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Prof. Dr. Matthias Mann

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Phone:+49 89 8578-2557Fax:+49 89 8578-2219
Email:mmann@...

MPI of Biochemistry

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Department of Proteomics and Signal Transduction

Matthias Mann Lab

 

ABOUT US

The department of proteomics and signal transduction develops and applies methods of mass spectrometry (MS)-based proteomics in a variety of biological areas.

It is led by Matthias Mann, who moved here in 2005 from earlier stations at the European Molecular Biology Laboratory (EMBL) and from the University of Southern Denmark (SDU). He is also affiliated with the NNF Center for Protein Research (University of Copenhagen).

NEWS

 

Cell-Type-Resolved Quantitative Proteomics of Murine Liver

Cell Metabolism

S. Babak Azimifar, Nagarjuna Nagaraj, Juergen Cox, Matthias Mann

Image: Max Iglesias

<p>Molecular Cell (2014)<br /><br />Christian Benda, Judith Ebert, Richard A. Scheltema, Herbert B. Schiller, Marc Baumg&auml;rtner, Fabien Bonneau, Matthias Mann, Elena Conti<br /><br /></p>

Structural Model of a CRISPR RNA-Silencing Complex Reveals the RNA-Target Cleavage Activity in Cmr4

Molecular Cell (2014)

Christian Benda, Judith Ebert, Richard A. Scheltema, Herbert B. Schiller, Marc Baumgärtner, Fabien Bonneau, Matthias Mann, Elena Conti

[more]
<p>MCP (2014)</p>
<p><br />Richard Alexander Scheltema, &nbsp;Jan-Peter Hauschild, Oliver Lange, Daniel Hornburg, Eduard Denisov, Eugen Damoc, Andreas Kuehn, Alexander Makarov and Matthias Mann</p>
<p>&nbsp;</p>

The Q Exactive HF, a Benchtop Mass Spectrometer with a Pre-filter, High Performance Quadrupole and an Ultra-High Field Orbitrap Analyzer

MCP (2014)


Richard Alexander Scheltema,  Jan-Peter Hauschild, Oliver Lange, Daniel Hornburg, Eduard Denisov, Eugen Damoc, Andreas Kuehn, Alexander Makarov and Matthias Mann

 

[more]
Cell Reports (2014)<br /><br />Kirti Sharma, Rochelle C.J. D&rsquo;Souza, Stefka Tyanova, Christoph Schaab, Jacek R. Wisniewski, Juergen Cox and Matthias Mann<br /><br />

Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling

Cell Reports (2014)

Kirti Sharma, Rochelle C.J. D’Souza, Stefka Tyanova, Christoph Schaab, Jacek R. Wisniewski, Juergen Cox and Matthias Mann

[more]

The growing landscape of lysine acetylation links metabolism and cell signalling

Nature Reviews Molecular Cell Biology 15, 536–550 (2014) doi:10.1038/nrm3841

Chunaram Choudhary, Brian T. Weinert, Yuya Nishida, Eric Verdin & Matthias Mann

[more]
Sci. Signal., 22 July 2014 - Vol. 7, Issue 335, p. rs5 - DOI: 10.1126/scisignal.2004856<br /><br /><br />J D'Souza RC, Knittle AM, Nagaraj N, van Dinther M, Choudhary C, Ten Dijke P, Mann M, Sharma K.<br /><br />

Time-resolved dissection of early phosphoproteome and ensuing proteome changes in response to TGF-β

Sci. Signal., 22 July 2014 - Vol. 7, Issue 335, p. rs5 - DOI: 10.1126/scisignal.2004856


J D'Souza RC, Knittle AM, Nagaraj N, van Dinther M, Choudhary C, Ten Dijke P, Mann M, Sharma K.

[more]

Complete proteome analysis and its uses in cell biology and biomedicine

Research talk at the Nobel Foundation, Stockholm, 17 October 2013

We have contributed a chapter to the book CIRCADIAN CLOCKS Handbook of Experimental Pharmacology edited by Martha Merrow and Achim Kramer

We review the proteomics approaches applied to date in the circadian field, and we also discuss the exciting potential of using cutting-edge proteomics technology in circadian biology.

Maria S. Robles and Matthias Mann, Proteomic Approaches in Circadian Biology in Circadian Clocks (Handbook of Experimental Pharmacology) 2013


Direct proteomic quantification of the secretome of activated immune cells.

Science. 2013 Apr 26

Eavesdropping on Immune Cells - Max Planck Scientists Analyze How the Immune System Communicates

Press Release (PDF)

PubMed

The Coming Age of Complete, Accurate, and Ubiquitous Proteomes

Molecular Cell, Volume 49, Issue 4, 583-590, 21 February 2013
Mann M, Kulak N, Nagaraj N, Cox J

High-resolution mass spectrometry (MS)-based proteomics has progressed tremendously over the years. For model organisms like yeast, we can now quantify complete proteomes in just a few hours.

more

EU Grant Awarded for Dementia Research

Max Planck Researchers receive 13.9 Million Euros in EU funding. The ERC Synergy Grant is the most highly endowed research grant of the European Union and was awarded this year for the first time.[more]

 

Press Release (PDF)


 

We have contributed a chapter to the Handbook of Systems Biology, edited by Marian Walhout, Job Dekker and Marc Vidal:  

 

Marco Hein, Kirti Sharma, Jürgen Cox and Matthias Mann, Proteomic Analysis of Cellular Systems, in Handbook of Systems Biology, 2013  

 

 

New Insights into a Virus Proteome

Max Planck Scientists Identify Unknown Proteins of the Herpesvirus[more]

 

Press Release (PDF)

 
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