Contact

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Prof. Dr. Karl Duderstadt
Group Leader
Phone:+49 89 8578-3033

MPI of Biochemistry,
Am Klopferspitz 18, 82152 Martinsried

http://www.biochem.mpg.de/duderstadt

Research

Chromosome replication is performed by a large multisubunit assembly, known as the replisome, which couples the unpackaging of parental DNA with the synthesis of new daughter strands. To ensure genome integrity, this sophisticated molecular machine must coordinate events over a broad range of time and length scales, from the breaking and reformation of chemical bonds within DNA polymerases to the large-scale structural rearrangements of chromosomes. We seek to define the operating principles that guide replisome function and understand how replisomes recognize and process obstacles encountered on parental chromosomes such as DNA lesions, unfavorable topological structures, and architectural factors.

Our vision is to use these studies to develop a general framework for understanding how networks of intra- and inter-molecular interactions can evolve to guide dynamic events within multiprotein complexes.

 
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