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Prof. Dr. Matthias Mann

Director
Phone:+49 89 8578-2557Fax:+49 89 8578-2412
Email:mmann@...

MPI of Biochemistry

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events

8th MaxQuant Summer School
July 4th - July 8th 2016
Andrew Wiles Building, Oxford, UK

MaxQuant Summer School 2016 in Oxford, UK

Tutorials

Video Tutorial

How to build a stage tipping syringe

Department of Proteomics and Signal Transduction

Matthias Mann Lab

 

ABOUT US

The department of proteomics and signal transduction develops and applies methods of mass spectrometry (MS)-based proteomics in a variety of biological areas.

It is led by Matthias Mann, who moved here in 2005 from earlier stations at the European Molecular Biology Laboratory (EMBL) and from the University of Southern Denmark (SDU). He is also affiliated with the NNF Center for Protein Research (University of Copenhagen).

NEWS



Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):E1673-82. doi: 10.1073/pnas.1519650113. Epub 2016 Feb 9.   Neufeld-Cohen A, Robles MS, Aviram R, Manella G, Adamovich Y, Ladeuix B, Nir D, Rousso-Noori L, Kuperman Y, Golik M, Mann M, Asher G  
Highlighted at www.pnas.org

Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):E1673-82. doi: 10.1073/pnas.1519650113. Epub 2016 Feb 9.

Neufeld-Cohen A, Robles MS, Aviram R, Manella G, Adamovich Y, Ladeuix B, Nir D, Rousso-Noori L, Kuperman Y, Golik M, Mann M, Asher G

Highlighted at www.pnas.org

cell systems, Volume 2, Issue 3, p185–195, 23 March 2016 Geyer et al. 
Preview

Cell Systems: featured article

Plasma Proteome Profiling to Assess Human Health and Disease

cell systems, Volume 2, Issue 3, p185–195, 23 March 2016
Geyer et al.

Preview

Identification of bona fide and verifiable substrates of the Parkinson’s disease kinase LRRK2 has eluded researchers for over ten years and was considered as one of the greatest challenges in the field. Using phosphoproteomics, we identified and validated Rab GTPases as key physiological LRRK2 substrates.      Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases   eLife, January 28, 2016  http://dx.doi.org/10.7554/eLife.12813   Steger, M et al.
Press Release Dispatch in Current Biology Comment in Movement Disorders

Breakthrough in Parkinson’s Research

Identification of bona fide and verifiable substrates of the Parkinson’s disease kinase LRRK2 has eluded researchers for over ten years and was considered as one of the greatest challenges in the field. Using phosphoproteomics, we identified and validated Rab GTPases as key physiological LRRK2 substrates.




Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases

eLife, January 28, 2016
http://dx.doi.org/10.7554/eLife.12813

Steger, M et al.

Press Release
Dispatch in Current Biology
Comment in Movement Disorders

Her Majesty the Queen of Denmark recognizes Matthias for his outstanding contribution to mankind in general, and science in particular.

Matthias Mann receives The Order of Dannebrog Knights Cross

Her Majesty the Queen of Denmark recognizes Matthias for his outstanding contribution to mankind in general, and science in particular. [more]

Matthias Mann awarded Inaugural Barry L. Karger Medal on October 16, 2015 at Northeastern University, Boston , US.

the Medal is a biennial award recognizing an individual who has significantly contributed to the development of new bioanalytical methods. [more]
Nat Neurosci. 2015 Nov 2. doi: 10.1038/nn.4160   Sharma K, Schmitt S, Bergner CG, Tyanova S, Kannaiyan N, Manrique-Hoyos N, Kongi K, Cantuti L, Hanisch UK, Philips MA, Rossner MJ, Mann M, Simons M 
 
Press Release

Cell type– and brain region–resolved mouse brain proteome

Nat Neurosci. 2015 Nov 2. doi: 10.1038/nn.4160

Sharma K, Schmitt S, Bergner CG, Tyanova S, Kannaiyan N, Manrique-Hoyos N, Kongi K, Cantuti L, Hanisch UK, Philips MA, Rossner MJ, Mann M, Simons M

 

Press Release

Cell 163(3):712-23 (2015). doi: 10.1016/j.cell.2015.09.053   Marco Y. Hein, Nina C. Hubner, Ina Poser, Jürgen Cox, Nagarjuna Nagaraj, Yusuke Toyoda, Igor A. Gak, Ina Weisswange, Jörg Mansfeld, Frank Buchholz, Anthony A. Hyman & Matthias Mann
 
Press Release
Research Highlight in Nature Reviews Molecular Cell Biology

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

Cell 163(3):712-23 (2015). doi: 10.1016/j.cell.2015.09.053

Marco Y. Hein, Nina C. Hubner, Ina Poser, Jürgen Cox, Nagarjuna Nagaraj, Yusuke Toyoda, Igor A. Gak, Ina Weisswange, Jörg Mansfeld, Frank Buchholz, Anthony A. Hyman & Matthias Mann

 

Press Release

Research Highlight in Nature Reviews Molecular Cell Biology

Nat Biotechnol. 2015 Aug 17. doi: 10.1038/nbt.3327.Humphrey SJ, Azimifar SB, Mann M. 
 
Press Release
Nature Biotechnology | NEWS AND VIEWS

High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics

Nat Biotechnol. 2015 Aug 17. doi: 10.1038/nbt.3327.

Humphrey SJ, Azimifar SB, Mann M.

 

Press Release

Nature Biotechnology | NEWS AND VIEWS

Mol Cell Proteomics. 2015 Jul;14(7):2014-29. doi: 10.1074/mcp.M114.047407.Beck S, Michalski A, Raether O, Lubeck M, Kaspar S, Goedecke N, Baessmann C, Hornburg D, Meier F, Paron I, Kulak NA, Cox J, Mann M

The Impact II, a Very High-Resolution Quadrupole Time-of-Flight Instrument (QTOF) for Deep Shotgun Proteomics

Mol Cell Proteomics. 2015 Jul;14(7):2014-29. doi: 10.1074/mcp.M114.047407.

Beck S, Michalski A, Raether O, Lubeck M, Kaspar S, Goedecke N, Baessmann C, Hornburg D, Meier F, Paron I, Kulak NA, Cox J, Mann M
Molecular Systems Biology, July 6, 2015H.B. Schiller, I.E. Fernandez, G. Burgstaller, C. Schaab, R.A. Scheltema, T. Schwarzmayr, T.M. Strom, O. Eickelberg and M. Mann

Time- and compartment-resolved proteome profiling of the extracellular niche in lung injury and repair

Molecular Systems Biology, July 6, 2015

H.B. Schiller, I.E. Fernandez, G. Burgstaller, C. Schaab, R.A. Scheltema, T. Schwarzmayr, T.M. Strom, O. Eickelberg and M. Mann [more]
Mol Cell Proteomics. 2015 Apr 17. Hosp F, Scheltema RA, Eberl C, Kulak NA, Keilhauer EC, Mayr K, Mann M.

A double-barrel LC-MS/MS system to quantify 96 interactomes per day

Mol Cell Proteomics. 2015 Apr 17.

Hosp F, Scheltema RA, Eberl C, Kulak NA, Keilhauer EC, Mayr K, Mann M. [more]
Cell, May 7, 2015 DOI: 10.1016/j.cell.2015.03.032 Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU.

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

Cell, May 7, 2015 DOI: 10.1016/j.cell.2015.03.032

Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU.
Science 1 May 2015Räschle M, Smeenk G, Hansen RK, Temu T, Oka Y, Hein MY, Nagaraj N, Long DT, Walter JC, Hofmann K, Storchova Z, Cox J, Bekker-Jensen S, Mailand N, Mann M

Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

Science 1 May 2015

Räschle M, Smeenk G, Hansen RK, Temu T, Oka Y, Hein MY, Nagaraj N, Long DT, Walter JC, Hofmann K, Storchova Z, Cox J, Bekker-Jensen S, Mailand N, Mann M
EMBO Rep. 2015 Feb 2Murgia M, Nagaraj N, Deshmukh AS, Zeiler M, Cancellara P, Moretti I, Reggiani C, Schiaffino S, Mann M

Single muscle fiber proteomics reveals unexpected mitochondrial specialization

EMBO Rep. 2015 Feb 2

Murgia M, Nagaraj N, Deshmukh AS, Zeiler M, Cancellara P, Moretti I, Reggiani C, Schiaffino S, Mann M
Mol Cell Proteomics (2015)Bassani-Sternberg M, Pletscher-Frankild S, Jensen LJ, Mann M

Mass spectrometry of HLA-I peptidomes reveals strong effects of protein abundance and turnover on antigen presentation

Mol Cell Proteomics (2015)

Bassani-Sternberg M, Pletscher-Frankild S, Jensen LJ, Mann M

[more]

 

Cell-Type-Resolved Quantitative Proteomics of Murine Liver

Cell Metabolism

S. Babak Azimifar, Nagarjuna Nagaraj, Juergen Cox, Matthias Mann

Image: Max Iglesias

Molecular Cell (2014)Christian Benda, Judith Ebert, Richard A. Scheltema, Herbert B. Schiller, Marc Baumgärtner, Fabien Bonneau, Matthias Mann, Elena Conti

Structural Model of a CRISPR RNA-Silencing Complex Reveals the RNA-Target Cleavage Activity in Cmr4

Molecular Cell (2014)

Christian Benda, Judith Ebert, Richard A. Scheltema, Herbert B. Schiller, Marc Baumgärtner, Fabien Bonneau, Matthias Mann, Elena Conti

[more]
MCP (2014)
Richard Alexander Scheltema,  Jan-Peter Hauschild, Oliver Lange, Daniel Hornburg, Eduard Denisov, Eugen Damoc, Andreas Kuehn, Alexander Makarov and Matthias Mann
 

The Q Exactive HF, a Benchtop Mass Spectrometer with a Pre-filter, High Performance Quadrupole and an Ultra-High Field Orbitrap Analyzer

MCP (2014)


Richard Alexander Scheltema,  Jan-Peter Hauschild, Oliver Lange, Daniel Hornburg, Eduard Denisov, Eugen Damoc, Andreas Kuehn, Alexander Makarov and Matthias Mann

 

[more]
Cell Reports (2014)Kirti Sharma, Rochelle C.J. D’Souza, Stefka Tyanova, Christoph Schaab, Jacek R. Wisniewski, Juergen Cox and Matthias Mann

Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling

Cell Reports (2014)

Kirti Sharma, Rochelle C.J. D’Souza, Stefka Tyanova, Christoph Schaab, Jacek R. Wisniewski, Juergen Cox and Matthias Mann

[more]

The growing landscape of lysine acetylation links metabolism and cell signalling

Nature Reviews Molecular Cell Biology 15, 536–550 (2014) doi:10.1038/nrm3841

Chunaram Choudhary, Brian T. Weinert, Yuya Nishida, Eric Verdin & Matthias Mann

[more]
Sci. Signal., 22 July 2014 - Vol. 7, Issue 335, p. rs5 - DOI: 10.1126/scisignal.2004856J D'Souza RC, Knittle AM, Nagaraj N, van Dinther M, Choudhary C, Ten Dijke P, Mann M, Sharma K.

Time-resolved dissection of early phosphoproteome and ensuing proteome changes in response to TGF-β

Sci. Signal., 22 July 2014 - Vol. 7, Issue 335, p. rs5 - DOI: 10.1126/scisignal.2004856


J D'Souza RC, Knittle AM, Nagaraj N, van Dinther M, Choudhary C, Ten Dijke P, Mann M, Sharma K.

[more]

Complete proteome analysis and its uses in cell biology and biomedicine

Research talk at the Nobel Foundation, Stockholm, 17 October 2013

We have contributed a chapter to the book CIRCADIAN CLOCKS Handbook of Experimental Pharmacology edited by Martha Merrow and Achim Kramer

We review the proteomics approaches applied to date in the circadian field, and we also discuss the exciting potential of using cutting-edge proteomics technology in circadian biology.

Maria S. Robles and Matthias Mann, Proteomic Approaches in Circadian Biology in Circadian Clocks (Handbook of Experimental Pharmacology) 2013


Direct proteomic quantification of the secretome of activated immune cells.

Science. 2013 Apr 26

Eavesdropping on Immune Cells - Max Planck Scientists Analyze How the Immune System Communicates

Press Release (PDF)

PubMed

The Coming Age of Complete, Accurate, and Ubiquitous Proteomes

Molecular Cell, Volume 49, Issue 4, 583-590, 21 February 2013
Mann M, Kulak N, Nagaraj N, Cox J

High-resolution mass spectrometry (MS)-based proteomics has progressed tremendously over the years. For model organisms like yeast, we can now quantify complete proteomes in just a few hours.

more

EU Grant Awarded for Dementia Research

Max Planck Researchers receive 13.9 Million Euros in EU funding. The ERC Synergy Grant is the most highly endowed research grant of the European Union and was awarded this year for the first time.[more]

 

Press Release (PDF)


 
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