A 128 x 128 CMOS Biosensor Array for Extracellular Recording of Neural Activity
Björn Eversmann, Martin Jenkner, Franz Hofmann, Christian Paulus, Ralf Brederlow, Birgit Holzapfl,
Peter Fromherz, Matthias Merz, Markus Brenner, Matthias Schreiter, Reinhard Gabl, Kurt Plehnert,
Michael Steinhauser, Gerald Eckstein, Doris Schmitt-Landsiedel and Roland Thewes
IEEE Journal of solid-state circuits 38 (2003) 2306-2317
Abstract
Sensor arrays are a key tool in the field of neuroscience
for noninvasive recording of the activity of biological networks,
such as dissociated neurons or neural tissue. A high-density
sensor array complementary metaloxidesemiconductor chip is
presented with 16 Kpixels, a frame rate of 2 kiloframes per second,
and a pitch of 7.8 µm 7.8 µm for imaging of neural activity. The
related circuit and system issues as well as process aspects are discussed.
A mismatch-canceling calibration circuitry with current
mode signal representation is used. Results from first biological experiments
are presented, which prove full functionality of the chip.
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