MPI für Biochemie  

Emeritus Group Membrane and Neurophysics
Peter Fromherz

 

A 128 x 128 CMOS Bio-Sensor Array for Extracellular Recording of Neural Activity

Björn Eversmann, Martin Jenkner, Christian Paulus, Franz Hofmann, Ralf Brederlow, Birgit Holzapfl, Peter Fromherz, Markus Brenner, Matthias Schreiter, Reinhard Gabl, Kurt Plehnert, Michael Steinhauser, Gerald Eckstein, Doris Schmitt-Landsiedel, Roland Thewes
ISSCC 2003

Abstract

Sensor arrays for non-invasive monitoring of neural signals from living cells are a key tool in neurosciences to study biological neural networks. Moreover, such sensor arrays open the way for fast and statistically significant cell-based pharma screening. The process and circuit design issues for a high-density CMOS chip with 16384 pixels on 1 mm2 are presented.



Snail neuron grown on a CMOS chip with 128x128 Transistors. The electrical activity of the neuron is recorded by the chip. (Chip fabricated by Infineon Technologies)