Dr. Hannes Mutschler
Group Leader
Phone:+49 89 8578-2327



Journal Publications

Cozens C*, Mutschler H*, Nelson GM, Houlihan G, Taylor AI, Holliger P. Enzymatic Synthesis of Nucleic Acids with Defined Regioisomeric 2′-5′ Linkages (2015) Angewandte Chemie International Edition, 54, 15570–15573
*joint first-author

Mutschler H, Wochner A, Holliger P. Freeze-thaw cycles as drivers of complex ribozyme assembly. (2015) Nature Chemistry, 7, 502–508

Mutschler H, Holliger P. Non-canonical 3'-5' extension of RNA with prebiotically plausible ribonucleoside 2', 3'-cyclic phosphates. (2014) Journal of the American Chemical Society, 136, 5193–5196.

Mutschler H, Meinhart A. ε/ζ systems: their role in resistance, virulence, and their potential for antibiotic development. (2011) Journal of Molecular Medicine, 89, 1183-1194.

Mutschler H, Gebhardt M, Shoeman RL, Meinhart A. A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis. (2011) PLoS Biology, 9, e1001033.

Lunde BM, Reichow SL, Kim M, Suh H, Leeper TC, Yang F, Mutschler H, Buratowski S, Meinhart A, Varani G. Cooperative interaction of transcription termination factors with the RNA polymerase II C-terminal domain. (2010) Nature Structural & Molecular Biology, 17, 1195-1201.

Mutschler H, Reinstein J, Meinhart A. Assembly dynamics and stability of the pneumococcal epsilon zeta antitoxin toxin (PezAT) system from Streptococcus pneumoniae. (2010) Journal of Biological Chemistry, 285, 21797-806.

Kress W, Mutschler H, Weber-Ban E. Both ATPase domains of ClpA are critical for processing of stable protein structures. (2009) Journal of Biological Chemistry, 284, 31441-52.

Vasiljeva L, Kim M*, Mutschler H*, Buratowski S, Meinhart A. The Nrd1-Nab3-Sen1 termination complex interacts with the Ser5-phosphorylated RNA polymerase II C-terminal domain. (2008) Nature Structural & Molecular Biology, 15, 795-804.
*contributed equally

Kress W, Mutschler H, Weber-Ban E. Assembly pathway of an AAA+ protein: tracking ClpA and ClpAP complex formation in real time. (2007) Biochemistry, 46, 6183-93.


Use of a new class of nucleotide sugar as antibiotic or cytostatic agent, Mutschler H, Meinhart A. WO Patent 2,012,038,097 (2012)

Book Chapters

Mutschler H, Meinhart A. Type II Toxin-Antitoxin Loci: The Epsilon/Zeta Family in: Prokaryotic Toxin-Antitoxins, 205-223. Springer Berlin Heidelberg (2013)

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