Regulation of Gene Expression

Regulation of Gene Expression - Publications

Busche S., Kremmer E. and Posern G. (2010):
E-cadherin regulates MAL-SRF-mediated transcription in epithelial cells
J. Cell Science 123, 2803-2809

Leitner L., Shaposhnikov D., Descot A., Hoffmann R. and Posern G. (2010):
Epithelial Protein Lost in Neoplasm alpha (Eplin-alpha) is transcriptionally regulated by G-actin and MAL/MRTF coactivators
Mol. Cancer 9 (1), 60

Descot A., Hoffmann R., Shaposhnikov D., Reschke M., Ullrich A. and Posern G. (2009):
Negative regulation of the EGFR-MAPK cascade by actin-MAL mediated Mig6/Errfi-1 induction
Mol. Cell 35 (3), 291-304

Stern S., Debre E., Stritt C., Berger J., Posern G. and Knoell B. (2009):
A nuclear actin function regulates neuronal motility by SRF dependent gene transcription
J. Neuroscience. 29 (14), 4512-4518

Descot A., Rex-Haffner M., Courtois G., Bluteau D., Menssen A., Mercher T., Bernard O.A., Treisman R., and Posern G. (2008):
OTT-MAL is a deregulated activator of serum response factor-dependent gene expression.
Mol. Cell. Biol. 28 (20), 6171-81.

Busche S., Descot A., Julien S., Genth H. and Posern G. (2008):
Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-Actin-MAL signalling
Journal of Cell Science , 121 (7), 1025-1035

Muehlich S., Cicha I., Garlichs CD., Krueger B., Posern G. and Goppelt-Struebe M. (2007):
Actin-dependent regulation of connective tissue growth factor (CTGF)
Am. J. Physiol. Cell Physiol., 292 (5), C1732-1738

Posern G. and Treisman R. (2006):
Actin' together: serum response factor, its cofactors and the link to signal transduction
Trends in Cell Biol. 16 (11), 588-596

Posern G., Miralles F., Guettler S. and Treisman R. (2004):
Mutant Actins which stabilise F-Actin use distinct mechanisms to activate the SRF coactivator MAL
EMBO J. 23 (20), 3973-3983

Miralles F., Posern G., Zaromytidou A. and Treisman R. (2003):
Actin dynamics control SRF activity by regulation of its coactivator MAL
Cell 113 (3), 329-342

Posern G., Sotiropoulos A. and Treisman R. (2002):
Mutant Actins reveal a role for unpolymerised actin in control of transcription by serum response factor
Mol. Biol. Cell 13 (12), 4167-4178

Schmidt M., Goebeler M., Posern G., Feller SM., Seitz CS., Brocker EB., Rapp UR., Ludwig S. (2000):
Ras-independent activation of the Raf/MEK/ERK pathway upon calcium-induced differentiation of keratinocytes
J. Biol. Chem. 275 (52), 41011-41017

Posern G., Rapp U. R. and Feller S. M. (2000):
The Crk signalling pathway contributes to the bombesin-induced activation of the small GTPase Rap1
Oncogene 19 (54), 6361-6368

Posern G., Saffrich R., Ansorge W. and Feller S. M. (2000):
Rapid lamellipodia formation in NGF-induced PC12 cells is dependent on Rac and PI3K activity
J. Cell. Physiol. 183, 416-424

Kardinal C., Konkol B., Schulz S., Posern G., Lin H., Adermann K., Eulitz M., Estrov Z., Talpaz M., Arlinghaus R. B. and Feller, S. M. (2000):
Cell-penetrating SH3 domain blocker peptides inhibit proliferation of primary blast cells from CML patients
FASEB J. 14 (11), 1529-1538

Sakkab D., Lewitzky M., Posern G., Schaeper U., Sachs M., Birchmeier W. and Feller, S. M. (2000):
Signaling of Hepatocyte Growth Factor / Scatter Factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL
J. Biol. Chem. 275 (15), 10772-10778

Voss J., Posern G., Hannemann J. R., Wiedemann L. M., Turhan A. G., Poirel H., Bernard O. A., Adermann K., Kardinal C. and Feller, S. M. (2000):The leukaemic oncoproteins Bcr-Abl and Tel-Abl(ETV6/Abl) have altered substrate preferences and activate similar intracellular signalling pathways
Oncogene 19, 1684-1690

Posern G., Weber C. K., Rapp U. R. and Feller S. M. (1998)
Activity of Rap 1 is regulated by bombesin, cell adhesion and cell density in NIH3T3 fibroblasts
J. Biol. Chem. 273 (38), 24297-24300

Posern G., Zheng J., Knudsen B., Kardinal C., Müller K., Voss J., Shishido T., Cowburn D., Cheng G., Wang B., Kruh G. D., Burrell S., Jakobson C., Lenz D., Zamborelli T., Adermann K., Hanafusa H. and Feller, S. M. (1998):
Development of highly selective SH3 binding peptides for Crk and CRKL which disrupt Crk complexes with DOCK180, SoS and C3G
Oncogene 16, 1903-1912

Feller, S. M., Posern G., Voss J., Kardinal C., Sakkab D., Zheng J., Knudsen B. (1998):
Physiological signals and oncogenesis mediated through Crk family adapter proteins
J. Cell. Physiol. 177, 535-552