Dr. Gurumoorthy Krishnamoorthy
Dr. Gurumoorthy Krishnamoorthy
Group leader
Phone:+49 89 8578-2464

MPI of Biochemistry,
Am Klopferspitz 18, 82152 Martinsried



Berer, K., Martinez, I., Walker, A., Kunkel, B., Schmitt-Kopplin, P., Walter, J., Krishnamoorthy, G. Dietary non-fermentable fiber prevents autoimmune neurological disease by changing gut metabolic and immune status.  Sci Rep 2018. 8, 10431.

Janakiraman, M & Krishnamoorthy, G. Emerging role of diet and microbiota interactions in neuroinflammation. Front Immunol 2018. 9,2067.

Spadaro, M., Winklmeier, S., Beltrán, E., Macrini, C., Höftberger, R., Schuh, E., Thaler Franziska, S., Gerdes, L.-A., Laurent, S., Gerhards, R., Brändle, S., Dornmair, K., Breithaupt, C., Krumbholz, M., Moser, M., Krishnamoorthy, G., Kamp, F., Jenne, D., Hohlfeld, R., Kümpfel, T., Lassmann, H., Kawakami, N., and Meinl, E.. Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein.  Ann Neurol 2018 In Press.


Berer, K., Gerdes, L. A., Cekanaviciute, E., Jia, X., Xiao, L., Xia, Z., Liu, C., Klotz, L., Stauffer, U., Baranzini, S. E., Kümpfel, T., Hohlfeld, R., Krishnamoorthy, G*., Wekerle, H*. 2017. Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A114, 10719-10724.                                                                                                                                                            *Corresponding authors                                                          



Rumble, J. M., Huber, A. K., Krishnamoorthy, G., Srinivasan, A., Giles, D. A., Zhang, X., Wang, L., Segal, B. M. 2015. Neutrophil-related factors as biomarkers in EAE and MS. J Exp Med. 212, 23-35


Koutrolos, M., Berer, K., Kawakami, N., Wekerle, H., Krishnamoorthy, G. 2014. Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS. Acta Neuropathol Commun. 2: 163.

Eberle, M., Ebel, P., Wegner, M.-S., Männich, J., Tafferner, N., Ferreiros, N., Birod, K., Schreiber, Y., Krishnamoorthy, G., Willecke, K., Geisslinger, G., Grösch, S., Schiffmann, S. 2014. Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent. Biochem Pharmacol 92: 326-335.

Berer, K., Boziki, M., Krishnamoorthy, G.  Selective accumulation of pro-inflammatory T cells in the intestine contributes to the resistance to autoimmune demyelinating disease. PLoS ONE 2014. 9 (2), e87876. 

Nischwitz, S., Faber, H., Sämann, P.G., Domingues, H.S., Krishnamoorthy, G., Knop, M., Müller-Sarnowski, F., Yassouridis, A., Weber, F. 2014. Interferon beta-1a reduces increased interleukin-16 levels in MS patients. Acta Neurologica Scandinavica  130: 46-52  

Ben-Nun, A., Kaushansky, N. Kawakami, N. Krishnamoorthy, G. Berer, K. Liblau, R. Hohlfeld, R. and Wekerle H. From classic to spontaneous and humanized models of multiple sclerosis: Impact on understanding pathogenesis and drug development. J Autoimmun. 2014. 54:33-50.

Berer, K., and Krishnamoorthy, G. Microbial view of central nervous system autoimmunity. FEBS Letters. 2014. 588: 4207-4213.


Mues,M., Bartholomäus, I., Thestrup, T., Griesbeck, O., Wekerle, H., Kawakami, N., Krishnamoorthy, G. Real-time in vivo analysis of T cell activation in the central nervous system using a genetically encoded calcium indicator. Nat Med.  2013. 19: 778-783.   

Wekerle, H., Berer, K., and Krishnamoorthy, G. Remote control-triggering of brain autoimmune disease in the gut. Curr Opin Immunol 2013. 25: 683-689.                    


Direnberger, S., Mues, M., Micale, V., Wotjak, C.T., Dietzel, S., Schubert, M., Scharr, A., Hassan, S., Wahl-Schott, C., Biel, M., Krishnamoorthy, G., Griesbeck, O. Biocompatibility of a genetically encoded calcium indicator in a transgenic mouse model. Nat Commun. 2012. 3, 1031.

Berer, K., Krishnamoorthy, G. Commensal gut flora and brain autoimmunity: a love or hate affair? Acta Neuropathologica 2012.1-13.

Wekerle, H., and Krishnamoorthy, G.  Brain autoimmunity: The CD8 Question(s)Immunity 2012. 37: 8-10. 


Berer, K., Mues, M., Koutroulos, M., Al Rasbi, Z., Boziki, M., Johner, C., Wekerle, H., Krishnamoorthy,G. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 2011. 479:538-541.                                                  

Varadarajulu, J., Lebar, M., Krishnamoorthy, G., Habelt, S., Lu, J., Bernard, W, I., Li, H., Holsboer, F., Turck, CW., Touma, C.  Increased anxiety-related behaviour in Hint1 knockout mice. Behav Brain Res. 2011.220:305-311.                                                

Fitzner, D., Schnaars, M., van, RD., Krishnamoorthy, G., Dibaj, P., Bakhti, M., Regen, T., Hanisch, UK., Simons, M. Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis. J Cell Sci. 2011.124:447-458.

Berer, K., Wekerle, H., and Krishnamoorthy, G.  B cells in spontaneous autoimmune diseases of the central nervous system. Mol Immunol 2011.48:1332-1337


Domingues, H. S., Mues, M., Lassmann, H., Wekerle, H., Krishnamoorthy, G.  Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. PLoS ONE 2010. 5(11): e15531.


Krishnamoorthy, G., Saxena, A., Mars, L. T., Domingues, H. S., Mentele, R., Ben-Nun, A., Lassmann, H., Dornmair, K., Kurschus, F. C., Liblau, R. S., Wekerle, H. Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis. Nat Med 2009. 15: 626-632.

Pollinger, B., Krishnamoorthy, G., Berer, K., Lassmann, H., Bosl, M. R., Dunn, R., Domingues, H. S., Holz, A., Kurschus, F. C., Wekerle, H. Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. J Exp Med. 2009.206: 1303-1316.

Krishnamoorthy, G., and Wekerle, H. EAE: an immunologist's magic eyeEur J Immunol 2009. 39: 2031-2035. 


Krishnamoorthy, G., Holz, A., and Wekerle, H. Experimental models of spontaneous autoimmune disease in the central nervous system. J Mol Med 2007. 85: 1161-1173.


Krishnamoorthy, G., Lassmann, H., Wekerle, H., Holz, A.  Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation. J Clin Invest 2006. 116: 2385-2392.


Gullapalli, S., Gurumoorthy, K., Kaul, C. L., and Ramarao, P. Role of L-type Ca2+ channels in attenuated morphine antinociception in streptozotocin-diabetic rats. Eur J Pharmacol 2002. 435: 187-194.  

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