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MPI für Biochemie  

Modeling of Protein Complexes
Friedrich Förster

Publications

 

Publication List on ResearcherID Google Scholar

Publications:
  1. Chen Y, Hrabe T, Pfeffer S, Pauly O, Mateus D, Navab N, Förster F.
    Detection and Identification of macromolecular complexes in cryo-electron tomograms using support vector machines.
    IEEE International Symposium on Biomedical Imaging Proceedings, accepted (2012). 
  2. Leitner A, Reischl R, Walzthoeni T, Herzog F, Bohn S, Foerster F, Aebersold R.
    Expanding the chemical cross-linking toolbox by the use of multiple proteases and enrichment by size exclusion chromatography.
    Mol. Cell. Proteomics (2012). PubMed
  3. Lasker K*, Förster F*, Bohn S, Walzthoeni T, Villa E, Unverdorben P, Beck F, Aebersold R, Sali A, Baumeister W.
    Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach
    Proc. Natl. Acad. Sci. USA 109 1380-7 (2012). PubMed
    * equal contribution
  4. Hrabe T, Chen Y, Pfeffer S, Kuhn-Cuellar L, Mangold AV, Förster F.
    PyTom: a python-based toolbox for localization of macromolecules in cryo-electron tomograms and subtomogram analysis.
    J. Struct. Biol. (2011). PubMed
  5. Sakata E, Bohn S, Mihalache O, Kiss P, Beck F, Nagy I, Nickell S, Tanaka K, Saeki Y, Förster F, Baumeister W.
    Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy.
    Proc. Natl. Acad. Sci. USA 109 1479-84 (2012). PubMed
  6. Pathare GR, Nagy I, Bohn S, Unverdorben P, Hubert A, Körner R, Nickell S, Lasker K, Sali A, Tamura T, Nishioka T, Förster F, Baumeister W, Bracher A.
    The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together.
    Proc. Natl. Acad. Sci. USA 109 149-54 (2012). PubMed.
  7. Bohn S, Förster F.
    The 26S Proteasome.
    Handbook of Proteolytic Enzymes (2012), in press.
  8. Förster F, Villa E, Thomas D, Korinek A, Baumeister W.
    Structure determination of macromolecular complexes by cryo-electron microscopy in vitro and in situ.
    In: Comprehensive Biophysics (2012), in press.
  9. Lucic V, Baumeister W, Förster F.
    Studying the macromolecular machinery of cells in situ by cryo-electron tomography.
    In: Comprehensive Biophysics (2012), in press.
  10. Förster F, Sakata E.
    26S Proteasome structure and function.
    Encyclopedia of Biological Chemistry (2012), in press.
  11. Sakata E, Stengel F, Zhou M, Saeki Y, Förster F, Baumeister W, Tanaka K, Fukunaga K, Robinson CVR.
    The catalytic activity of Ubp6 enhances maturation of the proteasomal regulatory particle.
    Mol. Cell 42 637-49 (2011) PubMed
  12. Hrabe T, Förster F.
    Structure determination by Single Particle Cryo Electron Tomography.
    In: Encyclopedia of Life Sciences (2011). ELS
  13. Bohn S, Beck F, Sakata E, Walzthoeni T, Beck M, Aebersold R, Förster F, Baumeister W, Nickell S.
    Structure of the 26S proteasome from Schizosaccharomyces pombe at sub-nanometer resolution.
    Proc. Natl. Acad. Sci. USA 107:20992-7 (2010) PubMed
  14. Abrahams et al.
    "4D biology for health and disease" workshop report
    N. Biotechnol. (2010) PubMed
  15. Förster F, Villa E.
    Integration of cryo-EM with atomic and protein-protein interaction data
    Meth. Enzymol. 483:47-72 (2010) PubMed
  16. Förster F, Han BG, Beck, M.
    Visual Proteomics
    Meth. Enzymol. 483:215-43 (2010) PubMed
  17. Förster F,  Lasker K, Nickell S, Sali A, Baumeister W.
    Towards an integrated structural model of the 26S proteasome.
    Mol. Cell. Proteomics 9:1666-77 (2010). PubMed
  18. Förster F,  Lasker K, Beck F, Nickell S, Sali A, Baumeister W.
    An atomic model AAA-ATPase/20S core particle sub-complex of the 26S proteasome.
    Biochem. Biophys. Res. Commun. 388:228-233 (2009). PubMed
  19. Nickell S, Beck F, Scheres S, Korinek A, Förster F, Lasker K, Mihalache O, Sun N, Nagy I, Sali A, Plitzko JM, Carazo JM, Mann M, Baumeister W,
    Insights into the molecular architecture of the 26S proteasome.
    Proc. Natl. Acad. Sci. USA 106:11943-7 (2009). PubMed
  20. Förster F, Webb B, Tsuruta H, Agard DA, Sali A,
    Integration of small angle X-ray scattering data and modeling for structure determination of multidomain proteins and complexes.
    J.Mol.Biol. 382:1089-1106 (2008). PubMed
  21. Krukenberg KA, Förster F., Rice LM, Sali A, Agard DA,
    novel conformation of E. coli Hsp90 in solution: insights into the conformational dynamics of Hsp90.
    Structure, 16:755-65 (2008). PubMed
    Faculty of 1000
  22. Alber F, Förster F, Korkin K, Topf M, Sali A,
    Integrating Diverse Data for Structure Determination of Macromolecular Assemblies.
    Annu. Rev. Biochem., 77:443-477 (2008). PubMed
  23. Förster F, Pruggnaller S, Seybert A, Frangakis AS,
    Classification of Cryo-Electron Sub-Tomograms using Constrained Correlation.
    J. Struct. Biol. 161:276-286 (2008). PubMed
  24. Beck M, Lucic V, Förster F, Baumeister W, Medalia O,
    Snapshots of Nuclear Pore Complexes in Action Taken by Cryoelectron Tomography.
    Nature 449:611-615 (2007). PubMed
  25. Förster F, Hegerl R,
    Structure determination in situ by averaging of tomograms.
    Methods Cell Biol. 79:741-67 (2007). PubMed
  26. Ortiz J, Förster F, Kürner J, Linaroudis A, Baumeister W,
    Mapping 70S ribosomes in intact cells by cryo-electron tomography and pattern recognition.
    J. Struct. Biol. 156:334-41 (2006). PubMed
    Faculty of 1000
  27. Briggs JA, Grünewald K, Glass B, Förster F, Kräusslich HG, Fuller SD,
    The Mechanism of HIV-1 core assembly: insights from three-dimensional reconstructions of authentic virions.
    Structure 14:15-20 (2006). PubMed
    Faculty of 1000
  28. Lucic V, Förster F, Baumeister W,
    Structural studies by electron tomography: from cells to molecules.
    Annu. Rev. Biochem. 74:833-65 (2005). PubMed
  29. Förster F, Medalia O, Zauberman N, Baumeister W, Fass D,
    Retrovirus envelope protein complex structure in situ studied by cryo-electron tomography.
    Proc. Natl. Acad. Sci. U S A 102:4729-34 (2005) PubMed pdf
    Financial Times Deutschland
  30. Miao JW, Förster F, Levi O,
    Equally sloped tomography with oversampling reconstruction.
    Phys. Rev. B. 7205:2103-2106 (2005). link
  31. Lucic V, Yang T, Schweikert G, Förster F, Baumeister W,
    Morphological characterization of molecular complexes present in the synaptic cleft.
    Structure. 13:423-34 (2005). PubMed
    Faculty of 1000
  32. Nickell S, Förster F, Linaroudis A, Net WD, Beck F, Hegerl R, Baumeister W, Plitzko JM,
    TOM software toolbox: acquisition and analysis for electron tomography.
    J. Struct. Biol. 149:227-34 (2005). PubMed
  33. Beck M, Förster F, Ecke M, Plitzko JM, Melchior F, Gerisch G, Baumeister W, Medalia O,
    Nuclear pore complex structure and dynamics revealed by cryoelectron tomography.
    Science. 306:1387-90 (2004). PubMed
    Faculty of 1000
  34. Frangakis AS, Förster F,
    Computational exploration of structural information from cryo-electron tomograms.
    Curr. Opin. Struct. Biol. 14:325-31 (2004). PubMed
  35. Kurz P, Förster F, Nordstrom L, Bihlmayer G, Blugel S,
    Ab initio treatment of noncollinear magnets with the full-potential linearized augmented plane wave method.
    Phys. Rev. B. 69 085317 (2004). pdf
  36. Frangakis AS, Böhm J, Förster F, Nickell S, Nicastro D, Typke D, Hegerl R, Baumeister W,
    Identification of macromolecular complexes in cryoelectron tomograms of phantom cells.
    Proc. Natl. Acad. Sci. USA. 99:14153-8 (2002). PubMed
  37. Plitzko, JM, Frangakis, AS, Nickell, S, Förster, F, Gross, A, Baumeister, W,
    In vivo veritas: electron cryotomography of cells.
    Trends Biotech. 20 (8 Suppl.) S40-S44 (2002). link
Theses:
  1. PhD Thesis: Quantitative Analyse von Kryoelektronentomogrammen mittels Korrelationsmethoden TU Muenchen
  2. Master Thesis: Untersuchung von nichtkollinearem Magnetismus in ultraduennen Filmen