F.-Ulrich Hartl

F.-Ulrich Hartl

Research Department Cellular Biochemistry

Molecular Chaperones, Protein Folding, Proteostasis, Aging and Neurodegenerative Diseases

Many proteins have complex molecular architectures that do not form efficiently via a spontaneous folding process. Helper proteins, called molecular chaperones, ensure that such proteins fold into their correct shape and do not clump together to non-functional (or even toxic) aggregates in living cells. Molecular chaperones therefore play an important role in maintaining a functional proteome, also referred to as protein homeostasis or proteostasis. Scientists in the Department "Cellular Biochemistry" investigate the mechanisms of molecular chaperone functions in protein folding and related cellular processes. They have elucidated the function of an important group of chaperones, the chaperonins, which are barrel-shaped complexes that enclose an unfolded protein molecule and allow it to fold in a shielded environment unimpaired by aggregation. The department also studies the role of toxic protein aggregates in neurodegenerative diseases such as Alzheimer's, Parkinson’s and Huntington's disease. The aggregates form in an age-dependent manner and interfere with key cellular functions. Understanding these mechanisms will provide important information in developing novel therapeutic strategies for this group of presently incurable conditions.

 

Research
Further Information on the research can be found here more

 

News


Congratulations to Cole Sitron

for winning the main poster prize at the

ASAP Collaborative Meeting, London, October 2023!

 

 

 

 

Thanks to the Hartl-Fighters for a wonderful

MPIB-Sommerfest 2023

 

MICHAEL GROPP RECEIVES JUNIOR SCIENTIST PUBLICATION AWARD  (JSPA)
The Max Planck Society awarded Michael Gropp with the JSPA for outstanding scientific achievements.

We would like to take this opportunity to congratulate Michael on his award and wish him all the best for his time as a Po​stDoc. more

 

Group Leaders


 

Sae-Hun Park Ph.D.

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