Publications

2016

Kank2 activates talin, reduces force  transduction across integrins and induces central adhesion formation.
Sun Z, Tseng HY, Tan S, Senger F, Kurzawa L, Dedden D, Mizuno N, Wasik AA, Thery M, Dunn AR, Fässler R. Nat Cell Biol. 2016 Sep;18(9):941-53. doi: 10.1038/ncb3402. Epub 2016 Aug 22. PMID: 27548916

2015

Side-binding proteins modulate actin filament dynamics.
Crevenna AH, Arciniega M, Dupont A, Mizuno N, Kowalska K, Lange OF, Wedlich-Söldner R, Lamb DC. Elife. 2015 Feb 23;4. doi: 10.7554/eLife.04599.

Structural insights into the cooperative remodeling of membranes by amphiphysin/BIN1
Julia Adam, Nirakar Basnet, Naoko Mizuno Sci Rep. 2015; 5: 15452. Published online 2015 Oct 21. doi: 10.1038/srep15452PMCID: PMC4614383

2014

Conformational Switching in PolyGln Amyloid Fibrils Resulting from a Single Amino Acid Insertion
Rick K. Huang, Ulrich Baxa, Gudrun Aldrian, Abdullah B. Ahmed, Joseph S. Wall, Naoko Mizuno, Oleg Antzutkin, Alasdair C. Steven, Andrey V. Kajava Biophys J. 2014 May 20; 106(10): 2134–2142. doi: 10.1016/j.bpj.2014.03.047 PMCID: PMC4052364

Architecture and ssDNA interaction of the Timeless-Tipin-RPA complex.
Witosch J, Wolf E, Mizuno N. Nucleic Acids Res. 2014 Nov 10;42(20):12912-27

Cofilin recruits F-actin to SPCA1 and promotes Ca2+-mediated secretory cargo sorting.
Kienzle C, Basnet N, Crevenna AH, Beck G, Habermann B, Mizuno N, von Blume J.; J Cell Biol. 2014 Sep 1;206(5):635-54.

Structural basis for the extended CAP-Gly domains of p150glued binding to microtubules and the implication for tubulin dynamics.
Wang Q, Crevenna AH, Kunze I, Mizuno N. Proc Natl Acad Sci U.S.A. 2014 111(31):11347-52.

2013

Molecular Basis of Tubulin Transport Within the Cilium by IFT74 and IFT81
Sagar Bhogaraju, Lukas Cajanek, Cécile Fort, Thierry Blisnick, Kristina Weber, Michael Taschner, Naoko Mizuno, Stefan Lamla, Philippe Bastin, Erich A. Nigg, Esben Lorentzen Science. Author manuscript; available in PMC 2015 Mar 15. Published in final edited form as: Science. 2013 Aug 30; 341(6149): 1009–1012. doi: 10.1126/science.1240985 PMCID: PMC4359902

MuB is an AAA+ ATPase that forms helical filaments to control target selection for DNA transposition.
Mizuno N, Dramicanin M, Mizuuchi M, Adam J, Wang Y, Han YW, Yang W, Steven AC, Mizuuchi K, Ramón-Maiques S.; Proc Natl Acad Sci U.S.A. 2013 110(27):E2441-50.

α-Synuclein Oligomers with Broken Helical Conformation Form Lipoprotein Nanoparticles.
Varkey J*, Mizuno N*, Hegde BG, Cheng N, Steven AC, Langen R.
J Biol Chem. 2013 288(24):17620-30. *Equally Contribution

2012

Remodeling of lipid vesicles into cylindrical micelles by alpha-synuclein in an extended alpha-helical conformation.
Mizuno N*, Varkey J, Kegulian NC, Hegde BG, Cheng N, Langen R*, Steven AC*.
J Biol Chem. 2012 287(35):29301-11. *Corresponding authors

Structural studies of ciliary components.
Mizuno N*, Taschner M, Engel BD, Lorentzen E*.
J Mol Biol. 2012 422(2):163-80. *Corresponding authors

Structural basis for iron piracy by pathogenic Neisseria.
Noinaj N, Easley NC, Oke M, Mizuno N, Gumbart J, Boura E, Steere AN, Zak O, Aisen P, Tajkhorshid E, Evans RW, Gorringe AR, Mason AB, Steven AC, Buchanan S.
Nature. 2012 483(7387):53-8.

2011

Structural Dependence of HET-s Amyloid Fibril Infectivity Assessed by Cryo Electron Microscopy.
Mizuno N, Baxa U and Steven AC. Proc Natl Acad Sci U.S.A. 2011 108(8):3252-57.

2010

Mechanism of breast cancer cytotoxicity by the triphenylphosphonium-conjugated redox agent mitoquinone: induction of autophagy and apoptosis.
V. Ashutosh Rao, Klein SR, Zielonka J, Mizuno N, Keller P, Joseph J, Kalyanaraman B, and Shacter E.
J Biol Chem. 2010 285(45):34447-59.

Membrane curvature induction and tubulation is a common feature of synucleins and apolipoproteins.
Varkey J, Isas JM, Mizuno N, Jensen MB, Bhatia VK, Jao CC, Petrlova J, Voss J, Stamou D, Steven AC, Langen R.
J Biol Chem. 2010 285(42):32486-93.

Multiple modes of endophilin-mediated conversion of lipid vesicles into coated tubes: implications for synaptic endocytosis.
Mizuno N, Jao C, Langen R and Steven AC.
J Biol Chem. 2010 285(30):23351-8.

The Antioxidant Transcription Factor Nrf2 Negatively Regulates Autophagy and Growth Arrest Induced by the Anticancer Redox Agent Mitoquinone.
V. Ashutosh Rao, Sarah R. Klein, Spencer J. Bonar, Jacek Zielonka, Naoko Mizuno, Jennifer S. Dickey, Paul W. Keller, Joy Joseph, Balaraman Kalyanaraman, Emily Shacter J Biol Chem. 2010 Nov 5; 285(45): 34447–34459. Published online 2010 Aug 30. doi: 10.1074/jbc.M110.133579PMCID: PMC2966059

2007

Three-dimensional structure of cytoplasmic dynein bound to microtubules.
Mizuno N, Narita A, Kon T, Sutoh K, Kikkawa M.
Proc Natl Acad Sci U S A. 2007 104(52):20832-7.

Molecular determination by electron microscopy of the dynein-microtubule complex structure.
Narita A, Mizuno N, Kikkawa M, Maéda Y.
J Mol Biol. 2007 372(5):1320-36.

Tau binding to MTs does not directly affect microtubule-based vesicle motility.
Morfini, G., Pigino, G., Mizuno, N., Kikkawa, M., and Brady, S.
J. Neurosci. Res. 2007 85(12):2620-30.

2005

Removal of tightly bound ADP induces distinct structural changes of the two tryptophan-containing regions of the ncd motor domain.
Morii, H., Shimizu, T., Mizuno, N., Edamatsu, M., Ogawa, K., Shimizu, Y., and Toyoshima, Y. Y.
J. Biochem. 2005 138(1):95-104.

2004

Dynein and kinesin share an overlapping microtubule-binding site.
Mizuno, N., Toba, S., Edamatsu, M., Watai-Nishii, J., Hirokawa, N., Toyoshima, Y. Y., and Kikkawa M.
EMBO J. 2004 23(13):2459-2467.

 
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