Sensor arrays for non-invasive monitoring of neural signals from living cells are a key tool in neurosciences to study biological neural networks. Moreover, such sensor arrays open the way for fast and statistically significant cell-based pharma screening. The process and circuit design issues for a high-density CMOS chip with 16384 pixels on 1 mm2 are presented.

Snail neuron grown on a CMOS chip with 128x128 Transistors. The electrical activity of the neuron is recorded by the chip. (Chip fabricated by Infineon Technologies)