Publications

2017

Ringer P, Weißl A, Cost AL, Freikamp A, Sabass B, Mehlich A, Tramier M, Rief M, Grashoff C. Multiplexing molecular tension sensors reveals piconewton force gradient across talin-1. Nature Methods 2017. [Epub 2017 Sep 18] »

Freikamp A, Mehlich A, Klingner C, Grashoff C. Investigating piconewton forces in cells by FRET-based molecular force microscopy. J. Struct. Biol. 2017 Jan; 197(1):37-42. [Epub 2016 Mar 12] »

2016

Freikamp A, Cost AL, Grashoff C. The Piconewton Force Awakens: Quantifying Mechanics in Cells. Trends Cell Biol. 2016 Nov; 26(11):838-847. [Epub 2016 Aug 17] »

2015

Austen K, Ringer P, Mehlich A, Chrostek-Grashoff A, Kluger C, Klingner C, Sabass B, Zent R, Rief M, Grashoff C. Extracellular rigidity sensing by talin isoform-specific mechanical linkages. Nat Cell Biol. 2015 Dec; 17(12):1597-1606. [Epub 2015 Nov 2] »

Cost AL, Ringer P, Chrostek-Grashoff A, Grashoff C. How to Measure Molecular Forces in Cells: A Guide to Evaluating Genetically-Encoded FRET-Based Tension Sensors. Cell Mol Bioeng. 2015; 8(1):96-105. [Epub 2014 Dec 2] »

2014

Leerberg JM, Gomez GA, Verma S, Moussa EJ, Wu SK, Priya R, Hoffman BD, Grashoff C, Schwartz MA, Yap AS. Tension-sensitive actin assembly supports contractility at the epithelial zonula adherens. Curr Biol. 2014 Aug 4; 24(15):1689-1699. [Epub 2014 Jul 24] »

2013

Kayser J, Haslbeck M, Dempfle L, Krause M, Grashoff C, Buchner J, Herrmann H, Bausch AR. The small heat shock protein Hsp27 affects assembly dynamics and structure of keratin intermediate filament networks. Biophys J. 2013 Oct 15; 105(8):1778-1785. »

Austen K, Kluger C, Freikamp A, Chrostek-Grashoff A, Grashoff C. Generation and Analysis of Biosensors to Measure Mechanical Forces Within Cells. Methods Mol Biol. 2013; 1066:169-184. »

Elad N, Volberg T, Patla I, Hirschfeld-Warneken V, Grashoff C, Spatz JP, Fässler R, Geiger B, Medalia O. The role of integrin-linked kinase in the molecular architecture of focal adhesions. J Cell Sci. 2013 Sep 15; 126(Pt 18):4099-4107. [Epub 2013 Jul 10] »

Moik D, Böttcher A, Makhina T, Grashoff C, Bulus N, Zent R, Fässler R. Mutations in the Paxillin-binding Site of Integrin-linked Kinase (ILK) Destabilize the Pseudokinase Domain and Cause Embryonic Lethality in Mice. J Biol Chem. 2013 Jun 28; 288(26):18863-18871. [Epub 2013 May 8] »

2012

Azimifar SB, Böttcher RT, Zanivan S, Grashoff C, Krüger M, Legate KR, Mann M, Fässler R. Induction of membrane circular dorsal ruffles requires co-signalling of integrin-ILK-complex and EGF receptor. J Cell Sci. 2012 Jan 15; 125(Pt 2):435-448. »

2011

Hoffman BD, Grashoff C, Schwartz MA. Dynamic molecular processes mediate cellular mechanotransduction. Nature. 2011 Jul 20; 475:316-323. »

2010

Patla I, Volberg T, Elad N, Hirschfeld-Warneken V, Grashoff C, Fassler R, Spatz JP, Geiger B, Medalia O. Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography. Nat Cell Biol. 2010 Sep; 12(9):909-915. [Epub 2010 Aug 8] »

Grashoff C, Hoffman BD, Brenner MD, Zhou R, Parsons M, Yang MT, McLean MA, Sligar SG, Chen CS, Ha T, Schwartz MA. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature. 2010 Jul 8; 466:263-266. »

Hortelano S, Lopez-Fontal R, Traves PG, Villa N, Grashoff C, Bosca L, Luque A. ILK mediates LPS-induced vascular adhesion receptor expression and subsequent leukocyte trans-endothelial migration. Cardiovasc Res. 2010 May 1; 86:283-292. [Epub 2010 Feb 17] »

2009

Stanchi F, Grashoff C, Nguemeni Yonga CF, Grall D, Fassler R, Van Obberghen-Schilling E. Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role the ILK kinase domain in the late stages of focal-adhesion maturation. J Cell Sci. 2009 Jun 1; 122:1800-1811. [Epub 2009 May 12] »

Bergmann S, Lang A, Rohde M, Agarwal V, Rennemeier C, Grashoff C, Preissner KT, Hammerschmidt S. Integrin-linked kinase is required for vitronectin-mediated internalization of Streptococcus pneumoniae by host cells. J Cell Sci. 2009 Jan 15; 122:256-267. »

2008

Maier S, Lutz R, Gelman L, Sarasa-Renedo A, Schenk S, Grashoff C, Chiquet M. Tenascin-C induction by cyclic strain requires integrin-linked kinase. Biochim Biophys Acta. 2008 Jun; 1783:1150-1162. [Epub 2008 Jan 26] »

2007

Lorenz K, Grashoff C, Torka R, Sakai T, Langbein L, Bloch W, Aumailley M, Fassler R. Integrin-linked kinase is required for epidermal and hair follicle morphogenesis. J Cell Biol. 2007 May 7; 177:501-513. »

2005

Gimona M, Grashoff C, Kopp P. Oktoberfest for adhesion structures. EMBO Rep. 2005 Oct; 6:922-926. »

2004

Grashoff C, Thievessen I, Lorenz K, Ussar S, Fassler R. Integrin-linked kinase: integrin's mysterious partner. Curr Opin Cell Biol. 2004 Oct; 16:565-571. »

2003

Grashoff C, Aszodi A, Sakai T, Hunziker EB, Fassler R. Integrin-linked kinase regulates chondrocyte shape and proliferation. EMBO Rep. 2003 Apr; 4:432-438. »

Sakai T, Li S, Docheva D, Grashoff C, Sakai K, Kostka G, Braun A, Pfeifer A, Yurchenco PD, Fassler R. Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev. 2003 Apr 1; 17:926-940. »

 
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