Contact

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Dr. Gurumoorthy Krishnamoorthy
Group leader
Phone:+49-89-8578 2464
Email:guru@...

MPI of Biochemistry,
Am Klopferspitz 18, 82152 Martinsried

http://www.biochem.mpg.de/krishnamoorthy

Publications

2017

Berer, K., Gerdes, L. A., Cekanaviciute, E., Jia, X., Xiao, L., Xia, Z., Liu, C., Klotz, L., Stauffer, U., Baranzini, S. E., Kümpfel, T., Hohlfeld, R., Krishnamoorthy, G*., Wekerle, H*. (2017). Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A.                                                                 *Corresponding authors

2015

Rumble, J. M., Huber, A. K., Krishnamoorthy, G., Srinivasan, A., Giles, D. A., Zhang, X., Wang, L., Segal, B. M. 2015. Neutrophil-related factors as biomarkers in EAE and MS. J Exp Med. 212, 23-35

2014

Koutrolos, M., Berer, K., Kawakami, N., Wekerle, H., Krishnamoorthy, G. 2014. Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS. Acta Neuropathol Commun. 2: 163.

Eberle, M., Ebel, P., Wegner, M.-S., Männich, J., Tafferner, N., Ferreiros, N., Birod, K., Schreiber, Y., Krishnamoorthy, G., Willecke, K., Geisslinger, G., Grösch, S., Schiffmann, S. 2014. Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent. Biochem Pharmacol 92: 326-335.

Berer, K., Boziki, M., Krishnamoorthy, G.  Selective accumulation of pro-inflammatory T cells in the intestine contributes to the resistance to autoimmune demyelinating disease. PLoS ONE 2014. 9 (2), e87876. 

Nischwitz, S., Faber, H., Sämann, P.G., Domingues, H.S., Krishnamoorthy, G., Knop, M., Müller-Sarnowski, F., Yassouridis, A., Weber, F. 2014. Interferon beta-1a reduces increased interleukin-16 levels in MS patients. Acta Neurologica Scandinavica  130: 46-52  

Ben-Nun, A., Kaushansky, N. Kawakami, N. Krishnamoorthy, G. Berer, K. Liblau, R. Hohlfeld, R. and Wekerle H. From classic to spontaneous and humanized models of multiple sclerosis: Impact on understanding pathogenesis and drug development. J Autoimmun. 2014. 54:33-50.

Berer, K., and Krishnamoorthy, G. Microbial view of central nervous system autoimmunity. FEBS Letters. 2014. 588: 4207-4213.

2013

Mues,M., Bartholomäus, I., Thestrup, T., Griesbeck, O., Wekerle, H., Kawakami, N., Krishnamoorthy, G. Real-time in vivo analysis of T cell activation in the central nervous system using a genetically encoded calcium indicator. Nat Med.  2013. 19: 778-783.   

Wekerle, H., Berer, K., and Krishnamoorthy, G. Remote control-triggering of brain autoimmune disease in the gut. Curr Opin Immunol 2013. 25: 683-689.                    

2012

Direnberger, S., Mues, M., Micale, V., Wotjak, C.T., Dietzel, S., Schubert, M., Scharr, A., Hassan, S., Wahl-Schott, C., Biel, M., Krishnamoorthy, G., Griesbeck, O. Biocompatibility of a genetically encoded calcium indicator in a transgenic mouse model. Nat Commun. 2012. 3, 1031.

Berer, K., Krishnamoorthy, G. Commensal gut flora and brain autoimmunity: a love or hate affair? Acta Neuropathologica 2012.1-13.

Wekerle, H., and Krishnamoorthy, G.  Brain autoimmunity: The CD8 Question(s)Immunity 2012. 37: 8-10. 

2011

Berer, K., Mues, M., Koutroulos, M., Al Rasbi, Z., Boziki, M., Johner, C., Wekerle, H., Krishnamoorthy,G. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 2011. 479:538-541.                                                  

Varadarajulu, J., Lebar, M., Krishnamoorthy, G., Habelt, S., Lu, J., Bernard, W, I., Li, H., Holsboer, F., Turck, CW., Touma, C.  Increased anxiety-related behaviour in Hint1 knockout mice. Behav Brain Res. 2011.220:305-311.                                                

Fitzner, D., Schnaars, M., van, RD., Krishnamoorthy, G., Dibaj, P., Bakhti, M., Regen, T., Hanisch, UK., Simons, M. Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis. J Cell Sci. 2011.124:447-458.

Berer, K., Wekerle, H., and Krishnamoorthy, G.  B cells in spontaneous autoimmune diseases of the central nervous system. Mol Immunol 2011.48:1332-1337

2010

Domingues, H. S., Mues, M., Lassmann, H., Wekerle, H., Krishnamoorthy, G.  Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. PLoS ONE 2010. 5(11): e15531.

2009

Krishnamoorthy, G., Saxena, A., Mars, L. T., Domingues, H. S., Mentele, R., Ben-Nun, A., Lassmann, H., Dornmair, K., Kurschus, F. C., Liblau, R. S., Wekerle, H. Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis. Nat Med 2009. 15: 626-632.

Pollinger, B., Krishnamoorthy, G., Berer, K., Lassmann, H., Bosl, M. R., Dunn, R., Domingues, H. S., Holz, A., Kurschus, F. C., Wekerle, H. Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. J Exp Med. 2009.206: 1303-1316.

Krishnamoorthy, G., and Wekerle, H. EAE: an immunologist's magic eyeEur J Immunol 2009. 39: 2031-2035. 

2007

Krishnamoorthy, G., Holz, A., and Wekerle, H. Experimental models of spontaneous autoimmune disease in the central nervous system. J Mol Med 2007. 85: 1161-1173.

2006

Krishnamoorthy, G., Lassmann, H., Wekerle, H., Holz, A.  Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation. J Clin Invest 2006. 116: 2385-2392.

2002

Gullapalli, S., Gurumoorthy, K., Kaul, C. L., and Ramarao, P. Role of L-type Ca2+ channels in attenuated morphine antinociception in streptozotocin-diabetic rats. Eur J Pharmacol 2002. 435: 187-194.  

 
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