Contact

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Dr. Gurumoorthy Krishnamoorthy
Group leader
Phone:+49-89-8578 2464
Email:guru@...

MPI of Biochemistry,
Am Klopferspitz 18, 82152 Martinsried

http://www.biochem.mpg.de/krishnamoorthy

Research

The factors responsible for the onset of MS are unknown. Microbial infections were commonly suspected as triggers of autoimmune diseases. However, there is an increase of MS incidence in western countries with decreasing prevalence of infections. To study the factors responsible for the spontaneous EAE onset, we compared germ-free (GF) (devoid of intestinal flora) and conventionally raised mice (SPF). [More]

Triggers of autoimmunity: a key role for gut flora

The factors responsible for the onset of MS are unknown. Microbial infections were commonly suspected as triggers of autoimmune diseases. However, there is an increase of MS incidence in western countries with decreasing prevalence of infections. To study the factors responsible for the spontaneous EAE onset, we compared germ-free (GF) (devoid of intestinal flora) and conventionally raised mice (SPF). [More]

It is becoming increasingly clear that both innate and adaptive immune responses are crucial initiators and drivers of multiple sclerosis (MS). The supporting evidence includes the following: immune cells infiltrating active MS lesions present signs of active reactivity; most risk genes favoring MS are involved in the control of (auto-)immune responses; in some subtypes of MS target autoantigens have been identified; and immunomodulatory therapies are beneficial in early stages of MS. [More]

Regulation of autoimmunity

It is becoming increasingly clear that both innate and adaptive immune responses are crucial initiators and drivers of multiple sclerosis (MS). The supporting evidence includes the following: immune cells infiltrating active MS lesions present signs of active reactivity; most risk genes favoring MS are involved in the control of (auto-)immune responses; in some subtypes of MS target autoantigens have been identified; and immunomodulatory therapies are beneficial in early stages of MS. [More]

In experimental studies, MS-like disease is typically induced in rodents either by active immunization using overwhelmingly strong immune adjuvants or injection of large numbers of pre-activated myelin-specific lymphocytes. These models, collectively termed as Experimental autoimmune encephalomyelitis (EAE), partially mimic. [More]

Transgenic models of nervous system autoimmunity

In experimental studies, MS-like disease is typically induced in rodents either by active immunization using overwhelmingly strong immune adjuvants or injection of large numbers of pre-activated myelin-specific lymphocytes. These models, collectively termed as Experimental autoimmune encephalomyelitis (EAE), partially mimic. [More]

 

 
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