Publications

2017


Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the pre-ribosomal protein Nop53.
Falk S, Tants JN, Basquin J, Thoms M, Hurt E, Sattler M, Conti E.
RNA. 2017 Sep 7. pii: rna.062901.117. doi: 10.1261/rna.062901.117. [Epub ahead of print]
Pubmed

Mpp6 Incorporation in the Nuclear Exosome Contributes to RNA Channeling through the Mtr4 Helicase.
Falk S, Bonneau F, Ebert J, Kögel A, Conti E.
Cell Rep. 2017 Sep 5;20(10):2279-2286. doi: 10.1016/j.celrep.2017.08.033.
Pubmed

Sen1 has unique structural features grafted on the architecture of the Upf1-like helicase family.
Leonaitė B, Han Z, Basquin J, Bonneau F, Libri D, Porrua O, Conti E.
EMBO J. 2017 Jun 1;36(11):1590-1604. doi: 10.15252/embj.201696174. Epub 2017 Apr 13.
Pubmed

Structure of a SMG8-SMG9 complex identifies a G-domain heterodimer in the NMD effector proteins.
Li L, Lingaraju M, Basquin C, Basquin J, Conti E.
RNA. 2017 Jul;23(7):1028-1034. doi: 10.1261/rna.061200.117. Epub 2017 Apr 7.
Pubmed

2016


The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex.
Schmidt C, Kowalinski E, Shanmuganathan V, Defenouillère Q, Braunger K, Heuer A, Pech M, Namane A, Berninghausen O, Fromont-Racine M, Jacquier A, Conti E, Becker T, Beckmann R.
Science. 2016 Dec 16;354(6318):1431-1433.
Pubmed

Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors.
Falk S, Finogenova K, Melko M, Benda C, Lykke-Andersen S, Jensen TH, Conti E.
Nat Commun. 2016 Dec 1;7:13573. doi: 10.1038/ncomms13573.
Pubmed

Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex.
Kowalinski E, Kögel A, Ebert J, Reichelt P, Stegmann E, Habermann B, Conti E.
Mol Cell. 2016 Jul 7;63(1):125-34. doi: 10.1016/j.molcel.2016.05.028.
Pubmed

Structural basis for the antagonistic roles of RNP-8 and GLD-3 in GLD-2 poly(A)-polymerase activity.
Nakel K, Bonneau F, Basquin C, Habermann B, Eckmann CR, Conti E.
RNA. 2016 Aug;22(8):1139-45. doi: 10.1261/rna.056598.116.
Pubmed

Molecular mechanism of processive 3' to 5' RNA translocation in the active subunit of the RNA exosome complex.
Vukovic L, Chipot C, Makino DL, Conti E, Schulten K.
J Am Chem Soc. 2016 Mar 30;138(12):4069-78. doi: 10.1021/jacs.5b12065.
Pubmed

2015


Structure of the RNA Helicase MLE Reveals the Molecular Mechanisms for Uridine Specificity and RNA-ATP Coupling.
Prabu JR, Müller M, Thomae AW, Schüssler S, Bonneau F, Becker PB, Conti E.
Mol Cell. 2015 Nov 5;60(3):487-99. doi: 10.1016/j.molcel.2015.10.011.
Pubmed

Structure of a Human 4E-T/DDX6/CNOT1 Complex Reveals the Different Interplay of DDX6-Binding Proteins with the CCR4-NOT Complex.
Ozgur S, Basquin J, Kamenska A, Filipowicz W, Standart N, Conti E.
Cell Rep. 2015 Oct 27;13(4):703-11. doi: 10.1016/j.celrep.2015.09.033. Epub 2015 Oct 17.
Pubmed

RNA degradation paths in a 12-subunit nuclear exosome complex.
Makino DL, Schuch B, Stegmann E, Baumgärtner M, Basquin C, Conti E.
Nature. 2015 Aug 6;524(7563):54-8. doi: 10.1038/nature14865. Epub 2015 Jul 29.
Pubmed

Structural basis for the activation of the C. elegans noncanonical cytoplasmic poly(A)-polymerase GLD‑2 by GLD‑3.
Nakel K, Bonneau F, Eckmann CR, Conti E.
Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8614-9. doi: 10.1073/pnas.1504648112. Epub 2015 Jun 29.
Pubmed

Analysis of protein-RNA interactions by UV-induced cross-linking and mass spectrometry.
Sharma K, Hrle A, Kramer K, Sachsenberg T, Staals RH, Randau L, Marchfelder A, van der Oost J, Kohlbacher O, Conti E, Urlaub H.
Methods. 2015 Nov 1;89:138-48. doi: 10.1016/j.ymeth.2015.06.005. Epub 2015 Jun 10.
Pubmed

Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases.
Kowalinski E, Schuller A, Green R, Conti E.
Structure. 2015 Jul 7;23(7):1336-43. doi: 10.1016/j.str.2015.04.018. Epub 2015 Jun 4.
Pubmed

Architecture of the Ubiquitylation Module of the Yeast Ccr4-Not Complex.
Bhaskar V, Basquin J, Conti E.
Structure. 2015 May 5;23(5):921-8. doi: 10.1016/j.str.2015.03.011. Epub 2015 Apr 23.
Pubmed

The conformational plasticity of eukaryotic RNA-dependent ATPases.
Ozgur S, Buchwald G, Falk S, Chakrabarti S, Prabu JR, Conti E.
FEBS J. 2015 Mar;282(5):850-63. doi: 10.1111/febs.13198. Epub 2015 Feb 4.
Pubmed

2014


The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase.
Schuch B, Feigenbutz M, Makino DL, Falk S, Basquin C, Mitchell P, Conti E.
EMBO J. 2014 Dec 1;33(23):2829-46. doi: 10.15252/embj.201488757. Epub 2014 Oct 15.
Pubmed

Structural Model of a CRISPR RNA-Silencing Complex Reveals the RNA-Target Cleavage Activity in Cmr4.
Benda C, Ebert J, Scheltema RA, Schiller HB, Baumgärtner M, Bonneau F, Mann M, Conti E.
Mol Cell. 2014 Oct 2;56(1):43-54. doi: 10.1016/j.molcel.2014.09.002.
Pubmed

The Molecular Architecture of the TRAMP Complex Reveals the Organization and Interplay of Its Two Catalytic Activities.
Falk S*, Weir JR*, Hentschel J, Reichelt P, Bonneau F, Conti E.
Mol Cell. 2014 Sep 18;55(6):856-67. doi: 10.1016/j.molcel.2014.07.020. Epub 2014 Aug 28.
Pubmed

Structural analyses of the CRISPR protein Csc2 reveal the RNA-binding interface of the type I-D Cas7 family.
Hrle A, Maier LK, Sharma K, Ebert J, Basquin C, Urlaub H, Marchfelder A, Conti E.
RNA Biol. 2014 Aug 12;11(8). [Epub ahead of print]
Pubmed

Simultaneous Assessment of Kinetic, Site-Specific, and Structural Aspects of Enzymatic Protein Phosphorylation.
van de Waterbeemd M, Lössl P, Gautier V, Marino F, Yamashita M, Conti E, Scholten A, Heck AJ.
Angew Chem Int Ed Engl. 2014 Sep 1;53(36):9660-4. doi: 10.1002/anie.201404637. Epub 2014 Jul 9.
Pubmed

Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6.
Chakrabarti S, Bonneau F, Schüssler S, Eppinger E, Conti E.
Nucleic Acids Res. 2014 Oct 1;42(14):9447-60. doi: 10.1093/nar/gku578. Epub 2014 Jul 10.
Pubmed

The structure of the Pan2-Pan3 core complex reveals cross-talk between deadenylase and pseudokinase.
Schäfer IB, Rode M, Bonneau F, Schüssler S, Conti E.
Nat Struct Mol Biol. 2014 Jul;21(7):591-8. doi: 10.1038/nsmb.2834. Epub 2014 Jun 1.
Pubmed

Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression.
Mathys H*, Basquin J*, Ozgur S, Czarnocki-Cieciura M, Bonneau F, Aartse A, Dziembowski A, Nowotny M, Conti E, Filipowicz W.
Mol Cell. 2014 Jun 5;54(5):751-65. doi: 10.1016/j.molcel.2014.03.036. Epub 2014 Apr 24.
Pubmed

In vitro assembly and activity of an archaeal CRISPR-Cas type I-A Cascade interference complex.
Plagens A, Tripp V, Daume M, Sharma K, Klingl A, Hrle A, Conti E, Urlaub H, Randau L.
Nucleic Acids Res. 2014 Apr 1;42(8):5125-38. doi: 10.1093/nar/gku120. Epub 2014 Feb 5.
Pubmed

2013


Crystal structure of the human eIF4AIII-CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domain.
Buchwald G, Schüssler S, Basquin C, Le Hir H, Conti E.
Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):E4611-8. doi: 10.1073/pnas.1314684110. Epub 2013 Nov 11.
Pubmed

Structure determination of an 11-subunit exosome in complex with RNA by molecular replacement.
Makino DL, Conti E.
Acta Crystallogr D Biol Crystallogr. 2013 Nov;69(Pt 11):2226-35. doi: 10.1107/S0907444913011438. Epub 2013 Oct 12.
Pubmed

Architecture of the Lsm1-7-Pat1 Complex: A Conserved Assembly in Eukaryotic mRNA Turnover
Sharif H, Conti E.
Cell Rep. 2013 Oct 31;5(2):283-91. doi: 10.1016/j.celrep.2013.10.004. Epub 2013 Oct 17.
Pubmed

Structure and RNA-binding properties of the Not1-Not2-Not5 module of the yeast Ccr4-Not complex.
Bhaskar V, Roudko V, Basquin J, Sharma K, Urlaub H, Séraphin B, Conti E.
Nat Struct Mol Biol. 2013 Nov;20(11):1281-8. doi: 10.1038/nsmb.2686. Epub 2013 Oct 13.
Pubmed

Structure and RNA-binding properties of the Type III-A CRISPR-associated protein Csm3.
Hrle A*, Su AA*, Ebert J, Benda C, Randau L, Conti E.
RNA Biol. 2013 Nov;10(11):1670-8. doi: 10.4161/rna.26500. Epub 2013 Sep 30.
Pubmed

The RNA exosome and proteasome: common principles of degradation control.
Makino DL, Halbach F, Conti E.
Nat Rev Mol Cell Biol. 2013 Aug 29. doi: 10.1038/nrm3657. Epub 2013 Aug 29.
Pubmed

The yeast ski complex: crystal structure and RNA channeling to the exosome complex.
Halbach F, Reichelt P, Rode M, Conti E.
Cell. 2013 Aug 15;154(4):814-26. doi: 10.1016/j.cell.2013.07.017.
Pubmed

Structural analysis of the yeast Dhh1-Pat1 complex reveals how Dhh1 engages Pat1, Edc3 and RNA in mutually exclusive interactions.
Sharif H, Özgür S, Sharma K, Basquin C, Urlaub H, Conti E.
Nucleic Acids Res. 2013 Sep 1;41(17):8377-90. doi: 10.1093/nar/gkt600. Epub 2013 Jul 12.
Pubmed

Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins.
von Moeller H, Lerner R, Ricciardi A, Basquin C, Marzluff WF, Conti E.
Nucleic Acids Res. 2013 Sep 1;41(16):7960-71. doi: 10.1093/nar/gkt558. Epub 2013 Jun 26.
Pubmed

Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex.
Makino DL, Baumgärtner M, Conti E.
Nature. 2013 Mar 7;495(7439):70-5. doi: 10.1038/nature11870. Epub 2013 Feb 3.
Pubmed

Deep transcriptome-sequencing and proteome analysis of the hydrothermal vent annelid Alvinella pompejana identifies the CvP-bias as a robust measure of eukaryotic thermostability.
Holder T, Basquin C, Ebert J, Randel N, Jollivet D, Conti E, Jékely G, Bono F.
Biol Direct. 2013 Jan 16;8:2. doi: 10.1186/1745-6150-8-2.
Pubmed

2012


Crystal structure of a 9-subunit archaeal exosome in pre-catalytic States of the phosphorolytic reaction.
Lorentzen E, Conti E.
Archaea. 2012;2012:721869. doi: 10.1155/2012/721869. Epub 2012 Dec 20.
Pubmed

Architecture of the Nuclease Module of the Yeast Ccr4-Not Complex: the Not1-Caf1-Ccr4 Interaction.
Basquin J*, Roudko VV*, Rode M, Basquin C, Séraphin B, Conti E.
Mol Cell. 2012 Oct 26;48(2):207-18. doi: 10.1016/j.molcel.2012.08.014. Epub 2012 Sep 6.
Pubmed

The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.
Melero R*, Buchwald G*, Castaño R, Raabe M, Gil D, Lázaro M, Urlaub H, Conti E, Llorca O.
Nat Struct Mol Biol. 2012 Apr 22;19(5):498-505, S1-2. doi: 10.1038/nsmb.2287.
Pubmed

Structural and Functional Organization of the Ska Complex, a Key Component of the Kinetochore-Microtubule Interface.
Jeyaprakash AA, Santamaria A, Jayachandran U, Chan YW, Benda C, Nigg EA, Conti E.
Mol Cell. 2012 May 11;46(3):274-86. doi: 10.1016/j.molcel.2012.03.005. Epub 2012 Apr 5.
Pubmed

The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex.
Murachelli AG, Ebert J, Basquin C, Le Hir H, Conti E.
Nat Struct Mol Biol. 2012 Mar 4;19(4):378-86. doi: 10.1038/nsmb.2242.
Pubmed

The crystal structure of S. cerevisiae Ski2, a DExH helicase associated with the cytoplasmic functions of the exosome.
Halbach F, Rode M, Conti E.
RNA. 2012 Jan;18(1):124-34. Epub 2011 Nov 23.
Pubmed

2011


Structural Basis for the Recognition of Phosphorylated Histone H3 by the Survivin Subunit of the Chromosomal Passenger Complex.
Jeyaprakash AA, Basquin C, Jayachandran U, Conti E.
Structure. 2011 Oct 27;19(11):1625-1634. Epub 2011 Oct 25.
Pubmed

Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and Its Regulation by Upf2.
Chakrabarti S, Jayachandran U, Bonneau F, Fiorini F, Basquin C, Domcke S, Le Hir H, Conti E.
Mol Cell. 2011 Mar 18;41(6):693-703.
Pubmed

2010


RNA channelling by the eukaryotic exosome.
Malet H, Topf M, Clare DK, Ebert J, Bonneau F, Basquin J, Drazkowska K, Tomecki R, Dziembowski A, Conti E, Saibil HR, Lorentzen E.
EMBO Rep. 2010 Dec;11(12):936-42. Epub 2010 Nov 12.
Pubmed

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay.
Kashima I, Jonas S, Jayachandran U, Buchwald G, Conti E, Lupas AN, Izaurralde E.
Genes Dev. 2010 Nov 1;24(21):2440-50. Epub 2010 Oct 7.
Pubmed

Four KH domains of the C. elegans Bicaudal-C ortholog GLD-3 form a globular structural platform.
Nakel K, Hartung SA, Bonneau F, Eckmann CR, Conti E.
RNA. 2010 Nov;16(11):2058-67. Epub 2010 Sep 7.
Pubmed

Structural analysis reveals the characteristic features of Mtr4, a DExH helicase involved in nuclear RNA processing and surveillance.
Weir JR, Bonneau F, Hentschel J, Conti E.
Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12139-44. Epub 2010 Jun 21.
Pubmed

Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex.
Buchwald G, Ebert J, Basquin C, Saulière J, Jayachandran U, Bono F, Le Hir H, Conti E.
Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10050-5. Epub 2010 May 17.
Pubmed

Nuclear export complexes in the frame.
Cook AG, Conti E.
Curr Opin Struct Biol. 2010 Apr;20(2):247-52. Epub 2010 Feb 18.
Pubmed

Nuclear Import Mechanism of the EJC Component Mago-Y14 Revealed by Structural Studies of Importin 13.
Bono F, Cook AG, Grünwald M, Ebert J, Conti E.
Mol Cell. 2010 Jan 29;37(2):211-222.
Pubmed

2009


The yeast exosome functions as a macromolecular cage to channel RNA substrates for degradation.
Bonneau F*, Basquin J*, Ebert J, Lorentzen E, Conti E.
Cell. 2009 Oct 30;139(3):547-59.
Pubmed

Structures of the tRNA export factor in the nuclear and cytosolic states.
Cook AG, Fukuhara N, Jinek M, Conti E.
Nature. 2009 Aug 13;461(7260):60-65.
Pubmed

Stable Kinetochore-Microtubule Interactions Depend on the Ska Complex and its New Component Ska3/C13orf3. 
Gaitanos TN, Santamaria A, Jeyaprakash AA, Wang B, Conti E, Nigg EA.
EMBO J. 2009 May 20;28(10):1442-52. Epub 2009 Apr 9.
Pubmed

The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner.
von Moeller H, Basquin C, Conti E.
Nat Struct Mol Biol. 2009 Mar;16(3):247-54. Epub 2009 Feb 15.
Pubmed

2008


Expression, reconstitution, and structure of an archaeal RNA degrading exosome.
Lorentzen E, Conti E.
Methods Enzymol. 2008;447:417-35.
Pubmed

Structural organization of the RNA degrading exosome.
Lorentzen E, Basquin J, Conti E.
Curr Opin Struct Biol. 2008 Dec;18(6):709-13.
Pubmed

The C-terminal region of Ge-1 presents conserved structural features required for P-body localization.
Jinek M, Eulalio A, Lingel A, Helms S, Conti E, Izaurralde E.
RNA. 2008 Oct;14(10):1991-8.
Pubmed

Structure of the active subunit of the yeast exosome core, Rrp44: diverse modes of substrate recruitment in the RNase II nuclease family.
Lorentzen E, Basquin J, Tomecki R, Dziembowski A, Conti E.
Mol Cell. 2008 Mar 28;29(6):717-28.
Pubmed

2007


Structure of a Survivin-Borealin-INCENP Core Complex Reveals How Chromosomal Passengers Travel Together.
Jeyaprakash AA, Klein UR, Lindner D, Ebert J, Nigg EA, Conti E.
Cell. 2007 Oct 19;131(2):271-85.
Pubmed

Structural biology of nucleocytoplasmic transport.
Cook A, Bono F, Jinek M, Conti E.
Annu Rev Biochem. 2007;76:647-71.
Pubmed

RNA channelling by the archaeal exosome.
Lorentzen E, Dziembowski A, Lindner D, Seraphin B, Conti E.
EMBO Rep. 2007 May;8(5):470-6.
Pubmed

A single subunit, Dis3, is essentially responsible for yeast exosome core activity.
Dziembowski A, Lorentzen E, Conti E, Seraphin B.
Nat Struct Mol Biol. 2007 Jan;14(1):15-22.
Pubmed

Structural and biochemical characterization of the yeast exosome component Rrp40.
Oddone A, Lorentzen E, Basquin J, Gasch A, Rybin V, Conti E, Sattler M.
EMBO Rep. 2007 Jan;8(1):63-9.
Pubmed

2006


Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex.
Glavan F, Behm-Ansmant I, Izaurralde E, Conti E.
EMBO J. 2006 Nov 1;25(21):5117-25.
Pubmed

Structural insights into the Notch-modifying glycosyltransferase Fringe.
Jinek M, Chen YW, Clausen H, Cohen SM, Conti E.
Nat Struct Mol Biol. 2006 Oct;13(10):945-6.
Pubmed

The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA.
Bono F, Ebert J, Lorentzen E, Conti E.
Cell. 2006 Aug 25;126(4):713-25.
Pubmed

Eukaryotic expression, purification, crystallization and preliminary X-ray analysis of murine Manic Fringe.
Jinek M, Conti E.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Aug 1;62(Pt 8):774-7.
Pubmed

The exosome and the proteasome: nano-compartments for degradation.
Lorentzen E, Conti E.
Cell. 2006 May 19;125(4):651-4. Review.
Pubmed

Chemical shift backbone assignments of TAP-N, the 31 kDa cargo-binding region of the protein TAP.
Pimienta G, Gabel F, Zanier K, Conti E, Sattler M.
J Biomol NMR. 2006;36 Suppl 1:23.
Pubmed

Karyopherin flexibility in nucleocytoplasmic transport.
Conti E, Muller CW, Stewart M.
Curr Opin Struct Biol. 2006 Apr;16(2):237-44. Review.
Pubmed

2005


Structural basis of 3' end RNA recognition and exoribonucleolytic cleavage by an exosome RNase PH core.
Lorentzen E, Conti E.
Mol Cell. 2005 Nov 11;20(3):473-81.
Pubmed

The archaeal exosome core is a hexameric ring structure with three catalytic subunits.
Lorentzen E, Walter P, Fribourg S, Evguenieva-Hackenberg E, Klug G, Conti E.
Nat Struct Mol Biol. 2005 Jul;12(7):575-81.
Pubmed

Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species.
Conti E, Izaurralde E.
Curr Opin Cell Biol. 2005 Jun;17(3):316-25. Review.
Pubmed

The structure of the nuclear export receptor Cse1 in its cytosolic state reveals a closed conformation incompatible with cargo binding.
Cook A, Fernandez E, Lindner D, Ebert J, Schlenstedt G, Conti E.
Mol Cell. 2005 Apr 29;18(3):355-67.
Pubmed

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway.
Fukuhara N, Ebert J, Unterholzner L, Lindner D, Izaurralde E, Conti E.
Mol Cell. 2005 Feb 18;17(4):537-47.
Pubmed

2004


The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha.
Jinek M, Rehwinkel J, Lazarus BD, Izaurralde E, Hanover JA, Conti E.
Nat Struct Mol Biol. 2004 Oct;11(10):1001-7.
Pubmed

Determinants for Aurora-A activation and Aurora-B discrimination by TPX2.
Bayliss R, Sardon T, Ebert J, Lindner D, Vernos I, Conti E.
Cell Cycle. 2004 Apr;3(4):404-7.
Pubmed

Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex.
Bono F, Ebert J, Unterholzner L, Guttler T, Izaurralde E, Conti E.
EMBO Rep. 2004 Mar;5(3):304-10.
Pubmed

Conformational variability of nucleo-cytoplasmic transport factors.
Fukuhara N, Fernandez E, Ebert J, Conti E, Svergun D.
J Biol Chem. 2004 Jan 16;279(3):2176-81.
Pubmed

2003


Structural basis of Aurora-A activation by TPX2 at the mitotic spindle.
Bayliss R, Sardon T, Vernos I, Conti E.
Mol Cell. 2003 Oct;12(4):851-62.
Pubmed

Structural similarity in the absence of sequence homology of the messenger RNA export factors Mtr2 and p15.
Fribourg S, Conti E.
EMBO Rep. 2003 Jul;4(7):699-703.
Pubmed

A novel mode of RBD-protein recognition in the Y14-Mago complex.
Fribourg S, Gatfield D, Izaurralde E, Conti E.
Nat Struct Biol. 2003 Jun;10(6):433-9.
Pubmed

2002


Structures of importins.
Conti E.
Results Probl Cell Differ. 2002;35:93-113. Review.
Pubmed

2001


Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor.
Fribourg S, Braun IC, Izaurralde E, Conti E.
Mol Cell. 2001 Sep;8(3):645-56.
Pubmed

Nucleocytoplasmic transport enters the atomic age.
Conti E, Izaurralde E.
Curr Opin Cell Biol. 2001 Jun;13(3):310-9. Review.
Pubmed

Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export.
Braun IC, Herold A, Rode M, Conti E, Izaurralde E.
J Biol Chem. 2001 Jun 8;276(23):20536-43.
Pubmed

2000


The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain.
Liker E, Fernandez E, Izaurralde E, Conti E.
EMBO J. 2000 Nov 1;19(21):5587-98.
Pubmed

Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha.
Conti E, Kuriyan J.
Structure. 2000 Mar 15;8(3):329-38.
Pubmed

1998


Structural basis for the inhibition of firefly luciferase by a general anesthetic.
Franks NP, Jenkins A, Conti E, Lieb WR, Brick P.
Biophys J. 1998 Nov;75(5):2205-11.
Pubmed

Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha.
Conti E, Uy M, Leighton L, Blobel G, Kuriyan J.
Cell. 1998 Jul 24;94(2):193-204.
Pubmed

X-ray and spectrophotometric studies of the binding of proflavin to the S1 specificity pocket of human alpha-thrombin.
Conti E, Rivetti C, Wonacott A, Brick P.
FEBS Lett. 1998 Mar 27;425(2):229-33.
Pubmed

 
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