Maintaining genetic integrity plays a central role in the biology of all forms of life. The genome is constantly exposed to the risk of DNA damage by endogenous and environmental factors such as redox radicals, alkylating agents or high-energy radiation. To repair and maintain genetic information, various sophisticated pathways have evolved to cope with different types of DNA lesions. Defects in DNA repair cause several syndromes as well as cancer. Our knowledge of the molecular basis of oncogenesis is still limited and a comprehensive understanding is required to develop prophylactic measures or new therapies. The research group works on the structural and functional characterization of DNA repair mechanisms using X-ray crystallography as the main tool.