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MPI für Biochemie  

Protein Analysis
Friedrich Lottspeich

Kidney Cancer

 

Kidney Carcinoma

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Identification of tumour marker in kidney cancer using microdissected tissue 


Epithelial neoplasms are increasingly common making up 2 % of all adult malignancies today. Renal cell carcinoma is the most common type of kidney cancer. It accounts for more than 90% of malignant kidney tumors. In 30 % of the patients metastasis in lung, skeleton, liver or brain are already present at the time of diagnosis. Of the remaining patients with initially no metastasis, 30 – 50 % relapse after surgery and usually succumb to the disease. 


Currently no early diagnostic marker is available nor is it possible to predict which tumors metastasize into the lymph nodes or distant organs. The lack of understanding of the underlying molecular mechanisms may cause a broad variety in prognosis. 


Within the present project, possible tumor markers have been identified using the ICPL-technology in combination with micro-dissected tissue. It has been shown, that even low amounts of material which can be achieved during biopsies of human organs is plenty enough to detect pathological markers.