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MPI für Biochemie  

Cellular Biochemistry
F.-Ulrich Hartl

Selected Publications

 

Bracher, A., Eisenreich, W., Schramek, N., Ritz, H., Götze, E., Herrmann, A., Gütlich, M., and Bacher, A. (1998), Biosynthesis of pteridines. NMR studies on the reaction mechanisms of GTP cyclohydrolase I, pyruvoyl tetrahydropterin synthase, and sepiapterin reductase, J. Biol. Chem. 273, 28132-28141.

Bracher, A., Perrakis, A., Dresbach, T., Betz, H., and Weissenhorn, W. (2000), The X-ray crystal structure of neuronal Sec1 from squid sheds new light on the role of this protein in exocytosis, Structure 8, 685-694.

Bracher, A. and Weissenhorn, W. (2002), Structural basis for the Golgi membrane recruitment of Sly1p by Sed5p. EMBO J. 21, 6114-6124.

Shomura, Y., Dragovic, Z., Chang, H.-C., Tzvetkov, N., Young, J.C., Brodsky, J.L., Guerriero, V., Hartl, F.U. and Bracher, A. (2005) Regulation of Hsp70 Function by HspBP1; Structural Analysis Reveals an Alternate Mechanism for Hsp70 Nucleotide Exchange. Mol. Cell 17, 367-379.

Roeben, A., Kofler, C., Nagy, I., Nickell, S., Hartl, F.U. and Bracher, A. (2006) Crystal Structure of an Archaeal Actin Homolog. J. Mol. Biol. 358, 145–156.

Dragovic, Z., Broadley, S.A., Shomura, Y., Bracher, A. and Hartl F.U. (2006) Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s. EMBO J. 25, 2519–2528.

Roeben, A., Plitzko, J.M., Körner, R., Böttcher, U.M.K., Siegers, K., Hayer-Hartl, M. and Bracher, A.* (2006) Structural basis for subunit assembly in UDP-glucose pyrophosphorylase from Saccharomyces cerevisiae. J. Mol. Biol. 364, 551-560.

Dragovic, Z., Shomura, Y., Tzvetkov, N., Hartl, F.U. and Bracher, A.* (2006) Fes1p acts as a nucleotide exchange factor for the ribosome-associated molecular chaperone Ssb1p. Biol. Chem. 387, 1593-1600.

Saschenbrecker, S., Bracher, A.*, Rao, K.V., Rao, B.V., Hartl, F.U.* and Hayer-Hartl, M.* (2007) Structure and function of RbcX, an assembly chaperone for hexadecameric Rubisco. Cell 129, 1189-1200.

Polier, S., Dragovic, Z., Hartl F.U.* and Bracher A.* (2008) Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding. Cell 133, 1068-1079.