Publications
2011
Taschner, M., Bhogaraju, S., Lorentzen, E., (2011) Architecture and function of IFT complex proteins in ciliogenesis, Differentiation, Nov 23. Epub ahead of print
Taschner, M., Bhogaraju, S., Vetter, M., Morawetz, M., and Lorentzen, E., (2011) Biochemical mapping of interactions within the intraflagellar transport (IFT) B core complex: IFT52 binds directly to four other IFT-B subunits, J Biol Chem, 286(30):26344-52
Bhogaraju, S., Taschner, M., Morawetz, M., Basquin, C. and Lorentzen, E., (2011) Crystal structure of the intraflagellar transport complex 25/27, EMBO J., 30(10):1907-18
Malet, H., and Lorentzen, E., (2011) Mechanisms of RNA recruitment by the exosome. RNA Biology, 8(3):398-403
2010
Malet, H., Topf, M., Clare, D.K., Ebert, J., Bonneau, F., Basquin, J., Drazkowska, K., Tomecki, R., Dziembowski, A., Conti, E., Saibil, H.R. and Lorentzen, E., (2010) RNA channeling by the eukaryotic exosome EMBO rep., 11, 936-42 (COVER)
2009
Bonneau, F., Basquin, J., Ebert, J., Lorentzen, E., and Conti, E., (2009) The yeast exosome functions as a macromolecular cage to channel RNA substrates for degradation, Cell, 139(3):547-59
2008
Lorentzen, E., Basquin, J., and Conti, E., (2008), Structural organization of the RNA degrading exosome, Curr Opin Struct Biol, 18:1-5
Lorentzen, E., and Conti, E., (2008) Expression, reconstitution and structure of an archaeal RNA degrading exosome, Methods in Enzymology, 447: 417-35
Lorentzen, E., Basquin, J., Tomecki, R., Dziembowski, A., and Conti, E. (2008) Structure of the active subunit of the yeast exosome core, Rrp44: diverse modes of substrate recruitment in the RNase II nuclease family, Molecular Cell, 29(6):717-28.
Pauluhn, A., Ahmed, H., Lorentzen, E., Buchinger, S., Schomburg, D., Siebers, B., and Pohl, E. (2008) Crystal structure and stereochemical studies of KD(P)G aldolase from Thermoproteus tenax, Proteins, 72(1):35-43
2007
Lorentzen, E., Dziembowski, A., Seraphin, B., and Conti, E. (2007) RNA channeling by the archaeal exosome, EMBO rep, 8(5):470-6
Dziembowski, A., Lorentzen, E., Conti, E., and Seraphin, B. (2007) A single subunit, Dis3, is essentially responsible for yeast exosome core activity, Nat Struct Mol Biol, 14(1):15-22
2006
Oddone, A., Lorentzen, E., Basquin, J., Gasch, A., Rybin, V., Conti, E., and Sattler, M. (2006) Structural and biochemical characterisation of the yeast exosome component Rrp40, EMBO rep, 8(1):63-9
Bono, F., Ebert, J., Lorentzen, E., and Conti, E. (2006) The crystal structure of the exon-junction complex reveals how it maintains a stable grip on mRNA, Cell, 126(4):713-25
Lorentzen, E. and Conti, E. (2006) The exosome and the proteasome: nano-compartments for degradation, Cell, 125(4):651-4.
2005
Walter, P., Klein, F., Lorentzen, E., Klug, G. and Evguenieva-Hackenberg, E. (2006) Characterisation of native and reconstituted exosome complexes from the hyperthermophilic archaeon Sulfolobus solfataricus, Molecular Microbiology, 62(4):1076-89.
Lorentzen, E. and Conti, E. (2005) Structural basis of 3’-end RNA recognition and exoribonucleolytic cleavage by an exosome RNase PH core, Molecular Cell, 20:473-81
Portnoy, V., Evguenieva-Hackenberg, E., Klein, F., Lorentzen, E., Klug, G. and Schuster, G. (2005) RNA polyadenylation in Archaea: not observed in Haloferax while the exosome polynucleotidylates RNA in Sulfolobus, EMBO rep, 6(12):1188-93.
Lorentzen, E., Walter, P., Fribourg, S., Evguenieva-Hackenberg, E., Klug, G. and Conti, E., (2005), The archaeal exosome core is a hexameric ring structure with three catalytic subunits, Nat Struct Mol Biol, 12(7):575-81
Lorentzen, E., Siebers, B., Hensel, R. and Pohl, E., (2005) The mechanism of the Schiff Base Forming Fructose-1,6-bisphosphate Aldolase: Structural analysis of reaction intermediates, Biochemistry, 44(11):4222-9
2004
Walden, H., Taylor, G.L., Lorentzen, E., Pohl, E., Lilie, H., Schramm, A., Knura, T., Stubbe, K., Tjaden, B. and Hensel, R. (2004) Structure and Function of a Regulated Archaeal Triosephosphate Isomerase Adapted to High Temperature, J Mol Biol, 342(3):861-75
Lorentzen, E., Hensel, R., Knura, T., Ahmed, H. and Pohl, E. (2004) Structural Basis of Allosteric Regulation and Substrate Specificity of the Non-phosphorylating Glyceraldehyde-3-phosphate Dehydrogenase from Thermoproteus tenax, J Mol Biol, 341:815-828
Lorentzen, E., Siebers, B., Hensel R. and Pohl, E., (2004) Structure, Function and Evolution of the Archaeal Class I Fructose-1,6-bisphosphate Aldolase, Biochem. Soc. Trans, 32(Pt 2):259-63
2003
Vega, M.C., Lorentzen, E., Linden A. and Wilmanns, M. (2003) Evolutionary Markers in the (alpha/beta)8 Barrel Fold, Current Opinion in Chemical Biology, 7(6):694-701
Lorentzen, E., Pohl, E., Zwart, P., Stark, A., Russell, R.B., Knura, T., Hensel, R. and Siebers, B. (2003) Crystal Structure of an Archaeal Class I Aldolase and the Evolution of (alpha/beta)8 Barrel Proteins, J Biol Chem, 278(47):47253-60