Publications

Publications 2005

Sasaki, T., Knyazev, P.G., Clout, N.J., Cheburkin, Y., Göhring, W., Ullrich, A., Timpl, R., and Hohenester, E. (2006) Structural Basis for Gas6-Axl Signalling. EMBO J.  25 (1), 80-87.

Stadler, C., Knyazev, P., Bange, J. and Ullrich, A. (2006) FGFR4 GLY388 Isotype Suppresses Motility of MDA-MB-231 Breast Cancer Cells by EDG-2 Gene Repression. Cell Signal.  18, 783-794.3

Szantai-Kis, C., Kövesdi, I., Erös, D., Banhegyi, P., Ullrich, A., Keri, G., and Örfi, L. (2006)
Prediction Oriented QSAR Modelling of EGFR Inhibition. Curr. Med. Chem. 13 (3), 277-287.

Erber, R., Eichelsbacher, U., Powajbo, V., Korn, T., Djonov, V., Lin, J., Hammes, H.-P., Grobholz, R., Ullrich, A. and Vajkoczy, P. (2006) EphB4 Controls Blood Vascular Morphogenesis During Postnatal Angiogenesis.
EMBO J.  25 (3), 628-641.

5.  Strebhardt, K., and Ullrich, A. (2006) Targeting Polo-Like Kinase 1 for Cancer Therapy. Nat. Rev. Cancer 6 (4), 321-330.

6.  Vajkoczy, P., Knyazev, P., Kunkel, A., Capelle, H.-H., Behrndt, S., von Tengg-Kobligk, H., Kiessling, F., Eichelsbacher, U., Essig, M., Read, T.-A., Erber, R., and Ullrich, A. (2006) Dominant-negative Inhibition of the Axl Receptor Tyrosine Kinase Suppresses Brain Tumor Cell Growth and Invasion, and Prolongs Survival. Proc. Natl. Acad. Sc. USA 103 (15), 5799-5804

7.  Sukocheva, O., Wadham, C., Albanese, N., Holmes, A., Verrier, E., Feng, F., Bernal, A., Derian, C.K., Ullrich, A., Vadas, M.A., and Xia, P. (2006) Estrogen Transactivates EGFR via the Sphingosine 1-Phosphate Receptor Edg-3: The Role of Sphingosine Kinase-1. J.  Cell.  Biol. 173 (2), 301-310.

8.  Anders, L., Mertins, P., Lammich, S., Murgia, M., Saftig, P., Haass, C. and Ullrich, A. (2006) Furin-, ADAM10- and g-Secretase-Mediated Cleavage of a Receptor Tyrosine Phosphatase and Regulation of b-Catenin’s Transcriptional Activity. Mol. Cell. Biol. 26 (10), 3917-3934.

9.  Ferby, I., Reschke, M., Kudlacek, O., Knyazev, P., Pante, G., Amman, K., Sommergruber, W., Kraut, N., Ullrich, A., Fässler, R., and Klein, R. (2006): Mig6 is a Negative Regulator of EGF Receptor-Mediated Skin Morphogenesis and Tumor Formation. Nat.  Med.  12 (5), 568-573.

10.         Streit, S., Mestel, D.S., Schmidt, M., Ullrich, A., and Berking, C. (2006) FGFR4 Arg388 Allele Correlates with Tumour Thickness and FGFR4 Protein Expression with Survival of Melanoma Patients. Br. J.  Cancer 94 (12), 1979-1886.

11.         Ruhe, J., Streit, S., Hart, S., and Ullrich, A. (2006) EGFR Signaling Leads to Downregulation of PTP-LAR via TACE-Mediated Proteolytic Processing. Cell Signal.  18 (9), 1515-1527.

12.         Fischer, O.M., Hart, S., and Ullrich, A. (2006) Dissecting the Epidermal Growth Factor Receptor Signal Transactivation Pathway. Methods Mol.  Biol.  327, 85-97.

13.         Thussbas, C., Nährig, J., Streit, S., Bange, J., Seebauer, M., Kates, R., Ulm, K., Kiechle, M., Höfler, H., Ullrich, A., and Harbeck, N. (2006) FGFR4 Arg388 Allele is Associated with Resistance to Adjuvant Therapy in Primary Breast Cancer. J.  Clin. Oncol.  24 (23), 3747-3755.

14.         Ramirez, B.S., Pestana, E.S., Hidalgo, G.G., Rodriguez, R.P., Ullrich, A., and Fernandez, L.E. (2006) Active Anti- Metastatic Immunotherapy in Lewis Lung Carcinoma with Self EGFR Extra Cellular Domain Protein in VSSP Adjuvant. Int. J. Cancer 119 (9), 2190-2199.

15.         Jiang, L.Q., Feng, X., Zhou, W., Knyazev, P.G., Ullrich, A., and Chen, Z. (2006) Csk-Binding Protein (Cbp) Negatively Regulates Epidermal Growth Factor-Induced Cell Transformation by Controlling Src Activation. Oncogene 25 (40), 5495-5506.

16.         Tanner, B., Hasenclever, D., Stern, K., Schormann, W., Bezler, M., Hermes, M., Brulport, M., Bauer, A., Schiffer, I.B., Gebhard, S., Schmidt, M., Steiner, E., Sehouli, J., Edelmann, J., Lauter, J., Lessig, R., Krishnamurthi, K., Ullrich, A., and Hengstler, J.G. (2006) ErbB-3 Predicts Survival in Ovarian Cancer. J. Clin. Oncol. 24 (26), 4317-4323.

17.         Streit S., Ruhe, J.E., Knyazev, P., Knyazeva, T., Iacobelli, S., Peter, S., Hoefler, H., and Ullrich, A. (2006) PTP-PEST Phosphatase Variations in Human Cancer. Cancer. Genet. Cytogenet. 170 (1), 48-53.

18.         Bhattacharya, I., and Ullrich, A. (2006) Endothelin-1 Inhibits Adipogenesis: Role of Phosphorylation of Akt and ERK 1/2. FEBS Letters 580 (24), 5765-5771.

19.         Strebhardt, K. and Ullrich, A. (2006) Another Look at Imatinib Mesylate. N Engl J Med 355 (23), 2481-2482.

20.         Wang, Y., Du, D., Fang, L.H., Yang, G., Zhang, C., Zeng, R., Ullrich, A., Lottspeich, F., and Chen, Z. (2006) Tyrosine Phosphorylated Par3 Regulates Epithelial Tight Junction Assembly promoted by EGFR Signaling. EMBO J. 25 (21), 5058-5070.

Publications 2005

Buschbeck, M., and Ullrich, A. (2005) The Unique C-Terminal Tail of the Mitogen-activated Protein Kinase ERK5 Regulates its Activation and Nuclear Shuttling. J Biol Chem.280(4):2659-67. 

Berger, I.R., Buschbeck, M., Bange, J., and Ullrich, A. (2005) Identification of a Transcriptionally Active hVH-5 Pseudogene on Human Chromosome 10q22.2. InPress Cancer Genetics and Cytogenetics

Htun-van der Horst, E., Murgia, M.., and Ullrich, A. (2005) Anti-HER-3 Monoclonal Antibodies Inhibit HER-3-mediated Signalling in Breast Cancer Cell Lines Resistant to Anti-HER-2; Anti-HER-3 Monoclonal Antibodies in Breast Cancer Therapy. In Press Int J Cancer

Buschbeck, M., Hofbauer, S., DiGroce, L., Keri, G., and Ullrich, A. (2005) Abl Kinase-sensitive Levels of ERK5 and its Intrinsic Basal Activity Contribute to Leukemia Cell Survival. EMBO Reports 6 (1), 63-69 

Fuchs, M., Hermannstädter, C., Specht, K., Knyazev, P., Ullrich, A., Rosivatz, E., Hutzler, P., Busch, R., Höfler, H., and Luber, B. (2005) Effect of Tumor-associated Mutant E-Cadherin Variants with Defects in Exons 8 or 9 on Matrix Metalloproteinase 3. J Cell Physiol 202 (3), 805-813

Htun-van der Horst, E., Weber, I., and Ullrich, A. (2005) Tyrosine Phosphorylation of PYK2 Mediates Heregulin-induced Glioma Invasion: Novel Heregulin/HER3-stimulated Signaling Pathway in Glioma. Int. J. Cancer, 113 (5), 689.698

Publications 2004

Htun van der Horst, E., Leupold, J.H., Schubbert, R., Ullrich, A., and Allgayer, H. (2004) TaqMan-based quantification of Invasive Cells in the Chick Embryo Metastasis Assay. Biotechniques, 37 (6), 940-942, 944, 946

Daub, H., Specht, K., and Ullrich, A. (2004) Strategies to Overcome Resistance to Targeted Protein Kinase Inhibitors. Nat. Rev. Drug Discov. 3 (12), 1001-1010 

Farhadi, M., Capelle, H.H., Erber, R., Ullrich, A., and Vajkoczy P. (2004) Combined Inhibition of VEGF and PDGF Signalling: Effects on Orthotopic Glioma Angiogenesis, Microcirculation, and Growth. J Vascular Res. 41 (1), 96-96 

Schäfer, B., Gschwind, A., and Ullrich, A. (2004) Distinct ADAM Metalloproteinases Regulate G Protein Coupled Receptor-Induced Cell Proliferation and Survival. J. Biol. Chem. 279 (46), 47929-47938 

Zhao, L., Hart, S., Chen, J., Melenhorst, J.J., Ernst, M., Stewart, C., Schaper,F., Heinrich, P.C., Ullrich,A., Robinson, G.W., and Hennighausen, L. (2004) Mammary Gland Remodeling Depends on gp130 Signaling Through Stat3 and MAPK. J. Biol.Chem. 279 (42), 44093-44100 

Fischer, O.M., Giordano, S., Comoglio, P.M., and Ullrich, A. (2004) Reactive Oxigen Species Mediate Met Receptor Transactivation by GPCRs and the EGFR in Human Carcinoma Cells. In Press J. Biol. Chem.

Ruschel, A. and Ullrich, A. (2004) Protein Tyrosine Kinase Syk Modulates EGFR Signalling in Human Mammary Epithelial Cells. In Press CLS. 

Blencke, S., Zech, B., Engkvist, O., Greff, Z., Örfi, L., Horváth, Z., Kéri, G., Ulrich, A., and Daub, F. (2004) Characterization of a Structural Determinant Controlling Protein Kinase Sinsitivity to Selective Inhibitors. Chem. Biol . 11 (5), 691-701

Streit, S., Bange, J., Fichtner, A., Ihrler, S., Issing, W., and Ullrich, A. (2004) Involvement of the FGFR4 Arg 388 Allele in Head and Neck Squamous Cell Carcinoma. Int. J. Cancer 111 (2), 213-217.

Cardone, L., Carlucci, A., Afaitati, A., Livigni, A., DeCristofaro, T., Garbi,C., Varrone, S., Ullrich, A., Gottesmann , M.E. , Avvedimento, E.V., and Feliciello,A. (2004) Mitochondrial AKAP121 Binds and Targets Protein Tyrosine Phosphatase D1, a Novel Positive Regulator of src Signaling. Mol. Cell. Biol . 24 (11), 4613-4626. 

Fischer, O.M., Hart, S., Gschwind, A., Prenzel, N., and Ullrich, A. (2004) Oxidative and Osmotic Stress Signaling in Tumor Cells is Mediated by ADAM Proteases and HB-EGF. Mol. Cell Biol. 24 (12), 5172-5183 

Koul, A., Herget, T., Klebl, B., and Ullrich, A. (2004) Interplay between Mycobacteria Host Signalling Pathways. Nat Rev Microbiol. 2, 189-202 

Gschwind, A., Fischer, O.M. and Ullrich, A. (2004) The Discovery of Receptor Tyrosine Kinases: Targets for Cancer Therapy. Nat. Rev. Cancer 4 (5), 361-170 

Neznanov, N., Neznanova, L, Kondratov.R.V., O'Rourke, D.M., Ullrich, A., and Gudkov, A.V. (2004) The Ability of Proteintyrosine Phosphatase SHP-1 to Suppress NF k B Can Be Inhibited by Dominant Negative Mutant of SIRP a . DNA Cell Biol 23(3), 175-182 

Gensler, M., Buschbeck, M. and Ullrich, A. (2004) Negative Regulation of HER2 Signaling by the PEST-Type Protein Tyrosine Phospahatase BDP1. J. Biol. Chem. 279 (13), 12110-6 

Hart, S., Fischer, O.M., and Ullrich, A. (2004) Cannabiniods Induce Cancer Cell Proliferation via TACE/ADAM17-Mediated Transactivation of the EGFR. Cancer Res. 64(6), 1943-50 

Pulido, R., Zuniga, A., and Ullrich, A. (2004) Detection of ERK1/2 Kinase Activities Using Affinity Reagents. Methods Mol. Biol. 250, 49-60 

Liu, Y., O'Connor, M.B., Mandell, K.J., Zen, K., Ullrich, A., Bühring, H.-J., and Parkos, C.A. (2004) Peptide-Mediated Inhibition of Neutrophil Transmigration by Blocking CD47 Interactions with Signal Regulatory Protein Alpha. J. Immunol. 172 (4), 2578-2585 

Schäfer, B., Gschwind, A., and Ullrich, A. (2004) Multiple G-Protein-Coupled Receptor Signals Converge on the Epidermal Growth Factor Receptor to Promote Migration and Invasion. Oncogene , 23, 991-999 

Erber, R., Thurnher, A., Katsen, A.D., Groth, G., Kerger, H., Hammes, H.P., Menger, M.D., Ullrich, A., and Vajkoczy, P. (2004) Combined Inhibition of VEGF and PDGF Signaling Enforces Tumor Vessel Regression by Interfering with Pericyte-Mediated Endothelial Cell Survival Mechanisms. FASEB J. (2), 338-340 

Publications 2003

Aoki, N., Ueno, S., Mano, H., Yamasaki, S., Shiota, M., Miyazaki , H., Yamaguchi-Aoki, Y., Matsuda, T., and Ullrich, A. (2003) Mutual Regulation of PTP20 and PTK Tec Activities by Tyrosine Phosphorylation and Dephosphorylation. J. Biol. Chem. 279 (11), 10765-75

Büchler, P., Reber, H.A., Ullrich, A., Shiroiki, M., Roth, M., Büchler M.W., Lavey, R.S., Friess, H., and Hines, O.J. (2003) Pancreatic Cancer Growth Is Inhibited by Blockade of VEGF-RII. Surgery 134 (5), 772-782

Hart, S., Gschwind, A., Roidl, A., and Ullrich, A. (2003) Epidermal Growth Factor Receptor Signal Transactivation. Chem. Probes in Biology , 93-103

Fischer, O.M., Hart, S., Gschwind, A., and Ullrich, A (2003) EGFR Signal Transactivation in Cancer Cells. Biochem Soc Trans 31 (6), 1203-1208 

Fischer, O.M., Streit, S., Hart, S., and Ullrich, A. (2003) Beyond Herceptin and Gleevec. Curr. Opin. Chem. Biol. 7 (4), 490-495 

Knyazev I., Cheburkin, I., Spiekermann, K., Peter S., Jenster, G., Bangma KH., Karelin, MI., Shkolnik, MI., Urbanskii, AI., Evtushenko, VI., Ullrich, A., and Knyazev, PG. (2003) Gene Expression Profiles of Protein Kinases and Phosphatases Obtained by Hybridization With cDNA Arrays: Molecular Portrait of Human Prostate Carcinoma. Mol Biol (Mosk.) 37 (1), 97-111 

Tejeda, M., Gaal, D., Csuka, O., Ullrich, A., Schwab, R., Pap, A., Horvath, A., and Keri, G. (2003) The Antitumour Effect of the Somatostatin Analogue TT-232 Depends on the Treatment Regimen. Cancer Detect Prev. 27 (2), 155-62 

Wu, Y., Chen, Z., and Ullrich, A. (2003) EGFR and FGFR Signaling Through FRS2 Is Subject to Negative Feedback Control by ERK1/2. Biol. Chem. 384, 1215-1226

Gschwind , A., Hart, S., Fischer, O.M., and Ullrich, A. (2003) TACE Cleavage of Proamphiregulin Regulates GPCR-Induced Proliferation and Motility of Cancer Cells. EMBO J . 22 (10), 2411-2421 

Minoo, P., Chughtai, N., Campiglio, M., Stein-Gerlach, M., Lebrun, J.J., Ullrich, A., and Ali, S. (2003) The Adapter Function of SHP-2 Downstream of the Prolactin Receptor Is Required for the Recruitment of p29, a Substrate of SHP-2. Cell Signal. 15 (3), 319-326 

Neznanov, N., Neznanova, L., Kondratov, R.V., Burdelya, L., Kandel, E.S., O'Rourke, D.M., Ullrich, A., and Gudkov, A.V. (2003) Dominant Negative Form of Signal-Regulatory Protein- a (SIRP a /SHPS-1) Inhibits Tumor Necrosis Factor-Mediated Apoptosis by Activation of NF- k B. J. Biol. Chem. 278 (6), 3809-15 

Su, I.H., Basavaraj, A., Krutchinsky, A.N., Hobert, O., Ullrich, A., Chait, B.T., and Tarakhovsky, A. (2003) Ezh2 Controls B Cell Development Through Histone H3 Methylation and Igh Rearrangement. Nature Immunol. 4 (2), 124-131 

Blencke, S., Ullrich, A., and Daub, H. (2003) Mutation of Threonine 766 in the Epidermal Growth Factor Receptor Reveals a Hotspot for Resistance Formation against Selective Tyrosine Kinase Inhibitors. J. Biol. Chem. 278 (17), 15435-40 

Shiota, M., Tanihiro, T., Nakagawa, Y., Aoki, N., Ishida, N., Miyazaki , K., Ulrich, A., and Miyazaki , H. (2003) Protein Tyrosine Phosphatase PTP20 Induces Actin Cytoskeleton Reorganization by Dephosphorylating p190Rho GAP in Rat Ovarian Granulosa Cells Stimulated with follicle-stimulating hormone. Mol. Endocrinol. 17 (4), 534-549 

Publications 2002

Cheburkin, I. , Knyazeva, T., Peter S., Karelin, MI., Shkolnik, MI., Evtushenko, VI., Hanson, KP., Ullrich, A., and Kniazev PG. (2002) Molecular Portrait of Human Kidney Carcinomas: The Gene Expression Profiling of Protein-Tyrosine Kinases and Tyrosine Phosphatases which Controlled Regulatory Signals in the Cells. Mol Biol (Mosk.) 36 (3), 480-90 

Kue, P.F., Taub, J.S., Harrington, L.B., Polakiewicz, R.D., Ullrich, A., and Daaka, Y. (2002) Lysophosphatidic Acid-Regulated Mitogenic ERK Signalling in Androgen-Insensitive Prostate Cancer PC-3 Cells. Int. J. Cancer 102 (6), 572-579 

Gschwind, A., Prenzel, N., and Ullrich, A. (2002) Lysophosphatidic Acid-Induced Squamous Cell Carcinoma Cell Proliferation and Motility Involves Epidermal Growth Factor Receptor Signal Transactivation. Cancer Res., 62, 6329-6336 

Sasaki, T., Knyazev P.G., Cheburkin, Y., Göhring, W., Tisi, D., Ullrich, A., Timpl, R., and Hohenester, E. (2002) Crystal Structure of a C-Terminal Fragment of Growth Arrest-Specific Protein Gas6. J. Biol. Chem . 277 (46), 44164-44170

Ullrich, A. (2002) Molecular Targets in Cancer Therapy and their Impact on Cancer Management. Oncology 63 (suppl), 1-5 

Zeng, J.-Z., Wang, H.-Y., Chen, Z.-J., Ullrich, A., and Wu, M.-C. (2002) Molecular Cloning and Characterization of a Novel Gene which is highly Expressed in Hepatocellular Carcinoma. Oncogene 21, 4932-4943 

Buschbeck, M., Eickhoff, J., Sommer, M.N., and Ullrich, A. (2002) Phosphotyrosine-Specific PTP-SL Regulates the ERK5 Signalling Pathway. J. Biol. Chem. 277, 29503-29509 

Marchetti, A., Tinari, N., Buttitta, F., Chella, A., Angeletti , C.A. , Sacco, R., Mucilli, F., Ullrich, A., and Iacobelli , S. (2002) Expression of 90K (Mac-2 BP) Correlates with distant Metastasis and Predicts Survival in Stage I non-small Cell Lung Cancer Patients . Cancer Res. 62 , 2535-2539 

Daub, H., Blencke, S., Habenberger, P., Kurtenbach, A., Dennenmoser, J., Wissing, J., Ullrich, A., and Cotton, M. (2002) Identification of SRPK1 and SRPK2 as the major Cellular Protein Kinases Phosphorylating Hepatitis B Virus Core Protein. J. of Virology 76, 8124-8137 

Wallasch, C., Crabtree, J.E., Bevec, D., Robinson, P.A., Wagner, H., and Ullrich, A. (2002) Heliobacter Pylori-Stimulated EGF Receptor Transativation Requires Metalloprotease Cleavage of HB-EGF. Biochem. & Biophys. Res. Communications 295, 695-701

Casanova, M.L., Larcher, F., Casanova, B., Murillas, R., Fernandez-Acenero, M.J., Villanueva, C., Martinez-Palacio, J., Ullrich, A., Conti, C.J., and Jorcano, J.L. (2002) A critical Role for ras -Mediated, Epidermal Growth Factor Receptor-Dependent Angiogenesis in Mouse Skin Carcinogenesis. Cancer Res. 62, 3402-3407 

Shawver, L.K., Slamon, D., and Ullrich, A. (2002) Smart Drugs: Tyrosine Kinase Inhibitors in Cancer Therapy. Cancer Cell 1, 117-123

Bange, J., Prechtel, D., Cheburkin, Y., Specht, K., Harbeck, N., Schmitt, M., Knyazeva, T., Müller, S., Gärtner, S., Sures, I., Wang, H., Imyanitov, E., Häring, H.U., Knyazev, P., Iacobelli , S., Höfler, H., and Ullrich, A. (2002) Cancer Progression and Tumor Cell Motility are Associated with the FGFR4 Arg388 Allele. Cancer Res. 62, 840-847 

Neznanov, N., Chumakov, K.P., Ullrich, A., Agol V.I., and Gudkov, A.V. (2002) Unstable Receptors Disappear from Cell Surface during Poliovirus Infection. Med. Sci. Monit. 8 (10), 391-396 

Strack, V., Krützfeldt, J., Kellerer, M., Lammers, R., Ullrich, A., and Häring, H.U. (2002) The Protein-Tyrosine Phosphase SHP2 is Phosphorylated on Serine Residues 576 and 591 by Protein Kinase C Isoforms Alpha, Beta1, Beta2 and Eta. Biochemistry-US 41 (2), 603-608 

Zwick, E., Bange, J., and Ullrich, A. (2002) Receptor Tyrosine Kinases as Targets for Anticancer Drugs. Trends in Mol. Med. 8 (1), 17-23 

 
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