Prof. Dr.  Karl Duderstadt
Prof. Dr. Karl Duderstadt
Group Leader
Phone:+49 89 8578-3033

MPI of Biochemistry,
Am Klopferspitz 18, 82152 Martinsried



Hill, F.R., van Oijen, A.M., and Duderstadt, K.E. Detection of kinetic change points in piece-wise linear single molecule motion. The Journal of Chemical Physics 148, 123317 (2018).


Scherr, M.J., Safaric, B., and Duderstadt, K.E. Noise in the Machine: Alternative Pathway Sampling is the Rule During DNA Replication. Bioessays 77, 1700159 (2017).

Lewis, J.S., Spenkelink, L.M., Jergic, S., Wood, E.A., Monachino, E., Horan, N.P., Duderstadt, K.E., Cox, M.M., Robinson, A., Dixon, N.E., and van Oijen, A. M. Single-molecule visualization of fast polymerase turnover in the bacterial replisome. Elife 6, 4846 (2017).


Duderstadt, K.E., Geertsema, H.J., Stratmann, S.A., Punter, C.M., Kulczyk, A.W., Richardson, C.C., and van Oijen, A.M. Simultaneous Real-Time Imaging of Leading and Lagging Strand Synthesis Reveals the Coordination Dynamics of Single Replisomes. Molecular Cell 64, 1035-1047 (2016).

Åberg, C., Duderstadt, K.E., and van Oijen, A.M. Stability versus exchange: a paradox in DNA replication. Nucleic Acids Research 44, 4846–4854 (2016). 


Geertsma, H.J., Duderstadt, K.E., and van Oijen, A.M. Single-­molecule observation of prokaryotic DNA replication. Methods in Enzymology 1300, 219-238 (2015).  


Duderstadt, K.E., ReyesLamothe, R., van Oijen, A.M., and Sherratt, D.J. ReplicationFork Dynamics. Cold Spring Harbor Perspectives in Biology (2013). 

Duderstadt, K.E., and Berger, J.M. A structural framework for replication origin opening by AAA+ initiation factors. Curr. Opin. Struc. Biol. 23, 144–153 (2013). 


Duderstadt, K.E., Chuang, K., and Berger, J.M. DNA stretching by bacterial initiators promotes replication origin opening. Nature 478, 209-­213 (2011). 


Duderstadt, K.E., Mott, M.L., Crisona, N.J., Chuang, K., Yang, H., and Berger, J.M. Origin remodeling and opening in bacteria rely on distinct assembly states of the DnaA initiator. J. Biol. Chem. 285, 28229-­28239 (2010).  

Dedeo, M.T., Duderstadt, K.E., Berger, J.M., and Francis, M. B. Nanoscale protein assemblies from a circular permutant of the tobacco mosaic virus. Nano Lett. 10, 181-­186 (2010). 


Duderstadt, K.E., and Berger, J.M. AAA+ ATPases in the initiation of DNA replication. Crit. Rev. Biochem. Mol. Biol. 43, 163187 (2008). 

van Petegem, F., Duderstadt, K.E., Clark, K.A., Wang M., and Minor, D.L., Jr. Alaninescanning mutagenesis defines a conserved energetic hotspot in the CaValpha1 AIDCaVbeta interaction site that is critical for channel modulation. Structure 16, 280294 (2008). 


Hanson, J.A., Duderstadt, K.E., Watkins, L. P., Bhattacharyya, S., Brokaw, J., Chu, J.W., and Yang, H. Illuminating the mechanistic roles of enzyme conformational dynamics. Proc. Natl. Acad. Sci. U. S. A. 104, 18055-­18060 (2007). 


Michelsen, K., Mrowiec, T., Duderstadt, K.E., Frey, S., Minor, D.L., Jr., Mayer, M.P., and Schwappach B. A multimeric membrane protein reveals 14-­3-­3 isoform specificity in forward transport in yeast. Traffic 7, 903-­916 (2006). 


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