Dr. Christian Biertümpfel
Dr. Christian Biertümpfel
Group Leader
Phone:+49 89 8578-3641

MPI of Biochemistry , Am Klopferspitz 18, 82152 Martinsreid

Molecular Mechanisms of DNA repair

Marvin Assent
Marvin Assent
PhD Student
Phone:+49 89 8578-3480

"My project consists of unraveling the mechanisms for translesion synthesis (TLS), which is a process used for tolerating DNA damage. As the cellular replication machinery stalls at the DNA lesion site, special polymerases can effectively bypass lesions and allow for DNA repair. The main focus of my project is to biochemically and structurally characterise these special TLS polymerases."

Sophia Beslmueller
Sophia Beslmueller
Master Student/Intern
Phone:+49 89 8578-3483

MPI of Biochemistry, Am Klopferspitz 18, 82152 Martinsried

"My project focuses on the Holliday junction resolvases MUS81-EME1 and SLX4-SLX. These proteins, which are conserved throughout eukaryotes, play a vital role in resolving recombination intermediates and we are especially interested in elucidating interactions with other proteins and study their activities with various DNA substrates."

Giulia Chiapparini
Giulia Chiapparini
PhD Student
Phone:+49 89 8578-3483

"Translesion DNA synthesis (TLS) is a fundamental DNA damage tolerance pathway, which allows the replicative machinery to bypass blocking lesions that could be present on the DNA and prevent DNA replication (e.g. UV-light induce crosslinks). The aim of my PhD project is to structurally and biochemically describe the interactions and functions of proteins involved in TLS, particularly TLS DNA polymerases and their interaction partners using techniques such as cryo-EM and X-ray crystallography"

Ying Zhu
Ying Zhu
Intern
Phone:+49 89 8578-3106

"The main aim of my project is to characterize 'minimal translesion complexes' that are sufficient to synthesize DNA across lesions. I want to find a stable system to perform biochemical and structural analyses"

Dr. Iuliia Iermak
Dr. Iuliia Iermak
Postdoc
Phone:+49 89 8578-3480

MPI of Biochemistry, Am Klopferspitz 18, 82152 Martinsried

"SLX4 is a coordinator of multiple DNA structure-specific endonucleases, and it is involved in multiple DNA repair pathways, including interstrand crosslinks repair, Holliday junction resolution, etc. Although a number of studies on SLX4 structure and functions are available, a complete picture of how the SLX4 regulates recognition and processing of DNA damage and interacts with other proteins is largely unclear. My project focuses on the structural and biochemical characterization of SLX4 and selected interaction partners using cryo-EM and X-ray crystallography as main techniques. "

Christopher Kuhn
Christopher Kuhn
Student
Phone:+49 89 8578-3641
Email:ckuhn@...

MPI of Biochemistry, Am Klopferspitz 18, 82152

"I am interested in Mechanism of DNA Repair and currently I am working on the characterization of the Holliday junction resolvase GEN1 in different biochemical contexts".

Dr. Shun-Hsiao Lee
Dr. Shun-Hsiao Lee
Postdoc
Phone:+49 89 8578-3641
Email:shlee@...

"In general I’m interested in the mechanisms of homologous recombination. My project focuses on the eukaryotic Holliday junction resolvase GEN1 which is one of the key players for removing DNA joint molecules during recombination and replication. Specifically, I'm trying to unravel the mechanism of GEN1 substrate recognition and the cleavage by using structural biology and biochemical tools."

Carina Vraschek
Carina Vraschek
PhD Student
Phone:+49 89 8578-3483

MPI of Biochemistry, Am Klopferspitz 18, 82152

"SLX4 is a platform protein involved in DNA damage repair. At the end of homologous recombination, Holliday Junctions need to be resolved and this process is carried out by SLX4 in association with other proteins such as SLX1, MUS81, and EME1. The details about the concerted cleavage reaction executed by the SLX4-SLX1-MUS81-EME1 complex remain unknown. In my project, I apply biochemical and structural methods in order to unravel the mechanisms of DNA binding and cleavage of the SLX4-SLX1-MUS81-EME1 complex."

Marcus Hammerl
Marcus Hammerl
Technical Assistance

MPI of Biochemistry, Am Klopferspitz 18, 82152 Martinsried

"I assist scientists with protein purification, ordering, and many other things in order to keep the lab running. I am also the person in charge of mantaining cell culture."

Dr. Alethia Villasenor
Dr. Alethia Villasenor
Lab manager/ support
Phone:+49 89 8578 3106

MPI of Biochemistry, Am Klopferspitz 18, 82152 Martinsried

"I work in a range of projects: from studying the the influence of cell cycle on DNA Repair to helping characterize DNA repair proteins. I also provide support and help in ordering, organizing and coordinating "

 
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