313-320.

Kaiser, M.; Milbradt A. G.; Moroder, L. (2002) Synthesis of TMC-95A analogues. Structure-based prediction of cyclization propensities of linear precursors. LIPS 9, 65-70.

Sperl, S.; Moroder, L.; Setyono-Han, B.; Foekens, J.; Schmalix, W.; Wosikowski, K. (2002) Highly selective inhibitors of the urokinase-type plasminogen activator. Papers Amer. Chem. Soc. 224 (MEDI Part) 2089.

Barth, D.; Musiol, H.-J.; Renner, C.; Frank, S.; Engel, J.; Moroder, L. (2002) Synthesis of trimeric collagen peptides with artificial and natural cystine knots. J. Peptide Sci. 8 (Suppl.), 205.

Kaiser, M.; Groll, M.; Huber, R.; Moroder, L. (2002) Synthesis of TMC-95A analogs as reversible inhibitors of eucaryotic proteasome. J. Peptide Sci. 8 (Suppl.), 166.

Stella, L.; Mazzuca, C.; Palleschi, A.; Venanzi, M.; Formaggio, F.; Toniolo, C.; Moroder, L.; Pispisa, B. (2002) Mechanism of membrane permeabilization by the lipopeptaibol trichogin GA IV and its fluorescent analogues. J. Peptide Sci. 8 (Suppl.), 76.

Venanzi, M.; Palleschi, A.; Stella, L.; Valeri, A.; Formaggio, F.; Toniolo, C.; Moroder, L.; Pispisa, B. (2002) Structural features of linear peptides in solution carrying new fluorescent analogues of tryptophan. J. Peptide Sci. 8 (Suppl.), 199.

Publications in Journals 2001

Renner, C.; Alefelder, S.; Bae, J. H.; Budisa, N.; Huber, R.; Moroder, L. (2001) Fluoro-prolines as tools for protein design and engineering. Angew. Chem. Int. Ed. 40, 923-925.

Cattani-Scholz, A.; Renner, C.; Oesterhelt, D.; Moroder, L. (2001) Photoresponsive dendritic azobenzene-peptides. ChemBioChem 2, 542-549.

Renner, C.; Moroder, L.; Holak, T.A. (2001) Analytical solution to the Lipari-Szabo model based on the reduced spectral density approximation offers a novel protocol for extracting motional parameters. J. Magn. Reson. 151, 32-39.

Bae, J.; Alefelder, S.; Kaiser, J. T.; Friedrich, R.; Moroder, L.; Huber, R.; Budisa, N. (2001) Incorporation of b-selenolo[3,2-b]pyrrolyl-alanine into proteins for phase determination in protein X-ray crystallography. J. Mol. Biol. 309, 925-936.

Budisa, N.; Alefelder, S.; Bae, J.; Golkik, R.; Minks, C.; Huber, R.; Moroder, L. (2001) Proteins with b-(thienopyrrolyl)alanines as alternative chromophores and pharmaceutically active amino acids. Protein Sci. 10,1281-1292.

Hellstern, S.; Pegoraro, S.; Karim, C. B.; Lustig, A.; Thomas, D. D.; Moroder, L.; Engel, J. (2001) Sarcolipin, the shorter homologue of phospholamban, forms oligomeric structures in detergent micelles and in liposomes. J. Biol. Chem. 276, 30845-30852.

Schaschke, N.; Matschiner, G.; Zettl, F.; Marquaerdt, U.; Bergner, A.; Bode, W.; Sommerhoff, C. P.; Moroder, L. (2001) Bivalent inhibition of β-tryptase. Chem. Biol. 8, 313-327.

Kallipolitou, A.; Deluca, D.; Majdic, U.; Lakämper, S.; Cross, R.; Mayhöfer, E.; Moroder, L.; Schliwa, M.; Woehlke, G. (2001) Unusual properties of the fungal conventional kinesin neck domain from Neuropsora crassa. EMBO J. 20, 6226-6235.

Escherich, A.; Lutz, J.; Escrieut, C.; Fourmy, D.; van Neuren, A. S.; Müller, G. Schafferhans, A.; Klebe, G.; Moroder, L. (2001) Peptide/benzodiazepine hybrids as ligands of CCKA and CCKB receptors. Biopolymers 56, 55-76.

Musiol, H.-J.; Moroder, L. (2001) N,N´-Di-tert-butoxycarbonyl-1H-benzotriazole-1-carboxamidine derivatives are highly reactive guanidinylating reagents. Org. Lett. 3, 3859-3861.

Köhler, A.; Bajorek, M.; Groll, M.; Moroder, L.; Rubin, D. M.; Huber, R.; Glickman, M. H.; Finley, D. (2001): The substrate translocation channel of the proteasome. Biochimie, 83, 325-332.

Gales, C.; Berge, C.; Moroder, L.; Pradayrol, L.; Fourmy, D.; Silvente-Poirot, S. (2001) Selective activationn of PKC-independent P42-P44 mitogen activating protein kinases pathway by a constitutive cholecystokinin 2 receptor mutant. FASEB J. 15 (Part 1), A572.

Golbik, R.; Budisa, N.; Renner, C.; Weyher-Stingl, E.; Rahfeld, J.-U.; Huber, R.; Fischer, G.; Moroder, L. (2001) Studies on folding of fluoroproline-substituted variants of barstar. Nova Acta Leopoldina (Supl. 16), 59-60.

Fiori, S.; Ottl, J.; Fonrobert, B.; Wachtveitl, J.; Moroder, L. (2001): Biophysical characterization of synthetic heterotrimeric collagen peptides as functional epitopes of collagen type I. Nova Acta Leopoldina (Supl. 16), 43-45.

Sperl, S.; Müller, M. M.; Wilhelm, O. G.; Schmitt, M.; Magdolen, V.; Moroder, L. (2001) The uPA/uPA receptor system as a target for tumor therapy. Drug News Perspect. 14, 401-411.

Publications in Journals

1966

1. Fontana, A.; Marchiori, F.; Moroder, L.; Scoffone, E. (1966) New removal conditions of sulfenyl groups in peptide synthesis. Tetrahedron Lett. 26, 2985-2987.

2. Fontana, A.; Marchiori, F.; Moroder, L. (1966) Uso di N-dinitrofenilsulfenil-amminoacidi nella sintesi di peptidi. Cim. Ind. 48, 1227.

3. Fontana, A.; Marchiori, F.; Moroder, L. (1966) On the sulfenyl method for the N-protection in peptide synthesis: 2,4-dinitrophenylsulfenyl residue as N-protecting group. Ric. Sci. 36, 261-266.

4. Fontana, A.; Marchiori, F.; Moroder, L.; Scoffone, E. (1966) Protezione del gruppo amminico mediante residui solfenici nella sintesi di peptidi. Nota II. Metodi di rimozione. Gazz. Chim. Ital. 96, 1313-1321.

5. Rocchi, R.; Marchiori, F.; Moroder, L.; Fontana, A.; Scoffone, E. (1966) Sintesi di peptidi analoghi dell‘ eicosapeptide N-terminale della ribonucleasi A. Nota V. Sintesi del (Lys-10)-peptide S. Gazz. Chim. Ital. 96, 1537-1548.

6. Marchiori, F.; Rocchi, R.; Moroder, L.; Scoffone, E. (1966) Sintesi di peptidi analoghi dell‘ eicosapeptide N-terminale della ribonucleasi A. Nota VI. Sintesi del (Tyr-8, Orn-10)-peptide S. Gazz. Chim. Ital. 96, 1549-1559.

7. Scoffone, E.; Rocchi, R.; Marchiori, F.; Moroder, L.; Marzotto, A. (1966) Sintesi degli analoghi Tyr8,Orn10 e Lys10 dell´eicosapeptide N-terminale della ribonucleasi A. Chim. Ind. 48, 1223.

1967

8. Scoffone, E.; Marchiori, F.; Moroder, L.; Rocchi, R.; Scatturin, A.; Tamburro, A. M. (1967) Studi conformazionali su ribonucleasi parzialmente sintetiche. Chim. Ind. 49, 535.

9. Scoffone, E.; Marchiori, F.; Moroder, L.; Rocchi, R. (1967) L´impiego della sintesi chimica nell´indagine conformazionale della ribonucleasi A. Chim. Ind. 49, 968.

10. Marchiori, F.; Rocchi, R.; Moroder, L.; Vidali, G.; Scoffone, E. (1967) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. Part III. A New synthesis of the C-terminal octapeptide 13-20. J. Chem. Soc. (C) 89-91.

11. Scoffone, E.; Rocchi, R.; Marchiori, F.; Moroder, L.; Marzotto, A.; Tamburro, A. M. (1967) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. Part VII. Synthesis of (Ile-8,Orn-10)- and (Ala-8,Orn-10)-eicosapeptides. J. Am. Chem. Soc. 89, 5450-5455.

12. Marzotto, A.; Marchiori, F.; Moroder, L.; Boni, R.; Gazigna, L. (1967) Enzymatic activity of partially synthetic ribonucleases. Biochim. Biophys. Acta 147, 26-31.

1968

13. Tamburro, A. M.; Scatturin, A.; Moroder, L. (1968) Far-ultraviolet optical rotatory dispersion and circular dichroism studies of bovine pancreatic ribonuclease A. Biochim. Biophys. Acta 154, 583-585.

14. Rocchi, R.; Moroder, L.; Marchiori, F.; Ferrarese, E.; Scoffone, E. (1968) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. VIII. Synthesis of (Ser-4,Orn-10)- and (Ser-5,Orn-10)-eicosapeptides. J. Am. Chem. Soc. 90, 5885-5889.

15. Marchiori, F.; Rocchi, R.; Moroder, L.; Fontana, A.; Scoffone, E. (1968) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. IX. Synthesis of (Ser-6,Orn-10)- and (Pro-6,Orn-10)-eicosapeptides. J. Am. Chem. Soc. 90, 5889-5894.

16. Rocchi, R.; Marchiori, F.; Scatturin, A.; Moroder, L.; Scoffone, E. (1968) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. X. Synthesis of (Gly-8,Orn-10)-S-peptide. Gazz. Chim. Ital. 98, 1270-1283.

1969

17. Rocchi, R.; Scatturin, A.; Moroder, L.; Marchiori, F.; Tamburro, A. M.; Scoffone, E. (1969) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. XI. Synthesis and conformational studies of (Orn-10,Nle-13)-S-peptide. J. Am. Chem. Soc. 91, 492-496.

18. Rocchi, R.; Marchiori, F.; Moroder, L.; Borin, G.; Scoffone, E. (1969) Synthesis of peptide analogs of the N-terminal sequence of ribonuclease A. XIII. Synthesis of des-Lys-7-(Orn-10)- and des-Phe-8-(Orn-10)-S-peptides. J. Am. Chem. Soc. 91, 3927-3931.

19. Moroder, L.; Marchiori, F.; Rocchi, R.; Fontana, A.; Scoffone, E. (1969) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. XII. Synthesis of des-Lys-1-(Orn-10)-, des-Lys-1,Glu-2-(Orn-10)- and des-Lys-1,Glu-2,Thr-3-(Orn-10)-S-peptide. J. Am. Chem. Soc. 91, 3921-3926.

20. Rocchi, R.; Marchiori, F.; Moroder, L.; Borin, G.; Scoffone, E. (1969) Effetto di alcune modifiche nelle posizioni 4, 5, 6 e 7 delle ribonucleasi S‘. Chim. Ind. 51, 518.

21. Marchiori, F.; Rocchi, R.; Moroder, L.; Borin, G.; Scoffone, E. (1969) Sull‘ importanza del carattere aromatico del residuo in posizione 8 nell‘ associazione tra peptide S e proteina S. Chim. Ind. 51, 518.

1970

22. Moroder, L.; Hofmann, K. (1970) Studies on polypeptides. XLVI. Synthesis of a stably labeled, biologically active adrenocorticotropin fragment. J. Med. Chem. 13, 839-843.

23. Hofmann, K.; Andreatta, R.; Bohn, H.; Moroder, L. (1970) Studies on polypeptides. XLV. Structure - function studies in the corticotropin series. J. Med. Chem. 13, 339-345.

1971

24. Borin, G.; Marchiori, F.; Rocchi, R.; Moroder, L.; Scoffone, E. (1971) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. XIV. Synthesis of (cyclopentyl-Gly-8,Orn-10)-S-peptide and related studies. Gazz. Chim. Ital. 101, 426-439.

1972

25. Borin, G.; Marchiori, F.; Moroder, L.; Rocchi, R.; Scoffone, E. (1972) On the role of the 4-6 N-terminal sequence in the ribonuclease S-peptide and S-protein association. Biochim. Biophys. Acta 271, 77-79.

26. Rocchi, R.; Borin, G.; Marchiori, F.; Moroder, L.; Peggion, E.; Scoffone, E.; Crescenzi, V.; Quadrifoglio, F. (1972) Interaction of S-protein with S-peptide and with synthetic S-peptide analogs. A spectroscopic and calorimetric investigation. Biochemistry 11, 50-57.

27. Marchiori, F.; Borin, G.; Moroder, L.; Rocchi, R.; Scoffone, E. (1972) Relation between structure and function in some partially synthetic ribonucleases S‘. I. Kinetic determinations. Biochim. Biophys. Acta 257, 210-221.

28. Borin, G.; Toniolo, C.; Moroder, L.; Marchiori, F.; Rocchi, R.; Scoffone, E. (1972) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. Part XV. Synthesis and guanidination of (Orn-10,Orn-12)-S-Peptide. Int. J. Peptide Protein Res. 4, 37-45.

29. Borin, G.; Moroder, L.; Marchiori, F.; Scoffone, E. (1972) Sintesi di frammenti peptidici corrispondenti all‘ intera sequenza primaria dell‘ iso-I-citocromo c di lievito. Chim. Ind. 54, 1139.




30. Scoffone, E.; Borin, G.; Moroder, L.; Marchiori, F. (1972) Approach to the total synthesis of a protein: baker‘s yeast iso-1-cytochrome c. Acta Vitaminol. Enzymol. 26, 204.

31. Moroder, L.; Borin, G.; Marchiori, F.; Scoffone, E. (1972) Synthetic peptides related to the entire sequence of yeast iso-I-cytochrome c. Biopolymers 11, 2191-2194.

1973

32. Moroder, L.; Borin, G.; Marchiori, F.; Scoffone, E. (1973) Studies on cytochrome c. Part I. Synthesis of the protected hexadecapeptide (sequence 1-16) of baker‘s yeast iso-I-cytochrome c. Biopolymers 12, 477-492.

33. Moroder, L.; Marchiori, F.; Borin, G.; Scoffone, E. (1973) Studies on cytochrome c. Part II. Synthesis of the protected heptapeptide (sequence 17-23) of baker‘s yeast iso-I-cytochrome c. Biopolymers 12, 493-505.

34. Moroder, L.; Borin, G.; Marchiori, F.; Scoffone, E. (1973) Studies on cytochrome c. Part III. Synthesis of the protected heneicosapeptide (sequence 24-44) of baker‘s yeast iso-I-cytochrome c. Biopolymers 12, 507-520.

35. Borin, G.; Moroder, L.; Marchiori, F.; Scoffone, E. (1973) Studies on cytochrome c. Part IV. Synthesis of the protected dodecapeptide (sequence 45-56) of baker‘s yeast iso-I-cytochrome c. Biopolymers 12, 521-534.

36. Borin, G.; Moroder, L.; Marchiori, F.; Scoffone, E. (1973) Studies on cytochrome c. Part V. Synthesis of the protected decapeptide (sequence 57-66) of baker‘s yeast iso-I-cytochrome c. Biopolymers 12, 693-700.

37. Moroder, L.; Marchiori, F.; Borin, G.; Scoffone, E. (1973) Studies on cytochrome c. Part VI. Synthesis of the protected pentadecapeptide (sequence 67-81) of baker‘s yeast iso-I-cytochrome c. Biopolymers 12, 701-720.

38. Moroder, L.; Borin, G.; Marchiori, F.; Scoffone, E. (1973) Studies on cytochrome c. Part VII. Synthesis of the protected undecapeptide (sequence 82-92) of baker‘s yeast iso-I-cytochrome c. Biopolymers 12, 721-728.

39. Moroder, L.; Marchiori, F.; Borin, G.; Scoffone, E. (1973) Studies on cytochrome C. Part VIII. Synthesis of the protected hexadecapeptide (sequence 93-108) of baker‘s yeast iso-I-cytochrome c. Biopolymers 12, 729-750.

1974

40. Moroder, L.; Borin, G.; Marchiori, F. and Scoffone, E. (1974) Untersuchungen über Cytochrom C. IX. Eine neue Synthese der Sequenz 93-108 des Iso-I-cytochroms C aus Bäckerhefe. Liebigs Ann. Chem. 213-224.

41. Borin, G.; Marchiori, F.; Moroder, L.; Rocchi, R.; Scoffone, E. (1974) Synthesis of analogs of the N-terminal eicosapeptide sequence of ribonuclease A. Part. XVI. Synthesis and guanidination of (Orn-10,Leu-11)- and (Orn-10,Lys-11)-S-peptide. Int. J. Peptide Protein Res. 6, 329-335.

42. Marchiori, F.; Borin, G.; Moroder, L.; Scoffone, E. (1974) Relation between structure and function in some partially synthetic ribonucleases S‘. Part II. Kinetic determinations on (Orn-10,Glu-11)-, (Orn-10,Leu-11)- and (Orn-10,Lys-11)-ribonuclease S‘. Int. J. Peptide Protein Res. 6, 337-345.

43. Marchiori, F.; Borin, G.; Moroder, L. (1974) Studies on ribonuclease S‘. The role of lysine-7 for activation of S-protein. Int. J. Peptide Protein Res. 6, 419-434.

44. Filippi, B.; Borin, G.; Marchiori, F.; Moroder, L.; Scoffone, E. (1974) Relazione tra attività e struttura in RNase S‘ parzialmente sintetiche. Studi cinetici e conformazionali su (Orn-10,Asn-14)-RNase S‘. Chim. Ind. 56, 850.

1975

45. Borin, G.; Marchiori, F.; Moroder, L.; Scoffone, E. (1975) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. Part XVII. Synthesis and guanidination of (Lys-4,Ala-7,Orn-10)- and (Ala-7,Orn-10)-S-peptide. Gazz. Chim. Ital. 105, 137-147.

46. Filippi, B.; Moroder, L.; Borin, G.; Samartsev, M.: Marchiori, F. (1975) Relation between structure and function in some partially synthetic ribonucleases S‘. Enzymic and spectroscopic investigation on (Orn-10,Asn-14)-RNase S‘ and 1e,7e,10d-triguanidino- (Orn-10,Asn-14)-RNase S‘. Eur. J. Biochem. 52, 65-76.

47. Moroder, L.; Filippi, B.; Borin, G.; Marchiori, F. (1975) Studies on cytochrome c. X. Synthesis of Na-benzyloxycarbonyl-(Thr-107)-dotetracontapeptide (sequence 67-108) of baker‘s yeast iso-I-cytochrome c. Biopolymers 14, 2061-2074.

48. Moroder, L.; Filippi, B.; Borin, G.; Marchiori, F. (1975) Studies on cytochrome c. XI. Circular dichroism studies on synthetic peptides related to the C-terminal region of baker‘s yeast iso-I-cytochrome c. Biopolymers 14, 2075-2093.

1976

49. Brandt, M.; Gullis, R. J.; Fischer, K.; Buchen, C.; Hamprecht, B., Moroder, L.; Wünsch, E. (1976) Enkephalin regulates the levels of cyclic nucleotides in neuroblastoma x glioma hybrid cells. Nature 262, 311-313.

50. Brandt, M.; Fischer, K.; Moroder, L.; Wünsch, E.; Hamprecht, B. (1976) Enkephalin evokes biochemical correlates of opiate tolerance and dependence in neuroblastoma x glioma hybrid cells. FEBS Lett. 68, 38-40.

51. Wünsch, E.; Wendlberger, G.; Hallett, A.; Jaeger, E.; Moroder, L.; Thamm, P.; Wilschowitz, L. (1976) Total synthesis of human big-gastrin-I and the Leu32-analogue. Acta Hepato-Gastroenterol. 23, 303.

52. Zieglgänsberger, W.; Fry, J. P.; Herz, A.; Moroder, L.; Wünsch, E. (1976) Enkephalin-induced inhibition of cortical neurones and the lack of this effect in morphine tolerant/dependent Rats. Brain Res. 115, 160-164.

53. Wünsch, E.; Jaeger, E.; Moroder, L.; Demling, L.; Domschke, W.; Reiss, M. (1976) Radioimmunoassay für Sekretin. Hoppe-Seyler‘s Z. Physiol. Chem. 357, 1417-1420.

54. Moroder, L.; Wackerle, L.; Wünsch, E. (1976) Fluorameisensäure-1-adamantylester, ein neues Reagenz zur Einführung der 1-Adamantyloxycarbonyl-Schutzgruppe. Hoppe-Seyler‘s Z. Physiol. Chem. 357, 1647-1650.

55. Moroder, L.; Hallett, A.; Wünsch, E.; Keller, O.; Wersin, G. (1976) Di-tert-Butyldicarbonat: ein vorteilhaftes Reagenz zur Einführung der tert-Butyloxycarbonyl-Schutzgruppe. Hoppe-Seyler‘s Z. Physiol. Chem. 357, 1651-1653.

56. Urbach, H. J.; Domschke, W.; Reiß, M.; Domschke, S.; Rosselin, G.; Wünsch, E.; Jaeger, E.; Moroder, L.; Demling, L. (1976) Superior immunoreactivity of 125I-(desamino-Tyr-bAla)-secretin with rabbit anti-secretin sera compared to 125I-secretin and 125I-6-tyrosyl-secretin. Horm. Metab. Res. 8, 459-461.

57. Filippi, B.; Borin, G.; Moroder, L.; Marchiori, F. (1976) Near-ultraviolet difference absorption and circular dichroism studies on partially synthetic ribonucleases S‘. Biochim. Biophys. Acta 454, 514-523.

58. Filippi, B.; Borin, G.; Moroder, L.; Marchiori, F. (1976) Far-ultraviolet difference absorption and circular dichroism studies on partially synthetic ribonucleases S‘. Biochim. Biophys. Acta 454, 524-538.

1977

59. Mitznegg, P.; Domschke, W.; Sprügel, W.; Domschke, S.; Subramanian, N.; Wünsch, E.; Moroder, L.; Demling, L. (1977) Enkephalins inhibit intestinal motility: mode of action. Acta Hepato-Gastroenterol. 24, 109-110.

60. Sprügel, W.; Mitznegg, P.; Domschke, W.; Domschke, S.; Wünsch, E.; Moroder, L.; Demling, L. (1977) Direct inhibitory effects of enkephalins on contractile responses in the guinea pig ileum. Gastroenterology 72, 1135

61. Wahlström, A.; Brandt, M.; Moroder, L.; Wünsch, E.; Lindeberg, G.; Ragnarsson, U.; Terenius, L.; Hamprecht, B. (1977) Peptides related to b-lipotropin with opioid activity. Effects on levels of adenosine 3‘:5‘-cyclic monophosphate in neuroblastoma x glioma hybrid cells. FEBS Lett. 77, 28-32.

62. Wünsch, E.; Wendlberger, G.; Hallett, A.; Jaeger, E.; Knof, S.; Moroder, L.; Scharf, R.; Schmidt, I.; Thamm, P.; Wilschowitz, L. (1977) Zur Totalsynthese des Human-Big-Gastrins-I und seines 32-Leucin-Analogons. Z. Naturforsch. 32c, 495-506.

63. Moroder, L.; Borin, G.; Filippi, B.; Stivanello, D.; Marchiori, F. (1977) Studies on cytochrome c. XII. Synthesis of the protected undecapeptide (sequence 66-67) and pentadecapeptide (sequence 66-80) of horse heart cytochrome c. Int. J. Peptide Protein Res. 10, 81-88.

64. Moroder, L.; Jaeger, E.; Wünsch, E.; Schulz, I.; Schlegel, W.; Bataille, D. (1977) Biological and immunological properties of secretin analogues. Acta Hepato-Gastroenterol. 24, 489.

65. Borin, G.; Filippi, B.; Moroder, L.; Santoni, C.; Marchiori, F. (1977) Kinetic and conformational studies on some partially synthetic ribonuclease S‘ analogues modified in position 8. Int. J. Peptide Protein Res. 10, 27-38.

1978

66. Wünsch, E.; Moroder, L.; Thamm, P.; Brown, J.; Pederson, R. (1978) GIP structure - a still unsolved problem. Acta Hepato-Gastroenterol. 25, 504.

67. Moroder, L.; Drees, F.; Jaeger, E.; Wünsch, E. (1978) Zur Synthese von [11-Leucin]-Human-Minigastrin-I. I. Mitteilung. Darstellung der Gesamtsequenz. Hoppe-Seyler‘s Z. Physiol. Chem. 359, 147-153.

68. Jaeger, E.; Thamm, P.; Schmidt, I.; Knof, S.; Moroder, L.; Wünsch, E. (1978) Zur Synthese von [11-Leucin]-Human-Minigastrin-I. II. Mitteilung. Reindarstellung des synthetischen Tridekapeptidamids sowie Isolierung und Strukturaufklärung eines Synthese-Nebenproduktes. Hoppe-Seyler‘s Z. Physiol. Chem. 359, 155-164.

69. Moroder, L.; Hallett, A.; Thamm, P.; Wilschowitz, L.; Brown, J. C.; Wünsch, E. (1978) Studies on gastric inhibitory polypeptide. Synthesis of the octatriacontapeptide GIP-1-38 with full insulinotropic activity. Scand. J. Gastroenterol. 13 (Suppl. 49) 129.

1979

70. Propst, F.; Moroder, L.; Wünsch, E.; Hamprecht, B. (1979) Influence of peptide hormones on the level of cyclic AMP in neuroblastoma x glioma hybrid cells. Acta Neurol. Belgica 79, 57.

71. Propst, F.; Moroder, L.; Wünsch, E.; Hamprecht, B. (1979) The influence of secretin, glucagon and other peptides, of amino acids, prostagladin endoperoxide analogues and diazepam on the level of adenosine 3‘,5‘-cyclic monophosphate in neuroblastoma x glioma hybrid cells. J. Neurochem. 32, 1495-1500.

72. Moroder, L.; Wilschowitz, L.; Jaeger, E.; Knof, S.; Thamm, P.; Wünsch, E. (1979) Synthese von Tyrosin-O-sulfat-haltigen Peptiden. Hoppe-Seyler‘s Z. Physiol. Chem. 360, 787-790.

73. Wendlberger, G.; Moroder, L.; Hallett, A.; Wünsch, E. (1979) Zur Synthese von Human-Big-Gastrin-I und seinem 32-Leucin-Analogon. 1. Mitteilung. Darstellung der Teilsequenzen 28-34, 23-27, 21-22 und 15-20. Mh. Chem. 110, 1301-1315.

74. Wendlberger, G.; Moroder, L.; Thamm, P.; Wilschowitz, L.; Wünsch, E. (1979) Zur Synthese von Human-Big-Gastrin-I und seinem 32-Leucin-Analogon. 2. Mitteilung. Darstellung der Teilsequenzen 9-14 und 1-8. Mh. Chem. 110, 1317-1330.

75. Lehnert, P.; Forell, M. M.; Jaeger, E.; Moroder, L. and Wünsch, E. (1979) Comparison of the biological activity of secretin and some related peptides. Dan. Med. Bull. 26, Suppl. 1, 20.

76. Wendlberger, G.; Moroder, L.; Hallett, A.; Wünsch, E. (1979) Zur Synthese von Human-Big-Gastrin-I und seinem 32-Leucin-Analogon. 3. Mitteilung. Darstellung der allseits geschützten Gesamtsequenzen. Mh. Chem. 110, 1407-1428.

1980

77. Moroder, L.; Jaeger, E.; Drees, F.; Gemeiner, M.; Knof, S.; Stelzel, H. P.; Thamm, P.; Bataille, D.; Domschke, S.; Schlegel, W.; Schulz, I.; Wünsch, E. (1980) Structure - function studies on gastrointestinal hormones. I. Synthesis of secretin analogs and their biological and immunological properties. Bioorg. Chem. 9, 27-54.

78. Moroder, L.; Gemeiner, M.; Göhring, W.; Jaeger, E.; Knof, S.; Scharf, R.; Thamm, P.; Wilschowitz, L.; Gardner, J. D.; Wünsch, E. (1980) A new synthesis of cholecystokinin-pancreozymin active peptides. Acta Hepato-Gastroenterol. 27, 72.

79. Peggion, E.; Jaeger, E.; Knof, S.; Moroder, L.; Wünsch, E. (1980) Circular dichroism studies on the conformation of gastrin related peptides. Regul. Pept. 1 Suppl., 86.

80. Gemeiner, M.; Moroder, L.; Pradayrol, L.; Wünsch, E. (1980) Total synthesis of porcine big-somatostatin (somatostatin-28). Regul. Pept. 1 Suppl., 41.

81. Wünsch, E.; Moroder, L.; Gemeiner, M.; Jaeger, E.; Ribet, A.; Pradayrol, L.; Vaysse, N. (1980) Totalsynthese von Somatostatin-28 (Big-Somatostatin). Z. Naturforsch. 35b, 911-919.

82. Chessa, G.; Filippi, B.; Borin, G.; Moroder, L.; Palumbo, M.; Marchiori, F. (1980) Inhibition of the cytochrome c/cytochrome c oxidase system by cytochrome c derivatives and related fragments. Hoppe-Seyler‘s Z. Physiol. Chem. 361, 1077-1091.

1981

83. Wünsch, E.; Moroder, L.; Wilschowitz, L.; Göhring, W.; Scharf, R.; Gardner, J. D. (1981) Zur Totalsynthese von Cholecystokinin-Pankreozymin. Darstellung des verknüpfungsfähigen „Schlüsselfragments“ der Sequenz 24-33. Hoppe-Seyler‘s Z. Physiol. Chem. 362, 143-152.

84. Moroder, L.; Gemeiner, M.; Pradayrol, L.; Wünsch, E. (1981) On the identity of natural and synthetic somatostatin-28. Acta Hepato-Gastroenterol. 28, 67.

85. Moroder, L.; Gemeiner, M.; Göhring, W.; Jaeger, E.; Thamm, P.; Wünsch, E. (1981) New synthesis of somatostatin according to the S-tert-butylthiocysteine procedure. Biopolymers 20, 17-37.

86. Peggion, E.; Jaeger, E.; Knof, S.; Moroder, L.; Wünsch, E. (1981) Conformational aspects of gastrin-related peptides: a circular dichroism study. Biopolymers 20, 633-652.

87. Valet, G.; Raffael, A.; Moroder, L.; Wünsch, E.; Ruhenstroth-Bauer, G. (1981) Fast intracellular pH determination in single cells by flow-cytometry. Naturwissenschaften 68, 265-266.

88. Moroder, L.; Gemeiner, M.; Göhring, W.; Jaeger, E.; Musiol, J.; Scharf, R.; Stocker, H.; Wünsch, E.; Pradayrol, L.; Vaysse, N.; Ribet, A. (1981) Totalsynthese von Somatostatin-28. Hoppe-Seyler‘s Z. Physiol. Chem. 362, 697-716.

89. Moroder, L.; Wilschowitz, L.; Gemeiner, M.; Göhring, W.; Knof, S.; Scharf, R.; Thamm, P.; Gardner, J. D.; Solomon, T. E.; Wünsch, E. (1981) Zur Synthese von Cholecystokinin-Pankreozymin. Darstellung von [28-Threonin, 31-Norleucin]- und [28-Threonin, 31-Leucin]-Cholecystokinin-Pankreozymin-(25-33)-Nonapeptid. Hoppe-Seyler‘s Z. Physiol. Chem. 362, 929-942.

90. Lehnert, P.; Forell, M. M.; Jaeger, E.; Moroder, L.; Wünsch, E. (1981) Hydrokinetic activity of secretin and secretin analogues, modified in the N-terminal sequence, and of vasoactive intestinal peptide in the dog pancreas. Digestion 22, 85-88.

91. Wünsch, E.; Jaeger, E.; Moroder, L.; Peggion, E.; Palumbo, M. (1981) Somatostatin-28. A conformational analysis. Biopolymers 20, 1741-1745.

92. Valet, G.; Raffael, A.; Moroder, L.; Wünsch, E.; Ruhenstroth-Bauer, G. (1981) Fast intracellular pH determination by flow-cytometry. Cytometry 2, 133-134.

93. Valet, G.; Raffael, A.; Ormerod, M.; Warnecke, H.; Benker, G.; Moroder, L.; Wünsch, E.; Ruhenstroth-Bauer, G. (1981) Antigens and the intracellular pH as sensitive markers for flow cytometric detection of tumor cells. Cytometry 2, 134.

94. Wünsch, E.; Moroder, L.; Göhring, W.; Thamm, P.; Scharf, R. (1981) Studies on enzymatic methods for processing hybrid proteins produced by recombinant DNA technology. Hoppe-Seyler‘s Z. Physiol. Chem. 362, 1285-1287.

95. Wünsch, E.; Moroder, L.; Keller, O. (1981) Synthesis of 2-(trimethylsilyl)ethyloxycarbonyl-amino acids and their use in peptide chemistry. Hoppe-Seyler‘s Z. Physiol. Chem. 362, 1289-1292.

96. Gespach, C.; Bataille, D.; Vauclin, N.; Rosselin, G.; Moroder, L.; Wünsch, E. (1981) Secretin binding sites coupled with adenylate cyclase in rat fundic membranes. Peptides 2 (Suppl. 2) 247-251.

1982

97. Moroder, L.; Göhring, W.; Borin, G.; Bali, J. P.; Previero, A.; Wünsch, E. (1982) Gastrin-related peptides and their biological properties. Acta Hepato-Gastroenterol. 29, 90.

98. Wünsch, E.; Moroder, L.; Nyfeler, R.; Jaeger, E. (1982) (Alkyldithio)carbonyl groups for protection of amino functions in peptide synthesis. Hoppe-Seyler‘s Z. Physiol. Chem. 363, 197-202.

99. Wünsch, E.; Moroder, L.; Gillessen, D.; Soerensen, U. B.; Bali, J.-P. (1982) Biological and immunological properties of human gastrin-I analogues. Hoppe-Seyler‘s Z. Physiol. Chem. 363, 665-669.

100. Moroder, L.; Göhring, W.; Thamm, P.; Wünsch, E.; Tatemoto, K.; Mutt, V.; Bataille, D. (1982) Total synthesis of PHI. Z. Naturforsch. 37b, 772-780.

101. Moroder, L.; Wünsch, E.; Vaysse, N.; Ribet, A. (1982) Synthesis of [8-norleucine]-somatostatin-28. Hoppe-Seyler‘s Z. Physiol. Chem. 363, 1247-1251.

102. Wünsch, E.; Moroder, L.; Romani, S. (1982) 1-(tert-Butylthio)-1,2-hydrazinedicarboxylic acid derivatives. New reagents for the introduction of the S-tert-butylthio group into cysteine and cysteine derivatives. Hoppe-Seyler‘s Z. Physiol. Chem. 363, 1461-1464.

103. Magous, R.; Bali, J.-P.; Moroder, L.; Previero, A. (1982) Effect of Nin-formylation of the tryptophan residue on gastrin (HG-13) binding and on gastric acid secretion. Eur. J. Pharm. 77, 11-16.

104. Previero, A.; Mourier, G.; Bali, J.-P.; Lignon, M. F.; Moroder, L. (1982) Na-Glycosylgastrin rlated pptides. Synthesis, caracterization and bological activity. Hoppe-Seylers‘s Z. Physiol. Chem. 363, 813-818.

105. Koulischer, D.; Moroder, L.; Deschodt-Lanckman, M. (1982) Degradation of cholecystokinin octapeptide, related fragments and analogs by human and rat plasma in vitro. Regul. Pept. 4, 127-139.

106. Koulischer, D.; Moroder, L.; Deschodt-Lanckman, M. (1982) Degradation of cholecystokinin octapeptide, related fragments and analogs by human and rat plasma in vitro. Arch. Int. Physiol. Biochim. Biophys. 90, B42-B43.

107. Magous, R.; Bali, J.-P.; Moroder, L. (1982) Gastrin receptor – Structure-binding relationships with peptides from gastrin family. Biol. Cell 45, SI199.

108. Lehnert, P.: Forell, M. M.; Spiessl, W.; Jaeger, E.; Moroder, L.; Wünsch, E. (1982) Interaction of secretin analogs and of VIP with secretin in the dog pancreas. Digestion 25, 26-27.

109. Esteve, J. P.; Vaysse, N.; Susini, C.; Fourmy, D.; Kunsch, J. M.; Pradayrol, L.; Wünsch, E.; Moroder, L.; Ribet, A. (1982) Bimodal regulation of pancreatic exocrine function in vitro by somatostatin-28. Digestion 25, 26-27.

110. Antoniotti, H.; Fagot-Revurat, P.; Pradayrol, L.; Chayvialle, J. A.; Moroder, L.; Wünsch, E.; Ribet, A. (1982) Specific determination of the N-terminal fragment of somatostatin-28 in rat pancreatic tissue. Digestion 25, 14.

1983

111. Moroder, L.; Nyfeler, R.; Gemeiner, M.; Kalbacher, H.; Wünsch, E. (1983) Immunoassays of peptide hormones and their chemical aspects. Biopolymers 22, 481-486.

112. Kalbacher, H.; Moroder, L.; Wünsch, E. (1983) Chemische Aspekte zur Verbesserung von Immunoassays für Peptidhormone. Hoppe-Seyler‘s Z. Physiol. Chem. 364, 344.

113. Esteve, J. P.; Vaysse, N.; Susini, C.; Kunsch, J. M.; Fourmy, D.; Pradayrol, L.; Wünsch, E.; Moroder, L.; Ribet, A. (1983) Bimodal regulation of pancreatic exocrine function in vitro by somatostatin-28. Am. J. Physiol. 245, 208G-216G.

114. Moroder, L.; Göhring, W.; Lucietto, P. L.; Musiol, H. J.; Scharf, R.; Thamm, P.; Bovermann, G.; Wünsch, E.; Lundberg, J.; Tatemoto, K.; Mutt, V. (1983) Synthesis of the porcine intestinal peptide PHI and its 24-glutamine analogue. Hoppe-Seyler‘s Z. Physiol. Chem. 364, 1563-1584.

115. Werner, S.; Hulting, A. L.; Hökfelt, T.; Eneroth, P.; Tatemoto, K.; Mutt, V.; Moroder, L.; Wünsch, E. (1983) Effect of the peptide PHI-27 on prolactin release in vitro. Neuroendocrinol. 37, 476-478.

116. Laburthe, M.; Amiranoff, B.; Boige, N.; Rouyer-Fessard, C.; Tatemoto, K.; Moroder, L. (1983) Interaction of GRF with VIP receptors and stimulation of adenylate cyclase in rat and human intestinal epithelial membranes. Comparison with PHI and secretin. FEBS Lett. 159, 89-92.

117. Peggion, E.; Mammi, S.; Palumbo, M.; Moroder, L.; Wünsch, E. (1983) Interaction of calcium ions with peptide hormones of the gastrin family. Biopolymers 22, 2443-2457.

118. Moroder, L.; Göhring, W.; Nyfeler, R.; Scharf, R.; Thamm, P.; Wendlberger, G. (1983) Zur Synthese von Human-Little-Gastrin-I und dessen Leucin-15-, Norleucin-15- und Methoxinin-15-Analoga. Hoppe-Seyler‘s Z. Physiol. Chem. 364, 157-171.

119. Antoniotti, H.; Fagot-Revurat, P.; Chayvialle, J. A.; Moroder, L.; Pradayrol, L.; Wünsch, E.; Ribet, A. (1983) Measurement of somatostatins in rat tissues using sequence specific radioimmunoassays. Regul. Pept. 2 Suppl., 45.

120. Laburthe, M.; Amiranoff, B.; Boige, N.; Rouyer-Fessard, C.; Tatemoto, K.; Moroder, L. (1983) GRF interaction with VIP receptors in human and rat intestinal epithelial membranes. Comparison with PHI and secretin. Regul. Pept. 6, 314.

121. Esteve, J. P.; Vaysse, N.; Susini, C.; Fourmy, D.; Kunsch, J. M.; Pradayrol, L.; Wünsch, E.; Moroder, L.; Ribet, A. (1983) Regulation of in vitro exocrione pancreatic function by somatostatin. Diabetes & Metabolism 9, R15.

122. Pradayrol, L.; Antoniotti, H.; Fagot-Revurat, P.; Chayvialle, J. A.; Moroder, L.; Wünsch, E.; Ribet, A. (1983) Activation of somatostatin precursors in rat-tissues by conjugation of gel-permeation chromatography and sequence specific RIA. Gastroenterology 84, 1276.

1984

123. Göhring, W.; Moroder, L.; Borin, G.; Lobbia, A.; Bali, J.-P.; Wünsch, E. (1984) Synthese von Gastrin-aktiven Peptiden. Untersuchungen zur Struktur-Wirkungsbeziehung des natürlichen Hormons Human-Little-Gastrin-I. Hoppe-Seyler‘s Z. Physiol. Chem. 365, 83-94.

124. Geiger, R.; Moroder, L.; Wünsch, E. (1984) Enzyme immunoassay of human gastrin. Fresenius Z. Anal. Chem. 317, 734-735.

125. Beglinger, C.; Solomon, T. E.; Gyr, K.; Moroder, L.; Wünsch, E. (1984) Exocrine pancreatic secretion in response to a new CCK-analog, CCK33 and caerulein in dogs. Regul. Pept. 8, 291-296.

126. Peggion, E.; Mammi, S.; Palumbo, M.; Moroder, L.; Wünsch, E. (1984) Interaction of metal ions with gastrointestinal hormones. Binding studies of Mg2+ to biologically active analogs of little-gastrin and minigastrin. Biopolymers 23, 1225-1240.

127. Geiger, R.; Moroder, L.; Wünsch, E. (1984) Zur Immunbestimmung von Peptidfaktoren. Neue, chemisch saubere Wege für den Gastrinimmunoassay. Tips Gastroenterol. Praxis 11, 9-12.

128. Geiger, R.; Moroder, L.; Wünsch, E. (1984) Cloning - an efficient improvement in immunoassays? Hepato-Gastroenterol. 31, 94.

129. Mourier, G.; Moroder, L.; Previero, A. (1984) Prevention of tryptophan oxidation during iodination of tyrosyl residues in peptides. Z. Naturforsch. 39b, 101-104.

130. Svoboda, M.; Lambert, M.; Moroder, L.; Christophe, J. (1984) One-step isocratic high-perfomance liquid chromatographic purification of radioiodinated and radioiodinated-photoactivable derivatives of cholecystokinin. J. Chromatogr. 296, 199-211.

131. Moroder, L.; Göhring, W.; Lucietto, P. L.; Scharf, R.; Wünsch, E. (1984) PHI: structure and biological activity. Biomed. Res. 5 Suppl., 41-48.

1985

132. Wünsch, E.; Moroder, L.; Nyfeler, R.; Kalbacher, H.; Gemeiner, M. (1985) Zur Immunbestimmung von Peptidfaktoren. I. Mitteilung. Synthese von Na-Maleoyl-Peptidwirkstoffen. Biol. Chem. Hoppe-Seyler 366, 53-61.

133. Peggion, E.; Foffani, M. T.; Wünsch, E.; Moroder, L.; Borin, G.; Goodman, M.; Mammi, S. (1985) Conformational properties of gastrin fragments of increasing chain length. Biopolymers 24, 647-666.

134. Pallai, P. V.; Struthers, R. S.; Goodman, M.; Moroder, L.; Wünsch, E.; Vale, W. (1985) Partial retro-inverso analogues of somatostatin: pairwise modifications at residues 7 and 8 and at residues 8 and 9. Biochemistry 24, 1933-1941.

135. Romani, S.; Bovermann, G.; Moroder, L.; Wünsch, E. (1985) N-(2-Nitrobenzenesulfenyl)-saccharin: a useful reagent in peptide synthesis. Synthesis 5, 512-514.

136. Romani, S.; Moroder, L.; Bovermann, G.; Wünsch, E. (1985) On the use of five-membered heterocycles in peptide chemistry. Synthesis 8, 738-742.

137. Peggion, E.; Foffani, M. T.; Moroder, L.; Wünsch, E. (1985) Effect of self-association on the conformation of gastrin-related peptides. CD study on pGlu-(Glu)4-Ala-Tyr-Gly-Trp-Nle-Asp-Phe-amide. Biopolymers 24, 2029-2033.

138. Laburthe, M.; Couvineau, A.; Rouyer-Fessard, C.; Moroder, L. (1985) Interaction of PHM, PHI and 24-glutamine PHI with human VIP receptors from colonic epithelium. Comparison with rat intestinal receptors. Life Sci. 36, 991-995.

139. Moroder, L.; Wünsch, E. (1985) Methodological aspects of the chemical synthesis of VIP - secretin – peptides. Regul. Pept. 3 Suppl., 4.

140. Gespach, C.; Bataille, D.; Vauclin, N.; Moroder, L.; Wünsch, E.; Rosselin, G. (1985) Secretin receptor activity in rat gastric glands. Binding studies, cAMP generation and pharmacology. Regul. Pept. 3 Suppl., 30.

1986

141. Mammi, S.; Goodman, M.; Peggion, E.; Foffani, M. T.; Moroder, L.; Wünsch, E. (1986) Conformational studies on gastrin related peptides by high resolution 1H-NMR. Int. J. Peptide Protein Res. 27, 145-152.

142. Wünsch, E.; Moroder, L.; Göhring, W.; Borin, G.; Calderan, A.; Bali, J.-P. (1986) Synthesis of human des-tryptophan-1,norleucine-12-minigastrin-II and its biological activities. FEBS Lett. 206, 203-207.

143. Gespach, C.; Bataille, D.; Vauclin, L.; Moroder, L.; Wünsch, E.; Rosselin, G. (1986) Secretin receptor activity in rat gastric glands. Binding studies, cAMP generation and pharmacology. Peptides 7 (Suppl.1) 155-163.

144. Peggion, E.; Foffani, M. T.; Wünsch, E.; Moroder, L.; Goodman, M.; Mammi, S. (1986) Interaction of calcium ions with gastrin fragments of increasing chain length. Biopolymers 25, 135-152.

1987

145. Romani, S.; Moroder, L.; Wünsch, E. (1987) Synthesis of the trypsin fragment 10-25/75-88 of mouse nerve growth factor. I. The protected tetradecapeptide 75-88. Int. J. Peptide Protein Res. 29, 99-106.

146. Romani, S.; Moroder, L.; Göhring, W.; Scharf, R.; Wünsch, E.; Barde, Y. A.; Thoenen, H. (1987) Synthesis of the trypsin fragment 10-25/75-88 of mouse nerve growth factor. II. The unsymmetrical double chain cystine peptide. Int. J. Peptide Protein Res. 29, 107-117.

147. Mammi, S.; Mammi, N. J.; Foffani, M. T.; Peggion, E.; Moroder, L.; Wünsch, E. (1987) Conformation of human little-gastrin and minigastrin analogs in surfactant solution. Biopolymers 26 Suppl., 1-10.

148. Moroder, L.; Bovermann, G.; Mourier, G.; Göhring, W.; Gemeiner, M.; Wünsch, E. (1987) Studies on immunoassays of peptide factors. II. Fluorescence enzyme immunoassay for human little-gastrin. Biol. Chem. Hoppe-Seyler 368, 831-838.

149. Moroder, L.; Mourier, G.; Dufresne, M.; Bovermann, G.; Göhring, W.; Gemeiner, M.; Wünsch, E. (1987) Studies on immunoassays of peptide factors. III. Gastrin/iso-1-cytochrome c as immunogen for raising anti-gastrin antisera. Biol. Chem. Hoppe-Seyler 368, 839-848.

150. Moroder, L.; Mourier, G.; Bovermann, G.; Dufresne, M.; Göhring, W.; Gemeiner, M.; Wünsch, E. (1987) Studies on immunoassays of peptide factors. IV. New synthesis of a gastrin/peroxidase conjugate. Biol. Chem. Hoppe-Seyler 368, 849-853.

151. Moroder, L.; Tzougraki, C.; Göhring, W.; Mourier, G.; Musiol, H. J.; Wünsch, E. (1987) Studies on immunoassays of peptide factors. V. Synthesis of cholecystokinin-58-(1-11)/iso-1-cytochrome c conjugate. Biol. Chem. Hoppe-Seyler 368, 855-861.

152. Borin, G.; Calderan, A.; Ruzza, P.; Moroder, L.; Göhring, W.; Bovermann, G.; Wünsch, E. (1987) Synthesis of human (15-Nle)-little-gastrin-II and des-1-Trp-(12-Nle)-minigastrin-II. Biol. Chem. Hoppe-Seyler 368, 1363-1373.

153. Farack, U. M.; Reiter, J.; Gross, M.; Moroder, L.; Wünsch, E.; Loeschke, K. (1987) Influence of vasoactive intestinal peptide, secretin, and Ala-4,Val-5-secretin on the net movements of electrolytes, fluids and mucus in the rat colon in vivo. Scand. J. Gastroenterol. 22, Suppl. 139, 32-36.

154. Bali, J.-P.; Magous, R.; Lignon, M. F.; Dubreuil, P.; Galleyrand, J. C.; Moroder, L.; Martinez, J, (1987) Influence of peptide length and sulfation of gastrin on the acid secretory potency and receptor affinity. Gastroenterol. Clin. Biol. 11, 737.

1988

155. Robbebrecht, P.; Damien, C.; Moroder, L.; Coy, D. H.; Wünsch, E.; Christophe, J. (1988) Receptor occupancy and adenylate cyclase activation in rat liver and heart membranes by 10 glucagon analogs modified in Position 2, 3, 4, 25, 27 and/or 29. Regul. Pept. 21, 117-128.

156. Moroder, L. (1988) A new reagent for the preparation of glycoconjugates. Biol. Chem. Hoppe-Seyler 369, 381-385.

157. Wünsch, E.; Moroder, L.; Göhring-Romani, S.; Musiol, H. J.; Göhring, W.; Bovermann, G. (1988) Synthesis of the bis-cystinyl-fragment 225-232/225‘-232‘ of the human IgG1 hinge region. Int. J. Peptide Protein Res. 32, 368-383.

1989

158. Moroder, L.; Gobbo, M.; Becker, G.; Wünsch, E. (1989) Synthesis of thiol-functionalized N-acetylmuramyl peptide congeners suitable for their conjugation to target molecules. Biol. Chem. Hoppe-Seyler 370, 365-375.

159. Wünsch, E.; Moroder, L.; Lerchen, H. G.; Christophe, J.; Svoboda, M. (1989) Synthesis of cholecystokinin-related peptides and their biological properties. Biol. Chem. Hoppe-Seyler 370, 317-321.

160. Moroder, L.; Dufresne, M.; Göhring, W.; Wünsch, E.; Leidinger, E.; Gemeiner, M. (1989) Muramyl-peptide/gastrin conjugates as potential immunogens. Biol. Chem. Hoppe-Seyler 370, 1209-1214.

161. Krois, D.; Dufresne, M.; Neumann, H.; Moroder, L.; Wünsch, E. (1989) On the hypothetical protein F154 of the TTV1 virus/thermoproteus tenax. Part III. Immunolgical identification of the protein with anti-peptide antibodies. Biol. Chem. Hoppe-Seyler 371, 43-48.

162. Fourmy, D.; Lopez, P.; Poirot, S.; Jimenez, J.; Dufresne, M.; Moroder, L.; Powers, S. P.; Vaysse, N. (1989) A new probe for affinity labelling pancreatic cholecystokinin receptor with minor modification of its structure. Eur. J. Biochem. 185, 397-403.

163. Mammi, S.; Foffani, M. T.; Peggion, E.; Galleyrand, J. C.; Bali, J.-P.; Simonetti, M.; Göhring, W.; Moroder, L.; Wünsch, E. (1989) Conformational and biological properties of the Ala10-analogue of human des-Trp1,Nle12-minigastrin. Biochemistry 28, 7182-7188.

164. Wünsch, E.; Moroder, L.; Lerchen, H. G.; Svoboda, M.; Christophe, J. (1989) Biological properties of 23-Ser(O-2-desoxy-a-D-galactosyl)-CCK-[23-33] and CCK-[22-33]. Hepato-Gastroenterol. 36, 40.

1990

165. Christophe, J.; Winand, J.; Poloczek, P.; Delporte, C.; Svoboda, M.; Moroder, L. (1990) Cholecystokinin receptors are distinguished kinetically by Biotinyl-Tyr-Gly-(Thr-28,Nle-31)-CCK-(25-33) (BTG-CCK-9) in rat pancreatic acini. Digestion 46, 132-133.

166. Moroder, L.; Hübener, G.; Göhring-Romani, S.; Göhring, W.; Musiol, H.-J.; Wünsch, E. (1990) Fully synthetic immunogens. Part I. Kinetic studies on air oxidation of the human IgG1 bis-cysteinyl fragment 225-232. Tetrahedron 46, 3305-3314.

167. Moroder, L.; Musiol, H.-J.; Siglmüller, G. (1990) Synthesis of 1,2-diacetyl-3-thioglycerols for lipid modification of peptides and proteins. Synthesis 10, 889-892.

168. Miercke, D. F.; Pattaroni, C.; Delaet, N.; Toy, A.; Goodman, M.; Tancredi, T.; Motta, A.; Temussi, P. A.; Moroder, L.; Bovermann, G.; Wünsch, E. (1990) Cyclic hexapeptides related to somatostatin. Conformational analysis employing 1H-NMR and molecular dynamics. Int. J. Peptide Protein Res. 36, 418-432.

169. Pattaroni, C.; Lucietto, P.; Goodman, M.; Yamamoto, G.; Vale, W.; Moroder, L.; Gazerro, L.; Göhring, W.; Schmied, B.; Wünsch, E. (1990) Cyclic hexapeptides related to somatostatin: synthesis and biological testing. Int. J. Peptide Protein Res. 36, 401-417.

1991

170. Tahiri-Jouti, N.; Dufresne, M.; Viguerie, N.; Fourmy, D.; Esteve, J.-P.; Rivier, J.; Moroder, L.; Susini, C.; Vaysse, N. (1991) Somatostatin-28 interacts with CCK receptor in brain and pancreas. Neuropeptides 19, 65-71.

171. Winand, J.; Poloczek, P.; Delporte, C.; Moroder, L.; Svoboda, M.; Christophe, J. (1991) Functional cholecystokinin receptors are distinguished kinetically by biotinyl-Tyr-Gly-(Thr-28,Nle-31)CCK(25-33) in rat pancreatic acini. Biochim. Biophys. Acta 1080, 181-190.

172. Wünsch, E.; Moroder, L.; Göhring-Romani, S.; Musiol, H.-J.; Göhring, W.; Scharf, R. (1991) Fully synthetic immunogens. Part II. Studies on parallel dimerization of the human IgG1 hinge fragment 225-232 with N- and C-terminal gastrin related extensions. Int. J. Peptide Protein Res. 37, 61-71.

173. Wünsch, E.; Moroder, L.; Hübener, G.; Musiol, H.-J.; von Grünigen, R.; Göhring, W.; Scharf, R.; Schneider, C. H. (1991) Fully synthetic immunogens. Part III. Synthesis of hinge peptide/gastrin conjugates and their immunological properties. Int. J. Peptide Protein Res. 37, 90-102.

174. von Grünigen, R.; Siglmüller, G.; Papini, A.; Köcher, K.; Traving, B.; Göhring, W.; Moroder, L. (1991) Enzyme immunoassay with captured hapten. A sensitive gastrin assay with biotinyl-gastrin derivatives. Biol. Chem. Hoppe-Seyler 372, 163-172.

175. Kobayashi, Y.; Sato, A.; Takashima, H.; Tamaoki, H.; Nishimura, S.; Kyogoku, Y.; Ikenaka, K.; Kondo, T.; Mikoshiba, K.; Hojo, H.; Aimoto, S.; Moroder, L. (1991) A new a-helical motif in membrane active peptides. Neurochem. Int. 18, 525-534.

176. Moroder, L.; Bali, J.-P.; Kobayashi, Y. (1991) Synthetic immunogens. Part IV: Conformational studies on gastrin conjugates with the human immunoglobulin G1 hinge peptide 225-232/225‘-232‘. Biopolymers 31, 595-604.

177. Kobayashi, Y.; Takashima, H.; Tamaoki, H.; Kyogoku, Y.; Lambert, P.; Kuroda, H.; Chino, N.; Watanabe, T.; Kimura, T.; Sakakibara, S.; Moroder, L. (1991) The cystine stabilized a-helix. A common structural motif of ion channel blocking neurotoxic peptides. Biopolymers 31, 1213-1220.

178. Kessler, H.; Mronga, S.; Müller, G.; Moroder, L.; Huber, R. (1991) Conformational analysis of a IgG1 hinge peptide derivative in solution determined by NMR spectroscopy and refined by restrained molecular dynamics simulations. Biopolymers 31, 1189-1204.

1992

179. Gemeiner, M.; Leidinger, E.; Miller, I.; Moroder, L. (1992) Immunomodulatory activity of 1,2-di-fattyacyl-3-mercaptoglycerol adducts. Biol. Chem. Hoppe-Seyler 373, 1085-1094.

180. Hübener, G.; Göhring, W.; Musiol, H.-J.; Moroder, L. (1992) Na-Trifluoroacetylation of N-terminal hydroxyamino acids. A new side reaction in peptide synthesis. Peptide Res. 5, 287-292.

181. Hadjiivanova, C.; Dufresne, M.; Poirot, S.; Sozzani, P.; Vaysse, N.; Moroder, L.; Fourmy, D. (1992) Pharmacological and biochemical characterization of cholecystokinin/gastrin receptors in developing rat pancreas. Age-related expression of distinct receptor glycoforms. Eur. J. Biochem. 204, 273-279.

182. Papini, A.; Rudolph, S.; Siglmüller, G.; Musiol, H.-J.; Göhring, W.; Moroder, L. (1992) Alkylation of histidine with maleimido-compounds. Int. J. Peptide Protein Res. 39, 348-355.

183. Romano, R.; Musiol, H.-J.; Weyher, E.; Dufresne, M.; Moroder, L. (1992) Peptide hormone - membrane interactions. The aggregational and conformational state of lipo-gastrin derivatives and their receptor binding affinity. Biopolymers 32, 1545-1558.

184. Moroder, L.; Papini, A.; Siglmüller, G.; Köcher, K.; Dörrer, E.; Schneider, C. H. (1992) Induction and detection of anti-peptide antibody specificity is critically affected by the mode of hapten presentation. Biol. Chem. Hoppe-Seyler 373, 315-321.

185. Moroder, L.; Musiol, H.-J.; Scharf, R. (1992) Aziridine-2-carboxylic acid. A reactive amino acid unit for a new class of cysteine-proteinase inhibitors. FEBS Lett. 299, 51-53.

186. Siedler, F.; Rudolph, S.; Musiol, H.-J.; Moroder, L. (1992) Synthesis of neo-glycosylated L-alanyl-D-isoglutamine derivatives as potential immunoadjuvants. Peptide Res. 5, 39-47.

187. Moroder, L.; Weyher, E.; D‘Ursi, A.; Picone, D.; Temussi, P. A. (1992) CD and NMR conformational studies on cholecystokinin peptides. Regul. Peptides 40, 213.

1993

188. Grams, F.; Huber, R.; Kress, L. F.; Moroder, L.; Bode, W. (1993): Activation of snake venom metalloproteinases by a cysteine switch-like mechanism. FEBS Lett. 335, 76-80.

189. Moroder, L.; Romano, R.; Guba, W.; Mierke, D. F.; Kessler, H.; Delporte, C.; Winand, J.; Christophe, J. (1993) New evidence for a membrane-bound pathway in hormone receptor binding. Biochemistry 32, 13551-13559.

190. Romano, R.; Bayerl, T. M.; Moroder, L. (1993) Lipophilic derivatization and its effect on the interaction of cholecystokinin (CCK)-nonapeptide with phospholipids. Biochim. Biophys. Acta 1151, 111-119.

191. Siedler, F.; Rudolph-Böhner, S.; Doi, M.; Musiol, H.-J.; Moroder, L. (1993) Redox potentials of active site bis-cysteinyl fragments of thiol-protein oxidoreductases. Biochemistry 32, 7488-7495.

192. Rudolph-Böhner, S.; Wu, J.-T.; Moroder, L. (1993) Identification and characterization of microcystin-LY from Microcystis Aeruginosa (Strain 298). Biol. Chem. Hoppe-Seyler 374, 635-640.

193. Korn, A.; Rudolph-Böhner, S.; Moroder, L.; Hiller, W. (1993) Synthesis and X-ray crystal structure of benzyl-(-)-(2S)-1-trityl-2-aziridinecarboxylate. Z. Naturforsch. 48b, 1146-1148.

194. Moroder, L.; Musiol, H.-J.; Köcher, K.; Bali, J.-P.; Schneider, C. H.; Guba, W.; Müller, G.; Mierke, D. F.; Kessler, H. (1993) Synthetic immunogens. The effect of the conformational space on biological and immunological responses to dimeric hormone constructs. Eur. J. Biochem. 212, 325-333.

195. Moroder, L.; Romano, R.; Weyher, E.; Svoboda, M.; Christophe, J. (1993) Circular dichroism study on fully bioactive CCK-peptides. Z. Naturforsch. 48b, 1419-1430.

196. Romano, R.; Dufresne, M.; Prost, M.-C.; Bali, J.-P.; Bayerl, T. M.; Moroder, L. (1993) Peptide hormone - membrane interactions. Intervesicular transfer of lipophilic gastrin derivatives to artificial membranes and their bioactivities. Biochim. Biophys. Acta 1145, 235-242.

197. Moroder, L.; D‘Ursi, A.; Picone, D.; Amodeo, P.; Temussi, P. A. (1993) Solution conformation of CCK-9, a cholecystokinin analog. Biochem. Biophys. Res. Commun. 190, 741-746.

198. Terness, P.; Moroder, L.; Marx, U.; Roelcke, D.; Welschof, M. (1993) IgG-mediated suppression of autoimmune B-cells. An indiotype-independent immunoregulatory mechanism. J. Immunol. 150, A240.

1994

199. Korn, A.; Rudolph-Böhner, S.; Moroder, L. (1994) On the synthesis of (2S)-aziridine-2-carboxylic acid containing peptides. Tetrahedron 50, 1717-1730.

200. Korn, A.; Rudolph-Böhner, S.; Moroder, L. (1994) A convenient synthesis of optically pure (2R,3R)-2,3-epoxysuccinyl-dipeptides. Tetrahedron 50, 8381-8392.

201. Leusch, A.; Jungblut, P. W.; Moroder, L. (1994) Design and synthesis of carboranyl peptides as carriers of 1,2-dicarbadodecaborane clusters. Synthesis, 305-308.

202. Moroder, L.; Romano, R. (1994) Synthesis, conformational and biological properties of lipophilic derivatives of gastrin and cholecystokinin peptides. Pure & Appl. Chem. 66, 2111-2114.

203. Musiol, H.-J.; Grams, F., Rudolph-Böhner, S.; Moroder, L. (1994) On the synthesis of phosphonamidate peptides. J. Org. Chem. 59, 6144-6146.

204. Musiol, H.-J.; Siedler, F.; Quarzago, D.; Moroder, L. (1994) Redox-active bis-cysteinyl-peptides. I. Synthesis of cyclic cystinyl-peptides by conventional methods in solution and on solid supports. Biopolymers 34, 1553-1562.

205. Rudolph-Böhner, S.; Mierke, D. F.; Moroder, L. (1994) Molecular structure of the cyanobacterial tumor promoting microcystins. FEBS Lett. 349, 319-323.

206. Siedler, F.; Quarzago, D.; Rudolph-Böhner, S.; Moroder, L. (1994) Redox-active bis-cysteinyl-peptides. II. Comparative study on the sequence-dependent tendency to disulfide loop formation. Biopolymers 34, 1563-1572.

1995

207. Karnbrock, W.; Musiol, H.-J.; Moroder, L. (1995) Enantioselective synthesis of (2S)-o-carboranylalanine via methylated bis-lactim ethers of 2,3-diketopiperazines. Tetrahedron 51, 1187-1196.

208. Korn, A.C.; Moroder, L. (1995) Enantioselective synthesis of diethyl (+)-(2S,3S)-trans-2,3-epithiosuccinate. J. Chem. Res. (S), 102-103.

209. Lutz, J., Weyher, E.; Moroder, L. (1995) Metal ion binding affinities of gastrin and CCK in membrane mimetic environments. J. Peptide Sci. 1, 360-370.

210. Mierke, D.; Rudolph-Böhner, S.; Müller, G.; Moroder, L. (1995) Structure of two microcystins. Refinement with NOEs and ensemble calculations. Biopolymers 36, 811-828.

211. Quarzago, D.; Moroder, L. (1995) Conformational analysis of bioactive peptides in reverse micelles as mimicry of cell membrane environments. LIPS 1, 171-177.

212. Terness, P.; Kohl, I.; Hübener, G.; Battistuta, R.; Moroder, L.; Welschof, M.; Dufter,C.; Finger, M.; Hain, C.; Jung, M.; Opelz, G. (1995) The natural human IgG-anti-F(ab´)2 antibody recognizes a conformational IgG1 hinge epitope. J. Immunol. 154, 6446-6452.

213. Dufresne, M.; Escrieut, C.; Clerc, P.; Sallan, C.; Kennedy, K.; Fanjul, M.; Mengod, G.; Real, F.; Moroder, L.; Vaysse, N.; Fourmy, D. (1995) Predominant expression of CCK-B/gastrin receptor in the human pancreas. Digestion 56, 280.

1996

214. Karnbrock, W.; Weyher, E.; Budisa, N.; Huber, R.; Moroder, L. (1996) A new efficient synthesis of acetyl-telluro- and acetyl-selenomethionine and their use in the biosynthesis of heavy-atom protein analogs. J. Amer. Chem. Soc. 118, 913-914.

215. Moroder, L.; Lutz, J.; Grams, F.; Rudolph-Böhner, S.; Ösapay, G.; Goodman, M.; Kolbeck, W. (1996) A new efficient method for the synthesis of 1,4-benzodiazepine-2,5-dione diversomers. Biopolymers 38, 295-300.

216. Moroder, L.; Besse, D.; Musiol, H. J.; Rudolph-Böhner, S.; Siedler, F. (1996) Oxidative folding of cystine-rich peptides vs. regioselective cysteine pairing strategies. Biopolymers (Pept. Sci.) 40, 207-234.

217. Qualmann, B.; Kessels, M. M.; Musiol, H. J.; Sierralta, W. D.; Jungblut, P. W.; Moroder, L. (1996) Synthesis of boron-rich lysine dendrimers as protein labels in electron microscopy. Angew. Chem. Int. Ed. Engl. 35, 909-911.

218. Siedler, F.; Weyher, E.; Moroder, L. (1996) Cysteine racemization in peptide synthesis. A new and facile detection method. J. Peptide Sci. 2, 271-275.

219. Schaschke, N.; Musiol, H. J.; Assfalg-Machleidt, I.; Machleidt, W.; Rudolph-Böhner, S.; Moroder, L. (1996) Cyclodextrins as templates for the presentation of protease inhibitors. FEBS Lett. 391, 297-301.

220. Terness, P.; Navolan, D.; Moroder, L.; Siedler, F.; Weyher, E.; Kohl, I.; Dufter, C.; Welschof, M.; Drugarin, D.; Schneider, F.; Opelz, G. (1996) Natural IgA-anti-(Fab´)2g autoantibody of healthy individuals and kidney graft recipients recognizes an IgG1 hinge region epitope. J. Immunol. 157, 4251-4257.

221. Ottl, J.; Battistutta, R.; Pieper, M.; Tschesche, H.; Bode, W.; Kühn, K.; Moroder, L. (1996) Design and synthesis of heterotrimeric collagen peptides with a built-in cystine-knot. Models for collagen catabolism by matrix-metalloproteases. FEBS Lett. 398, 31-36.

1997

222. Terness, P.; Kirschfink, M.; Navolan, D.; Moroder, L.; Siedler, F.; Drugarin, D.; Schneider, F.; Dufter, Ch.; Kohl, I.; Welschof, M.; Opelz, G.; Roelcke, D. (1997) Inverse correlation between IgG-anti-hinge region and anti-erytrocyte autoantibody in chronic benign and malignant cold agglutination. J. Clin. Immunol. 17, 220-227.

223. Moroder, L. (1997) On the mechanism of hormone recognition and binding by the CCK-B/gastrin receptor. J. Peptide Sci. 3, 1-14

224. Lutz, J.; Romano-Götsch, R.; Escrieut, C.; Fourmy, D.; Mathä, B.; Müller, G.; Kessler, H.; Moroder, L. (1997) Mapping of the ligand binding site of the cholecystokinin-B/gastrin receptor using lipo-gastrin peptides and molecular modelling. Biopolymers 41, 799-817.

225. Rudolph-Böhner, S.; Quarzago, D.; Czisch, M.; Ragnarsson, U.; Moroder, L. (1997) Conformational preferences of Leu-enkephalin in reverse micelles as membrane-mimicking environment. Biopolymers 41, 591-606.

226. Rudolph-Böhner, S.; Krüger, M.; Oesterhelt, D.; Moroder, L.; Nägele, T.; Wachtveitl, J. (1997) Photomodulation of conformational states of p-phenylazobenzyloxycarbonyl-L-proline and related peptides. J. Photochem. Photobiol. A-Chemistry, 105, 235-248 (erratum 1998: 117, 75-82).

227. Wachtveitl, J.; Nägele, T.; Puell, B.; Zinth, W.; Krüger, M.; Rudolph-Böhner, S.; Oesterhelt, D.; Moroder, L. (1997) Ultrafast photoisomerization of azobenzene compounds. J. Photochem. Photobiol. A-Chemistry, 105, 283-288.

228. Kennedy, K.; Gigoux, V.; Escrieut, C.; Maigret, B.; Martinez, J.; Moroder, L.; Fréhel, D.; Gully, D.; Vaysse, N.; Fourmy, D. (1997) Identification of two amino acids of the human cholecystokinin-A receptors that interact with the N-terminal moiety of cholecystokinin. J. Biol. Chem. 272, 2920-2926.

229. Philippe, C.; Lhoste, E. F.; Dufresne, M.; Moroder, L.; Corring, T.; Fourmy, D. (1997) Pharmacological and biomedical evidences for the simultaneous expression of CCK-B/gastrin and CCK-A receptors in the pig pancreas. Br. J. Pharmacol. 120, 447-454.

230. Besse, D.; Siedler, F.; Diercks, T.; Kessler, H.; Moroder, L. (1997) The redox potential of selenocystine in unconstrained cyclic peptides. Angew. Chem. Int. Ed. 36, 883-885.

231. Schaschke, N.; Assfalg-Machleidt, I.; Machleidt, W.; Turk, D.; Moroder, L. (1997) E-64 and related analogs as inhibitors of cathepsin B. On the role of the absolute configuration of the trans-epoxysuccinyl group. Bioorg. Med. Chem. 5, 1789-1797.

232. Besse, D., Budisa, N., Karnbrock, W., Minks, C., Musiol, H.-J., Pegoraro, S., Siedler, F., Weyher, E.; Moroder, L. (1997) Chalcogen-analogs of amino acids. Their use in X-ray crystallographic and folding studies of peptides and proteins. Biol. Chem. 378, 211-218.

233. Budisa, N., Karnbrock, W., Steinbacher, S., Humm, A., Prade, L., Neuefeind, T., Moroder, L.; Huber, R. (1997) Bioincorporation of telluromethionine into proteins. A promising new approach for X-ray structure analysis of proteins. J. Mol. Biol. 270, 616-623.

234. Epand, R. F.; Moroder, L.; Lutz, J.; Flanagan, T. D.; Nir, S.; Epand, R. M. (1997) Lipogastrins as potent inhibitors of viral fusion. Biochim. Biophys. Acta 1327, 259-268.

235. Besse, D.; Moroder, L. (1997) Synthesis of selenocysteine-peptides and their oxidation to diselenide-bridged compounds. J. Peptide Sci. 3, 442-453.

236. Escherich, A.; Ditzel, L.; Musiol, H.-J.; Groll, M.; Huber, R.; Moroder, L. (1997) Synthesis, kinetic characterization and X-ray analysis of peptide aldehydes as inhibitors of the 20S Proteasome from T. Acidophilum and S. Cerevisiae. Biol. Chem. 378, 893-898.

237. Terness, P.; Welschof, M.; Moldenhauer, G.; Jung, M.; Moroder, L.; Kirchhoff, F.; Kipriyanov, S.; Little, M.; Opelz, G. (1997) Idiotypic vaccine for treatment of human B-cell lymphoma. Construction of IgG variable regions from single malignant B cells. Human Immunol. 56, 17-27.

238. Terness, P.; Navolan, D.; Kohl, I.; Siedler, F.; Moroder, L.; Dufter, Ch.; Welschof, M.; Schneider, F.; Drugarin, D.; Opelz, G. (1997) Role of idiotype-independent anti-IgG autoantibodies in human kidney transplantation. Natural anti-F(ab´)2 antibodies recognize an IgG1 hinge region epitope. Transplantation Proceed. 29, 1412-1414.

239. Müller, J. C. D.; Graf von Roedern, E.; Grams, F.; Nagase, H.; Moroder, L. (1997) Non-peptidic cysteine derivatives as inhibitors of matrix metalloproteinases. Biol. Chem. 378, 1475-1480.

240. Schaschke, N.; Musiol, H. J.; Assfalg-Machleidt, I.; Machleidt, W.; Moroder, L. (1997) Oligopresentation of protease inhibitors with b-cyclodextrin as template. Bioorg. Med. Chem. Lett. 7, 2507-2512.

1998

241. Schaschke, N.; Assfalf-Machleidt, I.; Machleidt, W.; Moroder, L. (1998) Substrate/propeptide-derived endo-epoxysuccinylpeptides as highly potent and selective cathepsin B inhibitors. FEBS Lett. 421, 80-82.

242. von Roedern, E.; Grams, F.; Brandstetter, H.; Moroder, L. (1998) Synthesis of malonic acid-based inhibitors for matrix metalloproteinases. J. Med. Chem. 41, 339-345.

243. Budisa, N.; Minks, C.; Medrano, F. J.; Lutz, J.; Huber, R.; Moroder, L. (1998) Residue-specific bioincorporation of non-natural, biologically active amino acids into proteins as possible drug carriers. Structure and stability of the per-thiaproline mutant of annexin V. Proc. Natl. Acad. Sci. USA 95, 455-459.

244. Hofmann, A.; Escherich, A.; Lewit-Bentley, A.; Benz, J.; Raguenes-Nicol, C.; Russo-Marie, F.; Gerke, V.; Moroder, L.; Huber, R. (1998) Interactions of benzodiazepine derivatives with annexins. J. Biol. Chem. 273, 2885-2894.

245. Brandstetter, H.; Engh, R. A.; Graf von Roedern, E.; Moroder, L.; Huber, R.; Bode, W.; Grams, F. (1998) Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data. Protein Sci. 7, 1303-1309.

246. Nakazawa, T.; Ishii, M.; Musiol H.-J.; Moroder, L. (1998) Synthesis of a,b-dehydrotryptophan by the reaction of indole with b-(N-methylamino)dehydroalanine derivative. Tetrahedron Lett. 39, 1381-1384.

247. Schaschke, N.; Fiori S.; Weyher, E.; Escrieut, C.; Fourmy, D.; Müller, G.; Moroder, L. (1998) Cyclodextrin as carrier of peptide hormones. Conformational and biological properties of b-cyclodextrin/gastrin constructs. J. Am. Chem. Soc. 120, 7030-7038.

248. Budisa, N.; Huber, R.; Golbig, R.; Minks, C.; Weyher, E.; Moroder, L. (1998) Atomic mutations in Annexin V. Thermodynamic studies of isomorphous protein variants. Eur. J. Biochem. 353, 1-9.

249. Graf von Roedern, E.; Brandstetter, H.; Engh, R. A.; Bode, W.; Grams, F.; Moroder, L. (1998) Bis-substituted malonic acid hydroxamate derivatives as inhibitors of human neutrophil collagenase (MMP8). J. Med. Chem. 41, 3041-3047.

250. Tamaoki, H.; Miura, R.; Kusunoki, M.; Kyogoku, Y.; Kobayashi, Y.; Moroder, L. (1998) Folding motifs induced and stabilized by distinct cystine frameworks. Protein Engineering 11, 649-659.

251. Gabriel, B.; Stubbs, M. T.; Bergner, A.; Hauptmann, J.; Bode, W.; Stürzebecher, J.; Moroder, L. (1998) Structure-based design of benzamidine-type inhibitors of factor Xa. J. Med. Chem. 41, 4240-4250.

252. Pegoraro, S.; Fiori, S.; Rudolph-Böhner, S.; Watanabe, T. X.; Moroder, L. (1998) Isomorphous replacement of cystine with selenocystine in endothelin. Oxidative refolding, biological and conformational properties of [Sec3,Sec11,Nle7]-endothelin-1. J. Mol. Biol. 284, 779-792.

253. Gigoux, V.; Escrieut, C.; Silvente-Poirot, S.; Maigret, B.; Gouilleux, L.; Fehrentz, J.-A.; Gully, D.; Moroder, L.; Vaysse, N.; Fourmy, D. (1998): Met-195 of the cholecystokinin-A receptor interacts with the sulfated tyrosine of cholecystokinin and is crucial for receptor transition to high affinity state. J. Chem. Biol. 273, 14380-14386.

254. Gales, C.; Escrieut, C.; Fourmy, D.; Maigret, B.; Moroder, L.; Vaysse, N.; Poirot, S. S. (1998) Identification of a key residue involved in the activation of the cholecystokinin B receptor. Gastroenterology 114 (Suppl. II) G4681.

255. Gigoux, V.; Escrieut, Ch.; Silvente-Poirot, S.; Bouisson, M.; Maigret, B.; Gouilleux, L.; Fehrentz, J.-A.; Martinez, J.; Gully, D.; Moroder, L.; Vaysse, N.; Fourmy, D. (1998) Mapping of the CCK binding site of the CCK-A receptor and analysis of the interactions that stabilize its active state. Dig. Des. Sci. 43, 1884.

1999

256. Ottl, J.; Musiol, H.-J.; Moroder, L. (1999) Heterotrimeric collagen peptides containing functional epitopes. Synthesis of single-stranded collagen type I peptides related to the collagenase cleavage site. J. Pept. Sci. 5, 103-110.

257. Budisa, N.; Minks, C.; Alefelder, S.; Wenger, W.; Dong, F.; Moroder, L.; Huber, R. (1999) Toward the experimental codon reassignment in vivo. Protein building with an expanded amino acid repertoire. FASEB J. 13, 41-51.

258. Ottl, J.; Moroder, L. (1999) Assembly of multiple-chain polypeptide suprastructures with artificial cystine-knots. Tetrahedron Lett. 40, 1487-1490.

259. Ottl, J.; Moroder, L. (1999) Disulfide-bridged heterotrimeric collagen peptides containing the collagenase cleavage site of collagen type I. Synthesis and conformational properties. J. Am. Chem. Soc. 121, 653-661.

260. Loidl, G.; Groll, M.; Musiol, H.-J.; Ditzel, L.; Huber, R.; Moroder, L. (1999) Bifunctional inhibitors for the trypsin-like activity of eukaryotic proteasomes. Chem. Biol. 6, 197-204.

261. Pegoraro, S.; Fiori, S.; Cramer, J.; Rudolph-Böhner, S.; Moroder, L. (1999) The disulfide-coupled folding pathway of apamin as derived from diselenide-quenched analogs and intermediates. Protein Sci. 8, 1605-1613.

262. Le Dréan, G.; Le Huerou-Luron, I.; Gestin, M.; Desbois, C.; Romé, V.; Bernard, C.; Dufresne, M.; Moroder, L.; Gully, D.; Chayvialle, J. A.; Fourmy, D.; Guilloteau, P. (1999) Exogenous CCK and gastrin stimulate pancreatic exocrine secretion via CCK-A but also via CCK-B/gastrin receptors in the calf. Pflügers Archiv J. Physiol. 438, 86-93.

263. Fiori, S., Renner, C., Cramer, J., Pegoraro, S.; Moroder, L. (1999) Preferred conformation of endomorphin-1 in aqueous and membrane-mimetic environments. J. Mol. Biol. 291, 163-175.

264. Behrendt, R.; Renner, C.; Schenk, M.; Wang, F.; Wachtveitl, J.; Oesterhelt, D.; Moroder, L. (1999) Photomodulation of conformational states of cyclic peptides with a backbone-azobenzene moiety. Angew. Chem. Int. Ed. Engl. 38, 2771-2774.

265. Escherich, A.; Escrieut, C.; Fourmy, D.; Moroder, L. (1999) Benzotriazonine as a new core structure for the design of CCK-receptor antagonists. J. Pept. Sci. 5, 155-158.

266. Loidl, G.; Groll, M.; Musiol, H.-J.; Huber, R.; Moroder, L. (1999) Bivalency as a principle for proteasome inhibition. Proc. Natl. Acad. Sci. USA 96, 5418-5422.

267. Silvente-Poirot, S.; Escrieut, C.; Galès; C.; Fehrentz, J.-A.; Escherich, A.; Wank, S. A.; Martinez, J.; Moroder, L.; Maigret, B.; Bouisson, M.; Vaysse, N.; Fourmy, D. (1999) Evidence for a direct interaction between the penultimate aspartic acid of cholecystokinin and histidine 207 located in the second extracellular loop of the rat cholecystokinin B receptor. J. Biol. Chem. 274, 23191-23197.

268. Gigoux, V.; Escrieut, C.; Fehrentz, J.-A.; Poirot, S.; Maigret, B.; Moroder, L.; Gully, D.; Martinez, J.; Vaysse, N.; Fourmy, D. (1999) Arginine 336 and asparagine 333 of the human cholecystokinin-A receptor binding site interact with the penultimate aspartic acid and the C-terminal amide of cholecystokinin. J. Biol. Chem. 274, 20457-20464.

269. Minks, C.; Huber, R.; Moroder, L.; Budisa, N. (1999) Atomic mutations at the single tryptophan residue of human recombinant annexin V. Effects on structure, stability and activity. Biochemistry 38, 10649-10659.

270. van Neuren, A. S.; Müller, G.; Klebe, G.; Moroder, L. (1999) Molecular modelling studies in G-protein-coupled receptors. From sequence to structure? J. Recept. Signal Transduct. Res. 19, 341-353.

271. Gigoux, V.; Maigret, B.; Escrieut, C.; Silvente-Poirot, S.; Bouisson, M.; Fehrentz, J. A.; Moroder, L.; Gully, D.; Martinez, J.; Vaysse, N.; Fourmy, D. (1999) Arginine 197 of the cholecystokininn-A receptor binding site interacts with the sulfate of the peptide agonist cholecystokinin. Protein Sci. 8, 2347-2354.

272. Behrendt, R.; Schenk, M.; Musiol, H.-J.; Moroder, L. (1999) Photomodulation of conformational states. Synthesis of cyclic peptides with backbone-azobenzene moieties. J. Pept. Sci. 5, 519-529.

273. Budisa, N.; Moroder, L.; Huber, R. (1999) Structure and evolutionof the genetic cods viewed from the perspective of the experimentally expanded amino acid repertoire in vivo. Cell. Mol. Life Sci. 55, 1626-1635.

274. Cramer, J.; Fiori, S.; Müller, G.; Renner, C.; Pegoraro, S.; Moroder, L. (1999) Comparison of a Monte Carlo strategy with a combined DG/MDSA method for structure determination of bicyclic peptides. J. Mol. Model. 5, 287-295.

275. Silvente-Poirot, S.; Galés, C.; Escrieut, C.; Fourmy, D.; Maigret, B.; Moroder, L.; Vaysse, N. (1999) Asn367 and Asn391 within the highly conserved motif NPXXY of the rat cholecystokinin A and B receptors are essential to switch their receptors to an active conformation for different transduction pathways. Gastroenterology 116, G2780.

276. Hauptmann, J.; Gabriel, B.: Moroder, L.; Prasa, D.; Stürzebecher, J. (1999) Clearance of benzamidine-type thrombin and factor Xa inhibitors in rats: Influence of charged substituents. Thrombosis and Haemostasis, Suppl., 614.

2000

277. Ottl, J.; Gabriel, D.; Murphy, G.; Knäuper, V.; Tominaga, Y.; Nagase, H.; Bode, W.; Moroder, L. (2000) Recognition and catabolism of synthetic heterotrimeric collagen-peptides by matrix-metalloproteinases. Chem. Biol. 7, 119-132.

278. Loidl, G.; Musiol, H.-J.; Groll, M. Huber, R.; Moroder, L. (2000) Synthesis of bivalent inhibitors of eukaryotic proteasomes. J. Pept. Sci. 6, 36-46.

279. Loidl, G.; Musiol, H.-J.; Budisa, N.; Huber, R.; Poirot, S.; Fourmy, D.; Moroder, L. (2000) Synthesis of b-(1-azulenyl)-L-alanine as a potential blue-colored fluorescent tryptophan analog and its use in peptide synthesis. J. Pept. Sci. 6, 139-144.

280. Fiori, S.; Pegoraro, S.; Rudolph-Böhner, S.; Cramer, J.; Moroder, L. (2000) Synthesis and conformational analysis of apamin analogs with natural and non-natural cystine/selenocystine connectivities. Biopolymers 53, 550-564.

281. Schaschke, N.; Assfalg-Machleidt, I.; Machleidt, W.; Laßleben, T.; Sommerhoff, C.P.; Moroder, L. (2000) b-Cyclodextrin/epoxysuccinyl peptide conjugates: a new drug targeting system for tumor cells. Bioorg. Med. Chem. Lett. 10, 677-680.

282. Müller, J. C. D.; Ottl, J.; Moroder, L. (2000) Heterotrimeric collagen peptides as fluorogenic substrates. Synthesis, conformational properties and enzymatic digestion. Biochemistry 39, 5111-5116.

283. Frank, S.; Kammerer, R. A.; Hellstern, S.; Pegoraro, S.; Stetefeld, J.; Lustig, A.; Moroder, L.; Engel, J. (2000) Toward a high-resolution structure of phospholamban: design of soluble transmembrane domain mutants. Biochemistry 39, 6825-6831.

284. Sperl, S.; Bergner, A.; Stürzebecher, J.; Wilhelm, O. G.; Bode, W.; Moroder, L. (2000) Urethanyl-3-amidinophenylalanine derivatives as inhibitors of factor Xa. X-ray crystal structure of a trypsin/inhibitor complex and modeling studies. Biol. Chem. 381, 321-329.

285. Renner, C.; Behrendt, R.; Spörlein, S.; Wachtveitl, J.; Moroder, L. (2000) Photomodulation of conformational states. I. Mono- and bicyclic peptides with (4-amino)phenylazobenzoic acid as backbone constituent. Biopolymers 54, 489-500.

286. Renner, Ch.; Cramer, J.; Behrendt, B.; Moroder, L. (2000) Photomodulation of conformational states. II. Mono- and bicyclic peptides with (4-aminomethyl)phenylazobenzoic acid as backbone constituent. Biopolymers 54, 501-514.

287. Hu, B.; Finsinger, D.; Kai, P.; Guttenberg, Z.; Bärmann, M.; Kessler, H.; Escherich, A.; Moroder, L.; Böhm, J.; Baumeister, W.; Sackmann, E. (2000) Inter-vesicle crosslinking with integrin aIIbb3 and cyclic RGD-lipopeptide. A model of cell-adhesion processes. Biochemistry 39, 12284-12294.

288. Sperl., S.; Jacob, U.; Arroyo de Prada, N.; Stürzebecher, J.; Wilhelm, O. G.; Bode, W.; Magdolen, V.; Huber, R.; Moroder, L. (2000) (4-Amino)phenylguanidine derivatives as non-peptidic highly selective inhibitors of human urokinase. X-ray crystal structure of an uPA/inhibitor complex at 1.8 Å resolution. Proc. Natl. Acad. Sci. USA 97, 5113-5118.

289. Guttenberg, Z.; Bausch, A. R.; Hu, B.; Bruisma, R.; Moroder, L.; Sackmann, E. (2000) Measuring ligand-receptor unbinding forces with magnetic beads: molecular leverage? Langmuir 16, 8984-8993.

290. Scheufler, C.; Brinker, A.; Bourenkov, G.; Pegoraro, S.; Moroder, L.; Bartunik, H.; Hartl, F. U.; Moraefi, I. (2000) Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. Cell 101, 199-210.

291. Schaschke, N.; Assfalg-Machleidt, I.; Laßleben, Th.; Sommerhoff, C. P.; Moroder, L.; Machleidt, W. (2000) Epoxysuccinyl peptide-derived affinity labels for cathepsin B. FEBS Lett. 482, 91-96.

292. Minks, C.; Huber, R.; Moroder, L.; Budisa, N. (2000) Noninvasive tracing of recombinant proteins with "fluorophenylalanine-fingers". Anal. Biochem. 284, 29-34.

293. Galés, C.; Kowalski-Chauvel, A.; Dufour, M. N.; Seva, C.; Moroder, L.; Pradayrol, L.; Vaysse, N.; Fourmy, D.; Silvente-Poirot, S. (2000) Mutation of Asn-391 within the conserved NPXXY motif of the cholecystokinin B receptor abolishes G(q) protein activation without affecting its association with the receptor. J. Biol. Chem. 275, 17321-17327.

294. Escrieut, C.; Maigret B.; Silvente-Poirot, S.; Gigoux, V.; Martinez, J.; Moroder, L.; Bignon, E.; Vaysse, N.; Fourmy, D. (2000) Identification of residues of the human CCK-A receptor that are in interaction with the C-terminal phenylalanine of CCK. Gastroenterology 118 (Part 1, Suppl. 2) 1687.

295. Groll, M.; Bajorek, M.; Köhler, A.; Moroder, L.; Rubin, D. M.; Huber, R.; Glickman, M. H.; Finley, D. (2000) A gated channel into the proteasome core particle. Nature Struct. Biol. 7, 1062-1067.

296. Minks, C.; Alefelder, S.; Moroder, L.; Huber, R.; Budisa, N. (2000) Towards new protein engineering: in vivo building and folding of protein shuttles for drug delivery and targeting by the selective pressure incorporation (SPI) method. Tetrahedron 56, 9431-9442.

297. Song, H. K.; Hartmann, C.; Ramachandran, R.; Bochtler, M.; Behrendt, R.; Moroder, L.; Huber, R. (2000) Mutational studies on HsIU and its docking mode with HsIV. Proc. Natl. Acad. Sci. USA 97, 14103-14108.

2001

298. Renner, C.; Alefelder, S.; Bae, J. H.; Budisa, N.; Huber, R.; Moroder, L. (2001) Fluoro-prolines as tools for protein design and engineering. Angew. Chem. Int. Ed. 40, 923-925.

299. Cattani-Scholz, A.; Renner, C.; Oesterhelt, D.; Moroder, L. (2001) Photoresponsive dendritic azobenzene-peptides. ChemBioChem 2, 542-549.

300. Renner, C.; Moroder, L.; Holak, T.A. (2001) Analytical solution to the Lipari-Szabo model based on the reduced spectral density approximation offers a novel protocol for extracting motional parameters. J. Magn. Reson. 151, 32-39.

301. Bae, J.; Alefelder, S.; Kaiser, J. T.; Friedrich, R.; Moroder, L.; Huber, R.; Budisa, N. (2001) Incorporation of b-selenolo[3,2-b]pyrrolyl-alanine into proteins for phase determination in protein X-ray crystallography. J. Mol. Biol. 309, 925-936.

302. Budisa, N.; Alefelder, S.; Bae, J.; Golkik, R.; Minks, C.; Huber, R.; Moroder, L. (2001) Proteins with b-(thienopyrrolyl)alanines as alternative chromophores and pharmaceutically active amino acids. Protein Sci. 10,1281-1292.

303. Hellstern, S.; Pegoraro, S.; Karim, C. B.; Lustig, A.; Thomas, D. D.; Moroder, L.; Engel, J. (2001) Sarcolipin, the shorter homologue of phospholamban, forms oligomeric structures in detergent micelles and in liposomes. J. Biol. Chem. 276, 30845-30852.

304. Schaschke, N.; Matschiner, G.; Zettl, F.; Marquaerdt, U.; Bergner, A.; Bode, W.; Sommerhoff, C. P.; Moroder, L. (2001) Bivalent inhibition of β-tryptase. Chem. Biol. 8, 313-327.

305. Kallipolitou, A.; Deluca, D.; Majdic, U.; Lakämper, S.; Cross, R.; Mayhöfer, E.; Moroder, L.; Schliwa, M.; Woehlke, G. (2001) Unusual properties of the fungal conventional kinesin neck domain from Neuropsora crassa. EMBO J. 20, 6226-6235.

306. Escherich, A.; Lutz, J.; Escrieut, C.; Fourmy, D.; van Neuren, A. S.; Müller, G. Schafferhans, A.; Klebe, G.; Moroder, L. (2001) Peptide/benzodiazepine hybrids as ligands of CCKA and CCKB receptors. Biopolymers 56, 55-76.

307. Musiol, H.-J.; Moroder, L. (2001) N,N´-Di-tert-butoxycarbonyl-1H-benzotriazole-1-carboxamidine derivatives are highly reactive guanidinylating reagents. Org. Lett. 3, 3859-3861.

308. Köhler, A.; Bajorek, M.; Groll, M.; Moroder, L.; Rubin, D. M.; Huber, R.; Glickman, M. H.; Finley, D. (2001): The substrate translocation channel of the proteasome. Biochimie, 83, 325-332.

309. Gales, C.; Berge, C.; Moroder, L.; Pradayrol, L.; Fourmy, D.; Silvente-Poirot, S. (2001) Selective activationn of PKC-independent P42-P44 mitogen activating protein kinases pathway by a constitutive cholecystokinin 2 receptor mutant. FASEB J. 15 (Part 1), A572.

310. Golbik, R.; Budisa, N.; Renner, C.; Weyher-Stingl, E.; Rahfeld, J.-U.; Huber, R.; Fischer, G.; Moroder, L. (2001) Studies on folding of fluoroproline-substituted variants of barstar. Nova Acta Leopoldina (Supl. 16), 59-60.

311. Fiori, S.; Ottl, J.; Fonrobert, B.; Wachtveitl, J.; Moroder, L. (2001): Biophysical characterization of synthetic heterotrimeric collagen peptides as functional epitopes of collagen type I. Nova Acta Leopoldina (Supl. 16), 43-45.

312. Sperl, S.; Müller, M. M.; Wilhelm, O. G.; Schmitt, M.; Magdolen, V.; Moroder, L. (2001) The uPA/uPA receptor system as a target for tumor therapy. Drug News Perspect. 14, 401-411.

2002

313. Cattani-Scholz, A.; Renner, C.; Cabrele, C.; Behrendt, R.; Oesterhelt, D.; Moroder, L. (2002) Photoresponsive cyclic bis-cysteinyl-peptides as catalysts of oxidative protein folding. Angew. Chem. Int. Ed. 41, 289-292.

314. Escrieut, C.; Gigoux, V.; Archer, E.; Verrier, S.; Maigret, B.; Behrendt, R.; Moroder, L.; Bignon, E.; Silvente-Poirot, S.; Pradayrol, L.; Fourmy, D. (2002) The biologically crucial C-terminus of cholecystokinin and the non-peptide agonist SR-146,131 share a common binding site in the human CCK1 receptor. Evidence for a crucial role of Met-121 in the activation process. J. Biol. Chem. 277, 7546-7555.

315. Renner, C.; Behrendt, R.; Heim, N.; Moroder, L. (2002) Photomodulation of conformational states. III. Water-soluble bis-cysteinyl-peptides with (4-aminomethyl)phenylazobenzoic acid as backbone constituent. Biopolymers 63, 382-393.

316. Cabrele, C.; Cattani-Scholz, A.; Renner, C.; Behrendt, R.; Oesterhelt, D.; Moroder, L. (2002) Photomodulation of the redox and folding adjuvant properties of bis(cysteinyl)peptides. Eur. J. Org. Chem. 2144-2150.

317. Renner, C.; Schleicher, M.; Moroder, L.: Holak, T. A. (2002) Practical aspects of the 2D 15N-{1H}-NOE experiment. J. Biomol. NMR 23, 23-33.

318. Kaiser, M.; Groll, M.; Renner, C.; Huber, R.; Moroder, L. (2002) The core structure of TMC-95A is a promising lead for reversible proteasome inhibition. Angew. Chem. Int. Ed. 41, 780-783.

319. Saccà, B.; Moroder, L. (2002) Synthesis of heterotrimeric collagen peptides containing the α1β1 integrin recognition site of collagen type IV. J. Pept. Sci. 8, 192-204.

320. Saccà, B.; Barth, D.; Musiol, H.-J.; Moroder, L. (2002) Conformation-dependent side reactions in interstrand-disulfide bridging of trimeric collagenous peptides by regioselective cysteine chemistry. J. Pept. Sci. 8, 205-210.

321. Müller, M. M.; Sperl, S.; Stürzebecher, J.; Bode, W.; Moroder, L. (2002) (R)-3-Amidinophenylalanine-derived inhibitors of factor Xa with a novel active-site binding mode. Biol. Chem. 383, 1185-1191.

322. Fiori, S.; Saccá, B.; Moroder, L. (2002) Structural properties of a collagenous heterotrimer that mimics the collagenase cleavage site of collagen type I. J. Mol. Biol. 319, 1235-1242.

323. Spörlein, S.; Carstens, H.; Satzger, H.; Renner, C.; Behrendt, R.; Moroder, L.; Tavan, P.; Zinth, W.; Wachtveitl, J. (2002) Ultrafast spectroscopy reveals subnanosecond peptide conformational dynamics and validates molecular dynamics simulation. Proc. Natl. Acad. Sci. USA 99, 7998-8002.

324. Kerek, F.; Stimac, R.; Apell, H.-J.; Freudemann, F.; Moroder, L. (2002) Characterization of the macrocyclic carbon suboxide factors as potent Na,K-ATPase and SR Ca-ATPase inhibitors. Biochim. Biophys. Acta 1567, 213-220.

325. Hugel, T.; Holland, N. B.; Cattani, A.; Moroder, L.; Seitz, M.; Gaub, H. E. (2002) Single-molecule optomechanical cycle. Science 296, 1103-1106.

326. Cabrele, C.; Fiori, S.; Pegoraro, S.; Moroder, L. (2002) Redox-active bis(cysteinyl)peptides as catalysts for in vitro oxidative protein folding. Chem. Biol. 9, 731-740.

327. Albrizio, S.; Carotenuto, A.; Fattorusso, C.; Moroder, L.; Picone, D.; Temussi, P. A.; D´Ursi A. (2002) Environmental mimic of receptor interaction: conformational analysis of CCK-15 in solution. J. Med. Chem. 45, 762-769.

328. Saccà, B.; Sinner, E.-K.; Fiori, S.; Kaiser, J.; Lübken, Ch.; Eble, J. A.; Moroder, L. (2002) Structural characterization of the cell adhesion epitope of collagen type IV. ChemBioChem 9, 904-907.

329. Kim, J.-S.; Groll, M.; Musiol, H.-J.; Behrendt, R.; Kaiser, M.; Moroder, L.; Huber, R.; Brandstetter, H. (2002) Navigation inside a protease: substrate selection and product exit in the tricorn protease from Thermoplasma acidophilum. J. Mol. Biol. 324, 1041-1050.

330. Budisa, N.; Rubini, M.; Bae, J. H.; Weyher, E.; Wenger, W.; Golbick, R.; Huber, R.; Moroder, L. (2002) Global replacement of tryptophan with aminotryptophans generates non-invasive protein-based optical pH sensors. Angew. Chem. Int. Ed. 41, 4066-4069.

331. Saccà, B.; Renner, C.; Moroder, L. (2002) The chain register in heterotrimeric collagen peptides affects triple helix stability and folding kinetics. J. Mol. Biol. 324, 309-318.

332. Ashcroft, A. E.; Brinker, A.; Coyle, J. E.; Weber, F.; Kaiser, M.; Moroder, L.; Parsons, M. R.; Jager, J.; Hartl, U. F.; Hayer-Hartl, M.; Radford, S. E. (2002): Structural plasticity and non-covalent substrate binding in the GroEL apical domain: a study using electrospray ionisation mass spectrometry and fluorescence binding studies. J. Biol. Chem. 277, 33115-33126.

333. Giragossian, C.; Stone, S.; Papini, A. M.; Moroder, L.; Mierke, D. F. (2002) Conformational and molecular modeling studies of sulfated cholecystokinin-15. Biochem. Biophys. Res. Commun. 293, 1053-1059.

334. Fourmy, D.; Escrieut, C.; Archer, E.; Gales, C.; Gigoux, V.; Maigret, B.; Moroder, L.; Silvente-Poirot, S.; Martinez, J.; Fehrentz, J. A.; Pradayrol, L. (2002) Structure of cholecystokinin receptor binding sites and mechanisms of activation/inactivation by agonists/antagonists. Pharmacol. Toxicol. 91, 313-320.

335. Kaiser, M.; Milbradt A. G.; Moroder, L. (2002) Synthesis of TMC-95A analogues. Structure-based prediction of cyclization propensities of linear precursors. LIPS 9, 65-70.

336. Sperl, S.; Moroder, L.; Setyono-Han, B.; Foekens, J.; Schmalix, W.; Wosikowski, K. (2002) Highly selective inhibitors of the urokinase-type plasminogen activator. Papers Amer. Chem. Soc. 224 (MEDI Part) 2089.

337. Barth, D.; Musiol, H.-J.; Renner, C.; Frank, S.; Engel, J.; Moroder, L. (2002) Synthesis of trimeric collagen peptides with artificial and natural cystine knots. J. Peptide Sci. 8 (Suppl.), 205.

338. Kaiser, M.; Groll, M.; Huber, R.; Moroder, L. (2002) Synthesis of TMC-95A analogs as reversible inhibitors of eucaryotic proteasome. J. Peptide Sci. 8 (Suppl.), 166.

339. Stella, L.; Mazzuca, C.; Palleschi, A.; Venanzi, M.; Formaggio, F.; Toniolo, C.; Moroder, L.; Pispisa, B. (2002) Mechanism of membrane permeabilization by the lipopeptaibol trichogin GA IV and its fluorescent analogues. J. Peptide Sci. 8 (Suppl.), 76.

340. Venanzi, M.; Palleschi, A.; Stella, L.; Valeri, A.; Formaggio, F.; Toniolo, C.; Moroder, L.; Pispisa, B. (2002) Structural features of linear peptides in solution carrying new fluorescent analogues of tryptophan. J. Peptide Sci. 8 (Suppl.), 199.

2003

341. Schäfer, F.; Deluca, D.; Majdic, U.; Kirchner, J.; Schliwa, M.; Moroder, L.; Woehlke, G. (2003): A conserved tyrosine in the neck of a fungal kinesin regulates the catalytic motor core. EMBO J. 22, 450-458.

342. Gil-Parrado, S.; Assfalg-Machleidt, I.; F. Fiorino; Deluca, D.; Pfeiler, D.; Schaschke, N.; Moroder, L.; Machleidt, W. (2003) Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: enhancing cell permeability by conjugation with penetratin. Biol. Chem. 384,395-402.

343. Holland, N. B.; Hugel, T.; Neuert, G.; Cattani-Scholz, A.; Renner, C.; Oesterhelt, D.; Moroder, L.; Seitz, M.; Gaub, H. E. (2003) Single molecule force spectroscopy of azobenzene polymers: switching elasticity of single photochromic macromolecules. Macromolecules 36, 2015-2023.

344. Milbradt, A. G.; Kerek, F.; Moroder, L.; Renner, C. (2003) Structural characterization of hellethionins from Helleborus purpurescens. Biochemistry 42, 2404-2411.

345. Goennenwein, S.; Tanaka, M.; Hu, B.; Moroder, L.; Sackmann, E. (2003) Functional incorporation of integrins into solid supported membranes on ultrathin films of cellulose: impact on adhesion. Biophys. J. 85, 646-655.

346. Saccà, B.; Fiori, S.; Moroder, L. (2003) Studies of the local conformational properties of the cell-adhesion domain of collagen type IV in synthetic heterotrimeric peptides. Biochemistry 42, 3429-3436.

347. Galés, C.; Poirot, M.; Taillefer, J.; Bernard, M.; Martinez, J.; Moroder, L.; Chantal, E.; Pradayrol, L.; Fourmy, D.; Silvente-Poirot, S. (2003) Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis and structure/affinity studies. Mol. Pharmacol. 63, 973-982.

348. Barth, D.; Musiol, H.-J.; Schütt, M.; Fiori, S.; Milbradt, A. G.; Renner, C.; Moroder, L. (2003) The role of cystine knots in collagen folding and stability. I. Conformational properties of (Pro-Hyp-Gly)5 and (Pro-(4S)-FPro-Gly)5 model trimers with an artificial cystine knot. Chem. Eur. J. 9, 3692-3702.

349. Barth, D.; Kyrieleis, O.; Frank, S.; Renner, C.; Moroder, L. (2003) The role of cystine knots in collagen folding and stability. II. Conformational properties of (Pro-Hyp-Gly)n model trimers with N- and C-terminal collagen type III cystine knots. Chem. Eur. J. 9, 3703-3714.

350. Bredenbeck, J.; Helbing, J.; Behrendt, R.; Renner, C.; Moroder, L.; Wachtveitl J.; Hamm, P. (2003) Transient 2D-IR spectroscopy: snapshots of the non-equilibrium ensemble during the picosecond conformational transition of a small peptide. J. Phys. Chem. B 107, 8654-8660.

351. Bae, J. H.; Rubini, M.; Jung, G.; Wiegand, G.; Seifert, M. H.; Azim, M. K.; Kim, J.-S.; Zumbusch, A.; Holak, T. A.; Moroder, L.; Huber, R.; Budisa, N. (2003) Expansion of the genetic code enables design of a novel „gold“ class of green fluorescent proteins. J. Mol. Biol. 328, 1071-1081.

352. Deluca, D.; Woehlke, G.; Moroder, L. (2003) Synthesis and conformational characterization of peptides related to the neck domain of a fungal kinesin. J. Pept. Sci. 9, 203-211.

353. Bredenbeck, J.; Helbing, J.; Sieg, A.; Schrader, T.; Zinth, W.; Wachtveitl, J.; Renner, C.; Behrendt, R.; Moroder, L.; Hamm, P. (2003) Picosecond conformational transition and equilibration of a cyclic peptide. Proc. Natl. Acad. Sci. USA 100, 6452-6457.

354. Schütt, M.; Krupka, S.; Milbradt, A. G.; Deindl, S.; Sinner, E.-K.; Renner, C.; Oesterhelt D.; Moroder L. (2003) Photocontrol of cell adhesion processes. Model studies with cyclic azobenzene-RGD peptides. Chem. Biol. 10, 487-490.

355. Kaiser, M.; Siciliano, C.; Machleidt-Assfalg, I.; Groll, M.; Milbradt A. G.; Moroder L. (2003) Synthesis of a TMC-95A ketomethylene analog by cyclization via intramolecular Suzuki coupling. Org. Lett. 5, 3435-3437.

356. Kaiser, M.; Milbradt, A.G.; Renner, C.; Assfalg-Machleidt, I.; Groll, M.; Huber, R.; Moroder, L. (2003) Cyclic biphenyl ether tripeptides as proteasom inhibitors. Biopolymers 71, P432.

357. Müller, M. M.; Musiol, H.-J.; Moroder, L. (2003) Synthesis of guanidine compounds using resin-bound guanidinylating reagents. Biopolymers 71, 269.

358. Schütt, M.; Milbradt, A. G.; Moroder, L.; Renner, C. (2003) Light-induced two-state structural transition of a cyclic PDI-related azobenzene-peptide. Biopolymers 71, 131.

2004

359. Barth, D.; Milbradt, A. G.; Renner, C.; Moroder, L. (2004) (4R)- and (4S)-fluoroproline in position Xaa of the (Xaa-Yaa-Gly) collagen repeat affects severely triple-helix formation. ChemBioChem 5, 79-86.

360. Kaiser, M.; Milbradt, A. G.; Siciliano, C.; Assfalg-Machleidt, I.; Machleidt, W.; Groll, M.; Renner, C.; Moroder L. (2004) TMC-95A analogues with endocyclic biphenyl ether group as proteasome inhibitors. ChemBioDiv 1, 161-173.

361. Sartori, E.; Toffoletti, A.; Corvaja, C.; Moroder, L.; Formaggio, F.; Toniolo, C. (2004) An oligopeptide doubly labelled with an azulene chromophore and a TEMPO radical. New insights into azulene excited state properties. Chem. Phys. Lett. 385, 362-367.

362. Renner, C.; Fiori, S.; Fiorino, F.; Landgraf, D.; Deluca, D.; Mentler, M.; Grantner, K.; Parak, F. G.; Kretzschmar, H.; Moroder, L. (2004) Micellar environments induce structuring of the N-terminal tail of the prion protein. Biopolymers 73, 421-433.

363. Bae, J. H.; Pal, P. P.; Moroder, L.; Huber, R.; Budisa, N. (2004) Crystallographic evidence for isomeric chromophores in 3-fluorotyrosyl-green fluorescent protein. ChemBioChem 5, 720-722.

364. Renner, C.; Saccà, B.; Moroder, L. (2004) Synthetic heterotrimeric collagen peptides as mimics of cell adhesion sites of the basement membrane. Biopolymers (Peptide Science) 76, 34-47.

365. Wachtveitl, J.; Spörlein, S.; Satzger, H.; Fonrobert, B.; Renner, C.; Behrendt, R.; Oesterhelt, D.; Moroder, L.; Zinth, W. (2004) Ultrafast conformational dynamics in cyclic azobenzene peptides of increased flexibility. Biophys. J. 86, 2350-2362.

366. Štern, I.; Schaschke, N.; Moroder, L.; Turk, D. (2004) Crystal structure of NS-134 in complex with bovine cathepsin B: a two headed epoxysuccinyl inhibitor extends along the entire active site cleft. Biochem. J. 381, 511-517.

367. Kaiser, M.; Groll, M.; Siciliano, C.; Assfalg-Machleidt, I.; Weyher, E.; Kohno, J.; Milbradt, A. G.; Renner, C.; Huber, R.; Moroder, L. (2004) Binding mode of TMC-95A analogues to eukaryotic 20S proteasome. ChemBioChem 5, 1256-1266.

368. Venanzi, M.; Valeri, A.; Palleschi, A.; Stella, L.; Moroder, L.; Formaggio, F.; Toniolo, C.; Pispisa, B. (2004) Structural properties and photophysical behavior of conformationally constrained hexapeptides functionalized with a new fluorescent analog of tryptophan and a nitroxide radical quencher. Biopolymers 75, 128-139.

369. Pokidysheva, E.; Milbradt, A. G.; Meier, S.; Renner, C.; Häussinger, D.; Bächinger, H. P.; Moroder, L.; Grzesiek, S.; Holstein, T. W.; Özbek, S.;Engel, J. (2004):The structure of the Cys-rich terminal domains of Hydra minicollagen, which are involved in disulfide networks of the nematocyst wall. J. Biol. Chem. 279, 30395-30401.

370. Arnould, M.; Tassa, A.; Ferrand, A.; Archer, E.; Estève, J.-P.; Pénalba, V.; Portolan, G.; Escherich, A.; Moroder, L.; Fourmy, D.; Seva, C.; Dufresne, M. (2004): The G-protein coupled CCK2 receptor associates with phospholipase Cg1. FEBS Lett. 568/1-3, 89-93.

371. Sinner, E.-K.; Reuning, U.; Kök, F.N.; Saccá, B.; Moroder, L.; Knoll, W.; Oesterhelt, D. (2004) Incorporation of integrins into artificial planar lipid membranes: characterization by plasmon enhanced fluorescence spectroscopy. Anal. Biochem. 333, 216-224.

372. Özbek, S.; Pokidysheva, E.; Schwager, M.; Schulthess, T.; Tariq, N.; Barth, D.; Milbradt, A. G.; Moroder, M.; Engel, J.; Holstein, T. W. (2004) The glycoprotein NOWA and minicollagens are part of a disulfide-linked polymer that forms the cnidarian nematocyst wall. J. Biol. Chem. 279, 52016-52023.

373. Satzger, H.; Root, C.; Renner, C.; Behrendt, R.; Moroder, L.; Wachtveitl, J.; Zinth, W. (2004) Picosecond dynamics in water soluble azobenzene-peptides. Chem. Phys. Lett. 396, 191-197.

374. Giragossian, C.; Schaschke, N.; Moroder, L.; Mierke, D. F. (2004) Conformational and molecular modeling studies of beta-cyclodextrin-heptagastrin and the third extracellular loop of the cholecystokinin 2 receptor. Biochemistry 43, 2724-2731.

375. Archer, E.; Escrieut, C.; Martinez, L.; Maigret, B.; Logsdon, C.; Kopin, A.; Seva, C.; Dufresne, M.; Pradayrol, L.; Fourmy, D. (2004) Molecular mechanism underlying partial agonism mediated by G-protein-coupled receptor, human cholecystokinin-1 receptor. Regul. Pept. 122 (1), 5-5A2.

376. Escrieut, C.; Dufresne, M.; Seva, C.; Pradayrol, L.; Moroder, L.; Maigret, B.; Fourmy, D. (2004) Modeled stucture of a G-protein-coupled receptor, the human cholecystokinin-1 receptor. Regul. Pept. 122 (1), 5-5A3.

377. Vatinel, S.; Lopez, F.; Esteve, J.-P.; Monsarrat, B.; Moroder, L.; Pradayrol, L.; Dufresne, M.; Fourmy, D.; Seva, C. (2004) Proteomics approaches to identify signalling complexes interacting with the CCK2 receptor C-terminus. Regul. Pept. 122 (1), 46-46A.

378. Moroder, L. (2004) Murray Goodman (1928-2004): Peptide chemistry. Angew. Chem. Int. Ed. 43, 3628-3628.

379. Kaiser, M.; Groll, M.; Siciliano, C.; Assfalg-Machleidt, I.; Weyher, E.; Kohno, J.; Milbradt, A. G.; Renner, C.; Huber, R.; Moroder, L. (2004) Structural determination for 20S proteasome inhibition by TMC-95A. J. Pept. Sci. 10 (Suppl.), 211.

380. Milbradt, A. G.; Moroder, L.; Renner, C. (2004) The multiple cysteine-containing head domain of minicollagen from hydra nematocysts folds oxidatively into a compact globular structure. J. Pept. Sci. 10 (Suppl.), 229.

381. Moroder, L. (2004) Disulfides in peptides and proteins: a personal challenge from past to present. J. Pept. Sci. 10 (Suppl.), 89.

382. Musiol, H.-J.; Kaiser, M.; Dong, S.; Moroder, L. (2004) Click and ligation chemistry for the synthesis of GPI-anchored membrane proteins. J. Pept. Sci. 10 (Suppl.), 200.

383. Pfizer, J.; Assfalg-Machleidt, I.; Machleidt, W.; Moroder, L.; Schaschke, N. (2004) Primed site probing of papain-like cysteine proteases. J. Pept. Sci. 10 (Suppl.), 214.

2005

384. Renner, C.; Kusebauch, U.; Löweneck, M.; Milbradt, A. G.; Moroder, L. (2005): Azobenzene as photoresponsive conformational switch in cyclic peptides. J. Pept. Res. 65,4-14.

385. Musiol, H.-J.; Dong, S.; Kaiser, M.; Bausinger, R.; Zumbusch, A.; Moroder, L. (2005) Toward semisynthetic lipoproteins by convergent strategies based on click and ligation chemistry. ChemBioChem 6, 625-628.

386. Archer-Lahlou, E.; Tikhonova, I.; Escrieut, C.; Dufresne, M.; Seva, C.; Pradayrol, L.; Moroder, L.; Maigret, B.; Fourmy, D. (2005) Modeled structure of a G-protein-coupled receptor: the cholecystokinin-1 receptor. J. Med. Chem. 48, 180-191.

387. Mentler, M.; Weiss, A.; Grantner, K.; del Pino, P.; Deluca, D.; Fiori, S.; Renner, C.; Meyer Klaucke, W.; Moroder, L.; Bertsch, U.; Kretzschmar, H. A.; Tavan, P.; Parak, F. G. (2005) A new method to determine the structure of the metal environment in metalloproteins: investigation of the prion protein octapeptide repeat Cu2+ -complex. Eur. J. Biophys. 34, 97-112.

388. Moroder, L. (2005) Isosteric replacement of sulfur by other chalcogens in peptides and proteins. J. Pept. Sci. 11, 187-214.

389. Milbradt, A. G.; Löweneck, M.; Krupka, S. S.; Reif, M.; Sinner, E.-K.; Moroder, L.; Renner, C. (2005) Photomodulation of conformational states. IV. Integrin-binding RGD-Peptides with (4-aminomethyl)phenylazobenzoic acid as backbone constituent. Biopolymers 77, 304-313.

390. Carstens, H.; Renner, C.; Milbradt, A. G.; Moroder, L.; Tavan, P. (2005) Molecular dynamics simulations can predict multiple loop conformations of peptides as validated by NMR. Biochemistry 44, 4829-4840.

391. Archer-Lahlou, E.; Escrieut, C.; Clerc, P.; Martinez, J.; Moroder, L.; Logsdon, C.; Kopin, A.; Seva, C.; Dufresne, M.; Pradayrol, L.; Maigret, B.; Fourmy, D. (2005) Molecular mechanism underlying partial and full agonism mediated by the human cholecystokinin-1 receptor. J. Biol. Chem. 280, 10664-10774.

392. Pal, P. P.; Bae, J. H.; Azim, M. K.; Hess, P.; Friedrich, R.; Huber, R.; Moroder, L.; Budisa, N. (2005) Structural and spectral response of Aequorea victoria green fluorescent proteins to chromophore fluorination. Biochemistry 44, 3663-3672.

393. Moroder, L. (2005) Model peptides for protein folding and structure. J. Pept. Sci. 11, 258-261.

394. Moroder, L.; Musiol, H.-J.; Götz, M.; Renner, C. (2005) Synthesis of single- and multiple-stranded cystine-rich peptides. Biopolymers (Peptide Science) 80, 85-97.

395. Banke, I. L.; Arlt, M. J. E.; Mueller, M. M.; Sperl, S.; Stemberger, A.; Stürzebecher, J.; Amirkhosravi, A.; Moroder, L.; Krüger, A. (2005) Efficient inhibition of experimental metastasis and prolongation of survival by a factor Xa-specific synthetic serine protease inhibitor with weak anti-coagulant activity. Thromb. Haemost. 94, 1084-1093.

396. Dong, S.-L.; Löweneck, M.; Schrader, T. E.; Schreier, W.; Zinth, W.; Moroder, L.; Renner, C. (2006) A photo-controlled b-hairpin peptide. Chem. Eur. J. 12, 1114-1120.

397. Milbradt, A. G.; Boulègue, C.; Moroder, L.; Renner, C. (2005) The two cysteine-rich head domains of minicollagen from Hydra nematocysts differ in their cystine framework and overall fold despite an identical cysteine sequence pattern. J. Mol. Biol. 354, 591-600.

398. Mulinacci, B.; Breithaupt, C.; Pal, P. P.; Budisa, N.; Pazzagli, M.; Mazzari, B.; Rovero, P.; Moroder, L.; Papini, A. M. (2005) Cross-reactivity studies of rMOGED with synthetic putative autoantigens CSF114(Glc) and (N31(Glc)hMog(30-50) in multiple sclerosis patients´ sera. Biopolymers (Peptide Science) 80, 484.

399. Moroder, L. (2005) Peptides in the days of photonics. Biopolymers (Peptide Science) 80, 491.

400. Löweneck, M.; Dong, S.-L.; Schrader, T. E.; Schreier W. J.; Zinth, W.; Moroder, L.; Renner, C. (2005) A photocontrolled b-hairpin. Biopolymers (Peptide Science) 80, 547.

401. Barazza, A.; Renner, C.; Willem, M.; Moroder, L. (2005) Cyclic phenylstatine-based tetrapeptides as inhibitors of b-secretase. Biopolymers (Peptide Science) 80, 554.

402. Kusebauch, U.; Moroder, L.; Renner, C. (2005) Towards photo-controlled collagens. Biopolymers (Peptide Science) 80, 575.

403. Milbradt, A. G.; Boulegue, C.; Moroder, L.; Renner, C. (2005) The two cysteine rich head domains from Hydra minicollagen show different disulfide bridges and different novel folds despite identical cysteine sequence pattern. Biopolymers (Peptide Science) 80, 590.

404. Golbik, R.; Yu, C.; Weyher-Stingl, E.; Huber, R.; Moroder, L,; Budisa, N.; Schiene-Fischer, C. (2005) Peptidyl prolyl cis/trans isomerases: Comparative reactivities of cyclophilins, FK506-binding proteins and parvulins with fluorinated oligopeptide and protein substrates. Biochemistry 44, 16026-16034.

2006

405. Löweneck, M.; Milbradt, A.G.; Root, C.; Satzger, H.; Zinth, W.; Moroder, L.; Renner, C. (2006) A conformational two-state peptide model system containing an ultrafast, but soft light switch. Biophys. J. 90, 2099-2108.

406. Renner, C; Moroder, L. (2006) Azobenzene as conformational switch in model peptides. ChemBioChem, 7, 868-878.

407. Boulègue, C.; Milbradt, A. G.; Renner, C.; Moroder, L. (2006) Single proline residues can dictate folding pathways of cysteine-rich peptides. J. Mol. Biol. 358, 846-856.

408. Gonscherowski, V.; Becker, B. F.; Moroder, L.; Motrescu, E.; Gil- Parrado, S.; Gloe, T.; Keller, M.; Zahler, S. (2006) Calpains: a physiological regulator of the endothelial barrier? Amer. J. Physiology - Heart and Circulatory Physiology, 290, H2035-H2042.

409. Moroder; L. (2006) From basic synthesis to automated technology. ChemBioChem. 7, 551.

410. Groll, M.; Götz, M.; Kaiser, M.; Weyher, E.; Moroder, L. (2006) TMC-95 based inhibitor design provides evidence for the catalytic versatility of the proteasome. Chem. Biol., 13, 807-614.

411. Kusebauch, U.; Cadamuro, S. A.; Musiol, H.-J.; Lenz, M. O.; Wachtveitl, J.; Moroder, L.; Renner, C. (2006) Photo-Controlled Folding and Unfolding of a Collagen Triple Helix. Angew. Chem. Int. Ed., submitted.

412. Boulègue, C.; Musiol, H.-J.; Prasad, V.; Moroder, L. (2006) Synthesis of cystine-rich peptides. Chemistry Today, in press.

413. Fiorino, F.; Gil-Parrado, S.; Assfalg-Machleidt, I.; Machleidt, W.; Moroder, L. (2006) A new cell-permeable calpain inhibitor. J. Peptide Sci., in press.

Publications in Journals 2000

Ottl, J.; Gabriel, D.; Murphy, G.; Knäuper, V.; Tominaga, Y.; Nagase, H.; Bode, W.; Moroder, L. (2000) Recognition and catabolism of synthetic heterotrimeric collagen-peptides by matrix-metalloproteinases. Chem. Biol. 7, 119-132.

Loidl, G.; Musiol, H.-J.; Groll, M. Huber, R.; Moroder, L. (2000) Synthesis of bivalent inhibitors of eukaryotic proteasomes. J. Pept. Sci. 6, 36-46.

Loidl, G.; Musiol, H.-J.; Budisa, N.; Huber, R.; Poirot, S.; Fourmy, D.; Moroder, L. (2000) Synthesis of b-(1-azulenyl)-L-alanine as a potential blue-colored fluorescent tryptophan analog and its use in peptide synthesis. J. Pept. Sci. 6, 139-144.

Fiori, S.; Pegoraro, S.; Rudolph-Böhner, S.; Cramer, J.; Moroder, L. (2000) Synthesis and conformational analysis of apamin analogs with natural and non-natural cystine/selenocystine connectivities. Biopolymers 53, 550-564.

Schaschke, N.; Assfalg-Machleidt, I.; Machleidt, W.; Laßleben, T.; Sommerhoff, C.P.; Moroder, L. (2000) b-Cyclodextrin/epoxysuccinyl peptide conjugates: a new drug targeting system for tumor cells. Bioorg. Med. Chem. Lett. 10, 677-680.

Müller, J. C. D.; Ottl, J.; Moroder, L. (2000) Heterotrimeric collagen peptides as fluorogenic substrates. Synthesis, conformational properties and enzymatic digestion. Biochemistry 39, 5111-5116.

Frank, S.; Kammerer, R. A.; Hellstern, S.; Pegoraro, S.; Stetefeld, J.; Lustig, A.; Moroder, L.; Engel, J. (2000) Toward a high-resolution structure of phospholamban: design of soluble transmembrane domain mutants. Biochemistry 39, 6825-6831.

Sperl, S.; Bergner, A.; Stürzebecher, J.; Wilhelm, O. G.; Bode, W.; Moroder, L. (2000) Urethanyl-3-amidinophenylalanine derivatives as inhibitors of factor Xa. X-ray crystal structure of a trypsin/inhibitor complex and modeling studies. Biol. Chem. 381, 321-329.

Renner, C.; Behrendt, R.; Spörlein, S.; Wachtveitl, J.; Moroder, L. (2000) Photomodulation of conformational states. I. Mono- and bicyclic peptides with (4-amino)phenylazobenzoic acid as backbone constituent. Biopolymers 54, 489-500.

Renner, Ch.; Cramer, J.; Behrendt, B.; Moroder, L. (2000) Photomodulation of conformational states. II. Mono- and bicyclic peptides with (4-aminomethyl)phenylazobenzoic acid as backbone constituent. Biopolymers 54, 501-514.

Hu, B.; Finsinger, D.; Kai, P.; Guttenberg, Z.; Bärmann, M.; Kessler, H.; Escherich, A.; Moroder, L.; Böhm, J.; Baumeister, W.; Sackmann, E. (2000) Inter-vesicle crosslinking with integrin aIIbb3 and cyclic RGD-lipopeptide. A model of cell-adhesion processes. Biochemistry 39, 12284-12294.

Sperl., S.; Jacob, U.; Arroyo de Prada, N.; Stürzebecher, J.; Wilhelm, O. G.; Bode, W.; Magdolen, V.; Huber, R.; Moroder, L. (2000) (4-Amino)phenylguanidine derivatives as non-peptidic highly selective inhibitors of human urokinase. X-ray crystal structure of an uPA/inhibitor complex at 1.8 Å resolution. Proc. Natl. Acad. Sci. USA 97, 5113-5118.

Guttenberg, Z.; Bausch, A. R.; Hu, B.; Bruisma, R.; Moroder, L.; Sackmann, E. (2000) Measuring ligand-receptor unbinding forces with magnetic beads: molecular leverage? Langmuir 16, 8984-8993.

Scheufler, C.; Brinker, A.; Bourenkov, G.; Pegoraro, S.; Moroder, L.; Bartunik, H.; Hartl, F. U.; Moraefi, I. (2000) Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. Cell 101, 199-210.

Schaschke, N.; Assfalg-Machleidt, I.; Laßleben, Th.; Sommerhoff, C. P.; Moroder, L.; Machleidt, W. (2000) Epoxysuccinyl peptide-derived affinity labels for cathepsin B. FEBS Lett. 482, 91-96.

Minks, C.; Huber, R.; Moroder, L.; Budisa, N. (2000) Noninvasive tracing of recombinant proteins with "fluorophenylalanine-fingers". Anal. Biochem. 284, 29-34.

Galés, C.; Kowalski-Chauvel, A.; Dufour, M. N.; Seva, C.; Moroder, L.; Pradayrol, L.; Vaysse, N.; Fourmy, D.; Silvente-Poirot, S. (2000) Mutation of Asn-391 within the conserved NPXXY motif of the cholecystokinin B receptor abolishes G(q) protein activation without affecting its association with the receptor. J. Biol. Chem. 275, 17321-17327.

Escrieut, C.; Maigret B.; Silvente-Poirot, S.; Gigoux, V.; Martinez, J.; Moroder, L.; Bignon, E.; Vaysse, N.; Fourmy, D. (2000) Identification of residues of the human CCK-A receptor that are in interaction with the C-terminal phenylalanine of CCK. Gastroenterology 118 (Part 1, Suppl. 2) 1687.

Groll, M.; Bajorek, M.; Köhler, A.; Moroder, L.; Rubin, D. M.; Huber, R.; Glickman, M. H.; Finley, D. (2000) A gated channel into the proteasome core particle. Nature Struct. Biol. 7, 1062-1067.

Minks, C.; Alefelder, S.; Moroder, L.; Huber, R.; Budisa, N. (2000) Towards new protein engineering: in vivo building and folding of protein shuttles for drug delivery and targeting by the selective pressure incorporation (SPI) method. Tetrahedron 56, 9431-9442.

Song, H. K.; Hartmann, C.; Ramachandran, R.; Bochtler, M.; Behrendt, R.; Moroder, L.; Huber, R. (2000) Mutational studies on HsIU and its docking mode with HsIV. Proc. Natl. Acad. Sci. USA 97, 14103-14108.

Publications in Journals 1999

Ottl, J.; Musiol, H.-J.; Moroder, L. (1999) Heterotrimeric collagen peptides containing functional epitopes. Synthesis of single-stranded collagen type I peptides related to the collagenase cleavage site. J. Pept. Sci. 5, 103-110.

Budisa, N.; Minks, C.; Alefelder, S.; Wenger, W.; Dong, F.; Moroder, L.; Huber, R. (1999) Toward the experimental codon reassignment in vivo. Protein building with an expanded amino acid repertoire. FASEB J. 13, 41-51.

Ottl, J.; Moroder, L. (1999) Assembly of multiple-chain polypeptide suprastructures with artificial cystine-knots. Tetrahedron Lett. 40, 1487-1490.

Ottl, J.; Moroder, L. (1999) Disulfide-bridged heterotrimeric collagen peptides containing the collagenase cleavage site of collagen type I. Synthesis and conformational properties. J. Am. Chem. Soc. 121, 653-661.

Loidl, G.; Groll, M.; Musiol, H.-J.; Ditzel, L.; Huber, R.; Moroder, L. (1999) Bifunctional inhibitors for the trypsin-like activity of eukaryotic proteasomes. Chem. Biol. 6, 197-204.

Pegoraro, S.; Fiori, S.; Cramer, J.; Rudolph-Böhner, S.; Moroder, L. (1999) The disulfide-coupled folding pathway of apamin as derived from diselenide-quenched analogs and intermediates. Protein Sci. 8, 1605-1613.

Le Dréan, G.; Le Huerou-Luron, I.; Gestin, M.; Desbois, C.; Romé, V.; Bernard, C.; Dufresne, M.; Moroder, L.; Gully, D.; Chayvialle, J. A.; Fourmy, D.; Guilloteau, P. (1999) Exogenous CCK and gastrin stimulate pancreatic exocrine secretion via CCK-A but also via CCK-B/gastrin receptors in the calf. Pflügers Archiv J. Physiol. 438, 86-93.

Fiori, S., Renner, C., Cramer, J., Pegoraro, S.; Moroder, L. (1999) Preferred conformation of endomorphin-1 in aqueous and membrane-mimetic environments. J. Mol. Biol. 291, 163-175.

Behrendt, R.; Renner, C.; Schenk, M.; Wang, F.; Wachtveitl, J.; Oesterhelt, D.; Moroder, L. (1999) Photomodulation of conformational states of cyclic peptides with a backbone-azobenzene moiety. Angew. Chem. Int. Ed. Engl. 38, 2771-2774.

Escherich, A.; Escrieut, C.; Fourmy, D.; Moroder, L. (1999) Benzotriazonine as a new core structure for the design of CCK-receptor antagonists. J. Pept. Sci. 5, 155-158.

Loidl, G.; Groll, M.; Musiol, H.-J.; Huber, R.; Moroder, L. (1999) Bivalency as a principle for proteasome inhibition. Proc. Natl. Acad. Sci. USA 96, 5418-5422.

Silvente-Poirot, S.; Escrieut, C.; Galès; C.; Fehrentz, J.-A.; Escherich, A.; Wank, S. A.; Martinez, J.; Moroder, L.; Maigret, B.; Bouisson, M.; Vaysse, N.; Fourmy, D. (1999) Evidence for a direct interaction between the penultimate aspartic acid of cholecystokinin and histidine 207 located in the second extracellular loop of the rat cholecystokinin B receptor. J. Biol. Chem. 274, 23191-23197.

Gigoux, V.; Escrieut, C.; Fehrentz, J.-A.; Poirot, S.; Maigret, B.; Moroder, L.; Gully, D.; Martinez, J.; Vaysse, N.; Fourmy, D. (1999) Arginine 336 and asparagine 333 of the human cholecystokinin-A receptor binding site interact with the penultimate aspartic acid and the C-terminal amide of cholecystokinin. J. Biol. Chem. 274, 20457-20464.

Minks, C.; Huber, R.; Moroder, L.; Budisa, N. (1999) Atomic mutations at the single tryptophan residue of human recombinant annexin V. Effects on structure, stability and activity. Biochemistry 38, 10649-10659.

van Neuren, A. S.; Müller, G.; Klebe, G.; Moroder, L. (1999) Molecular modelling studies in G-protein-coupled receptors. From sequence to structure? J. Recept. Signal Transduct. Res. 19, 341-353.

Gigoux, V.; Maigret, B.; Escrieut, C.; Silvente-Poirot, S.; Bouisson, M.; Fehrentz, J. A.; Moroder, L.; Gully, D.; Martinez, J.; Vaysse, N.; Fourmy, D. (1999) Arginine 197 of the cholecystokininn-A receptor binding site interacts with the sulfate of the peptide agonist cholecystokinin. Protein Sci. 8, 2347-2354.

Behrendt, R.; Schenk, M.; Musiol, H.-J.; Moroder, L. (1999) Photomodulation of conformational states. Synthesis of cyclic peptides with backbone-azobenzene moieties. J. Pept. Sci. 5, 519-529.

Budisa, N.; Moroder, L.; Huber, R. (1999) Structure and evolutionof the genetic cods viewed from the perspective of the experimentally expanded amino acid repertoire in vivo. Cell. Mol. Life Sci. 55, 1626-1635.

Cramer, J.; Fiori, S.; Müller, G.; Renner, C.; Pegoraro, S.; Moroder, L. (1999) Comparison of a Monte Carlo strategy with a combined DG/MDSA method for structure determination of bicyclic peptides. J. Mol. Model. 5, 287-295.

Silvente-Poirot, S.; Galés, C.; Escrieut, C.; Fourmy, D.; Maigret, B.; Moroder, L.; Vaysse, N. (1999) Asn367 and Asn391 within the highly conserved motif NPXXY of the rat cholecystokinin A and B receptors are essential to switch their receptors to an active conformation for different transduction pathways. Gastroenterology 116, G2780.

Hauptmann, J.; Gabriel, B.: Moroder, L.; Prasa, D.; Stürzebecher, J. (1999) Clearance of benzamidine-type thrombin and factor Xa inhibitors in rats: Influence of charged substituents. Thrombosis and Haemostasis, Suppl., 614.

Publications in Journals 1998

Schaschke, N.; Assfalf-Machleidt, I.; Machleidt, W.; Moroder, L. (1998) Substrate/propeptide-derived endo-epoxysuccinylpeptides as highly potent and selective cathepsin B inhibitors. FEBS Lett. 421, 80-82.

von Roedern, E.; Grams, F.; Brandstetter, H.; Moroder, L. (1998) Synthesis of malonic acid-based inhibitors for matrix metalloproteinases. J. Med. Chem. 41, 339-345.

Budisa, N.; Minks, C.; Medrano, F. J.; Lutz, J.; Huber, R.; Moroder, L. (1998) Residue-specific bioincorporation of non-natural, biologically active amino acids into proteins as possible drug carriers. Structure and stability of the per-thiaproline mutant of annexin V. Proc. Natl. Acad. Sci. USA 95, 455-459.

Hofmann, A.; Escherich, A.; Lewit-Bentley, A.; Benz, J.; Raguenes-Nicol, C.; Russo-Marie, F.; Gerke, V.; Moroder, L.; Huber, R. (1998) Interactions of benzodiazepine derivatives with annexins. J. Biol. Chem. 273, 2885-2894.

Brandstetter, H.; Engh, R. A.; Graf von Roedern, E.; Moroder, L.; Huber, R.; Bode, W.; Grams, F. (1998) Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data. Protein Sci. 7, 1303-1309.

Nakazawa, T.; Ishii, M.; Musiol H.-J.; Moroder, L. (1998) Synthesis of a,b-dehydrotryptophan by the reaction of indole with b-(N-methylamino)dehydroalanine derivative. Tetrahedron Lett. 39, 1381-1384.

Schaschke, N.; Fiori S.; Weyher, E.; Escrieut, C.; Fourmy, D.; Müller, G.; Moroder, L. (1998) Cyclodextrin as carrier of peptide hormones. Conformational and biological properties of b-cyclodextrin/gastrin constructs. J. Am. Chem. Soc. 120, 7030-7038.

Budisa, N.; Huber, R.; Golbig, R.; Minks, C.; Weyher, E.; Moroder, L. (1998) Atomic mutations in Annexin V. Thermodynamic studies of isomorphous protein variants. Eur. J. Biochem. 353, 1-9.

Graf von Roedern, E.; Brandstetter, H.; Engh, R. A.; Bode, W.; Grams, F.; Moroder, L. (1998) Bis-substituted malonic acid hydroxamate derivatives as inhibitors of human neutrophil collagenase (MMP8). J. Med. Chem. 41, 3041-3047.

Tamaoki, H.; Miura, R.; Kusunoki, M.; Kyogoku, Y.; Kobayashi, Y.; Moroder, L. (1998) Folding motifs induced and stabilized by distinct cystine frameworks. Protein Engineering 11, 649-659.

Gabriel, B.; Stubbs, M. T.; Bergner, A.; Hauptmann, J.; Bode, W.; Stürzebecher, J.; Moroder, L. (1998) Structure-based design of benzamidine-type inhibitors of factor Xa. J. Med. Chem. 41, 4240-4250.

Pegoraro, S.; Fiori, S.; Rudolph-Böhner, S.; Watanabe, T. X.; Moroder, L. (1998) Isomorphous replacement of cystine with selenocystine in endothelin. Oxidative refolding, biological and conformational properties of [Sec3,Sec11,Nle7]-endothelin-1. J. Mol. Biol. 284, 779-792.

Gigoux, V.; Escrieut, C.; Silvente-Poirot, S.; Maigret, B.; Gouilleux, L.; Fehrentz, J.-A.; Gully, D.; Moroder, L.; Vaysse, N.; Fourmy, D. (1998): Met-195 of the cholecystokinin-A receptor interacts with the sulfated tyrosine of cholecystokinin and is crucial for receptor transition to high affinity state. J. Chem. Biol. 273, 14380-14386.

Gales, C.; Escrieut, C.; Fourmy, D.; Maigret, B.; Moroder, L.; Vaysse, N.; Poirot, S. S. (1998) Identification of a key residue involved in the activation of the cholecystokinin B receptor. Gastroenterology 114 (Suppl. II) G4681.

Gigoux, V.; Escrieut, Ch.; Silvente-Poirot, S.; Bouisson, M.; Maigret, B.; Gouilleux, L.; Fehrentz, J.-A.; Martinez, J.; Gully, D.; Moroder, L.; Vaysse, N.; Fourmy, D. (1998) Mapping of the CCK binding site of the CCK-A receptor and analysis of the interactions that stabilize its active state. Dig. Des. Sci. 43, 1884.

Publications in Journals 1997

Terness, P.; Kirschfink, M.; Navolan, D.; Moroder, L.; Siedler, F.; Drugarin, D.; Schneider, F.; Dufter, Ch.; Kohl, I.; Welschof, M.; Opelz, G.; Roelcke, D. (1997) Inverse correlation between IgG-anti-hinge region and anti-erytrocyte autoantibody in chronic benign and malignant cold agglutination. J. Clin. Immunol. 17, 220-227.

Moroder, L. (1997) On the mechanism of hormone recognition and binding by the CCK-B/gastrin receptor. J. Peptide Sci. 3, 1-14

Lutz, J.; Romano-Götsch, R.; Escrieut, C.; Fourmy, D.; Mathä, B.; Müller, G.; Kessler, H.; Moroder, L. (1997) Mapping of the ligand binding site of the cholecystokinin-B/gastrin receptor using lipo-gastrin peptides and molecular modelling. Biopolymers 41, 799-817.

Rudolph-Böhner, S.; Quarzago, D.; Czisch, M.; Ragnarsson, U.; Moroder, L. (1997) Conformational preferences of Leu-enkephalin in reverse micelles as membrane-mimicking environment. Biopolymers 41, 591-606.

Rudolph-Böhner, S.; Krüger, M.; Oesterhelt, D.; Moroder, L.; Nägele, T.; Wachtveitl, J. (1997) Photomodulation of conformational states of p-phenylazobenzyloxycarbonyl-L-proline and related peptides. J. Photochem. Photobiol. A-Chemistry, 105, 235-248 (erratum 1998: 117, 75-82).

Wachtveitl, J.; Nägele, T.; Puell, B.; Zinth, W.; Krüger, M.; Rudolph-Böhner, S.; Oesterhelt, D.; Moroder, L. (1997) Ultrafast photoisomerization of azobenzene compounds. J. Photochem. Photobiol. A-Chemistry, 105, 283-288.

Kennedy, K.; Gigoux, V.; Escrieut, C.; Maigret, B.; Martinez, J.; Moroder, L.; Fréhel, D.; Gully, D.; Vaysse, N.; Fourmy, D. (1997) Identification of two amino acids of the human cholecystokinin-A receptors that interact with the N-terminal moiety of cholecystokinin. J. Biol. Chem. 272, 2920-2926.

Philippe, C.; Lhoste, E. F.; Dufresne, M.; Moroder, L.; Corring, T.; Fourmy, D. (1997) Pharmacological and biomedical evidences for the simultaneous expression of CCK-B/gastrin and CCK-A receptors in the pig pancreas. Br. J. Pharmacol. 120, 447-454.

Besse, D.; Siedler, F.; Diercks, T.; Kessler, H.; Moroder, L. (1997) The redox potential of selenocystine in unconstrained cyclic peptides. Angew. Chem. Int. Ed. 36, 883-885.

Schaschke, N.; Assfalg-Machleidt, I.; Machleidt, W.; Turk, D.; Moroder, L. (1997) E-64 and related analogs as inhibitors of cathepsin B. On the role of the absolute configuration of the trans-epoxysuccinyl group. Bioorg. Med. Chem. 5, 1789-1797.

Besse, D., Budisa, N., Karnbrock, W., Minks, C., Musiol, H.-J., Pegoraro, S., Siedler, F., Weyher, E.; Moroder, L. (1997) Chalcogen-analogs of amino acids. Their use in X-ray crystallographic and folding studies of peptides and proteins. Biol. Chem. 378, 211-218.

Budisa, N., Karnbrock, W., Steinbacher, S., Humm, A., Prade, L., Neuefeind, T., Moroder, L.; Huber, R. (1997) Bioincorporation of telluromethionine into proteins. A promising new approach for X-ray structure analysis of proteins. J. Mol. Biol. 270, 616-623.

Epand, R. F.; Moroder, L.; Lutz, J.; Flanagan, T. D.; Nir, S.; Epand, R. M. (1997) Lipogastrins as potent inhibitors of viral fusion. Biochim. Biophys. Acta 1327, 259-268.

Besse, D.; Moroder, L. (1997) Synthesis of selenocysteine-peptides and their oxidation to diselenide-bridged compounds. J. Peptide Sci. 3, 442-453.

Escherich, A.; Ditzel, L.; Musiol, H.-J.; Groll, M.; Huber, R.; Moroder, L. (1997) Synthesis, kinetic characterization and X-ray analysis of peptide aldehydes as inhibitors of the 20S Proteasome from T. Acidophilum and S. Cerevisiae. Biol. Chem. 378, 893-898.

Terness, P.; Welschof, M.; Moldenhauer, G.; Jung, M.; Moroder, L.; Kirchhoff, F.; Kipriyanov, S.; Little, M.; Opelz, G. (1997) Idiotypic vaccine for treatment of human B-cell lymphoma. Construction of IgG variable regions from single malignant B cells. Human Immunol. 56, 17-27.

Terness, P.; Navolan, D.; Kohl, I.; Siedler, F.; Moroder, L.; Dufter, Ch.; Welschof, M.; Schneider, F.; Drugarin, D.; Opelz, G. (1997) Role of idiotype-independent anti-IgG autoantibodies in human kidney transplantation. Natural anti-F(ab´)2 antibodies recognize an IgG1 hinge region epitope. Transplantation Proceed. 29, 1412-1414.

Müller, J. C. D.; Graf von Roedern, E.; Grams, F.; Nagase, H.; Moroder, L. (1997) Non-peptidic cysteine derivatives as inhibitors of matrix metalloproteinases. Biol. Chem. 378, 1475-1480.

Schaschke, N.; Musiol, H. J.; Assfalg-Machleidt, I.; Machleidt, W.; Moroder, L. (1997) Oligopresentation of protease inhibitors with b-cyclodextrin as template. Bioorg. Med. Chem. Lett. 7, 2507-2512.

Publications in Journals 1996

Karnbrock, W.; Weyher, E.; Budisa, N.; Huber, R.; Moroder, L. (1996) A new efficient synthesis of acetyl-telluro- and acetyl-selenomethionine and their use in the biosynthesis of heavy-atom protein analogs. J. Amer. Chem. Soc. 118, 913-914.

Moroder, L.; Lutz, J.; Grams, F.; Rudolph-Böhner, S.; Ösapay, G.; Goodman, M.; Kolbeck, W. (1996) A new efficient method for the synthesis of 1,4-benzodiazepine-2,5-dione diversomers. Biopolymers 38, 295-300.

Moroder, L.; Besse, D.; Musiol, H. J.; Rudolph-Böhner, S.; Siedler, F. (1996) Oxidative folding of cystine-rich peptides vs. regioselective cysteine pairing strategies. Biopolymers (Pept. Sci.) 40, 207-234.

Qualmann, B.; Kessels, M. M.; Musiol, H. J.; Sierralta, W. D.; Jungblut, P. W.; Moroder, L. (1996) Synthesis of boron-rich lysine dendrimers as protein labels in electron microscopy. Angew. Chem. Int. Ed. Engl. 35, 909-911.

Siedler, F.; Weyher, E.; Moroder, L. (1996) Cysteine racemization in peptide synthesis. A new and facile detection method. J. Peptide Sci. 2, 271-275.


Schaschke, N.; Musiol, H. J.; Assfalg-Machleidt, I.; Machleidt, W.; Rudolph-Böhner, S.; Moroder, L. (1996) Cyclodextrins as templates for the presentation of protease inhibitors. FEBS Lett. 391, 297-301.

Terness, P.; Navolan, D.; Moroder, L.; Siedler, F.; Weyher, E.; Kohl, I.; Dufter, C.; Welschof, M.; Drugarin, D.; Schneider, F.; Opelz, G. (1996) Natural IgA-anti-(Fab´)2g autoantibody of healthy individuals and kidney graft recipients recognizes an IgG1 hinge region epitope. J. Immunol. 157, 4251-4257.

Ottl, J.; Battistutta, R.; Pieper, M.; Tschesche, H.; Bode, W.; Kühn, K.; Moroder, L. (1996) Design and synthesis of heterotrimeric collagen peptides with a built-in cystine-knot. Models for collagen catabolism by matrix-metalloproteases. FEBS Lett. 398, 31-36.

Publications in Journals 1995

Karnbrock, W.; Musiol, H.-J.; Moroder, L. (1995) Enantioselective synthesis of (2S)-o-carboranylalanine via methylated bis-lactim ethers of 2,3-diketopiperazines. Tetrahedron 51, 1187-1196.

Korn, A.C.; Moroder, L. (1995) Enantioselective synthesis of diethyl (+)-(2S,3S)-trans-2,3-epithiosuccinate. J. Chem. Res. (S), 102-103.

Lutz, J., Weyher, E.; Moroder, L. (1995) Metal ion binding affinities of gastrin and CCK in membrane mimetic environments. J. Peptide Sci. 1, 360-370.

Mierke, D.; Rudolph-Böhner, S.; Müller, G.; Moroder, L. (1995) Structure of two microcystins. Refinement with NOEs and ensemble calculations. Biopolymers 36, 811-828.

Quarzago, D.; Moroder, L. (1995) Conformational analysis of bioactive peptides in reverse micelles as mimicry of cell membrane environments. LIPS 1, 171-177.

Terness, P.; Kohl, I.; Hübener, G.; Battistuta, R.; Moroder, L.; Welschof, M.; Dufter,C.; Finger, M.; Hain, C.; Jung, M.; Opelz, G. (1995) The natural human IgG-anti-F(ab´)2 antibody recognizes a conformational IgG1 hinge epitope. J. Immunol. 154, 6446-6452.

Dufresne, M.; Escrieut, C.; Clerc, P.; Sallan, C.; Kennedy, K.; Fanjul, M.; Mengod, G.; Real, F.; Moroder, L.; Vaysse, N.; Fourmy, D. (1995) Predominant expression of CCK-B/gastrin receptor in the human pancreas. Digestion 56, 280.

Publications in Journals 1994

Korn, A.; Rudolph-Böhner, S.; Moroder, L. (1994) On the synthesis of (2S)-aziridine-2-carboxylic acid containing peptides. Tetrahedron 50, 1717-1730.

Korn, A.; Rudolph-Böhner, S.; Moroder, L. (1994) A convenient synthesis of optically pure (2R,3R)-2,3-epoxysuccinyl-dipeptides. Tetrahedron 50, 8381-8392.

Leusch, A.; Jungblut, P. W.; Moroder, L. (1994) Design and synthesis of carboranyl peptides as carriers of 1,2-dicarbadodecaborane clusters. Synthesis, 305-308.

Moroder, L.; Romano, R. (1994) Synthesis, conformational and biological properties of lipophilic derivatives of gastrin and cholecystokinin peptides. Pure & Appl. Chem. 66, 2111-2114.

Musiol, H.-J.; Grams, F., Rudolph-Böhner, S.; Moroder, L. (1994) On the synthesis of phosphonamidate peptides. J. Org. Chem. 59, 6144-6146.

Musiol, H.-J.; Siedler, F.; Quarzago, D.; Moroder, L. (1994) Redox-active bis-cysteinyl-peptides. I. Synthesis of cyclic cystinyl-peptides by conventional methods in solution and on solid supports. Biopolymers 34, 1553-1562.

Rudolph-Böhner, S.; Mierke, D. F.; Moroder, L. (1994) Molecular structure of the cyanobacterial tumor promoting microcystins. FEBS Lett. 349, 319-323.

Siedler, F.; Quarzago, D.; Rudolph-Böhner, S.; Moroder, L. (1994) Redox-active bis-cysteinyl-peptides. II. Comparative study on the sequence-dependent tendency to disulfide loop formation. Biopolymers 34, 1563-1572.

Publications in Journals 1993

Grams, F.; Huber, R.; Kress, L. F.; Moroder, L.; Bode, W. (1993): Activation of snake venom metalloproteinases by a cysteine switch-like mechanism. FEBS Lett. 335, 76-80.

Moroder, L.; Romano, R.; Guba, W.; Mierke, D. F.; Kessler, H.; Delporte, C.; Winand, J.; Christophe, J. (1993) New evidence for a membrane-bound pathway in hormone receptor binding. Biochemistry 32, 13551-13559.

Romano, R.; Bayerl, T. M.; Moroder, L. (1993) Lipophilic derivatization and its effect on the interaction of cholecystokinin (CCK)-nonapeptide with phospholipids. Biochim. Biophys. Acta 1151, 111-119.

Siedler, F.; Rudolph-Böhner, S.; Doi, M.; Musiol, H.-J.; Moroder, L. (1993) Redox potentials of active site bis-cysteinyl fragments of thiol-protein oxidoreductases. Biochemistry 32, 7488-7495.

Rudolph-Böhner, S.; Wu, J.-T.; Moroder, L. (1993) Identification and characterization of microcystin-LY from Microcystis Aeruginosa (Strain 298). Biol. Chem. Hoppe-Seyler 374, 635-640.

Korn, A.; Rudolph-Böhner, S.; Moroder, L.; Hiller, W. (1993) Synthesis and X-ray crystal structure of benzyl-(-)-(2S)-1-trityl-2-aziridinecarboxylate. Z. Naturforsch. 48b, 1146-1148.

Moroder, L.; Musiol, H.-J.; Köcher, K.; Bali, J.-P.; Schneider, C. H.; Guba, W.; Müller, G.; Mierke, D. F.; Kessler, H. (1993) Synthetic immunogens. The effect of the conformational space on biological and immunological responses to dimeric hormone constructs. Eur. J. Biochem. 212, 325-333.

Moroder, L.; Romano, R.; Weyher, E.; Svoboda, M.; Christophe, J. (1993) Circular dichroism study on fully bioactive CCK-peptides. Z. Naturforsch. 48b, 1419-1430.

Romano, R.; Dufresne, M.; Prost, M.-C.; Bali, J.-P.; Bayerl, T. M.; Moroder, L. (1993) Peptide hormone - membrane interactions. Intervesicular transfer of lipophilic gastrin derivatives to artificial membranes and their bioactivities. Biochim. Biophys. Acta 1145, 235-242.

Moroder, L.; D‘Ursi, A.; Picone, D.; Amodeo, P.; Temussi, P. A. (1993) Solution conformation of CCK-9, a cholecystokinin analog. Biochem. Biophys. Res. Commun. 190, 741-746.

Terness, P.; Moroder, L.; Marx, U.; Roelcke, D.; Welschof, M. (1993) IgG-mediated suppression of autoimmune B-cells. An indiotype-independent immunoregulatory mechanism. J. Immunol. 150, A240.

Publications in Journals 1992

Gemeiner, M.; Leidinger, E.; Miller, I.; Moroder, L. (1992) Immunomodulatory activity of 1,2-di-fattyacyl-3-mercaptoglycerol adducts. Biol. Chem. Hoppe-Seyler 373, 1085-1094.

Hübener, G.; Göhring, W.; Musiol, H.-J.; Moroder, L. (1992) Na-Trifluoroacetylation of N-terminal hydroxyamino acids. A new side reaction in peptide synthesis. Peptide Res. 5, 287-292.

Hadjiivanova, C.; Dufresne, M.; Poirot, S.; Sozzani, P.; Vaysse, N.; Moroder, L.; Fourmy, D. (1992) Pharmacological and biochemical characterization of cholecystokinin/gastrin receptors in developing rat pancreas. Age-related expression of distinct receptor glycoforms. Eur. J. Biochem. 204, 273-279.

Papini, A.; Rudolph, S.; Siglmüller, G.; Musiol, H.-J.; Göhring, W.; Moroder, L. (1992) Alkylation of histidine with maleimido-compounds. Int. J. Peptide Protein Res. 39, 348-355.

Romano, R.; Musiol, H.-J.; Weyher, E.; Dufresne, M.; Moroder, L. (1992) Peptide hormone - membrane interactions. The aggregational and conformational state of lipo-gastrin derivatives and their receptor binding affinity. Biopolymers 32, 1545-1558.

Moroder, L.; Papini, A.; Siglmüller, G.; Köcher, K.; Dörrer, E.; Schneider, C. H. (1992) Induction and detection of anti-peptide antibody specificity is critically affected by the mode of hapten presentation. Biol. Chem. Hoppe-Seyler 373, 315-321.

Moroder, L.; Musiol, H.-J.; Scharf, R. (1992) Aziridine-2-carboxylic acid. A reactive amino acid unit for a new class of cysteine-proteinase inhibitors. FEBS Lett. 299, 51-53.

Siedler, F.; Rudolph, S.; Musiol, H.-J.; Moroder, L. (1992) Synthesis of neo-glycosylated L-alanyl-D-isoglutamine derivatives as potential immunoadjuvants. Peptide Res. 5, 39-47.

Moroder, L.; Weyher, E.; D‘Ursi, A.; Picone, D.; Temussi, P. A. (1992) CD and NMR conformational studies on cholecystokinin peptides. Regul. Peptides 40, 213.

Publications in Journals 1991

Tahiri-Jouti, N.; Dufresne, M.; Viguerie, N.; Fourmy, D.; Esteve, J.-P.; Rivier, J.; Moroder, L.; Susini, C.; Vaysse, N. (1991) Somatostatin-28 interacts with CCK receptor in brain and pancreas. Neuropeptides 19, 65-71.

Winand, J.; Poloczek, P.; Delporte, C.; Moroder, L.; Svoboda, M.; Christophe, J. (1991) Functional cholecystokinin receptors are distinguished kinetically by biotinyl-Tyr-Gly-(Thr-28,Nle-31)CCK(25-33) in rat pancreatic acini. Biochim. Biophys. Acta 1080, 181-190.

Wünsch, E.; Moroder, L.; Göhring-Romani, S.; Musiol, H.-J.; Göhring, W.; Scharf, R. (1991) Fully synthetic immunogens. Part II. Studies on parallel dimerization of the human IgG1 hinge fragment 225-232 with N- and C-terminal gastrin related extensions. Int. J. Peptide Protein Res. 37, 61-71.

Wünsch, E.; Moroder, L.; Hübener, G.; Musiol, H.-J.; von Grünigen, R.; Göhring, W.; Scharf, R.; Schneider, C. H. (1991) Fully synthetic immunogens. Part III. Synthesis of hinge peptide/gastrin conjugates and their immunological properties. Int. J. Peptide Protein Res. 37, 90-102.

von Grünigen, R.; Siglmüller, G.; Papini, A.; Köcher, K.; Traving, B.; Göhring, W.; Moroder, L. (1991) Enzyme immunoassay with captured hapten. A sensitive gastrin assay with biotinyl-gastrin derivatives. Biol. Chem. Hoppe-Seyler 372, 163-172.

Kobayashi, Y.; Sato, A.; Takashima, H.; Tamaoki, H.; Nishimura, S.; Kyogoku, Y.; Ikenaka, K.; Kondo, T.; Mikoshiba, K.; Hojo, H.; Aimoto, S.; Moroder, L. (1991) A new a-helical motif in membrane active peptides. Neurochem. Int. 18, 525-534.

Moroder, L.; Bali, J.-P.; Kobayashi, Y. (1991) Synthetic immunogens. Part IV: Conformational studies on gastrin conjugates with the human immunoglobulin G1 hinge peptide 225-232/225‘-232‘. Biopolymers 31, 595-604.

Kobayashi, Y.; Takashima, H.; Tamaoki, H.; Kyogoku, Y.; Lambert, P.; Kuroda, H.; Chino, N.; Watanabe, T.; Kimura, T.; Sakakibara, S.; Moroder, L. (1991) The cystine stabilized a-helix. A common structural motif of ion channel blocking neurotoxic peptides. Biopolymers 31, 1213-1220.

Kessler, H.; Mronga, S.; Müller, G.; Moroder, L.; Huber, R. (1991) Conformational analysis of a IgG1 hinge peptide derivative in solution determined by NMR spectroscopy and refined by restrained molecular dynamics simulations. Biopolymers 31, 1189-1204.

Publications in Journals 1990

Christophe, J.; Winand, J.; Poloczek, P.; Delporte, C.; Svoboda, M.; Moroder, L. (1990) Cholecystokinin receptors are distinguished kinetically by Biotinyl-Tyr-Gly-(Thr-28,Nle-31)-CCK-(25-33) (BTG-CCK-9) in rat pancreatic acini. Digestion 46, 132-133.

Moroder, L.; Hübener, G.; Göhring-Romani, S.; Göhring, W.; Musiol, H.-J.; Wünsch, E. (1990) Fully synthetic immunogens. Part I. Kinetic studies on air oxidation of the human IgG1 bis-cysteinyl fragment 225-232. Tetrahedron 46, 3305-3314.

Moroder, L.; Musiol, H.-J.; Siglmüller, G. (1990) Synthesis of 1,2-diacetyl-3-thioglycerols for lipid modification of peptides and proteins. Synthesis 10, 889-892.

Miercke, D. F.; Pattaroni, C.; Delaet, N.; Toy, A.; Goodman, M.; Tancredi, T.; Motta, A.; Temussi, P. A.; Moroder, L.; Bovermann, G.; Wünsch, E. (1990) Cyclic hexapeptides related to somatostatin. Conformational analysis employing 1H-NMR and molecular dynamics. Int. J. Peptide Protein Res. 36, 418-432.

Pattaroni, C.; Lucietto, P.; Goodman, M.; Yamamoto, G.; Vale, W.; Moroder, L.; Gazerro, L.; Göhring, W.; Schmied, B.; Wünsch, E. (1990) Cyclic hexapeptides related to somatostatin: synthesis and biological testing. Int. J. Peptide Protein Res. 36, 401-417.

Publications in Journals 1989

Moroder, L.; Gobbo, M.; Becker, G.; Wünsch, E. (1989) Synthesis of thiol-functionalized N-acetylmuramyl peptide congeners suitable for their conjugation to target molecules. Biol. Chem. Hoppe-Seyler 370, 365-375.

Wünsch, E.; Moroder, L.; Lerchen, H. G.; Christophe, J.; Svoboda, M. (1989) Synthesis of cholecystokinin-related peptides and their biological properties. Biol. Chem. Hoppe-Seyler 370, 317-321.

Moroder, L.; Dufresne, M.; Göhring, W.; Wünsch, E.; Leidinger, E.; Gemeiner, M. (1989) Muramyl-peptide/gastrin conjugates as potential immunogens. Biol. Chem. Hoppe-Seyler 370, 1209-1214.

Krois, D.; Dufresne, M.; Neumann, H.; Moroder, L.; Wünsch, E. (1989) On the hypothetical protein F154 of the TTV1 virus/thermoproteus tenax. Part III. Immunolgical identification of the protein with anti-peptide antibodies. Biol. Chem. Hoppe-Seyler 371, 43-48.

Fourmy, D.; Lopez, P.; Poirot, S.; Jimenez, J.; Dufresne, M.; Moroder, L.; Powers, S. P.; Vaysse, N. (1989) A new probe for affinity labelling pancreatic cholecystokinin receptor with minor modification of its structure. Eur. J. Biochem. 185, 397-403.

Mammi, S.; Foffani, M. T.; Peggion, E.; Galleyrand, J. C.; Bali, J.-P.; Simonetti, M.; Göhring, W.; Moroder, L.; Wünsch, E. (1989) Conformational and biological properties of the Ala10-analogue of human des-Trp1,Nle12-minigastrin. Biochemistry 28, 7182-7188.

Wünsch, E.; Moroder, L.; Lerchen, H. G.; Svoboda, M.; Christophe, J. (1989) Biological properties of 23-Ser(O-2-desoxy-a-D-galactosyl)-CCK-[23-33] and CCK-[22-33]. Hepato-Gastroenterol. 36, 40.

Publications in Journals 1988

Robbebrecht, P.; Damien, C.; Moroder, L.; Coy, D. H.; Wünsch, E.; Christophe, J. (1988) Receptor occupancy and adenylate cyclase activation in rat liver and heart membranes by 10 glucagon analogs modified in Position 2, 3, 4, 25, 27 and/or 29. Regul. Pept. 21, 117-128.

Moroder, L. (1988) A new reagent for the preparation of glycoconjugates. Biol. Chem. Hoppe-Seyler 369, 381-385.

Wünsch, E.; Moroder, L.; Göhring-Romani, S.; Musiol, H. J.; Göhring, W.; Bovermann, G. (1988) Synthesis of the bis-cystinyl-fragment 225-232/225‘-232‘ of the human IgG1 hinge region. Int. J. Peptide Protein Res. 32, 368-383.

Publications in Journals 1987

Romani, S.; Moroder, L.; Wünsch, E. (1987) Synthesis of the trypsin fragment 10-25/75-88 of mouse nerve growth factor. I. The protected tetradecapeptide 75-88. Int. J. Peptide Protein Res. 29, 99-106.

Romani, S.; Moroder, L.; Göhring, W.; Scharf, R.; Wünsch, E.; Barde, Y. A.; Thoenen, H. (1987) Synthesis of the trypsin fragment 10-25/75-88 of mouse nerve growth factor. II. The unsymmetrical double chain cystine peptide. Int. J. Peptide Protein Res. 29, 107-117.

Mammi, S.; Mammi, N. J.; Foffani, M. T.; Peggion, E.; Moroder, L.; Wünsch, E. (1987) Conformation of human little-gastrin and minigastrin analogs in surfactant solution. Biopolymers 26 Suppl., 1-10.

Moroder, L.; Bovermann, G.; Mourier, G.; Göhring, W.; Gemeiner, M.; Wünsch, E. (1987) Studies on immunoassays of peptide factors. II. Fluorescence enzyme immunoassay for human little-gastrin. Biol. Chem. Hoppe-Seyler 368, 831-838.

Moroder, L.; Mourier, G.; Dufresne, M.; Bovermann, G.; Göhring, W.; Gemeiner, M.; Wünsch, E. (1987) Studies on immunoassays of peptide factors. III. Gastrin/iso-1-cytochrome c as immunogen for raising anti-gastrin antisera. Biol. Chem. Hoppe-Seyler 368, 839-848.

Moroder, L.; Mourier, G.; Bovermann, G.; Dufresne, M.; Göhring, W.; Gemeiner, M.; Wünsch, E. (1987) Studies on immunoassays of peptide factors. IV. New synthesis of a gastrin/peroxidase conjugate. Biol. Chem. Hoppe-Seyler 368, 849-853.

Moroder, L.; Tzougraki, C.; Göhring, W.; Mourier, G.; Musiol, H. J.; Wünsch, E. (1987) Studies on immunoassays of peptide factors. V. Synthesis of cholecystokinin-58-(1-11)/iso-1-cytochrome c conjugate. Biol. Chem. Hoppe-Seyler 368, 855-861.

Borin, G.; Calderan, A.; Ruzza, P.; Moroder, L.; Göhring, W.; Bovermann, G.; Wünsch, E. (1987) Synthesis of human (15-Nle)-little-gastrin-II and des-1-Trp-(12-Nle)-minigastrin-II. Biol. Chem. Hoppe-Seyler 368, 1363-1373.

Farack, U. M.; Reiter, J.; Gross, M.; Moroder, L.; Wünsch, E.; Loeschke, K. (1987) Influence of vasoactive intestinal peptide, secretin, and Ala-4,Val-5-secretin on the net movements of electrolytes, fluids and mucus in the rat colon in vivo. Scand. J. Gastroenterol. 22, Suppl. 139, 32-36.

Bali, J.-P.; Magous, R.; Lignon, M. F.; Dubreuil, P.; Galleyrand, J. C.; Moroder, L.; Martinez, J, (1987) Influence of peptide length and sulfation of gastrin on the acid secretory potency and receptor affinity. Gastroenterol. Clin. Biol. 11, 737.

Publications in Journals 1986

Mammi, S.; Goodman, M.; Peggion, E.; Foffani, M. T.; Moroder, L.; Wünsch, E. (1986) Conformational studies on gastrin related peptides by high resolution 1H-NMR. Int. J. Peptide Protein Res. 27, 145-152.

Wünsch, E.; Moroder, L.; Göhring, W.; Borin, G.; Calderan, A.; Bali, J.-P. (1986) Synthesis of human des-tryptophan-1,norleucine-12-minigastrin-II and its biological activities. FEBS Lett. 206, 203-207.

Gespach, C.; Bataille, D.; Vauclin, L.; Moroder, L.; Wünsch, E.; Rosselin, G. (1986) Secretin receptor activity in rat gastric glands. Binding studies, cAMP generation and pharmacology. Peptides 7 (Suppl.1) 155-163.

Peggion, E.; Foffani, M. T.; Wünsch, E.; Moroder, L.; Goodman, M.; Mammi, S. (1986) Interaction of calcium ions with gastrin fragments of increasing chain length. Biopolymers 25, 135-152.

Publications in Journals 1985

Wünsch, E.; Moroder, L.; Nyfeler, R.; Kalbacher, H.; Gemeiner, M. (1985) Zur Immunbestimmung von Peptidfaktoren. I. Mitteilung. Synthese von Na-Maleoyl-Peptidwirkstoffen. Biol. Chem. Hoppe-Seyler 366, 53-61.

Peggion, E.; Foffani, M. T.; Wünsch, E.; Moroder, L.; Borin, G.; Goodman, M.; Mammi, S. (1985) Conformational properties of gastrin fragments of increasing chain length. Biopolymers 24, 647-666.

Pallai, P. V.; Struthers, R. S.; Goodman, M.; Moroder, L.; Wünsch, E.; Vale, W. (1985) Partial retro-inverso analogues of somatostatin: pairwise modifications at residues 7 and 8 and at residues 8 and 9. Biochemistry 24, 1933-1941.

Romani, S.; Bovermann, G.; Moroder, L.; Wünsch, E. (1985) N-(2-Nitrobenzenesulfenyl)-saccharin: a useful reagent in peptide synthesis. Synthesis 5, 512-514.

Romani, S.; Moroder, L.; Bovermann, G.; Wünsch, E. (1985) On the use of five-membered heterocycles in peptide chemistry. Synthesis 8, 738-742.

Peggion, E.; Foffani, M. T.; Moroder, L.; Wünsch, E. (1985) Effect of self-association on the conformation of gastrin-related peptides. CD study on pGlu-(Glu)4-Ala-Tyr-Gly-Trp-Nle-Asp-Phe-amide. Biopolymers 24, 2029-2033.

Laburthe, M.; Couvineau, A.; Rouyer-Fessard, C.; Moroder, L. (1985) Interaction of PHM, PHI and 24-glutamine PHI with human VIP receptors from colonic epithelium. Comparison with rat intestinal receptors. Life Sci. 36, 991-995.

Moroder, L.; Wünsch, E. (1985) Methodological aspects of the chemical synthesis of VIP - secretin – peptides. Regul. Pept. 3 Suppl., 4.

Gespach, C.; Bataille, D.; Vauclin, N.; Moroder, L.; Wünsch, E.; Rosselin, G. (1985) Secretin receptor activity in rat gastric glands. Binding studies, cAMP generation and pharmacology. Regul. Pept. 3 Suppl., 30.

Publications in Journals 1984

Göhring, W.; Moroder, L.; Borin, G.; Lobbia, A.; Bali, J.-P.; Wünsch, E. (1984) Synthese von Gastrin-aktiven Peptiden. Untersuchungen zur Struktur-Wirkungsbeziehung des natürlichen Hormons Human-Little-Gastrin-I. Hoppe-Seyler‘s Z. Physiol. Chem. 365, 83-94.

Geiger, R.; Moroder, L.; Wünsch, E. (1984) Enzyme immunoassay of human gastrin. Fresenius Z. Anal. Chem. 317, 734-735.

Beglinger, C.; Solomon, T. E.; Gyr, K.; Moroder, L.; Wünsch, E. (1984) Exocrine pancreatic secretion in response to a new CCK-analog, CCK33 and caerulein in dogs. Regul. Pept. 8, 291-296.

Peggion, E.; Mammi, S.; Palumbo, M.; Moroder, L.; Wünsch, E. (1984) Interaction of metal ions with gastrointestinal hormones. Binding studies of Mg2+ to biologically active analogs of little-gastrin and minigastrin. Biopolymers 23, 1225-1240.

Geiger, R.; Moroder, L.; Wünsch, E. (1984) Zur Immunbestimmung von Peptidfaktoren. Neue, chemisch saubere Wege für den Gastrinimmunoassay. Tips Gastroenterol. Praxis 11, 9-12.

Geiger, R.; Moroder, L.; Wünsch, E. (1984) Cloning - an efficient improvement in immunoassays? Hepato-Gastroenterol. 31, 94.

Mourier, G.; Moroder, L.; Previero, A. (1984) Prevention of tryptophan oxidation during iodination of tyrosyl residues in peptides. Z. Naturforsch. 39b, 101-104.

Svoboda, M.; Lambert, M.; Moroder, L.; Christophe, J. (1984) One-step isocratic high-perfomance liquid chromatographic purification of radioiodinated and radioiodinated-photoactivable derivatives of cholecystokinin. J. Chromatogr. 296, 199-211.

Moroder, L.; Göhring, W.; Lucietto, P. L.; Scharf, R.; Wünsch, E. (1984) PHI: structure and biological activity. Biomed. Res. 5 Suppl., 41-48.

Publications in Journals 1983

Moroder, L.; Nyfeler, R.; Gemeiner, M.; Kalbacher, H.; Wünsch, E. (1983) Immunoassays of peptide hormones and their chemical aspects. Biopolymers 22, 481-486.

Kalbacher, H.; Moroder, L.; Wünsch, E. (1983) Chemische Aspekte zur Verbesserung von Immunoassays für Peptidhormone. Hoppe-Seyler‘s Z. Physiol. Chem. 364, 344.

Esteve, J. P.; Vaysse, N.; Susini, C.; Kunsch, J. M.; Fourmy, D.; Pradayrol, L.; Wünsch, E.; Moroder, L.; Ribet, A. (1983) Bimodal regulation of pancreatic exocrine function in vitro by somatostatin-28. Am. J. Physiol. 245, 208G-216G.

Moroder, L.; Göhring, W.; Lucietto, P. L.; Musiol, H. J.; Scharf, R.; Thamm, P.; Bovermann, G.; Wünsch, E.; Lundberg, J.; Tatemoto, K.; Mutt, V. (1983) Synthesis of the porcine intestinal peptide PHI and its 24-glutamine analogue. Hoppe-Seyler‘s Z. Physiol. Chem. 364, 1563-1584.

Werner, S.; Hulting, A. L.; Hökfelt, T.; Eneroth, P.; Tatemoto, K.; Mutt, V.; Moroder, L.; Wünsch, E. (1983) Effect of the peptide PHI-27 on prolactin release in vitro. Neuroendocrinol. 37, 476-478.

Laburthe, M.; Amiranoff, B.; Boige, N.; Rouyer-Fessard, C.; Tatemoto, K.; Moroder, L. (1983) Interaction of GRF with VIP receptors and stimulation of adenylate cyclase in rat and human intestinal epithelial membranes. Comparison with PHI and secretin. FEBS Lett. 159, 89-92.

Peggion, E.; Mammi, S.; Palumbo, M.; Moroder, L.; Wünsch, E. (1983) Interaction of calcium ions with peptide hormones of the gastrin family. Biopolymers 22, 2443-2457.

Moroder, L.; Göhring, W.; Nyfeler, R.; Scharf, R.; Thamm, P.; Wendlberger, G. (1983) Zur Synthese von Human-Little-Gastrin-I und dessen Leucin-15-, Norleucin-15- und Methoxinin-15-Analoga. Hoppe-Seyler‘s Z. Physiol. Chem. 364, 157-171.

Antoniotti, H.; Fagot-Revurat, P.; Chayvialle, J. A.; Moroder, L.; Pradayrol, L.; Wünsch, E.; Ribet, A. (1983) Measurement of somatostatins in rat tissues using sequence specific radioimmunoassays. Regul. Pept. 2 Suppl., 45.

Laburthe, M.; Amiranoff, B.; Boige, N.; Rouyer-Fessard, C.; Tatemoto, K.; Moroder, L. (1983) GRF interaction with VIP receptors in human and rat intestinal epithelial membranes. Comparison with PHI and secretin. Regul. Pept. 6, 314.

Esteve, J. P.; Vaysse, N.; Susini, C.; Fourmy, D.; Kunsch, J. M.; Pradayrol, L.; Wünsch, E.; Moroder, L.; Ribet, A. (1983) Regulation of in vitro exocrione pancreatic function by somatostatin. Diabetes & Metabolism 9, R15.

Pradayrol, L.; Antoniotti, H.; Fagot-Revurat, P.; Chayvialle, J. A.; Moroder, L.; Wünsch, E.; Ribet, A. (1983) Activation of somatostatin precursors in rat-tissues by conjugation of gel-permeation chromatography and sequence specific RIA. Gastroenterology 84, 1276.

Publications in Journals 1982

Moroder, L.; Göhring, W.; Borin, G.; Bali, J. P.; Previero, A.; Wünsch, E. (1982) Gastrin-related peptides and their biological properties. Acta Hepato-Gastroenterol. 29, 90.

Wünsch, E.; Moroder, L.; Nyfeler, R.; Jaeger, E. (1982) (Alkyldithio)carbonyl groups for protection of amino functions in peptide synthesis. Hoppe-Seyler‘s Z. Physiol. Chem. 363, 197-202.

Wünsch, E.; Moroder, L.; Gillessen, D.; Soerensen, U. B.; Bali, J.-P. (1982) Biological and immunological properties of human gastrin-I analogues. Hoppe-Seyler‘s Z. Physiol. Chem. 363, 665-669.

Moroder, L.; Göhring, W.; Thamm, P.; Wünsch, E.; Tatemoto, K.; Mutt, V.; Bataille, D. (1982) Total synthesis of PHI. Z. Naturforsch. 37b, 772-780.

Moroder, L.; Wünsch, E.; Vaysse, N.; Ribet, A. (1982) Synthesis of [8-norleucine]-somatostatin-28. Hoppe-Seyler‘s Z. Physiol. Chem. 363, 1247-1251.

Wünsch, E.; Moroder, L.; Romani, S. (1982) 1-(tert-Butylthio)-1,2-hydrazinedicarboxylic acid derivatives. New reagents for the introduction of the S-tert-butylthio group into cysteine and cysteine derivatives. Hoppe-Seyler‘s Z. Physiol. Chem. 363, 1461-1464.

Magous, R.; Bali, J.-P.; Moroder, L.; Previero, A. (1982) Effect of Nin-formylation of the tryptophan residue on gastrin (HG-13) binding and on gastric acid secretion. Eur. J. Pharm. 77, 11-16.

Previero, A.; Mourier, G.; Bali, J.-P.; Lignon, M. F.; Moroder, L. (1982) Na-Glycosylgastrin rlated pptides. Synthesis, caracterization and bological activity. Hoppe-Seylers‘s Z. Physiol. Chem. 363, 813-818.

Koulischer, D.; Moroder, L.; Deschodt-Lanckman, M. (1982) Degradation of cholecystokinin octapeptide, related fragments and analogs by human and rat plasma in vitro. Regul. Pept. 4, 127-139.

Koulischer, D.; Moroder, L.; Deschodt-Lanckman, M. (1982) Degradation of cholecystokinin octapeptide, related fragments and analogs by human and rat plasma in vitro. Arch. Int. Physiol. Biochim. Biophys. 90, B42-B43.

Magous, R.; Bali, J.-P.; Moroder, L. (1982) Gastrin receptor – Structure-binding relationships with peptides from gastrin family. Biol. Cell 45, SI199.

Lehnert, P.: Forell, M. M.; Spiessl, W.; Jaeger, E.; Moroder, L.; Wünsch, E. (1982) Interaction of secretin analogs and of VIP with secretin in the dog pancreas. Digestion 25, 26-27.

Esteve, J. P.; Vaysse, N.; Susini, C.; Fourmy, D.; Kunsch, J. M.; Pradayrol, L.; Wünsch, E.; Moroder, L.; Ribet, A. (1982) Bimodal regulation of pancreatic exocrine function in vitro by somatostatin-28. Digestion 25, 26-27.

Antoniotti, H.; Fagot-Revurat, P.; Pradayrol, L.; Chayvialle, J. A.; Moroder, L.; Wünsch, E.; Ribet, A. (1982) Specific determination of the N-terminal fragment of somatostatin-28 in rat pancreatic tissue. Digestion 25, 14.

Publications in Journals 1981

Wünsch, E.; Moroder, L.; Wilschowitz, L.; Göhring, W.; Scharf, R.; Gardner, J. D. (1981) Zur Totalsynthese von Cholecystokinin-Pankreozymin. Darstellung des verknüpfungsfähigen „Schlüsselfragments“ der Sequenz 24-33. Hoppe-Seyler‘s Z. Physiol. Chem. 362, 143-152.

Moroder, L.; Gemeiner, M.; Pradayrol, L.; Wünsch, E. (1981) On the identity of natural and synthetic somatostatin-28. Acta Hepato-Gastroenterol. 28, 67.

Moroder, L.; Gemeiner, M.; Göhring, W.; Jaeger, E.; Thamm, P.; Wünsch, E. (1981) New synthesis of somatostatin according to the S-tert-butylthiocysteine procedure. Biopolymers 20, 17-37.

Peggion, E.; Jaeger, E.; Knof, S.; Moroder, L.; Wünsch, E. (1981) Conformational aspects of gastrin-related peptides: a circular dichroism study. Biopolymers 20, 633-652.

Valet, G.; Raffael, A.; Moroder, L.; Wünsch, E.; Ruhenstroth-Bauer, G. (1981) Fast intracellular pH determination in single cells by flow-cytometry. Naturwissenschaften 68, 265-266.

Moroder, L.; Gemeiner, M.; Göhring, W.; Jaeger, E.; Musiol, J.; Scharf, R.; Stocker, H.; Wünsch, E.; Pradayrol, L.; Vaysse, N.; Ribet, A. (1981) Totalsynthese von Somatostatin-28. Hoppe-Seyler‘s Z. Physiol. Chem. 362, 697-716.

Moroder, L.; Wilschowitz, L.; Gemeiner, M.; Göhring, W.; Knof, S.; Scharf, R.; Thamm, P.; Gardner, J. D.; Solomon, T. E.; Wünsch, E. (1981) Zur Synthese von Cholecystokinin-Pankreozymin. Darstellung von [28-Threonin, 31-Norleucin]- und [28-Threonin, 31-Leucin]-Cholecystokinin-Pankreozymin-(25-33)-Nonapeptid. Hoppe-Seyler‘s Z. Physiol. Chem. 362, 929-942.

Lehnert, P.; Forell, M. M.; Jaeger, E.; Moroder, L.; Wünsch, E. (1981) Hydrokinetic activity of secretin and secretin analogues, modified in the N-terminal sequence, and of vasoactive intestinal peptide in the dog pancreas. Digestion 22, 85-88.

Wünsch, E.; Jaeger, E.; Moroder, L.; Peggion, E.; Palumbo, M. (1981) Somatostatin-28. A conformational analysis. Biopolymers 20, 1741-1745.

Valet, G.; Raffael, A.; Moroder, L.; Wünsch, E.; Ruhenstroth-Bauer, G. (1981) Fast intracellular pH determination by flow-cytometry. Cytometry 2, 133-134.

Valet, G.; Raffael, A.; Ormerod, M.; Warnecke, H.; Benker, G.; Moroder, L.; Wünsch, E.; Ruhenstroth-Bauer, G. (1981) Antigens and the intracellular pH as sensitive markers for flow cytometric detection of tumor cells. Cytometry 2, 134.

Wünsch, E.; Moroder, L.; Göhring, W.; Thamm, P.; Scharf, R. (1981) Studies on enzymatic methods for processing hybrid proteins produced by recombinant DNA technology. Hoppe-Seyler‘s Z. Physiol. Chem. 362, 1285-1287.

Wünsch, E.; Moroder, L.; Keller, O. (1981) Synthesis of 2-(trimethylsilyl)ethyloxycarbonyl-amino acids and their use in peptide chemistry. Hoppe-Seyler‘s Z. Physiol. Chem. 362, 1289-1292.

Gespach, C.; Bataille, D.; Vauclin, N.; Rosselin, G.; Moroder, L.; Wünsch, E. (1981) Secretin binding sites coupled with adenylate cyclase in rat fundic membranes. Peptides 2 (Suppl. 2) 247-251.

Publications in Journals 1980

Moroder, L.; Jaeger, E.; Drees, F.; Gemeiner, M.; Knof, S.; Stelzel, H. P.; Thamm, P.; Bataille, D.; Domschke, S.; Schlegel, W.; Schulz, I.; Wünsch, E. (1980) Structure - function studies on gastrointestinal hormones. I. Synthesis of secretin analogs and their biological and immunological properties. Bioorg. Chem. 9, 27-54.

Moroder, L.; Gemeiner, M.; Göhring, W.; Jaeger, E.; Knof, S.; Scharf, R.; Thamm, P.; Wilschowitz, L.; Gardner, J. D.; Wünsch, E. (1980) A new synthesis of cholecystokinin-pancreozymin active peptides. Acta Hepato-Gastroenterol. 27, 72.

Peggion, E.; Jaeger, E.; Knof, S.; Moroder, L.; Wünsch, E. (1980) Circular dichroism studies on the conformation of gastrin related peptides. Regul. Pept. 1 Suppl., 86.

Gemeiner, M.; Moroder, L.; Pradayrol, L.; Wünsch, E. (1980) Total synthesis of porcine big-somatostatin (somatostatin-28). Regul. Pept. 1 Suppl., 41.

Wünsch, E.; Moroder, L.; Gemeiner, M.; Jaeger, E.; Ribet, A.; Pradayrol, L.; Vaysse, N. (1980) Totalsynthese von Somatostatin-28 (Big-Somatostatin). Z. Naturforsch. 35b, 911-919.

Chessa, G.; Filippi, B.; Borin, G.; Moroder, L.; Palumbo, M.; Marchiori, F. (1980) Inhibition of the cytochrome c/cytochrome c oxidase system by cytochrome c derivatives and related fragments. Hoppe-Seyler‘s Z. Physiol. Chem. 361, 1077-1091.

Publications in Journals 1979

Propst, F.; Moroder, L.; Wünsch, E.; Hamprecht, B. (1979) Influence of peptide hormones on the level of cyclic AMP in neuroblastoma x glioma hybrid cells. Acta Neurol. Belgica 79, 57.

Propst, F.; Moroder, L.; Wünsch, E.; Hamprecht, B. (1979) The influence of secretin, glucagon and other peptides, of amino acids, prostagladin endoperoxide analogues and diazepam on the level of adenosine 3‘,5‘-cyclic monophosphate in neuroblastoma x glioma hybrid cells. J. Neurochem. 32, 1495-1500.

Moroder, L.; Wilschowitz, L.; Jaeger, E.; Knof, S.; Thamm, P.; Wünsch, E. (1979) Synthese von Tyrosin-O-sulfat-haltigen Peptiden. Hoppe-Seyler‘s Z. Physiol. Chem. 360, 787-790.

Wendlberger, G.; Moroder, L.; Hallett, A.; Wünsch, E. (1979) Zur Synthese von Human-Big-Gastrin-I und seinem 32-Leucin-Analogon. 1. Mitteilung. Darstellung der Teilsequenzen 28-34, 23-27, 21-22 und 15-20. Mh. Chem. 110, 1301-1315.

Wendlberger, G.; Moroder, L.; Thamm, P.; Wilschowitz, L.; Wünsch, E. (1979) Zur Synthese von Human-Big-Gastrin-I und seinem 32-Leucin-Analogon. 2. Mitteilung. Darstellung der Teilsequenzen 9-14 und 1-8. Mh. Chem. 110, 1317-1330.

Lehnert, P.; Forell, M. M.; Jaeger, E.; Moroder, L. and Wünsch, E. (1979) Comparison of the biological activity of secretin and some related peptides. Dan. Med. Bull. 26, Suppl. 1, 20.

Wendlberger, G.; Moroder, L.; Hallett, A.; Wünsch, E. (1979) Zur Synthese von Human-Big-Gastrin-I und seinem 32-Leucin-Analogon. 3. Mitteilung. Darstellung der allseits geschützten Gesamtsequenzen. Mh. Chem. 110, 1407-1428.

Publications in Journals 1978

Wünsch, E.; Moroder, L.; Thamm, P.; Brown, J.; Pederson, R. (1978) GIP structure - a still unsolved problem. Acta Hepato-Gastroenterol. 25, 504.

Moroder, L.; Drees, F.; Jaeger, E.; Wünsch, E. (1978) Zur Synthese von [11-Leucin]-Human-Minigastrin-I. I. Mitteilung. Darstellung der Gesamtsequenz. Hoppe-Seyler‘s Z. Physiol. Chem. 359, 147-153.

Jaeger, E.; Thamm, P.; Schmidt, I.; Knof, S.; Moroder, L.; Wünsch, E. (1978) Zur Synthese von [11-Leucin]-Human-Minigastrin-I. II. Mitteilung. Reindarstellung des synthetischen Tridekapeptidamids sowie Isolierung und Strukturaufklärung eines Synthese-Nebenproduktes. Hoppe-Seyler‘s Z. Physiol. Chem. 359, 155-164.

Moroder, L.; Hallett, A.; Thamm, P.; Wilschowitz, L.; Brown, J. C.; Wünsch, E. (1978) Studies on gastric inhibitory polypeptide. Synthesis of the octatriacontapeptide GIP-1-38 with full insulinotropic activity. Scand. J. Gastroenterol. 13 (Suppl. 49) 129.

Publications in Journals 1977

Mitznegg, P.; Domschke, W.; Sprügel, W.; Domschke, S.; Subramanian, N.; Wünsch, E.; Moroder, L.; Demling, L. (1977) Enkephalins inhibit intestinal motility: mode of action. Acta Hepato-Gastroenterol. 24, 109-110.

Sprügel, W.; Mitznegg, P.; Domschke, W.; Domschke, S.; Wünsch, E.; Moroder, L.; Demling, L. (1977) Direct inhibitory effects of enkephalins on contractile responses in the guinea pig ileum. Gastroenterology 72, 1135

Wahlström, A.; Brandt, M.; Moroder, L.; Wünsch, E.; Lindeberg, G.; Ragnarsson, U.; Terenius, L.; Hamprecht, B. (1977) Peptides related to b-lipotropin with opioid activity. Effects on levels of adenosine 3‘:5‘-cyclic monophosphate in neuroblastoma x glioma hybrid cells. FEBS Lett. 77, 28-32.

Wünsch, E.; Wendlberger, G.; Hallett, A.; Jaeger, E.; Knof, S.; Moroder, L.; Scharf, R.; Schmidt, I.; Thamm, P.; Wilschowitz, L. (1977) Zur Totalsynthese des Human-Big-Gastrins-I und seines 32-Leucin-Analogons. Z. Naturforsch. 32c, 495-506.

Moroder, L.; Borin, G.; Filippi, B.; Stivanello, D.; Marchiori, F. (1977) Studies on cytochrome c. XII. Synthesis of the protected undecapeptide (sequence 66-67) and pentadecapeptide (sequence 66-80) of horse heart cytochrome c. Int. J. Peptide Protein Res. 10, 81-88.

Moroder, L.; Jaeger, E.; Wünsch, E.; Schulz, I.; Schlegel, W.; Bataille, D. (1977) Biological and immunological properties of secretin analogues. Acta Hepato-Gastroenterol. 24, 489.

Borin, G.; Filippi, B.; Moroder, L.; Santoni, C.; Marchiori, F. (1977) Kinetic and conformational studies on some partially synthetic ribonuclease S‘ analogues modified in position 8. Int. J. Peptide Protein Res. 10, 27-38.

Publications in Journals 1976

Brandt, M.; Gullis, R. J.; Fischer, K.; Buchen, C.; Hamprecht, B., Moroder, L.; Wünsch, E. (1976) Enkephalin regulates the levels of cyclic nucleotides in neuroblastoma x glioma hybrid cells. Nature 262, 311-313.

Brandt, M.; Fischer, K.; Moroder, L.; Wünsch, E.; Hamprecht, B. (1976) Enkephalin evokes biochemical correlates of opiate tolerance and dependence in neuroblastoma x glioma hybrid cells. FEBS Lett. 68, 38-40.

Wünsch, E.; Wendlberger, G.; Hallett, A.; Jaeger, E.; Moroder, L.; Thamm, P.; Wilschowitz, L. (1976) Total synthesis of human big-gastrin-I and the Leu32-analogue. Acta Hepato-Gastroenterol. 23, 303.

Zieglgänsberger, W.; Fry, J. P.; Herz, A.; Moroder, L.; Wünsch, E. (1976) Enkephalin-induced inhibition of cortical neurones and the lack of this effect in morphine tolerant/dependent Rats. Brain Res. 115, 160-164.

Wünsch, E.; Jaeger, E.; Moroder, L.; Demling, L.; Domschke, W.; Reiss, M. (1976) Radioimmunoassay für Sekretin. Hoppe-Seyler‘s Z. Physiol. Chem. 357, 1417-1420.

Moroder, L.; Wackerle, L.; Wünsch, E. (1976) Fluorameisensäure-1-adamantylester, ein neues Reagenz zur Einführung der 1-Adamantyloxycarbonyl-Schutzgruppe. Hoppe-Seyler‘s Z. Physiol. Chem. 357, 1647-1650.

Moroder, L.; Hallett, A.; Wünsch, E.; Keller, O.; Wersin, G. (1976) Di-tert-Butyldicarbonat: ein vorteilhaftes Reagenz zur Einführung der tert-Butyloxycarbonyl-Schutzgruppe. Hoppe-Seyler‘s Z. Physiol. Chem. 357, 1651-1653.

Urbach, H. J.; Domschke, W.; Reiß, M.; Domschke, S.; Rosselin, G.; Wünsch, E.; Jaeger, E.; Moroder, L.; Demling, L. (1976) Superior immunoreactivity of 125I-(desamino-Tyr-bAla)-secretin with rabbit anti-secretin sera compared to 125I-secretin and 125I-6-tyrosyl-secretin. Horm. Metab. Res. 8, 459-461.

Filippi, B.; Borin, G.; Moroder, L.; Marchiori, F. (1976) Near-ultraviolet difference absorption and circular dichroism studies on partially synthetic ribonucleases S‘. Biochim. Biophys. Acta 454, 514-523.

Filippi, B.; Borin, G.; Moroder, L.; Marchiori, F. (1976) Far-ultraviolet difference absorption and circular dichroism studies on partially synthetic ribonucleases S‘. Biochim. Biophys. Acta 454, 524-538.

Publications in Journals 1975

Borin, G.; Marchiori, F.; Moroder, L.; Scoffone, E. (1975) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. Part XVII. Synthesis and guanidination of (Lys-4,Ala-7,Orn-10)- and (Ala-7,Orn-10)-S-peptide. Gazz. Chim. Ital. 105, 137-147.

Filippi, B.; Moroder, L.; Borin, G.; Samartsev, M.: Marchiori, F. (1975) Relation between structure and function in some partially synthetic ribonucleases S‘. Enzymic and spectroscopic investigation on (Orn-10,Asn-14)-RNase S‘ and 1e,7e,10d-triguanidino- (Orn-10,Asn-14)-RNase S‘. Eur. J. Biochem. 52, 65-76.

Moroder, L.; Filippi, B.; Borin, G.; Marchiori, F. (1975) Studies on cytochrome c. X. Synthesis of Na-benzyloxycarbonyl-(Thr-107)-dotetracontapeptide (sequence 67-108) of baker‘s yeast iso-I-cytochrome c. Biopolymers 14, 2061-2074.

Moroder, L.; Filippi, B.; Borin, G.; Marchiori, F. (1975) Studies on cytochrome c. XI. Circular dichroism studies on synthetic peptides related to the C-terminal region of baker‘s yeast iso-I-cytochrome c. Biopolymers 14, 2075-2093.

Publications in Journals 1974

Moroder, L.; Borin, G.; Marchiori, F. and Scoffone, E. (1974) Untersuchungen über Cytochrom C. IX. Eine neue Synthese der Sequenz 93-108 des Iso-I-cytochroms C aus Bäckerhefe. Liebigs Ann. Chem. 213-224.

Borin, G.; Marchiori, F.; Moroder, L.; Rocchi, R.; Scoffone, E. (1974) Synthesis of analogs of the N-terminal eicosapeptide sequence of ribonuclease A. Part. XVI. Synthesis and guanidination of (Orn-10,Leu-11)- and (Orn-10,Lys-11)-S-peptide. Int. J. Peptide Protein Res. 6, 329-335.

Marchiori, F.; Borin, G.; Moroder, L.; Scoffone, E. (1974) Relation between structure and function in some partially synthetic ribonucleases S‘. Part II. Kinetic determinations on (Orn-10,Glu-11)-, (Orn-10,Leu-11)- and (Orn-10,Lys-11)-ribonuclease S‘. Int. J. Peptide Protein Res. 6, 337-345.

Marchiori, F.; Borin, G.; Moroder, L. (1974) Studies on ribonuclease S‘. The role of lysine-7 for activation of S-protein. Int. J. Peptide Protein Res. 6, 419-434.

Filippi, B.; Borin, G.; Marchiori, F.; Moroder, L.; Scoffone, E. (1974) Relazione tra attività e struttura in RNase S‘ parzialmente sintetiche. Studi cinetici e conformazionali su (Orn-10,Asn-14)-RNase S‘. Chim. Ind. 56, 850.

Publications in Journals 1973

Moroder, L.; Borin, G.; Marchiori, F.; Scoffone, E. (1973) Studies on cytochrome c. Part I. Synthesis of the protected hexadecapeptide (sequence 1-16) of baker‘s yeast iso-I-cytochrome c. Biopolymers 12, 477-492.

Moroder, L.; Marchiori, F.; Borin, G.; Scoffone, E. (1973) Studies on cytochrome c. Part II. Synthesis of the protected heptapeptide (sequence 17-23) of baker‘s yeast iso-I-cytochrome c. Biopolymers 12, 493-505.

Moroder, L.; Borin, G.; Marchiori, F.; Scoffone, E. (1973) Studies on cytochrome c. Part III. Synthesis of the protected heneicosapeptide (sequence 24-44) of baker‘s yeast iso-I-cytochrome c. Biopolymers 12, 507-520.

Borin, G.; Moroder, L.; Marchiori, F.; Scoffone, E. (1973) Studies on cytochrome c. Part IV. Synthesis of the protected dodecapeptide (sequence 45-56) of baker‘s yeast iso-I-cytochrome c. Biopolymers 12, 521-534.

Borin, G.; Moroder, L.; Marchiori, F.; Scoffone, E. (1973) Studies on cytochrome c. Part V. Synthesis of the protected decapeptide (sequence 57-66) of baker‘s yeast iso-I-cytochrome c. Biopolymers 12, 693-700.

Moroder, L.; Marchiori, F.; Borin, G.; Scoffone, E. (1973) Studies on cytochrome c. Part VI. Synthesis of the protected pentadecapeptide (sequence 67-81) of baker‘s yeast iso-I-cytochrome c. Biopolymers 12, 701-720.

Moroder, L.; Borin, G.; Marchiori, F.; Scoffone, E. (1973) Studies on cytochrome c. Part VII. Synthesis of the protected undecapeptide (sequence 82-92) of baker‘s yeast iso-I-cytochrome c. Biopolymers 12, 721-728.

Moroder, L.; Marchiori, F.; Borin, G.; Scoffone, E. (1973) Studies on cytochrome C. Part VIII. Synthesis of the protected hexadecapeptide (sequence 93-108) of baker‘s yeast iso-I-cytochrome c. Biopolymers 12, 729-750.

Publications in Journals 1972

Borin, G.; Marchiori, F.; Moroder, L.; Rocchi, R.; Scoffone, E. (1972) On the role of the 4-6 N-terminal sequence in the ribonuclease S-peptide and S-protein association. Biochim. Biophys. Acta 271, 77-79.

Rocchi, R.; Borin, G.; Marchiori, F.; Moroder, L.; Peggion, E.; Scoffone, E.; Crescenzi, V.; Quadrifoglio, F. (1972) Interaction of S-protein with S-peptide and with synthetic S-peptide analogs. A spectroscopic and calorimetric investigation. Biochemistry 11, 50-57.

Marchiori, F.; Borin, G.; Moroder, L.; Rocchi, R.; Scoffone, E. (1972) Relation between structure and function in some partially synthetic ribonucleases S‘. I. Kinetic determinations. Biochim. Biophys. Acta 257, 210-221.

Borin, G.; Toniolo, C.; Moroder, L.; Marchiori, F.; Rocchi, R.; Scoffone, E. (1972) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. Part XV. Synthesis and guanidination of (Orn-10,Orn-12)-S-Peptide. Int. J. Peptide Protein Res. 4, 37-45.

Borin, G.; Moroder, L.; Marchiori, F.; Scoffone, E. (1972) Sintesi di frammenti peptidici corrispondenti all‘ intera sequenza primaria dell‘ iso-I-citocromo c di lievito. Chim. Ind. 54, 1139.




Scoffone, E.; Borin, G.; Moroder, L.; Marchiori, F. (1972) Approach to the total synthesis of a protein: baker‘s yeast iso-1-cytochrome c. Acta Vitaminol. Enzymol. 26, 204.

Moroder, L.; Borin, G.; Marchiori, F.; Scoffone, E. (1972) Synthetic peptides related to the entire sequence of yeast iso-I-cytochrome c. Biopolymers 11, 2191-2194.

Publications in Journals 1971

Borin, G.; Marchiori, F.; Rocchi, R.; Moroder, L.; Scoffone, E. (1971) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. XIV. Synthesis of (cyclopentyl-Gly-8,Orn-10)-S-peptide and related studies. Gazz. Chim. Ital. 101, 426-439.

Publications in Journals 1970

Moroder, L.; Hofmann, K. (1970) Studies on polypeptides. XLVI. Synthesis of a stably labeled, biologically active adrenocorticotropin fragment. J. Med. Chem. 13, 839-843.

Hofmann, K.; Andreatta, R.; Bohn, H.; Moroder, L. (1970) Studies on polypeptides. XLV. Structure - function studies in the corticotropin series. J. Med. Chem. 13, 339-345.

Publications in Journals 1969

Rocchi, R.; Scatturin, A.; Moroder, L.; Marchiori, F.; Tamburro, A. M.; Scoffone, E. (1969) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. XI. Synthesis and conformational studies of (Orn-10,Nle-13)-S-peptide. J. Am. Chem. Soc. 91, 492-496.

Rocchi, R.; Marchiori, F.; Moroder, L.; Borin, G.; Scoffone, E. (1969) Synthesis of peptide analogs of the N-terminal sequence of ribonuclease A. XIII. Synthesis of des-Lys-7-(Orn-10)- and des-Phe-8-(Orn-10)-S-peptides. J. Am. Chem. Soc. 91, 3927-3931.

Moroder, L.; Marchiori, F.; Rocchi, R.; Fontana, A.; Scoffone, E. (1969) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. XII. Synthesis of des-Lys-1-(Orn-10)-, des-Lys-1,Glu-2-(Orn-10)- and des-Lys-1,Glu-2,Thr-3-(Orn-10)-S-peptide. J. Am. Chem. Soc. 91, 3921-3926.

Rocchi, R.; Marchiori, F.; Moroder, L.; Borin, G.; Scoffone, E. (1969) Effetto di alcune modifiche nelle posizioni 4, 5, 6 e 7 delle ribonucleasi S‘. Chim. Ind. 51, 518.

Marchiori, F.; Rocchi, R.; Moroder, L.; Borin, G.; Scoffone, E. (1969) Sull‘ importanza del carattere aromatico del residuo in posizione 8 nell‘ associazione tra peptide S e proteina S. Chim. Ind. 51, 518.

Publications in Journals 1968

Tamburro, A. M.; Scatturin, A.; Moroder, L. (1968) Far-ultraviolet optical rotatory dispersion and circular dichroism studies of bovine pancreatic ribonuclease A. Biochim. Biophys. Acta 154, 583-585.

Rocchi, R.; Moroder, L.; Marchiori, F.; Ferrarese, E.; Scoffone, E. (1968) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. VIII. Synthesis of (Ser-4,Orn-10)- and (Ser-5,Orn-10)-eicosapeptides. J. Am. Chem. Soc. 90, 5885-5889.

Marchiori, F.; Rocchi, R.; Moroder, L.; Fontana, A.; Scoffone, E. (1968) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. IX. Synthesis of (Ser-6,Orn-10)- and (Pro-6,Orn-10)-eicosapeptides. J. Am. Chem. Soc. 90, 5889-5894.

Rocchi, R.; Marchiori, F.; Scatturin, A.; Moroder, L.; Scoffone, E. (1968) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. X. Synthesis of (Gly-8,Orn-10)-S-peptide. Gazz. Chim. Ital. 98, 1270-1283.

Publications in Journals 1967

Scoffone, E.; Marchiori, F.; Moroder, L.; Rocchi, R.; Scatturin, A.; Tamburro, A. M. (1967) Studi conformazionali su ribonucleasi parzialmente sintetiche. Chim. Ind. 49, 535.

Scoffone, E.; Marchiori, F.; Moroder, L.; Rocchi, R. (1967) L´impiego della sintesi chimica nell´indagine conformazionale della ribonucleasi A. Chim. Ind. 49, 968.

Marchiori, F.; Rocchi, R.; Moroder, L.; Vidali, G.; Scoffone, E. (1967) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. Part III. A New synthesis of the C-terminal octapeptide 13-20. J. Chem. Soc. (C) 89-91.

Scoffone, E.; Rocchi, R.; Marchiori, F.; Moroder, L.; Marzotto, A.; Tamburro, A. M. (1967) Synthesis of peptide analogs of the N-terminal eicosapeptide sequence of ribonuclease A. Part VII. Synthesis of (Ile-8,Orn-10)- and (Ala-8,Orn-10)-eicosapeptides. J. Am. Chem. Soc. 89, 5450-5455.

Marzotto, A.; Marchiori, F.; Moroder, L.; Boni, R.; Gazigna, L. (1967) Enzymatic activity of partially synthetic ribonucleases. Biochim. Biophys. Acta 147, 26-31.

Publications in Journals 1966

Fontana, A.; Marchiori, F.; Moroder, L.; Scoffone, E. (1966) New removal conditions of sulfenyl groups in peptide synthesis. Tetrahedron Lett. 26, 2985-2987.

Fontana, A.; Marchiori, F.; Moroder, L. (1966) Uso di N-dinitrofenilsulfenil-amminoacidi nella sintesi di peptidi. Cim. Ind. 48, 1227.

Fontana, A.; Marchiori, F.; Moroder, L. (1966) On the sulfenyl method for the N-protection in peptide synthesis: 2,4-dinitrophenylsulfenyl residue as N-protecting group. Ric. Sci. 36, 261-266.

Fontana, A.; Marchiori, F.; Moroder, L.; Scoffone, E. (1966) Protezione del gruppo amminico mediante residui solfenici nella sintesi di peptidi. Nota II. Metodi di rimozione. Gazz. Chim. Ital. 96, 1313-1321.

Rocchi, R.; Marchiori, F.; Moroder, L.; Fontana, A.; Scoffone, E. (1966) Sintesi di peptidi analoghi dell‘ eicosapeptide N-terminale della ribonucleasi A. Nota V. Sintesi del (Lys-10)-peptide S. Gazz. Chim. Ital. 96, 1537-1548.

Marchiori, F.; Rocchi, R.; Moroder, L.; Scoffone, E. (1966) Sintesi di peptidi analoghi dell‘ eicosapeptide N-terminale della ribonucleasi A. Nota VI. Sintesi del (Tyr-8, Orn-10)-peptide S. Gazz. Chim. Ital. 96, 1549-1559.

Scoffone, E.; Rocchi, R.; Marchiori, F.; Moroder, L.; Marzotto, A. (1966) Sintesi degli analoghi Tyr8,Orn10 e Lys10 dell´eicosapeptide N-terminale della ribonucleasi A. Chim. Ind. 48, 1223.

 
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