The project related department for Protein Analytics has been established in 1990 and is headed by Dr. Friedrich Lottspeich.
The primary focus of the group is in method development in protein analytics and proteomics. Mass spectrometry, amino acid sequencing, protocols for sample preparation and improved and more sensitive protein identification methods by mass spectrometry are established.
The ICPL-technology (Isotope coded protein label) has been developed as a powerful tool to identify and relatively quantify thousands of proteins within complex protein mixtures.
All these techniques are directly used in many collaborative projects within the institute, with universities and Max-Planck-Institutes throughout Germany
One biological research project is the Hypusin containing protein, its structure-function relationship and the elucidation of the function of this higly conserved protein.
The goal of the MONACO project focuses on the mode of action of new lead compounds for drug discovery from natural sources related to tradititional chinese medicine. A HepG2 cellline is treated with isolated natural compounds under standarized conditions, to elucidate the proteome profile.
Within the Kidney Cancer project tumour marker are identified, using microdissected tissue as source for proteome analysis.
Another tumour project deals with identification of marker proteins out of plasma from patients with Colon Carcinoma.
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